An economic analysis of grid-connected residential solar photovoltaic power systems

Prepared for the United States Dept. of Energy under Contract no. EX-76-A-01-2295, Task order 37.The question of the utility grid-connected residential market for photovoltaics is examined from a user-ownership perspective. The price is calculated at which the user would be economically indifferent between having a photovoltaic system and not having a system. To accomplish this, a uniform methodology is defined to determine the value to the user-owner of weather-dependent electric generation technologies. Two models are implemented for three regions of the United States, the first of which is a previously developed simulation of a photovoltaic residence. The second is an economic valuation model which is required to translate the ouputs from the simulation into breakeven array prices. Special care is taken to specify the input assumptions used in the models. The accompanying analysis includes a method for analyzing the year-to-year variation in hourly solar radiation data and a discussion of the appropriate discount rate to apply to homeowner investments in photovoltaic systems. The results of this study indicate that for the regions characterized by Boston, Omaha, and Phoenix, under the assumptions noted, photovoltaic module breakeven costs for the residential application are in the range of $.68,$.43 and $1.27 per peak system watt respectively (.42, .24, .89 per peak module watt)

A High Performance H2-Cl2 Fuel Cell for Space Power Applications

NASA has numerous airborne/spaceborne applications for which high power and energy density power sources are needed. The proton exchange membrane fuel cell (PEMFC) is an attractive candidate for such a power source. PEMFC's offer many advantages for airborne/spaceborne applications. They have high power and energy densities, convert fuel to electrical power with high efficiency at both part and full load, and can rapidly startup and shutdown. In addition, PEMFC's are lightweight and operate silently. A significant impediment to the attainment of very high power and energy densities by PEMFC's is their current exclusive reliance on oxygen as the oxidant. Conventional PEMFC's oxidize hydrogen at the anode and reduce oxygen at the cathode. The electrode kinetics of oxygen reduction are known to be highly irreversible, incurring large overpotential losses. In addition, the modest open circuit potential of 1.2V for the H2-O2 fuel cell is unattainable due to mixed potential effects at the oxygen electrode. Because of the high overpotential losses, cells using H2 and O2 are capable of achieving high current densities only at very low cell voltages, greatly curtailing their power output. Based on experimental work on chlorine reduction in a gas diffusion electrode, we believe significant increases in both the energy and power densities of PEMFC systems can be achieved by employing chlorine as an alternative oxidant

Inductively coupled argon plasma as an ion source for mass spectrometric determination of trace elements

Solution aerosols are injected into an inductlvety coupled argon plasma (ICP) to generate a relatively high number density of positive ions derived from elemental constituents. A small fraction of these ions is extracted through a sampling orifice into a differentially pumped vacuum system housing an ion lens and quadrupole mass spectrometer. The positive ion mass spectrum obtained during nebullration of a typical solvent (1 % HNO, in H20) consists mainly of ArH\u27, Ar\u27, H30+, H20+, NO\u27, 02\u27, HO+, Ar2\u27, Ar2H+, and Ar2+. The mass spectra of the trace elements studied consist principally of singly charged monatomic (M\u27) or oxide (MO\u27) ions in the correct relatlve isotopic abundances. Analytical calibration curves obtained in an integration mode show a working range covering nearly 4 orders of magnitude with detection limits of 0.002-0.06 pg/mL for those elements studied. This approach offers a direct means of performing trace elemental and isotopic determinations on solutions by mass spectrometry

The performance and durability of single-layer sol-gel anti-reflection coatings applied to solar module cover glass

A significant source of energy loss in photovoltaic (PV) modules is caused by reflection from the front cover glass surface. Reflection from the cover glass causes a loss of ~4% at the air-glass interface. Only a single air-glass interface can be coated on crystalline silicon solar modules as an ethylene-vinyl acetate (EVA) layer is inserted between the cover glass and the silicon absorber. A single-layer anti-reflection coating (ARC) on the outer surface of the cover glass is effective at reducing reflection losses over the wavelength range of most PV devices. The coating investigated in this work reduces the reflectance loss at the glass surface by 74%. However, the long-term durability of sol-gel coatings has not been established particularly for use in hot and humid climates. In this work, we investigate the damage resistance of a single-layer closed-surface hard coat ARC, deposited using sol-gel methods by applying a variety of accelerated weathering, scratch and abrasion test methods. The reflectance of the sol-gel ARC was measured and then the coating was put through a series of durability and environmental tests. The coating is resistant to damage from heating and can withstand temperatures higher than the phase change temperature of soda-lime glass. Scratch testing demonstrated that the sol-gel AR is relatively hard and difficult to remove from the substrate surface. Pull tests and cross-hatch testing also confirmed the strong adhesion of the coating. Weathering experiments show some degradation in weighted average reflectance, particularly an increase in reflectance of 0.6–0.9% after 1000 h of exposure to damp heat. Testing also showed a vulnerability to exposure to acid. These results indicate that the performance of this type of ARC could deteriorate and possibly delaminate in humid climate conditions The ARC had a low water contact angle, which means the coatings are hydrophilic and, therefore, hygroscopic increasing the risk of water damage over extended periods of time. This work shows that sol-gel anti-reflection coatings are currently unsuitable for use on PV and are unlikely to remain durable across the 25 year industry standard

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Tracking genomic cancer evolution for precision medicine: The Lung TRACERx Study

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types

Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

The electrocardiographic QRS duration, a measure of ventricular depolarization and conduction, is associated with cardiovascular mortality. While single nucleotide polymorphisms (SNPs) associated with QRS duration have been identified at 22 loci in populations of European descent, the genetic architecture of QRS duration in non-European populations is largely unknown. We therefore performed a genome-wide association study (GWAS) meta-analysis of QRS duration in 13,031 African Americans from ten cohorts and a transethnic GWAS meta-analysis with additional results from populations of European descent. In the African American GWAS, a single genome-wide significant SNP association was identified (rs3922844, P = 4 × 10−14) in intron 16 of SCN5A, a voltage-gated cardiac sodium channel gene. The QRS-prolonging rs3922844 C allele was also associated with decreased SCN5A RNA expression in human atrial tissue (P = 1.1 × 10−4). High density genotyping revealed that the SCN5A association region in African Americans was confined to intron 16. Transethnic GWAS meta-analysis identified novel SNP associations on chromosome 18 in MYL12A (rs1662342, P = 4.9 × 10−8) and chromosome 1 near CD1E and SPTA1 (rs7547997, P = 7.9 × 10−9). The 22 QRS loci previously identified in populations of European descent were enriched for significant SNP associations with QRS duration in African Americans (P = 9.9 × 10−7), and index SNP associations in or near SCN5A, SCN10A, CDKN1A, NFIA, HAND1, TBX5 and SETBP1 replicated in African Americans. In summary, rs3922844 was associated with QRS duration and SCN5A expression, two novel QRS loci were identified using transethnic meta-analysis, and a significant proportion of QRS–SNP associations discovered in populations of European descent were transferable to African Americans when adequate power was achieved