Prácticas de gestión humana y su impacto en el desempeño organizacional : un estudio de caso sectorial

Administrador (a) de EmpresasPregrad

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero (2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16-0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26-0·57; p<0·0001, compared with the VIR-N1-Storm group). Interpretation: The presence of a so-called viral storm is associated with increased all-cause death in patients admitted to the intensive care unit with severe COVID-19. Preventing this viral storm could help to reduce poor outcomes. Viral storm could be an enrichment marker for treatment with antivirals or purification devices to remove viral components from the blood.This work was supported by grants from the Instituto de Salud Carlos III (FONDO-COVID19, COV20/00110, CIBERES, 06/06/0028; AT), Proyectos de Investigación en Salud (PI19/00590; JFB-M), Miguel Servet (CP20/00041; DdG-C), Sara Borrell (CD018/0123; APT), and Predoctorales de Formación en Investigación en Salud (FI20/00278; AdF). We also received funds from Programa de Donaciones Estar Preparados, UNESPA (Madrid, Spain), and from the Canadian Institutes of Health Research (CIHR OV2–170357; DJK and JFB-M), Research Nova Scotia, Li-Ka Shing Foundation (DJK), and finally by a Research Grant 2020 from ESCMID (APT). COV20/00110, PI19/00590, CP20/00041, CD018/0123, FI20/00278 were co-funded by European Regional Development Fund and European Social Fund (A way to make Europe, and Investing in your future). We thank the IRB-Lleida Biobank 119 (B.0000682) and Plataforma Biobancos PT17/0015/0027 in Lleida, the Hospital Clinic Barcelona (HCB)-IDIBAPS biobank in Barcelona, and the National DNA Bank and the Hospital Universitario de Salamanca biobank (both in Salamanca) for their logistical support with sample processing and storage. We are indebted to the Fundació Glòria Soler for its contribution and support to the COVIDBANK of HCBIDIBAPS Biobank. This work was not supported by any pharmaceutical company or other agency.S

Estado actual de las colecciones biológicas del Herbario UPTC mediante la identificación de agentes contaminantes

Grupo de Investigación Herbario UPTC, Escuela de Ciencias Biológicas, Facultad de Ciencias Básicas.El Herbario UPTC está centrado en la colecta de especímenes del Departamento de Boyacá (Colombia). Cuenta actualmente con 17.119 ejemplares entre angiospermas, helechos, briofitos y líquenes. Dado el valor científico, histórico y cultural de cada ejemplar y sus datos es necesario proteger la colección de daños o alteraciones que puedan afectar su uso futuro, teniendo como principio la conservación preventiva. Algunos ejemplares de la colección presentaron signos de aparente contaminación por posibles insectos y hongos, lo cual motivó la realización de este proyecto

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]11 página

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Comportamiento informacional: revisión de teorías posibles para su estudio

El artículo tiene como objetivo identificar las posturas teóricas que influyen en los estudios de comportamiento informacional para el contexto universitario cubano. El análisis de contenido fue utilizado para estudiar las teorías que influyen en el estudio comportamiento informacional. Se determina que: 1) los estudios de CHI implican adoptar una visión interdisciplinar para precisar la complejidad de su cuerpo epistemológico, teórico y práctico, 2) Las teorías que con mayor precisión se ajustan a los estudios de CHI en el contexto universitario cubano son: Perspectiva Cognitiva, Principio de Zipf o del Menor Esfuerzo, Teoría General de Sistemas, Usos y Gratificaciones, Sense-Making. Se concluye que la disciplina Comportamiento Informacional se legitima cada vez más dentro de las Ciencias de la Información con un enfoque interdisciplinar.The aim of the article is to identify the theoretical positions that influence information behavior studies for the Cuban university context. Content analysis was used to study the theories that influence the study. It was determined that: 1) the CHI studies imply an interdisciplinary vision for the complexity of its epistemological, theoretical and practical body, 2) The theories that more precisely fit the CHI studies in the Cuban university context are: Cognitive Perspective, Zipf Principle or Least Effort, General Theory of Systems, Uses and Gratifications, Sense-Making. It is concluded that the Information Behavior discipline is increasingly legitimized within the Information Sciences with an interdisciplinary approach

