Hair-thread strangulation syndrome in childhood: a systematic review.

Hair-thread strangulation syndrome describes the constriction of a body part by a tightly wound hair or thread. This research aims to review the literature about this entity. A systematic review was performed to characterise hair-thread strangulation syndrome in subjects aged ≤16 years. This pre-registered review (PROSPERO ID: CRD42022363996) followed the PRISMA methodology. Subjects with digital strangulation were significantly younger (median = 4.0 [interquartile range: 2.0-6.1] months; n = 143) than females with genital strangulation (9.0 [6.8-11] years; n = 36), males with genital strangulation (5.1 [1.9-8.0] years; n = 36), and subjects with non-digital and non-genital strangulation (24 [13-48] months; n = 11). Digital strangulation was followed by an amputation in five (3.5%) and a reconstructive surgical intervention in seven (4.9%) cases. Sequelae occurred in four (11%) cases after female genital strangulation: clitoris autoamputation (n = 2) and surgical removal of a necrotic labium minus (n = 2). Severe complications were observed in 14 (39%) cases with male genital strangulation: urethral fistula (n = 7), urethral transection (n = 2), and partial penile autoamputation (n = 5). A partial uvular autoamputation was observed in one case (9.0%) with non-digital and non-genital strangulation. Early recognition and management are crucial to avoid sequelae or long-term care in hair-thread strangulation syndrome

Calcium electroporation and electrochemotherapy for cancer treatment:Importance of cell membrane composition investigated by lipidomics, calorimetry and in vitro efficacy

Abstract Calcium electroporation is a novel anti-cancer treatment investigated in clinical trials. We explored cell sensitivity to calcium electroporation and electroporation with bleomycin, using viability assays at different time and temperature points, as well as heat calorimetry, lipidomics, and flow cytometry. Three cell lines: HT29 (colon cancer), MDA-MB231 (breast cancer), and HDF-n (normal fibroblasts) were investigated for; (a) cell survival dependent on time of addition of drug relative to electroporation (1.2 kV/cm, 8 pulses, 99 µs, 1 Hz), at different temperatures (37 °C, 27 °C, 17 °C); (b) heat capacity profiles obtained by differential scanning calorimetry without added calcium; (c) lipid composition by mass spectrometry; (d) phosphatidylserine in the plasma membrane outer leaflet using flow cytometry. Temperature as well as time of drug administration affected treatment efficacy in HT29 and HDF-n cells, but not MDA-MB231 cells. Interestingly the HT29 cell line displayed a higher phase transition temperature (approximately 20 °C) versus 14 °C (HDF-n) and 15 °C (MDA-MB231). Furthermore the HT29 cell membranes had a higher ratio of ethers to esters, and a higher expression of phosphatidylserine in the outer leaflet. In conclusion, lipid composition and heat capacity of the membrane might influence permeabilisation of cells and thereby the effect of calcium electroporation and electrochemotherapy

Many analysts, one data set: making transparent how variations in analytic choices affect results

Twenty-nine teams involving 61 analysts used the same data set to address the same research question: whether soccer referees are more likely to give red cards to dark-skin-toned players than to light-skin-toned players. Analytic approaches varied widely across the teams, and the estimated effect sizes ranged from 0.89 to 2.93 (Mdn = 1.31) in odds-ratio units. Twenty teams (69%) found a statistically significant positive effect, and 9 teams (31%) did not observe a significant relationship. Overall, the 29 different analyses used 21 unique combinations of covariates. Neither analysts’ prior beliefs about the effect of interest nor their level of expertise readily explained the variation in the outcomes of the analyses. Peer ratings of the quality of the analyses also did not account for the variability. These findings suggest that significant variation in the results of analyses of complex data may be difficult to avoid, even by experts with honest intentions. Crowdsourcing data analysis, a strategy in which numerous research teams are recruited to simultaneously investigate the same research question, makes transparent how defensible, yet subjective, analytic choices influence research results

Sperm whale long-range echolocation sounds revealed by ANTARES, a deep-sea neutrino telescope

