RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Bones as an alive organ consist of about 70 mineral and 30 organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway. © 2020 Mohammad Tobeiha et al

Understanding Graphitic Carbon Nitride as Photocatalyst: A Case Study on Thermal Engineering of Physical and Chemical Features

Rationalizing material features according to the adopted synthetic strategy, aiming then to tune them on demand, is among the most relevant purposes of investigation in materials science. Herein, the systematic analysis of the dependence of graphitic carbon nitride (g-C3N4) physical characteristics on the decomposition temperature of urea, rationalizing the impact of synthetic temperature on several characteristics of the materials (degree of N–H condensation, carbon vs nitrogen content, structural parameters, photoluminescence lifetime, surface area, pores volume), is discussed. g-C3N4 nanostructures are fabricated by thermal decomposition of urea at different temperatures under ambient atmosphere, obtaining an almost ideal stoichiometry (C/N = 0.72) when setting the temperature at 600 °C. The samples show structural, textural, compositional, and optical differences directly depending on the fabrication temperature: specific surface area, pore volume and size, intralayer distance, and speed of radiative recombination of photogenerated charges are proportionally enhanced by increasing the synthesis temperature. The role played by all the physicochemical features of the prepared samples in promoting the catalytic degradation of Rhodamine B is investigated, highlighting their synergistic role in enhancing the catalytic efficiency. Significant differences in the dye degradation are recorded when using either UV or solar simulated light, demonstrating that Rhodamine B photosensitization rules the process.Validerad;2024;Nivå 2;2024-04-23 (joosat);Full text license: CC BY-NC-ND</p

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway

Understanding Graphitic Carbon Nitride as Photocatalyst: A Case Study on Thermal Engineering of Physical and Chemical Features

Rationalizing material features according to the adopted synthetic strategy, aiming then to tune them on demand, is among the most relevant purposes of investigation in materials science. Herein, the systematic analysis of the dependence of graphitic carbon nitride (g-C3N4) physical characteristics on the decomposition temperature of urea, rationalizing the impact of synthetic temperature on several characteristics of the materials (degree of N–H condensation, carbon vs nitrogen content, structural parameters, photoluminescence lifetime, surface area, pores volume), is discussed. g-C3N4 nanostructures are fabricated by thermal decomposition of urea at different temperatures under ambient atmosphere, obtaining an almost ideal stoichiometry (C/N = 0.72) when setting the temperature at 600 °C. The samples show structural, textural, compositional, and optical differences directly depending on the fabrication temperature: specific surface area, pore volume and size, intralayer distance, and speed of radiative recombination of photogenerated charges are proportionally enhanced by increasing the synthesis temperature. The role played by all the physicochemical features of the prepared samples in promoting the catalytic degradation of Rhodamine B is investigated, highlighting their synergistic role in enhancing the catalytic efficiency. Significant differences in the dye degradation are recorded when using either UV or solar simulated light, demonstrating that Rhodamine B photosensitization rules the process.Validerad;2024;Nivå 2;2024-04-23 (joosat);Full text license: CC BY-NC-ND</p