365 research outputs found
Inflammatory breast cancer: dynamic contrast-enhanced MR in patients receiving bevacizumab. Initial experience
To retrospectively compare three dynamic contrast material-enhanced
magnetic resonance (MR) imaging (dynamic MR imaging) analytic methods to
determine the parameter or combination of parameters most strongly associated
with changes in tumor microvasculature during treatment with bevacizumab alone
and bevacizumab plus chemotherapy in patients with inflammatory or locally
advanced breast cancer. MATERIALS AND METHODS: This study was conducted in
accordance with the institutional review board of the National Cancer Institute
and was compliant with the Privacy Act of 1974. Informed consent was obtained
from all patients. Patients with inflammatory or locally advanced breast cancer
were treated with one cycle of bevacizumab alone (cycle 1) followed by six cycles
of combination bevacizumab and chemotherapy (cycles 2-7). Serial dynamic MR
images were obtained, and the kinetic parameters measured by using three dynamic
analytic MR methods (heuristic, Brix, and general kinetic models) and two
region-of-interest strategies were compared by using two-sided statistical tests.
A P value of .01 was required for significance. RESULTS: In 19 patients, with use
of a whole-tumor region of interest, the authors observed a significant decrease
in the median values of three parameters measured from baseline to cycle 1:
forward transfer rate constant (Ktrans) (-34% relative change, P=.003), backflow
compartmental rate constant extravascular and extracellular to plasma (Kep) (-15%
relative change, P<.001), and integrated area under the gadolinium concentration
curve (IAUGC) at 180 seconds (-23% relative change, P=.009). A trend toward
differences in the heuristic slope of the washout curve between responders and
nonresponders to therapy was observed after cycle 1 (bevacizumab alone, P=.02).
The median relative change in slope of the wash-in curve from baseline to cycle 4
was significantly different between responders and nonresponders (P=.009).
CONCLUSION: The dynamic contrast-enhanced MR parameters Ktrans, Kep, and IAUGC at
180 seconds appear to have the strongest association with early physiologic
response to bevacizumab. Clinical trial registration no. NCT0001654
Measurement of the Branching Fraction for B->eta' K and Search for B->eta'pi+
We report measurements for two-body charmless B decays with an eta' meson in
the final state. Using 11.1X10^6 BBbar pairs collected with the Belle detector,
we find BF(B^+ ->eta'K^+)=(79^+12_-11 +-9)x10^-6 and BF(B^0 ->
eta'K^0)=(55^+19_-16 +-8)x10^-6, where the first and second errors are
statistical and systematic, respectively. No signal is observed in the mode B^+
-> eta' pi^+, and we set a 90% confidence level upper limit of BF(B^+->
eta'pi^+) eta'K^+- decays is
investigated and a limit at 90% confidence level of -0.20<Acp<0.32 is obtained.Comment: Submitted to Physics Letters
Observation of Cabibbo-suppressed and W-exchange Lambda_c^+ baryon decays
We present measurements of the Cabibbo-suppressed decays Lambda_c^+ -->
Lambda0 K+ and Lambda_c^+ --> Sigma0 K+ (both first observations), Lambda_c^+
--> Sigma+ K+ pi- (seen with large statistics for the first time), Lambda_c^+
--> p K+ K- and Lambda_c^+ --> p phi (measured with improved accuracy).
Improved branching ratio measurements for the decays Lambda_c^+ --> Sigma+ K+
K- and Lambda_c^+ --> Sigma+ phi, which are attributed to W-exchange diagrams,
are shown. We also present the first evidence for Lambda_c^+ --> Xi(1690)^0 K+
and set an upper limit on the non-resonant decay Lambda_c^+ --> Sigma+ K+ K-.
This analysis was performed using 32.6 fb^{-1} of data collected by the Belle
detector at the asymmetric e+ e- collider KEKB.Comment: Submitted to Phys. Lett. B. v2: A small correction to the Authorlist
was made. An earlier version of this analysis was released as
BELLE-CONF-0130, hep-ex/010800
Measurement of the inclusive semileptonic branching fraction of B mesons and |Vcb|
We present a measurement of the electron spectrum from inclusive semileptonic
{\it B} decay, using 5.1 fb of data collected with the
Belle detector. A high-momentum lepton tag was used to separate the
semileptonic {\it B} decay electrons from secondary decay electrons. We
obtained the branching fraction, , with minimal model dependence.
