Precipitation In The Central Amazon Basin: - The Isotopic Composition Of Rain And Atmospheric Moisture At Belém And Manaus

In order to improve the understanding of the water in the Amazon Basin, samples of rain and moisture were collected daily at Belém and Manaus from August 78 to January 80. All isotope data are presented. The most depleted values, sometimes lower than - 10‰ in δ18O at Belém or Manaus, were encountered during the rainy season (January-April). Possible causes of the seasonal differences in tne isotope pattern are discussed.No período de agosto de 1978 a janeiro de 1980, foram feitas coletas diárias de amostras de águas de chuva e de vapor d'água do ar em Belém e Manaus, a fim de ampliar os conhecimentos a cerca de parâmetros ligados ao ciclo da água na bacia Amazônica. Estão apresentados os dados isotópicos referentes as amostras. Os valores mais negativos ocorreram durante o período chuvoso (janeiro-abril), atingindo muitas vezes, valores de δ18O menores do que - 10‰. São discutidas as possíveis causas dessas composições.", 'p

Active debris multi-removal mission concept based on hybrid propulsion

During the last 40 years, the mass of the artificial objects in orbit increased quite steadily at the rate of about 145 metric tons annually, leading to about 7000 metric tons. Most of the cross-sectional area and mass (97% in low Earth orbit) is concentrated in about 4500 intact abandoned objects plus a further 1000 operational spacecraft. Analyses have shown that the most effective mitigation strategy should focus on the disposal of objects with larger cross-sectional area and mass from densely populated orbits. Recent NASA results have shown that the worldwide adoption of mitigation measures in conjunction with active yearly removal of approximately 0.2–0.5% of the abandoned objects would stabilize the debris population. Targets would have typical masses between 500 and 1000 kg in the case of spacecraft, and of more than 1000 kg for rocket upper stages. In the case of Cosmos-3M second stages, more than one object is located nearly in the same orbital plane. This provides the opportunity of multi-removal missions, more suitable for yearly removal rate and cost reduction needs. This paper deals with the feasibility study of a mission for the active removal of large abandoned objects in low Earth orbit. In particular, a mission is studied in which the removal of two Cosmos-3M second stages, that are numerous in low Earth orbit, is considered. The removal system relies on a Chaser spacecraft which performs rendezvous maneuvers with the two targets. The first Cosmos-3M stage is captured and an autonomous de-orbiting kit, carried by the Chaser, is attached to it. The de-orbiting kit includes a Hybrid Propulsion Module, which is remotely ignited to perform stage disposal and controlled reentry after Chaser separation. Then, the second Cosmos-3M stage is captured and, in this case, the primary propulsion system of the Chaser is used for the disposal of the mated configuration. Critical mission aspects and related technologies are investigated at a preliminary level. In particular, an innovative electro-adhesive system for target capture, a mechanical system for the hard docking with the target and a hybrid propulsion system suitable for rendezvous, de-orbiting and controlled reentry operations are analyzed. This is performed on the basis of a preliminary mission profile, in which suitable rendezvous and disposal strategies have been considered and investigated by numerical analysis. A preliminary system mass budget is also performed, showing that the Chaser overall mass is about 1350 kg, including a primary propulsion system of about 300 kg and a de-orbiting kit with a mass of about 200 kg. This system is suitable to be launched with VEGA, actually the cheapest European space launcher

