294 research outputs found
The spectral energy distribution of PKS 2004-447: a compact steep-spectrum source and possible radio-loud narrow-line Seyfert 1 galaxy
(abridged) The spectral energy distribution (SED) of the compact steep
spectrum (CSS) source and possible radio-loud narrow-line Seyfert 1 galaxy
(NLS1), PKS2004-447, is presented. Five out of six well studied RL NLS1 share
this dual classification (optically defined as a NLS1 with radio definition of
a CSS or giga-hertz peaked spectrum (GPS) source). The SED is created from
simultaneous observations at radio (ATCA), optical/NIR (Siding Spring) and
UV/X-ray (XMM-Newton) wavelengths. The X-ray data show evidence of short-term
variability, a possible soft excess, and negligible absorption. Together with
the rest of the SED, the X-ray emission is excessive in comparison to
synchrotron plus synchrotron self-Compton (SSC) models. The SED can be
described with a two component model consisting of extended synchrotron/SSC
emission with Comptonisation in the X-rays, though SSC models with a very high
electron-to-magnetic energy density ratio cannot be excluded either. The peak
emission in the SED appears to be in the near infrared, which can be attributed
to thermal emission from a dusty torus. Analysis of a non-contemporaneous, low
resolution optical spectrum suggests that the narrow-line region (NLR) is much
more reddened than the X-ray emitting region suggesting that the gas-to-dust
ratio in PKS2004-447 may be very different then in our own Galaxy. Long-term
radio monitoring of PKS2004-447 shows a rather constant light curve over nearly
a six month period with the exception of one outburst when the 6.65GHz flux
increased by ~35% over 19 days. In comparison to general samples of GPS
sources, which appear to be X-ray weak, NLS1-CSS/GPS sources possess stronger
X-ray emission relative to radio, and lower intrinsic absorption than GPS
sources of similar X-ray luminosity.Comment: 10 pages, 8 figures. Accepted for publication in MNRA
Reverberation Mapping and the Physics of Active Galactic Nuclei
Reverberation-mapping campaigns have revolutionized our understanding of AGN.
They have allowed the direct determination of the broad-line region size,
enabled mapping of the gas distribution around the central black hole, and are
starting to resolve the continuum source structure. This review describes the
recent and successful campaigns of the International AGN Watch consortium,
outlines the theoretical background of reverberation mapping and the
calculation of transfer functions, and addresses the fundamental difficulties
of such experiments. It shows that such large-scale experiments have resulted
in a ``new BLR'' which is considerably different from the one we knew just ten
years ago. We discuss in some detail the more important new results, including
the luminosity-size-mass relationship for AGN, and suggest ways to proceed in
the near future.Comment: Review article to appear in Astronomical Time Series, Proceedings of
the Wise Observatory 25th Ann. Symposium. 24 pages including 7 figure
Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients
<p>Abstract</p> <p>Background</p> <p>Lung infection by various organisms is a characteristic feature of cystic fibrosis (CF). <it>CFTR </it>genotype effects acquisition of <it>Pseudomonas aeruginosa (Pa)</it>, however the effect on acquisition of other infectious organisms that frequently precede <it>Pa </it>is relatively unknown. Understanding the role of CFTR in the acquisition of organisms first detected in patients may help guide symptomatic and molecular-based treatment for CF.</p> <p>Methods</p> <p>Lung infection, defined as a single positive respiratory tract culture, was assessed for 13 organisms in 1,381 individuals with CF. Subjects were divided by predicted CFTR function: 'Residual': carrying at least one partial function <it>CFTR </it>mutation (class IV or V) and 'Minimal' those who do not carry a partial function mutation. Kaplan-Meier estimates were created to assess <it>CFTR </it>effect on age of acquisition for each organism. Cox proportional hazard models were performed to control for possible cofactors. A separate Cox regression was used to determine whether defining infection with <it>Pa</it>, mucoid <it>Pa </it>or <it>Aspergillus (Asp) </it>using alternative criteria affected the results. The influence of severity of lung disease at the time of acquisition was evaluated using stratified Cox regression methods by lung disease categories.</p> <p>Results</p> <p>Subjects with 'Minimal' CFTR function had a higher hazard than patients with 'Residual' function for acquisition of 9 of 13 organisms studied (HR ranging from 1.7 to 3.78 based on the organism studied). Subjects with minimal CFTR function acquired infection at a younger age than those with residual function for 12 of 13 organisms (p-values ranging: < 0.001 to 0.017). Minimal CFTR function also associated with younger age of infection when 3 alternative definitions of infection with <it>Pa</it>, mucoid <it>Pa </it>or <it>Asp </it>were employed. Risk of infection is correlated with CFTR function for 8 of 9 organisms in patients with good lung function (>90%ile) but only 1 of 9 organisms in those with poorer lung function (<50%ile).</p> <p>Conclusions</p> <p>Residual CFTR function correlates with later onset of respiratory tract infection by a wide spectrum of organisms frequently cultured from CF patients. The protective effect conferred by residual CFTR function is diminished in CF patients with more advanced lung disease.</p
Continuing the conversation about public health ethics: education for public health professionals in Europe
An important related question is why we should teach public health ethics. Fundamentally, we must teach public health ethics because ethical practice creates and maintains public trust and public health cannot function without public trust. To serve the public—whether through controlling an outbreak of an infectious disease, preparing for or responding to public health emergencies, or reducing the impact of non-communicable diseases—communities and individuals must trust our decisions and actions. This trust grows in large part from past successes, transparent and participatory decision making, and ethical management of the inevitable moral tensions that arise in our work.S
