Multiscale spatial distribution of macrofauna response to fishery pressure

Trawling is one of the most damaging activities for fauna living at the ocean resulting in simultaneous pulse and chronic impacts on benthic communities on multiple spatio-temporal scales. Recently, high quality Vessel Monitoring by Satellite (VMS) data provides spatio-temporal information of swept area by fishery trawlers. Using this huge amount of information in combination with about 20 environmental descriptors, we aim to tease apart the effect of species endogenous features (i.e. dispersal capability) and exogenous factors (i.e. environmental conditions) on the fauna responses to fishery and its related spatial scales. We analyse data of 300 grab-samples taken in the German Bight (North Sea), encompassing 140 macrobenthic species collected on a regular grid over an area of about 8000 km2. We use Moran Eigenvector Maps to model patterns of potential connectivity between locations and shed light on which spatial scales fisheries, environmental characteristics, and macrobenthos are linked. Finally, we show maps of fauna response to fishery. We argue that despite the importance of proper quantification of fishing pressure and other human activities, shedding light on the effects and response to such activities is crucial for a sound understanding of the processes that shape ecosystems and diversity distribution

Wear and Migration of Highly Cross-Linked and Conventional Cemented Polyethylene Cups with Cobalt Chrome or Oxinium Femoral Heads: A Randomized Radiostereometric Study of 150 Patients

ABSTRACT: This randomized study was performed to compare wear and migration of five different cemented total hip joint articulations in 150 patients. The patients received either a Charnley femoral stem with a 22.2 mm head or a Spectron EF femoral stem with a 28 mm head. The Charnley articulated with a g-sterilized Charnley Ogee acetabular cup. The Spectron EF was used with either EtOsterilized non-cross-linked polyethylene (Reflection All-Poly) or highly cross-linked (Reflection All-Poly XLPE) cups, combined with either cobalt chrome (CoCr) or Oxinium femoral heads. The patients were followed with repeated RSA measurements for 2 years. After 2 years, the EtO-sterilized non-cross-linked Reflection All-Poly cups had more than four times higher proximal penetration than its highly cross-linked counterpart. Use of Oxinium femoral heads did not affect penetration at 2 years compared to heads made of CoCr. Further follow-up is needed to evaluate the benefits, if any, of Oxinium femoral heads in the clinical setting. The Charnley Ogee was not outperformed by the more recently introduced implants in our study. We conclude that this prostheses still represents a standard against which new implants can be measured. Osteolysis induced by wear debris of ultra-high molecular weight polyethylene (UHMWPE) is considered the most common cause for failure of total hip arthroplasties (THA). 1 Sterilization technique and UHMWPE quality are related to wear. 2 Sterilization with gamma irradiation in air breaks the polymer chains and generates free radicals. Free radicals may combine with each other creating cross-links between adjacent molecules, which reduces abrasive wear. However, they entail the disadvantage of oxidative degradation of polyethylene (PE) when exposed to the body's oxidative environment, which may lead to deterioration of mechanical properties. 3 To address the problem, sterilization methods in inert environments with ethylene oxide (EtO) or gas plasma were introduced. However, these methods do not have the benefits of cross-linking, and an earlier report showed increase in early in vivo wear after EtO sterilization. 4 Highly cross-linked polyethylenes (HXLPE) provides a considerable reduction of wear compared to conventional polyethylene (PE). Concerns of PE wear have also been addressed by introducing alternative femoral head materials. Oxidized zirconium (Oxinium, Smith & Nephew) was introduced in the last decade for use in THA. Radiostereometric analysis (RSA) enables in vivo measurement of relative 3D motion in the range of 0.1 mm and 0.058. Due to its accuracy, few patients are needed to obtain satisfactory statistical power. With RSA the degree of migration during the first years after surgery correlates with the implant's longterm performance. We wanted to evaluate wear and migration patterns of the cemented highly cross-linked Reflection All-Poly XLPE cup and its non-irradiated counterpart, the cemented Reflection All-Poly cup, when articulating with either Oxinium or traditional cobalt chrome (CoCr) femoral heads (Smith & Nephew). Our null hypothesis was that wear and migration were equal to the Charnley Ogee prostheses (DePuy Intl

Trends in demographics and outcome of patients presenting with traumatic brain injury

