Study of the Problems of Persons with Disability (PWD) Using FRMs

In this paper authors find the interrelations and the hidden pattern of the problems faced by the PWDs and their caretakers using Fuzzy Relational Maps (FRMs). Here they have taken the problems faced by the rural persons with disabilities in Melmalayanur and Kurinjipadi Blocks, Tamil Nadu, India

On adjacent vertex distinguishing total coloring of quadrilateral snake

In this paper, we prove the existence of the adjacent vertex distinguishing total coloringnof quadrilateral snake, double quadrilateral snake, alternate quadrilateral snake and double alternate quadrilateral snake in detail. Also, we present an algorithm to obtain the adjacent vertex distinguishing total coloring of these quadrilateral graph family. The minimum number of colors required to give an adjacent vertex distinguishing total coloring (abbreviated as AVDTC) to the graph G is denoted by avt(G)

Odd and Even Ratio Edge Antimagic Labeling

In this paper we introduce a new labeling namely odd and even ratio edge antimagic labeling and study the existence of this labeling for basic graph structures .&nbsp

Consensus guidelines for the use and interpretation of angiogenesis assays

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference

A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression

Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the activation of tumour promoting target genes such as VEGF, MMPs, Flt-1, Ang-1 etc. which plays a pivotal role in adaptation of tumour cells to hypoxia. Increased HIF-α and its nuclear translocation have been correlated with pronounced angiogenesis, aggressive tumour growth and poor patient prognosis leading to current interest in HIF-1α as an anticancer drug target. Benzophenone-1B (4-(1H-benzimidazol-2-ylmethoxy)-3,5-dimethylphenyl-(4-methoxyphenyl) methanone, or BP-1B) is a new antineoplastic agent with potential angiopreventive effects. Current investigation reports the cellular biochemical modulation underlying BP-1B cytotoxic/antiangiogenic effects. Experimental evidences postulate that BP-1B exhibits the tumour specific cytotoxic actions against various cancer types with prolonged action. Moreover BP-1B efficiently counteracts endothelial cell capillary formation in in-vitro, in-vivo non-tumour and tumour angiogenic systems. Molecular signaling studies reveal that BP-1B arrests nuclear translocation of HIF-1α devoid of p42/44 pathway under CoCl2 induced hypoxic conditions in various cancer cells thereby leading to abrogated HIF-1α dependent activation of VEGF-A, Flt-1, MMP-2, MMP -9 and Ang-1 angiogenic factors resulting in retarded cell migration and invasions. The in-vitro results were reproducible in the reliable in-vivo solid tumour model. Taken together, we conclude that BP-1B impairs angiogenesis by blocking nuclear localization of HIF-1α which can be translated into a potent HIF-1α inhibitor