Otozomal dominant polikistik böbrek hastalığında ürogenital kistlerin semen parametreleri üzerine etkisi var mı ?

WOS: 000374928100006OBJECTIVE: Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disease with cysts in many organs including the urogenital tract. The aim of the study was to evaluate the relationship between urogenital cysts, semen pathologies and infertility in ADPKD. MATERIAL and METHODS: Male ADPKD patients aged 18-60 with creatinine clearance years higher than 60 ml/min were included. All patients had magnetic resonance imaging of the urinary system and pelvis, scrotal Doppler ultrasonography and sperm analysis. The results were compared with those of a healthy control group. RESULTS: 27 patients and 17 volunteers were included. Seminal vesicle and prostate cysts were detected in four (15%) and six (22%) patients, respectively. Five of the 23 married patients (21%) had infertility and this rate was higher than in the control group (p=0.044). The ratio of sperms with normal morphology and progressive motility was lower, and the rate of hypospermia, oligozoospermia, azospermia, asthenozoospermia and teratozoospermia were higher in the patient group. There was no significant difference between patients with/without urogenital cysts regarding seminal pathologies. CONCLUSION: Seminal abnormalities and infertility are more frequent in patients with ADPKD. Defects in spermatogenesis and sperm motility may be related to urogenital cysts as well as ciliary pathologies. There is a need for further studies evaluating the role of urogenital cysts in semen pathologies.AMAÇ: Otozomal dominant polikistik böbrek hastalığı (ODPBH) ürogenital sistemle birlikte birçok organda kist oluşumuna neden olabilen sistemik bir hastalıktır. Çalışmada, ODPBH olan bireylerde ürogenital kistler ile semen patolojileri ve infertilite ilişkisi değerlendirilmiştir. GEREÇ ve YÖNTEMLER: Çalışmaya 18-60 yaşları arasında, kreatinin klirensi 60 ml/dakika/1.73 m2’nin üzerinde, ODPBH olan erkekler dahil edildi. Tüm hastalara üriner sistem ve pelvik manyetik rezonans(MR) inceleme, skrotal Doppler ultrasonografi ve semen analizi yapıldı. Sonuçlar sağlıklı kontrol grubu ile karşılaştırıldı. BULGULAR: Yirmiyedi hasta ve 17 gönüllü çalışmaya dahil edildi. Seminal vezikül kisti 4(%15), prostat kisti 6 (%22) hastada tespit edildi. Kontrol grubundan daha sık olarak, evli olan 23 hastanın 5’inde (%21) infertilite mevcuttu (p=0.044). Normal morfolojili sperm oranları ve ileri motilite daha düşük, hipospermi, oligozoospermi, azospermi, asthenozoospermi ve teratozoospermi oranları hasta grubunda daha yüksekti. Ürogenital kisti olan/olmayan hastalarda semen patolojileri açısından anlamlı fark yoktu. SONUÇ: Seminal anormallikler ve infertilite ODPBH olanlarda daha sıktır. Spermatogenez ve sperm motilite defektleri siliar patolojiler gibi urogenital kistlerle ilişkili olabilir. Ürogenital kistlerin semen patolojilerindeki rolünü değerlendirmek için ileri çalışmalara ihtiyaç vardır

Uniesienie odcinka ST w odprowadzeniu aVR podczas próby wysiłkowej może wskazywać na zwężenie pnia lewej tętnicy wieńcowej