Objective To analyze the trends in demographics and outcomes of patients presenting with traumatic brain injury by performing a retrospective database review of the Illinois Department of Public Health (IDPH) Trauma Registry. Methods We utilized the IDPH Trauma Registry to retrieve data on patients treated for traumatic brain injuries at our large, tertiary care hospital from 2004 to 2012, inclusive. From this data, logistic regression models were used to analyze and compare basic demographics such as age, sex, and clinical outcome. Results Three thousand and thirty-nine patients were analyzed with a mean age of 43 (standard deviation, 24) and a median age of 41 (interquartile range, 23 to 60). Over the study period, patients’ age increased steadily from 32 to 49 years. The percentage of female patients increased, from 16.4% to 27.5% over the last 4 years. Overall mortality was greater for males than females (22.1% vs. 17.3%; odds ratio [OR], 1.36; 95% confidence interval [CI], 1.10 to 1.68). Mortality decreased over the period (OR, 0.88; 95% CI, 0.85 to 0.91), with a greater decrease in females (OR, 0.84; 95% CI, 0.78 to 0.90) than in males (OR, 0.90; 95% CI, 0.86 to 0.94). Conclusion Although the age of patients presenting with traumatic brain injury is increasing substantially, the data suggests that overall mortality appears to be decreasing, and this decrease appears to be greater in females than in males. These changes in trends found in the IDPH Trauma Registry supports the importance for further analysis of other reliable public datasets to identify areas of future study

Layer-by-Layer Assembled Nanowire Networks Enable Graph Theoretical Design of Multifunctional Coatings

Multifunctional coatings are central for information, biomedical, transportation and energy technologies. These coatings must possess hard-to-attain properties and be scalable, adaptable, and sustainable, which makes layer-by-layer assembly (LBL) of nanomaterials uniquely suitable for these technologies. What remains largely unexplored is that LBL enables computational methodologies for structural design of these composites. Utilizing silver nanowires (NWs), we develop and validate a graph theoretical (GT) description of their LBL composites. GT successfully describes the multilayer structure with nonrandom disorder and enables simultaneous rapid assessment of several properties of electrical conductivity, electromagnetic transparency, and anisotropy. GT models for property assessment can be rapidly validated due to (1) quasi-2D confinement of NWs and (2) accurate microscopy data for stochastic organization of the NW networks. We finally show that spray-assisted LBL offers direct translation of the GT-based design of composite coatings to additive, scalable manufacturing of drone wings with straightforward extensions to other technologies

Of babies and bath water: Is there any place for Austin and Grice in interpersonal pragmatics?

This paper discusses a particular strand of interpersonal pragmatics that may be known as ‘discursive’ pragmatics and attempts to delineate what is entailed in such an approach. Some scholars may characterise it as placing emphasis on participant evaluations, others may foreground the analysis of contextualised and sequential texts, while still others consider it to include both of these. In general, though, discursive pragmatics often seems to involve a reaction to, and a contrast with, so-called Gricean intention-based approaches. In this paper I argue that, far from discarding the insights of Grice, Austin and others, a discursive approach to interpersonal pragmatics should embrace those aspects of non-discursive pragmatics that provide us with a ‘tool-kit’ and a vocabulary for examining talk-in-interaction. At the same time, I will argue that the shortcomings of the speaker-based, intention- focused pragmatics can be compensated for, not by privileging hearer evaluations of meaning, but by taking an ethnographic and, to some extent, ethnomethodological approach to the analysis of naturally-occurring discourse data. By providing a critique of Locher and Watts’ (2005) paradigmatic example of a discursive approach to politeness and then a sample analysis of interactional data, I demonstrate how a combination of insights from Gricean pragmatics and from ethnomethodology allows the analyst to comment on the construction and negotiation of meaning in discourse, without having recourse to notions of either intention or evaluation

IL‐27 and TGFβ mediated expansion of Th1 and adaptive regulatory T cells expressing IL‐10 correlates with bacterial burden and disease severity in pulmonary tuberculosis

CD4(+) T cell expression of IL-10 is an important mechanism controlling immunity to tuberculosis (TB). To identify the CD4(+) T cell subsets producing IL-10 in human TB, we enumerated the frequencies of IL-10 expressing CD4(+) T cell subsets following TB—antigen stimulation of cells from individuals with pulmonary (PTB) and latent TB (LTB). We first demonstrate that TB antigens induce an expansion of IL-10 expressing Th1 (IL-10(+), IFNγ(+), T-bet(+)), Th2 (IL-10(+), IL-4(+), GATA-3(+)), Th9 (IL-10(+), IL-9(+), IL-4(−)), Th17 (IL-10(+), IL-17(+), IFNγ(−)), and natural and adaptive regulatory T cells [nTregs; IL-10(+), CD4(+), CD25(+), Foxp3(+) and aTregs; IL-10 single(+), CD4(+), CD25(−), Foxp3(−)] in PTB and LTB individuals, with frequencies being significantly higher in the former. However, only Th1 cells and adaptive Tregs expressing IL-10 exhibit a positive relationship with bacterial burdens and extent of disease in PTB. Finally, we show that IL-27 and TGFβ play an important role in the regulation of IL-10(+) Th cell subsets. Thus, active PTB is characterized by an IL-27 and TGFβ mediated expansion of IL-10 expressing CD4(+) T cell subsets, with IL-10(+) Th1 and IL-10(+) aTreg cells playing a potentially pivotal role in the pathogenesis of active disease

