19 research outputs found
Exile Vol. XXIII no. 1
PROSE
The White Butterfly by Dalton Trevisan (translated from the Portugese by Alexis Levitin) 5-6
Natural Selection by Anne Tomfohrde 7-14
Stuck a Feather in His Cap... (for Boo) by Tim Cockey 15-18
An Act of Violence by William McNaughton 19-22
Shall We Now Praise Famous Men? by Lawrence Weber 23-24
POETRY
Wake by Dawn Patnode 26
Pebble by Lenore Mayhew 27
Bien: yo respeto... by José Mårtà 28
Yes: I respect by José Mårtà (translated from the Spanish by Joan Straub) 29
untitled by Mary Schloss 30
Nursing Home by Tim Cockey 31
Maia by Betsy Sloan 32
untitled by Loranna Franz 33
Momento Num Cafe by Manuel Banderia 34
Moment in a Café by Manuel Banderia (translated from the Portoguese by Alexis Levitin) 35
Pleiades by Dawn Patnode 36-37
untitled by Sharon Singleton 39
Travel by Libby Thomas 40
untitled by José Pretlow 41
MelancolĂa by RubĂ©n DarĂo 42
Melancholy by RubĂ©n DarĂo (translated from the Spanish by Joan Straub) 43
Lake Shore Drive by Alison Orleans 44
Repudiation by Tona Dickerson 45
Auvers 1889 by Dawn Patnode 47
Retreat by Deb Allbery 48
An Illusion Of Dancing Figures by Lawrence Weber 50-58
Cloud by Lenore Mayhew 59
ESSAYS
Climbing \u27earth\u27s undying monument\u27 by Richard H. Soaper, Jr. 61-71
A Program for the American Land by Lindy Davies 72-77
Kerouac and His Critics (For Amy) by John Kralik 80-82
Cover photograph from a late nineteenth century glass negative found in an Ohio antique shop and used with the permission of its owner
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Simulating Surveys for ELT-MOSAIC: Status of the MOSAIC Science Case after Phase A
International audienceWe present the consolidated scientific case for multi-object spectroscopy with the MOSAIC concept on the European ELT. The cases span the full range of ELT science and require either 'high multiplex' or 'high definition' observations to best exploit the excellent sensitivity and wide field-of-view of the telescope. Following scientific prioritisation by the Science Team during the recent Phase A study of the MOSAIC concept, we highlight four key surveys designed for the instrument using detailed simulations of its scientific performance. We discuss future ways to optimise the conceptual design of MOSAIC in Phase B, and illustrate its competitiveness and unique capabilities by comparison with other facilities that will be available in the 2020s
Simulating surveys for ELT-MOSAIC: Status of the MOSAIC science case after phase A
We present the consolidated scientific case for multi-object spectroscopy with the MOSAIC concept on the European ELT. The cases span the full range of ELT science and require either âhigh multiplexâ or âhigh definitionâ observations to best exploit the excellent sensitivity and wide field-of-view of the telescope. Following scientific prioritisation by the Science Team during the recent Phase A study of the MOSAIC concept, we highlight four key surveys designed for the instrument using detailed simulations of its scientific performance. We discuss future ways to optimise the conceptual design of MOSAIC in Phase B, and illustrate its competitiveness and unique capabilities by comparison with other facilities that will be available in the 2020s