Background: Exercise treadmill testing (ETT) is the most widely used method for evaluating patients with coronary artery disease. Predicting the left main coronary artery (LMCA) disease before invasive procedures is very important in risk assessment because of its severe clinical outcome. Aim: To examine whether ST elevation in lead aVR during ETT may suggest LMCA disease since the lead aVR is the reciprocal lead of LMCA. Methods: In this study, 61 patients with positive ETT were included. The study group consisted of 21 patients with ST elevation in lead aVR. Forty patients, also having positive ETT, but without ST elevation in lead aVR comprised the control group. All patients underwent coronary angiography. Results: Coronary angiography in the study group revealed significant LMCA stenosis in 16 (76%) patients, whereas LMCA disease was present in only 3 (8%) patients from the control group. There was no significant coronary artery stenosis in 5 patients in the study group and 12 patients in the control group. Of the 16 patients who had LMCA stenosis, 9 had isolated LMCA disease and 7 had additional stenotic lesions in LAD or circumflex coronary arteries. The sensitivity and specificity of ST segment elevation in lead aVR during ETT was 84% and 88%, respectively. The values of positive and negative predictive value of this finding in diagnosing the presence of LMCA were 76% and 93%, respectively. Conclusions: ST segment elevation in lead aVR during ETT may point to a high probability of the presence of LMCA disease. Kardiol Pol 2010; 68, 10: 1107-1111Wstęp: Test wysiłkowy (TW) na ruchomej bieżni jest najpowszechniej stosowaną metodą rozpoznawania choroby wieńcowej. Możliwość przewidywania zwężenia pnia lewej tętnicy wieńcowej (LTW) przed zabiegami inwazyjnymi jest bardzo ważna w ocenie ryzyka ze względu na poważne następstwa kliniczne tego stanu. Cel: Celem pracy było zbadanie, czy uniesienie odcinka ST w odprowadzeniu aVR podczas TW może wskazywać na zwężenie pnia LTW, ponieważ w tym odprowadzeniu uwidaczniają się "lustrzane" zmiany wynikające ze zwężenia pnia LTW. Metody: Do badania włączono 61 pacjentów z dodatnim wynikiem TW. Grupa badana składała się z 21 chorych z uniesieniem odcinka ST w odprowadzeniu aVR, a grupę kontrolną stanowiło 40 osób z dodatnim wynikiem TW, ale bez uniesienia odcinka ST w odprowadzeniu aVR. U wszystkich pacjentów wykonano koronarografię. Wyniki: Koronarografia wykazała istotne zwężenie pnia LTW u 16 (76%) pacjentów w grupie badanej, natomiast tylko u 3 (8%) osób w grupie kontrolnej. Istotnych zwężeń tętnic wieńcowych nie stwierdzono u 5 chorych w grupie badanej i u 12 pacjentów w grupie kontrolnej. U 9 spośród 16 pacjentów ze zwężeniem pnia LTW w grupie badanej było to izolowane zwężenie, natomiast u 7 osób występowało dodatkowo zwężenie gałęzi przedniej zstępującej lub gałęzi okalającej. Czułość i swoistość uniesienia odcinka ST w odprowadzeniu aVR podczas TW wyniosły odpowiednio 84% i 88%, a dodatnia i ujemna wartość prognostyczna tego objawu w rozpoznawaniu zwężenia pnia LTW wyniosł,y odpowiednio 76% i 93%. Wnioski: Uniesienie odcinka ST w odprowadzeniu aVR podczas TW może wskazywać z dużym prawdopodobieństwem na obecność zwężenia pnia LTW. Kardiol Pol 2010; 68, 10: 1107-111

Characteristics and Survival Data of Patients With Primary Focal Segmental Segmental Glomerulosclerosis: Tsn-Goldmulti-Center Study

60th ERA Congress -- JUN 15-18, 2023 -- Milan, ITALY[No abstract available

Incidence of Type 1 diabetes in children aged below 18 years during 2013-2015 in Northwest Turkey

Azizoglu, Mehmet (Trakya author) Dilek, Emine (Trakya author)Objective: To assess the incidence of type I diabetes mellitus (T1DM) in children under 18 years of age in the northwest region of Turkey during 2013-2015. Methods: All newly diagnosed T1DM cases were recorded prospectively during 2013-2015. Total, as well as gender and age group specific (0-4, 5-9. 10-14 and 15-17 age) mean incidences per 100,000 per year were calculated. Results: There were 1,773 patients diagnosed during 2013-2015 (588 cases in 2013, 592 cases in 2014, 593 cases in 2015). Of these, 862 (48.6 %) were girls and 911 (51.4%)were boys. The mean age at diagnosis was 9.2 +/- 4.2 years and it was not significantly different between girls (9.0 +/- 4.1 years) and boys (9.4 +/- 4.4 years) (p = 0.052). The crude mean incidence was 8.99/100.000 confidence interval (CI) (95% CI: 8.58-9.42). Although mean incidence was similar between boys [8.98/100.000 (CI: 8.40 to 9.58)] and girls [9.01/100.000 (CI: 8.42 to 9.63)], there was male predominance in all groups except for 5-9 year age group. The standardized mean incidence was 9.02/100.000 according to the World Health Organization standard population. The mean incidence for the 0-4, 5-9, 10-14 and 15-17 age groups was 6.13, 11.68, 11.7 and 5.04/1 00.000 respectively. The incidence of T1DM was similar over the course of three years (p = 0.95). A significant increase in the proportion of cases diagnosed was observed in the autumn-winter seasons. Conclusion: The northwest region of Turkey experienced an intermediate incidence of T1DM over the period of the study

Incidence of Type 1 Diabetes in Children Aged Below 18 Years during 2013-2015 in Northwest Turkey

Objective: To assess the incidence of type I diabetes mellitus (T1DM) in children under 18 years of age in the northwest region of Turkey during 2013-2015