[EN] Despite dedicated research has been carried out to adequately map the distribution of the sperm whale in the Mediterranean Sea, unlike other regions of the world, the species population status is still presently uncertain. The analysis of two years of continuous acoustic data provided by the ANTARES neutrino telescope revealed the year-round presence of sperm whales in the Ligurian Sea, probably associated with the availability of cephalopods in the region. The presence of the Ligurian Sea sperm whales was demonstrated through the real-time analysis of audio data streamed from a cabled-to- shore deep-sea observatory that allowed the hourly tracking of their long-range echolocation behaviour on the Internet. Interestingly, the same acoustic analysis indicated that the occurrence of surface shipping noise would apparently not condition the foraging behaviour of the sperm whale in the area, since shipping noise was almost always present when sperm whales were acoustically detected. The continuous presence of the sperm whale in the region confirms the ecological value of the Ligurian sea and the importance of ANTARES to help monitoring its ecosystemsThe authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a lenergie atomique et aux energies alternatives (CEA), la Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINECO), Prometeo and Grisolia programs of Generalitat Valenciana and MultiDark, Spain; Agence de l'Oriental and CNRST, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilitiesAndre, M.; Caballé, A.; Van Der Schaar, M.; Solsona, A.; Houégnigan, L.; Zaugg, S.; Sanchez, AM.... (2017). Sperm whale long-range echolocation sounds revealed by ANTARES, a deep-sea neutrino telescope. Scientific Reports. 7:1-12. https://doi.org/10.1038/srep45517S1127Aguilar, J. A. et al. ANTARES: the first undersea neutrino telescope. Nucl Inst and Met Phys Res A. 656, 11–38 (2011a).Aguilar, J. A. et al. AMADEUS - The Acoustic Neutrino Detection Test System of the ANTARES Deep-Sea Neutrino Telescope -. Nucl Inst and Met Phys Res A. 626–627, 128–143 (2011b).Ruhl, H. et al. Societal need for improved understanding of climate change, anthropogenic impacts, and geo-hazard warning drive development of ocean observatories in European Seas. Prog Oceanog. 91, 1–33 (2011).Tamburini, C. et al. Deep-sea bioluminescence blooms after dense water formation at the ocean surface. PLoS One. 8(7), e67523. doi: 10.1371/journal.pone.0067523 (2013).Van Haren, H. et al. Acoustic and optical variations during rapid downward motion episodes in the deep North Western Mediterranean. Deep Sea Res I. 58, 875–884 (2011).Van der Graaf, A. J. et al. European Marine Strategy Framework Directive - Good Environmental Status (MSFD GES): Report of the Technical Subgroup on Underwater noise and other forms of energy (2012).Hatch, L. T., Clark, C. W., Van Parijs, S. M., Frankel, A. S. & Ponirakis, D. W. Quantifying Loss of Acoustic Communication Space for Right Whales in and around a U.S. National Marine Sanctuary. Conserv Biol. 26, 983–994 (2012).André, M. et al. Low-frequency sounds induce acoustic trauma in cephalopods. Front. Ecol. Environ. 9, 489–493 (2011).Solé, M. et al. Does exposure to noise from human activities compromise sensory information from cephalopod statocysts? Deep Sea Res. II. 95, 160–181 (2013).Solé, M. et al. Ultrastructural damage of Loligo vulgaris and Illex coindetii statocysts after low frequency sound exposure. PLoS One 8(10), e78825. doi: 10.1371/journal.pone.0078825 (2013).André, M. et al. Listening to the Deep: Live monitoring of ocean noise and cetacean acoustic signals. Mar Pollut Bull. 63, 18–26 (2011).Whitehead, H. Sperm whales: social evolution in the ocean(The University of Chicago Press, Chicaho, 2003).Mohl, B., Wahlberg, M., Madsen, P. T., Heerfordt, A. & Lund, A. The monopulsed nature of sperm whale clicks. J Acous Soc Am. 114, 1143–1154 (2003).André, M., Johansson, T., Delory, E. & van der Schaar, M. Foraging on squid: the sperm whale mid-range sonar. Jour Mar Biol Assoc. 87, 59–67 (2007).Madsen, P., Wahlberg, M. & Møhl, B. Male sperm whale (Physeter macrocephalus) acoustics in a high-latitude habitat: implications for echolocation and communication. Behav Ecol Sociobiol. 53, 31, doi: 10.1007/s00265-002-0548-1 (2002).Gannier, A., Drouot, V. & Goold, J. C. Distribution and relative abundance of sperm whales in the Mediterranean Sea . Mar Ecol Prog Ser. 243, 281–293 (2000).Drouot, V., Gannier, A. & Gould, J. C. Summer social distribution of sperm whales in the Mediterranean Sea. J Mar Biol Ass. 84, 675–680 (2004).Pavan, G. et al. G. Short Term and Long Term Bioacoustic Monitoring of the Marine Environment. Results from NEMO ONDE Experiment and Way Ahead in Computational bioacoustics for assessing biodiversity . Proceedings of the International Expert meeting on IT-based detection of bioacoustical patterns(ed. Frommolt, K. H., Rolf Bardeli, R. & Clausen, M. ) 7–14 (Federal Agency for Nature Conservation, Bonn, 2008).Frantzis, A. et al. Sperm whale presence off South-West Crete, Eastern Mediterranean Sea in Proc. 13th Ann. Conf. ECS. 214–217 (Eur Res Cet, Valencia, 1999).Notarbartolo-Di-Sciara, G. Sperm whales, Physeter macrocephalus, in the Mediterranean Sea: a summary of status, threats, and conservation recommendations. Aquatic Conserv. Mar. Freshw. Ecosyst. 24, 4–10. doi: 10.1002/aqc.2409 (2014).Pace, D. S., Mussi, B., Gordon, J. C. D. & Würtz, M. Ecology, Behaviour and Conservation of Sperm Whale in the Mediterranean Sea in Aquatic Conserv . Mar. Freshw. Ecosyst. 24 (ed. Wiley, J. ) 1–118 (Wiley Online library, 2014).Rendell, L. E. & Frantzis, A. Mediterranean sperm whales, Physeter macrocephalus: the precarious state of a lost tribe In Medit. Mar. Mam. Ecol. Cons. 75 (ed. Notarbartolo di Sciara, G., Podestà, M. P. & Curry, B. E. ) 37–74, doi: 10.1016/bs.amb.2016.08.001 (Advances in Marine Biology, Academic Press/Elsevier, 2016).Di Natale, A. & Notarbartolo di Sciara, G. A review of the passive fishing nets and trap fisheries in the Mediterranean Sea and of the cetacean bycatch In Gillnets and cetaceans(ed. Perrin, W. F., Donovan, G. P. & Barlow, J. ) 189–202 (Rep Int Whal Comm, 1994).Jaquet, N., Whitehead, H. & Lewis, M. Relationship between sperm whale distribution and primary productivity over large spatial scale in the Pacific ocean. Eur Res Cet. 9, 188–192 (1995).Millot, C. Circulation in the Western Mediterranean Sea. Oceanol Acta. 10, 143–150 (1987).Morel, A. & André, J. M. Pigment distribution and primary production in the Western Mediterranean as derived from coastal zone color scanner observations. J Geophy Res. 96, 2685–12698 (1991).Crépon, M., Wald, L. & Monget, J. M. Low-frequency waves in the Ligurian Sea during December 1977. J Geophys Res. 87, 595–600 (1982).Prieur, L. & Sathyendranath, S. An optical classification of coastal and oceanic waters based on the specific spectral absorption curves of phytoplankton pigments, dissolved organic matter, and other particulate materials. Limnol Oceanogr. 26, 671–89 (1981).Kawakami, T. A review of sperm whale food. 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The pipeline project: Pre-publication independent replications of a single laboratory's research pipeline