Active debris removal space mission concepts based on hybrid propulsion

During the last 40 years, the mass of the artificial objects in orbit increased quite steadily at the rate of about 145 metric tons annually, leading to a about 7000 metric tons. Most of the cross-sectional area and mass (97% in LEO) is concentrated in about 4500 intact abandoned objects plus a further 1000 operational spacecrafts. Analyses have shown that the most effective mitigation strategy should focus on the disposal of objects with larger cross-sectional area and mass from densely populated orbits. Recent NASA results have shown that worldwide adoption of mitigation measures in conjunction with active yearly removal of approximately 0.1% of the abandoned objects would stabilize the debris population. Targets would have typical masses between 500 and 1000 kg in the case of spacecraft, and of more than 1000 kg for rocket upper stages. In the case of Cosmos-3M 2nd stages, more than one object are located nearly in the same orbital plane. This provides the opportunity of multi-removal missions, more suitable for yearly removal rate and cost reduction needs. This paper identifies the requirements of two alternative space mission concepts for multiple active removal of large debris objects from LEO, as well as at investigating related technological and operational issues. The first concept relies on flying a multi-removal space platform carrying a number of Hybrid Engine Modules (HEMs) to dock with the pre-selected targets, according to a pre-fixed removal sequence. Each target is then de-orbited in a controlled way by firing the attached HEM package. Alternatively, the partial contribution of the atmospheric drag could be exploited to perform a cost-free altitude lowering. In this respect, the primary propulsion system of the multi-removal space platform could be used to leave the targeted debris into an orbit where the atmosphere effect is significant and a HEM could be attached on it for the atmospheric reentry. In such a way, thanks to the natural decay, the final burn for a controlled reentry will require less Delta-V. This second option introduces the question of in-orbit HEM aging, though a significant mass saving is expected, depending on mission details. With reference to the alternative mission concepts, particular attention will be given to multiple removal feasibility. These aspects will be investigated by using analytical models and numerical simulations. In addition, technological solutions relevant to mission and system aspects will be identified. Results will be used to compare the different mission concepts

A Combined Study on the Use of the Child Behavior Checklist 1½–5 for Identifying Autism Spectrum Disorders at 18 Months

The capacity of the Child Behavior Checklist 1½–5 (CBCL 1½–5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology

Hadronic final states in deep-inelastic scattering with Sherpa

We extend the multi-purpose Monte-Carlo event generator Sherpa to include processes in deeply inelastic lepton-nucleon scattering. Hadronic final states in this kinematical setting are characterised by the presence of multiple kinematical scales, which were up to now accounted for only by specific resummations in individual kinematical regions. Using an extension of the recently introduced method for merging truncated parton showers with higher-order tree-level matrix elements, it is possible to obtain predictions which are reliable in all kinematical limits. Different hadronic final states, defined by jets or individual hadrons, in deep-inelastic scattering are analysed and the corresponding results are compared to HERA data. The various sources of theoretical uncertainties of the approach are discussed and quantified. The extension to deeply inelastic processes provides the opportunity to validate the merging of matrix elements and parton showers in multi-scale kinematics inaccessible in other collider environments. It also allows to use HERA data on hadronic final states in the tuning of hadronisation models.Comment: 32 pages, 22 figure

Changes in socioeconomic resources and mental health after the second COVID-19 wave (2020-2021): a longitudinal study in Switzerland

BACKGROUND: During the 2020/2021 winter, the labour market was under the impact of the COVID-19 pandemic. Changes in socioeconomic resources during this period could have influenced individual mental health. This association may have been mitigated or exacerbated by subjective risk perceptions, such as perceived risk of getting infected with SARS-CoV-2 or perception of the national economic situation. Therefore, we aimed to determine if changes in financial resources and employment situation during and after the second COVID-19 wave were prospectively associated with depression, anxiety and stress, and whether perceptions of the national economic situation and of the risk of getting infected modified this association. METHODS: One thousand seven hundred fifty nine participants from a nation-wide population-based eCohort in Switzerland were followed between November 2020 and September 2021. Financial resources and employment status were assessed twice (Nov2020-Mar2021, May-Jul 2021). Mental health was assessed after the second measurement of financial resources and employment status, using the Depression, Anxiety and Stress Scale (DASS-21). We modelled DASS-21 scores with linear regression, adjusting for demographics, health status, social relationships and changes in workload, and tested interactions with subjective risk perceptions. RESULTS: We observed scores above thresholds for normal levels for 16% (95%CI = 15-18) of participants for depression, 8% (95%CI = 7-10) for anxiety, and 10% (95%CI = 9-12) for stress. Compared to continuously comfortable or sufficient financial resources, continuously precarious or insufficient resources were associated with worse scores for all outcomes. Increased financial resources were associated with higher anxiety. In the working-age group, shifting from full to part-time employment was associated with higher stress and anxiety. Perceiving the Swiss economic situation as worrisome was associated with higher anxiety in participants who lost financial resources or had continuously precarious or insufficient resources. CONCLUSION: This study confirms the association of economic stressors and mental health during the COVID-19 pandemic and highlights the exacerbating role of subjective risk perception on this association