A randomized study on migration of the Spectron EF and the Charnley flanged 40 cemented femoral components using radiostereometric analysis at 2 years

Background and purpose: We performed a randomized study to determine the migration patterns of the Spectron EF femoral stem and to compare them with those of the Charnley stem, which is regarded by many as the gold standard for comparison of implants due to its extensive documentation. Patients and methods: 150 patients with a mean age of 70 years were randomized, single-blinded, to receive either a cemented Charnley flanged 40 monoblock, stainless steel, vaquasheen surface femoral stem with a 22.2-mm head (n = 30) or a cemented Spectron EF modular, matte, straight, collared, cobalt-chrome femoral stem with a 28-mm femoral head and a roughened proximal third of the stem (n = 120). The patients were followed with repeated radiostereometric analysis for 2 years to assess migration. Results: At 2 years, stem retroversion was 2.3° and 0.7° (p < 0.001) and posterior translation was 0.44 mm and 0.17 mm (p = 0.002) for the Charnley group (n = 26) and the Spectron EF group (n = 74), respectively. Subsidence was 0.26 mm for the Charnley and 0.20 mm for the Spectron EF (p = 0.5). Interpretation: The Spectron EF femoral stem was more stable than the Charnley flanged 40 stem in our study when evaluated at 2 years. In a report from the Norwegian arthroplasty register, the Spectron EF stem had a higher revision rate due to aseptic loosening beyond 5 years than the Charnley. Initial stability is not invariably related to good long-term results. Our results emphasize the importance of prospective long-term follow-up of prosthetic implants in clinical trials and national registries and a stepwise introduction of implants

Strongyloides stercoralis Coinfection Is Associated With Greater Disease Severity, Higher Bacterial Burden, and Elevated Plasma Matrix Metalloproteinases in Pulmonary Tuberculosis

BACKGROUND: Helminths and tuberculosis (TB) largely overlap at the population level. Whether helminth infections influence disease severity and bacterial burdens in TB is not well understood. METHODS: This study was conducted to examine the disease severity in a cohort of pulmonary TB (PTB) individuals with (Ss+) or without (Ss−) seropositivity for Strongyloides stercoralis infection. RESULTS: Ss+ was associated with increased risk of cavitation (odds ratio [OR], 4.54; 95% confidence interval [CI], 2.33–9.04; P < .0001) and bilateral lung involvement (OR, 5.97; 95% CI, 3.03–12.09; P < .0001) in PTB individuals. Ss+ was also associated with higher bacterial burdens (OR, 7.57; 95% CI, 4.18–14.05; P < .0001) in PTB individuals. After multivariate analysis adjusting for covariates, Ss+ was still associated with greater risk of cavitation (adjusted OR [aOR], 3.99; 95% CI, 1.73–9.19; P = .0014), bilateral lung involvement (aOR, 4.09; 95% CI, 1.78–9.41; P = .0011), and higher bacterial burden (aOR, 9.32; 95% CI, 6.30–13.96; P < .0001). Finally, Ss+ was also associated with higher plasma levels of matrix metalloproteinases ([MMP]-1, -2, -7, -8, and -9) in PTB individuals. CONCLUSIONS: Therefore, our data demonstrate that coexistent Ss infection is associated with greater disease severity and higher bacterial burden in PTB. Our data also demonstrate enhanced plasma levels of MMPs in coinfected individuals, suggesting a plausible biological mechanism for these effects

Neuroprotective Actions of Estradiol and Novel Estrogen Analogs in Ischemia: Translational Implications

This review highlights our investigations into the neuroprotective efficacy of estradiol and other estrogenic agents in a clinically relevant animal model of transient global ischemia, which causes selective, delayed death of hippocampal CA1 neurons and associated cognitive deficits. We find that estradiol rescues a significant number of CA1 pyramidal neurons that would otherwise die in response to global ischemia, and this is true when hormone is provided as a long-term pretreatment at physiological doses or as an acute treatment at the time of reperfusion. In addition to enhancing neuronal survival, both forms of estradiol treatment induce measurable cognitive benefit in young animals. Moreover, estradiol and estrogen analogs that do not bind classical nuclear estrogen receptors retain their neuroprotective efficacy in middle-aged females deprived of ovarian hormones for a prolonged duration (8 weeks). Thus, non-feminizing estrogens may represent a new therapeutic approach for treating the neuronal damage associated with global ischemia