The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity
Peer reviewedPublisher PD
Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
BACKGROUND:In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.METHODS:A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70Gy (62.4-75Gy).RESULTS:At a median follow-up of 14months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.CONCLUSIONS:IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at [email protected]
Detailed maps of interstellar clouds in front of omega Centauri: Small-scale structures in the Galactic Disc-Halo interface
We used the multiplex capabilities of the AAOmega spectrograph at the
Anglo-Australian Telescope to create a half-square-degree map of the neutral
and low-ionized ISM in front of the nearby (~5 kpc), most massive Galactic
globular cluster, omega Centauri. Its redshifted, metal-poor and hot horizontal
branch stars probe the medium-strong Ca II K and Na I D2 line absorption, and
weak absorption in the lambda5780 and lambda5797 Diffuse Interstellar Bands
(DIBs), on scales around a parsec. The kinematical and thermodynamical picture
emerging from these data is that we predominantly probe the warm neutral medium
and weakly-ionized medium of the Galactic Disc-Halo interface, ~0.3-1 kpc above
the mid-plane. A comparison with Spitzer Space Telescope 24-micron and
DIRBE/IRAS maps of the warm and cold dust emission confirms that both Na I and
Ca II trace the overall column density of the warm neutral and weakly-ionized
medium. Clear signatures are seen of the depletion of calcium atoms from the
gas phase into dust grains. Curiously, the coarse DIRBE/IRAS map is a more
reliable representation of the relative reddening between sightlines than the
Na I and Ca II absorption-line measurements, most likely because the latter are
sensitive to fluctuations in the local ionization conditions. The behaviour of
the DIBs is consistent with the lambda5780 band being stronger than the
lambda5797 band in regions where the ultraviolet radiation level is relatively
high, as in the Disc-Halo interface. This region corresponds to a sigma-type
cloud. In all, our maps and simple analytical model calculations show in
unprecedented detail that small-scale density and/or ionization structures
exist in the extra-planar gas of a spiral galaxy. (abridged)Comment: Accepted for publication in MNRA
The Schnitzler syndrome
The Schnitzler syndrome is a rare and underdiagnosed entity which is considered today as being a paradigm of an acquired/late onset auto-inflammatory disease. It associates a chronic urticarial skin rash, corresponding from the clinico-pathological viewpoint to a neutrophilic urticarial dermatosis, a monoclonal IgM component and at least 2 of the following signs: fever, joint and/or bone pain, enlarged lymph nodes, spleen and/or liver, increased ESR, increased neutrophil count, abnormal bone imaging findings. It is a chronic disease with only one known case of spontaneous remission. Except of the severe alteration of quality of life related mainly to the rash, fever and pain, complications include severe inflammatory anemia and AA amyloidosis. About 20% of patients will develop a lymphoproliferative disorder, mainly Waldenström disease and lymphoma, a percentage close to other patients with IgM MGUS. It was exceedingly difficult to treat patients with this syndrome until the IL-1 receptor antagonist anakinra became available. Anakinra allows a complete control of all signs within hours after the first injection, but patients need continuous treatment with daily injections
Association between the Cytotoxic T-Lymphocyte Antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis
<p>Abstract</p> <p>Background</p> <p>As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer risks, but previous results have been conflicting.</p> <p>Methods</p> <p>We preformed a meta-analysis using 22 eligible case-control studies (including 32 datasets) with a total of 11,273 patients and 13,179 controls to summarize the existing data on the association between the <it>CTLA-4 </it>+49G > A polymorphism and cancer risk.</p> <p>Results</p> <p>Compared with the common <it>CTLA-4 </it>+49G > A GG genotype, the carriers of variant genotypes (<it>CTLA-4 </it>+49 GC/CC) had a 1.24-fold elevated risk of cancer (95% CI = 1.18-1.32, <it>P </it>< 0.05) under the dominant genetic model, as estimated using a fixed effect model. The effect of the <it>CTLA-4 </it>+49G > A polymorphism was further evaluated using stratification analysis. In four breast cancer studies, patients with the variant genotypes had a significantly increased risk of breast cancer (OR = 1.31, 95% CI = 1.17-1.48, <it>P </it>< 0.00001). A similar result was found in three skin cancer studies (OR = 1.30, 95% CI = 1.10-1.52, <it>P </it>= 0.001). In 26 solid tumor studies, subjects with the variant genotypes had a significantly higher risk of developing solid tumors (OR = 1.25, 95% CI = 1.18-1.33, <it>P </it>< 0.00001) compared with the 6 non-solid tumor studies (OR = 1.08, 95% CI = 0.79-1.48, <it>P </it>= 0.62). Patients with variant genotypes had significantly increased risk of non-epithelial tumors and epithelial tumors, with ORs of 1.23 (95% CI = 1.14-1.32, <it>P </it>< 0.00001) and 1.29 (95% CI = 1.17-1.41, <it>P </it>< 0.00001), respectively. It was also demonstrated that the increased risk of cancer associated with <it>CTLA-4 </it>+49G > A variant genotypes was more pronounced in Caucasians (OR = 1.29, 95% CI = 1.13-1.47, <it>P </it>= 0.0002), Asians (OR = 1.23, 95% CI = 1.16-1.32, <it>P </it>< 0.00001) and Chinese (OR = 1.23, 95% CI = 1.15-1.31, <it>P </it>< 0.00001).</p> <p>Conclusion</p> <p>Our meta-analysis suggests that the <it>CTLA-4 </it>+49G > A polymorphism genotypes (GA + AA) might be associated with an increased risk of cancer, especially in Caucasians and Chinese.</p
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