The structure of Chariklo's rings from stellar occultations

Two narrow and dense rings (called C1R and C2R) were discovered around the Centaur object (10199) Chariklo during a stellar occultation observed on 2013 June 3. Following this discovery, we planned observations of several occultations by Chariklo's system in order to better characterize the physical properties of the ring and main body. Here, we use 12 successful occulations by Chariklo observed between 2014 and 2016. They provide ring profiles (physical width, opacity, edge structure) and constraints on the radii and pole position. Our new observations are currently consistent with the circular ring solution and pole position, to within the $\pm 3.3$ km formal uncertainty for the ring radii derived by Braga-Ribas et al. The six resolved C1R profiles reveal significant width variations from $\sim 5$ to 7.5 km. The width of the fainter ring C2R is less constrained, and may vary between 0.1 and 1 km. The inner and outer edges of C1R are consistent with infinitely sharp boundaries, with typical upper limits of one kilometer for the transition zone between the ring and empty space. No constraint on the sharpness of C2R's edges is available. A 1$\sigma$ upper limit of $\sim 20$ m is derived for the equivalent width of narrow (physical width <4 km) rings up to distances of 12,000 km, counted in the ring plane

A social and ecological assessment of tropical land uses at multiple scales: the Sustainable amazon network

Science has a critical role to play in guiding more sustainable development trajectories. Here, we present the Sustainable Amazon Network (Rede Amazônia Sustentável, RAS): a multidisciplinary research initiative involving more than 30 partner organizations working to assess both social and ecological dimensions of land-use sustainability in eastern Brazilian Amazonia. The research approach adopted by RAS offers three advantages for addressing land-use sustainability problems: (i) the collection of synchronized and co-located ecological and socioeconomic data across broad gradients of past and present human use; (ii) a nested sampling design to aid comparison of ecological and socioeconomic conditions associated with different land uses across local, landscape and regional scales; and (iii) a strong engagement with a wide variety of actors and non-research institutions. Here, we elaborate on these key features, and identify the ways in which RAS can help in highlighting those problems in most urgent need of attention, and in guiding improvements in land-use sustainability in Amazonia and elsewhere in the tropics. We also discuss some of the practical lessons, limitations and realities faced during the development of the RAS initiative so far

Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms

Background: Juvenile myelomonocytic leukaemia (JMML) and chronic myelomonocytic leukaemia (CMML) are myelodysplastic myeloproliferative (MDS/MPN) neoplasms with unfavourable prognosis and without effective chemotherapy treatment. Trabectedin is a DNA minor groove binder acting as a modulator of transcription and interfering with DNA repair mechanisms; it causes selective depletion of cells of the myelomonocytic lineage. We hypothesised that trabectedin might have an antitumour effect on MDS/MPN. Methods: Malignant CD14+ monocytes and CD34+ haematopoietic progenitor cells were isolated from peripheral blood/bone marrow mononuclear cells. The inhibition of CFU-GM colonies and the apoptotic effect on CD14+ and CD34+ induced by trabectedin were evaluated. Trabectedin's effects were also investigated in vitro on THP-1, and in vitro and in vivo on MV-4-11 cell lines. Results: On CMML/JMML cells, obtained from 20 patients with CMML and 13 patients with JMML, trabectedin - at concentration pharmacologically reasonable, 1-5 nM - strongly induced apoptosis and inhibition of growth of haematopoietic progenitors (CFU-GM). In these leukaemic cells, trabectedin downregulated the expression of genes belonging to the Rho GTPases pathway (RAS superfamily) having a critical role in cell growth and cytoskeletal dynamics. Its selective activity on myelomonocytic malignant cells was confirmed also on in vitro THP-1 cell line and on in vitro and in vivo MV-4-11 cell line models. Conclusions: Trabectedin could be good candidate for clinical studies in JMML/CMML patients

A genome-wide scan for common alleles affecting risk for autism

Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C