From this measurement, we derive a value for the Cabibbo-Kobayashi-Maskawa
matrix element .Comment: 16 pages, 3 figures, 3 table
Determination of |Vcb| using the semileptonic decay \bar{B}^0 --> D^{*+}e^-\bar{\nu}
We present a measurement of the Cabibbo-Kobayashi-Maskawa (CKM) matrix
element |Vcb| using a 10.2 fb^{-1} data sample recorded at the \Upsilon(4S)
resonance with the Belle detector at the KEKB asymmetric e^+e^- storage ring.
By extrapolating the differential decay width of the \bar{B}^0 -->
D^{*+}e^-\bar{\nu} decay to the kinematic limit at which the D^{*+} is at rest
with respect to the \bar{B}^0, we extract the product of |Vcb| with the
normalization of the decay form factor F(1), |Vcb |F(1)=
(3.54+/-0.19+/-0.18)x10^{-2}, where the first error is statistical and the
second is systematic. A value of |Vcb| = (3.88+/-0.21+/-0.20+/-0.19)x10^{-2} is
obtained using a theoretical calculation of F(1), where the third error is due
to the theoretical uncertainty in the value of F(1). The branching fraction
B(\bar{B}^0 --> D^{*+}e^-\bar{\nu}) is measured to be
(4.59+/-0.23+/-0.40)x10^{-2}.Comment: 20 pages, 6 figures, elsart.cls, submitted to PL
A Measurement of the Branching Fraction for the Inclusive B --> X(s) gamma Decays with the Belle Detector
We have measured the branching fraction of the inclusive radiative B meson
decay B --> X(s) gamma to be Br(B->X(s)gamma)=(3.36 +/- 0.53(stat) +/-
0.42(sys) +0.50-0.54(th)) x 10^{-4}.
The result is based on a sample of 6.07 x 10^6 BBbar events collected at the
Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric e^+e^-
storage ring.Comment: 14 pages, 6 Postsript figures, uses elsart.cl
Measurement of W Polarisation at LEP
The three different helicity states of W bosons produced in the reaction e+
e- -> W+ W- -> l nu q q~ at LEP are studied using leptonic and hadronic W
decays. Data at centre-of-mass energies \sqrt s = 183-209 GeV are used to
measure the polarisation of W bosons, and its dependence on the W boson
production angle. The fraction of longitudinally polarised W bosons is measured
to be 0.218 \pm 0.027 \pm 0.016 where the first uncertainty is statistical and
the second systematic, in agreement with the Standard Model expectation
Search for Anomalous Couplings in the Higgs Sector at LEP
Anomalous couplings of the Higgs boson are searched for through the processes
e^+ e^- -> H gamma, e^+ e^- -> e^+ e^- H and e^+ e^- -> HZ. The mass range 70
GeV < m_H < 190 GeV is explored using 602 pb^-1 of integrated luminosity
collected with the L3 detector at LEP at centre-of-mass energies
sqrt(s)=189-209 GeV. The Higgs decay channels H -> ffbar, H -> gamma gamma, H
-> Z\gamma and H -> WW^(*) are considered and no evidence is found for
anomalous Higgs production or decay. Limits on the anomalous couplings d, db,
Delta(g1z), Delta(kappa_gamma) and xi^2 are derived as well as limits on the H
-> gamma gamma and H -> Z gamma decay rates
Measurement of W Polarisation at LEP
The three different helicity states of W bosons produced in the reaction e+
e- -> W+ W- -> l nu q q~ at LEP are studied using leptonic and hadronic W
decays. Data at centre-of-mass energies \sqrt s = 183-209 GeV are used to
measure the polarisation of W bosons, and its dependence on the W boson
production angle. The fraction of longitudinally polarised W bosons is measured
to be 0.218 \pm 0.027 \pm 0.016 where the first uncertainty is statistical and
the second systematic, in agreement with the Standard Model expectation
Bose-Einstein Correlations of Neutral and Charged Pions in Hadronic Z Decays
Bose-Einstein correlations of both neutral and like-sign charged pion pairs
are measured in a sample of 2 million hadronic Z decays collected with the L3
detector at LEP. The analysis is performed in the four-momentum difference
range 300 MeV < Q < 2 GeV. The radius of the neutral pion source is found to be
smaller than that of charged pions. This result is in qualitative agreement
with the string fragmentation model
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