This crowdsourced project introduces a collaborative approach to improving the reproducibility of scientific research, in which findings are replicated in qualified independent laboratories before (rather than after) they are published. Our goal is to establish a non-adversarial replication process with highly informative final results. To illustrate the Pre-Publication Independent Replication (PPIR) approach, 25 research groups conducted replications of all ten moral judgment effects which the last author and his collaborators had “in the pipeline” as of August 2014. Six findings replicated according to all replication criteria, one finding replicated but with a significantly smaller effect size than the original, one finding replicated consistently in the original culture but not outside of it, and two findings failed to find support. In total, 40% of the original findings failed at least one major replication criterion. Potential ways to implement and incentivize pre-publication independent replication on a large scale are discussed

Data from a pre-publication independent replication initiative examining ten moral judgement effects

We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings. Unlike any previous replication project, this dataset includes the data from not only the replications but also from the original studies, creating a unique corpus that researchers can use to better understand reproducibility and irreproducibility in science

Pathways to care for people for dementia: an international multi-centre study

Objective: the aim of the present study was to characterize the clinical pathways that people with dementia (PwD) in different countries follow to reach specialized dementia care. Methods: we recruited 548 consecutive clinical attendees with a standardized diagnosis of dementia, in 19 specialized public centers for dementia care in 15 countries. The WHO “Encounter Form”, a standardized schedule that enables data concerning basic socio-demographic, clinical and pathways data to be gathered, was completed for each participant. Results: the median time from the appearance of the first symptoms to the first contact with specialist dementia care was 56 weeks. The primary point of access to care was the general practitioners (55.8%). Psychiatrists, geriatricians and neurologists represented the most important second point of access. In about a third of cases, PwD were prescribed psychotropic drugs (mostly antidepressants and tranquillizers). Psychosocial interventions (such as psychological counselling, psychotherapy and practical advice) were delivered in less than 3% of situations. The analyses of the ‘pathways diagram’ revealed that the path of PwD to receiving care is complex, diverse across countries, and that there are important barriers to clinical care. Conclusions: the study of pathways followed by PwD to reach specialized care has implications for the subsequent course and the outcome of dementia. Insights into local differences in the clinical presentations and the implementation of currently available dementia care are essential to develop more tailored strategies for these patients, locally, nationally and internationally

Data from a pre-publication independent replication initiative examining ten moral judgement effects

We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings. Unlike any previous replication project, this dataset includes the data from not only the replications but also from the original studies, creating a unique corpus that researchers can use to better understand reproducibility and irreproducibility in science.Link_to_subscribed_fulltex