Construcción del vínculo afectivo en las díadas madres hijos en adolescentes de la Comuna 18-Cali

La maternidad es un estado de carácter tanto físico como psicológico que ha tenido diversas connotaciones a lo largo del tiempo y de las diferentes culturas. A pesar de ser una condición natural, se convierte en una problemática cuando se presenta en edades más tempranas dentro de un sector donde las situaciones de vulnerabilidad son recurrentes, lo que incide negativamente en la calidad del tiempo y dentro de la interacción entre madre e hijo. Este estudio cualitativo con diseño fenomenológico, tuvo como objetivo caracterizar las creencias y prácticas relacionadas con la construcción del vínculo afectivo a través de la experiencia personal de tres madres adolescentes entre los 15 y 19 años, pertenecientes a la comuna 18 de la ciudad de Cali, con sus hijos en edades comprendidas entre los seis y nueves meses. Se implementó la técnica de entrevista en profundidad y la observación para la recolección de los datos, los cuales permitieron conocer la relevancia que tienen los legados intergeneracionales como cimientos para establecer lazos afectivos entre la madre y el hijo. Entre los resultados, se encontró que los lazos afectivos se establecen en la medida en que la madre va percibiendo en esta interacción a su hijo como un sujeto activo, donde él, tiene tanto necesidades biológicas como emocionales; requiere atención, cuidado, etc. siendo un agente protagónico en la construcción de este vínculo. Además, dentro de este proceso, se ponen en juego las necesidades afectivas, expectativas y dificultades propias de la madre adolescente con su familia de origen. Los hermanos juegan un papel preponderante en la infancia de las participantes, en razón al apoyo, cercanía, acompañamiento y consuelo que les brindaron ante la prolongada ausencia de sus figuras parentales. En cuanto a la situación de vulnerabilidad en que se encuentran las madres participantes, ninguna percibe esta condición como una dificultad para la construcción del vínculo afectivo con sus hijos, puesto que obtuvieron una constante ayuda por parte de las redes de apoyo informales (vecinas, familia de su pareja y en especial, la de sus suegras)

EVALUACIÓN DE MÉTODOS PARA ERRADICAR HONGOS ENDÓFITOS DE SEMILLAS DE Brachiaria decumbens Stapf

La adaptación de plantas a ambientes extremos puede depender de la asociación con hongos endófitos de raíces. Sin embargo, las demostraciones del papel de esos endófitos en las simbiosis son limitadas si no se experimenta con plantas libres de ellos. Este estudio adaptó y evaluó un sistema de germinación masivo de semillas (SGMS) para probar métodos de desinfección de semillas de Brachiaria. decumbens en estudios con hongos endófitos de raíces. Con este sistema se evaluaron en semillas métodos de desinfección externa (Soluciones de NaOCl al 5% ó Ca(ClO)2 al 7,14%, o calor [60°C] en baño de agua u horno en varios tiempos), e interna (Captan™ y Benomil 50WP (0,1 mg/ml)). El SGMS fue adecuado para el desarrollo de plántulas de B. decumbens ya que en cinco días se obtiene abundante material de trabajo (7 a 10 plántulas). Adicionalmente, los métodos de desinfección externa disminuyeron la actividad microbiológica superficial en semillas, comparardo con el control (agua). Aplicar NaOCl (5%) resultó en mayor germinación y desarrollo de plántulas, pero no fue posible eliminar estructuras internas de hongos de las raíces, lo que sugiere una relación innata planta–endófito en pasto B. decumbens, que impide obtener plantas libres de endófitos. Algunas implicaciones experimentales son presentadas y discutidas a la luz de estos resultados