142 research outputs found
Mixtures of ultracold atoms in one-dimensional disordered potentials
We study interacting one-dimensional two-component mixtures of cold atoms in a random potential, and extend the results reported earlier [Phys. Rev. Lett. 105, 115301 (2010)]. We construct the phase diagram of a disordered Bose-Fermi mixture as a function of the strength of the Bose-Bose and Bose-Fermi interactions, and the ratio of the bosonic sound velocity and the Fermi velocity. Performing renormalization group and variational calculations, three phases are identified: (i) a fully delocalized two-component Luttinger liquid with superfluid bosons and fermions, (ii) a fully localized phase with both components pinned by disorder, and (iii) an intermediate phase where fermions are localized but bosons are superfluid. Within the variational approach, each phase corresponds to a different level of replica symmetry breaking. In the fully localized phase we find that the bosonic and fermionic localization lengths can largely differ. We also compute the long-wavelength asymptotic behavior of the momentum distribution as well as that of the structure factor of the atoms (both experimentally accessible), and discuss how the three phases can be experimentally distinguished
The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146339/1/mmi14000-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146339/2/mmi14000.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146339/3/mmi14000_am.pd
The Dynamics of Ecosystems, Biodiversity Management and Social Institutions at High Northern Latitudes
Ecosystems at high latitudes are highly dynamic, influenced
by a multitude of large-scale disturbances. Due to global
change processes these systems may be expected to be
particularly vulnerable, affecting the sustained production
of renewable wood resources and abundance of plants
and animals on which local cultures depend. In this paper,
we assess the implications of new understandings of high
northern latitude ecosystems and what must be done to
manage systems for resilience. We suggest that the focus
of land management should shift from recovery from local
disturbance to sustaining ecosystem functions in the face
of change and disruption. The role of biodiversity as insurance
for allowing a system to reorganize and develop during
the disturbance and reorganization phases needs to be
addressed in management and policy. We emphasize that
the current concepts of ecological reserves and protected
areas need to be reconsidered to developp dynamic tools
for sustainable management of ecosystems in face of
change. Characteristics of what may be considered as customary
reserves at high latitudes are often consistent with
a more dynamic view of reserves. We suggest new directions
for addressing biodiversity management in dynamic
landscapes at high latitudes, and provide empirical examples
of insights from unconventional perspectives that may
help improve the potential for sustainable management of
biodiversity and the generation of ecosystem services
Microwave studies of the fractional Josephson effect in HgTe-based Josephson junctions
The rise of topological phases of matter is strongly connected to their
potential to host Majorana bound states, a powerful ingredient in the search
for a robust, topologically protected, quantum information processing. In order
to produce such states, a method of choice is to induce superconductivity in
topological insulators. The engineering of the interplay between
superconductivity and the electronic properties of a topological insulator is a
challenging task and it is consequently very important to understand the
physics of simple superconducting devices such as Josephson junctions, in which
new topological properties are expected to emerge. In this article, we review
recent experiments investigating topological superconductivity in topological
insulators, using microwave excitation and detection techniques. More
precisely, we have fabricated and studied topological Josephson junctions made
of HgTe weak links in contact with two Al or Nb contacts. In such devices, we
have observed two signatures of the fractional Josephson effect, which is
expected to emerge from topologically-protected gapless Andreev bound states.
We first recall the theoretical background on topological Josephson junctions,
then move to the experimental observations. Then, we assess the topological
origin of the observed features and conclude with an outlook towards more
advanced microwave spectroscopy experiments, currently under development.Comment: Lectures given at the San Sebastian Topological Matter School 2017,
published in "Topological Matter. Springer Series in Solid-State Sciences,
vol 190. Springer
Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review
Inhibition of epidermoid carcinoma A431 cell growth and angiogenesis in nude mice by early and late treatment with a novel dextran derivative
Comparative transcriptomic analysis reveals similarities and dissimilarities in saccharomyces cerevisiae wine strains response to nitrogen availability
Nitrogen levels in grape-juices are of major importance in winemaking ensuring adequate yeast growth and fermentation performance. Here we used a comparative transcriptome analysis to uncover wine yeasts responses to nitrogen availability during fermentation. Gene expression was assessed in three genetically and phenotypically divergent commercial wine strains (CEG, VL1 and QA23), under low (67 mg/L) and high nitrogen (670 mg/L) regimes, at three time points during fermentation (12h, 24h and 96h). Two-way ANOVA analysis of each fermentation condition led to the identification of genes whose expression was dependent on strain, fermentation stage and on the interaction of both factors. The high fermenter yeast strain QA23 was more clearly distinct from the other two strains, by differential expression of genes involved in flocculation, mitochondrial functions, energy generation and protein folding and stabilization. For all strains, higher transcriptional variability due to fermentation stage was seen in the high nitrogen fermentations. A positive correlation between maximum fermentation rate and the expression of genes involved in stress response was observed. The finding of common genes correlated with both fermentation activity and nitrogen up-take underlies the role of nitrogen on yeast fermentative fitness. The comparative analysis of genes differentially expressed between both fermentation conditions at 12h, where the main difference was the level of nitrogen available, showed the highest variability amongst strains revealing strain-specific responses. Nevertheless, we were able to identify a small set of genes whose expression profiles can quantitatively assess the common response of the yeast strains to varying nitrogen conditions. The use of three contrasting yeast strains in gene expression analysis prompts the identification of more reliable, accurate and reproducible biomarkers that will facilitate the diagnosis of deficiency of this nutrient in the grape-musts and the development of strategies to optimize yeast performance in industrial fermentations
Quorum Sensing Signaling Molecules Produced by Reference and Emerging Soft-Rot Bacteria (Dickeya and Pectobacterium spp.)
International audienceBACKGROUND: Several small diffusible molecules are involved in bacterial quorum sensing and virulence. The production of autoinducers-1 and -2, quinolone, indole and γ-amino butyrate signaling molecules was investigated in a set of soft-rot bacteria belonging to six Dickeya or Pectobacterium species including recent or emerging potato isolates. METHODOLOGY/PRINCIPAL FINDINGS: Using bacterial biosensors, immunoassay, and chromatographic analysis, we showed that soft-rot bacteria have the common ability to produce transiently during their exponential phase of growth the N-3-oxo-hexanoyl- or the N-3-oxo-octanoyl-l-homoserine lactones and a molecule of the autoinducer-2 family. Dickeya spp. produced in addition the indole-3-acetic acid in tryptophan-rich conditions. All these signaling molecules have been identified for the first time in the novel Dickeya solani species. In contrast, quinolone and γ-amino butyrate signals were not identified and the corresponding synthases are not present in the available genomes of soft-rot bacteria. To determine if the variations of signal production according to growth phase could result from expression modifications of the corresponding synthase gene, the respective mRNA levels were estimated by reverse transcriptase-PCR. While the N-acyl-homoserine lactone production is systematically correlated to the synthase expression, that of the autoinducer-2 follows the expression of an enzyme upstream in the activated methyl cycle and providing its precursor, rather than the expression of its own synthase. CONCLUSIONS/SIGNIFICANCE: Despite sharing the S-adenosylmethionine precursor, no strong link was detected between the production kinetics or metabolic pathways of autoinducers-1 and -2. In contrast, the signaling pathway of autoinducer-2 seems to be switched off by the indole-3-acetic acid pathway under tryptophan control. It therefore appears that the two genera of soft-rot bacteria have similarities but also differences in the mechanisms of communication via the diffusible molecules. Our results designate autoinducer-1 lactones as the main targets for a global biocontrol of soft-rot bacteria communications, including those of emerging isolates
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