Organization of cheerleading competition ''CCU Cheer Cup Ústí 2015''

64 stran, 18 stran příloh :barevné ilustrace, tabulkyTato teoreticko-empirická práce má za úkol popis projektu závodu v cheerleadingu, konkrétně soutěž ''CCU Cheer Cup Ústí 2015''. Důraz je kladen především na specifika závodu v tomto sportovním odvětví a syntézu teoretických znalostí s praxí v tomto konkrétním případě. V teoretických částech práce je podrobněji rozvedena struktura projektu sportovního závodu a souhrnný přehled o tomto sportovním odvětví. Dále je pak popisován závod samotný, součástí práce je i menší kvantitativní výzkum. V závěru jsou diskutovány poznatky z této konkrétní události v souvislosti s aktuálním lokálním i globálním stavem v tomto sporotvním odvětví

Porous Mullite Ceramic Modification with Nano-WO3

Mullite and mullite–alumina ceramics materials with dominance of the mullite phase are used in different areas of technology and materials science. Porous mullite ceramics materials can be used simultaneously as refractory heat insulators and also as materials for constructional elements. The purpose of this work was to investigate the WO3 nanoparticle influence on the evolution of the aluminum tungstate and zircon crystalline phases in mullite ceramics due to stabilization effects caused by different microsize ZrO2 and WO3 . The use of nano-WO3 prevented the dissociation of zircon in the ceramic samples with magnesia-stabilized zirconia (MSZ), increased porosity by approximately 60 ± 1%, increased the intensity of the aluminum tungstate phase, decreased bulk density by approximately 1.32 ± 0.01 g/cm3 , and increased thermal shock resistance by ensuring a loss of less than 5% of the elastic modulus after 10 cycles of thermal shock

Influence of thermal treatment and combustible additives on properties of Latvian clay ceramics pellets

Porous ceramic pellets for possible environmental application were produced from different Latvian clays by sintering at different temperatures. Their characteristics and influence of additives were analysed using X-ray diffraction, mercury porosimetry and BET tests. The obtained ceramic pellets from calcareous clays after immersion in distilled water change its pH value, which affects their capability to adsorb ions or molecules on the surface. The sorption capabilities are dependent on the pH level of water solution, composition of clays, and used adsorbate. Porosity of the produced pellets is mostly within range from 15 to 25 % throughout all sintering temperatures with a slight decrease at 1050 °C. The specific surface area has a wide range up to 30 m2/g. The highest surface area has pellets sintered at lower temperatures. The adsorption capability of pellets was evaluated using water solutions with different ions. The most promising results were obtained with iodine sorption. For most pellets the sorption capacity was 12.7 mg/g, although for the pellets sintered at 1050 °C it was lower

Informační zvyky uživatelů informačního systému Masarykovy univerzity : průzkum mezi studenty informačních studií a knihovnictví

Příspěvek shrnuje výzkum bakalářských a magisterských studentů oboru Informační studia a knihovnictví Masarykovy univerzity v Brně. Hlavním cílem výzkumu bylo analyzovat a charakterizovat Informační zvyky uživatelů informačního systému Masarykovy univerzity. Výzkumu jsme zaměřili tak, aby výsledky posloužily designu školení nových studentů, kteří se učí s informačním systémem Masarykovy univerzity pracovat. Popsali jsme informační zvyky uživatelů při práci se systémem. Informační zvyky jsme rozdělili do dvou segmentů – zvyky při přihlašování a odhlašování, které souvisí s informační bezpečností a zvyky při využívání funkcí a aplikací systému, které mají vliv na efektivitu studia. Odhalení uživatelských zvyků může přispět k porozumění vzniku problémů uživatelů a umožnit školitelům upozorňovat na takové možnosti a funkce systému, které pomohou problémům předcházet. Příspěvek obsahuje teoretický úvod, který vysvětluje kontext výzkumu, a zmiňuje některé obdobné tematické výzkumy. Dále jsou přiblíženy metodologické postupy, interpretovány výsledky a závěrem jsou diskutovány silné a slabé stránky výzkumu.The paper describes a research conducted on bachelor and masters students of Information and library studies at Masaryk University in Brno. The main aim of the research was to analyse information habits of users of information system of Masaryk University. We focused our research so that the results could serve to design training for new students, who will work with the information system of Masaryk University. We describe the users´ information habits, which are observable during users work with the system. We divided them into two segments – habits when logging in and out, so we focused on the issue of information security. And then on the features and applications of the system that have an impact on the effectiveness of study. If we describe these users´ habits, we can understand, which problem users have and point out to functions and options of the system that could prevent these problems. This report contains a theoretical introduction, it explains the context of the research and there are mentioned some similar researches. Next there are the methodological progresses approximated, results interpreted and in the conclusion there are the strengths and weaknesses discussed

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice

Myeloid cells lacking STAT3 promote antitumor responses of NK and T cells but it is unknown if this crosstalk affects development of autochthonous tumors. We deleted STAT3 in murine myeloid cells (STAT3(Δm)) and examined the effect on the development of autochthonous colorectal cancers (CRCs). Formation of Azoxymethane/Dextransulfate (AOM/DSS)-induced CRCs was strongly suppressed in STAT3(Δm) mice. Gene expression profiling showed strong activation of T cells in the stroma of STAT3(Δm) CRCs. Moreover, STAT3(Δm) host mice were better able to control the growth of transplanted MC38 colorectal tumor cells which are known to be killed in a T cell-dependent manner. These data suggest that myeloid cells lacking STAT3 control formation of CRCs mainly via cross activation of T cells. Interestingly, the few CRCs that formed in STAT3(Δm) mice displayed enhanced stromalization but appeared normal in size indicating that they have acquired ways to escape enhanced tumor surveillance. We found that CRCs in STAT3(Δm) mice consistently activate STAT3 signaling which is implicated in immune evasion and might be a target to prevent tumor relapse

Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1

Cytomegalovirus (CMV) has a high prevalence worldwide, is often fatal for immunocompromised patients, and causes bone marrow suppression. Deficiency of signal transducer and activator of transcription 1 (STAT1) results in severely impaired antiviral immunity. We have used cell-type restricted deletion of Stat1 to determine the importance of myeloid cell activity for the defense against murine CMV (MCMV). We show that myeloid STAT1 limits MCMV burden and infection-associated pathology in the spleen but does not affect ultimate clearance of infection. Unexpectedly, we found an essential role of myeloid STAT1 in the induction of extramedullary hematopoiesis (EMH). The EMH-promoting function of STAT1 was not restricted to MCMV infection but was also observed during CpG oligodeoxynucleotide-induced sterile inflammation. Collectively, we provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen

IDO1 + Paneth cells promote immune escape of colorectal cancer

Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an important strategy to revert immunosuppression. However, the underlying mechanisms of immune escape are still poorly understood. Here we discover Indoleamine-2,3-dioxygenase-1 (IDO1)+ Paneth cells in the stem cell niche of intestinal crypts and tumors, which promoted immune escape of colorectal cancer (CRC). Ido1 expression in Paneth cells was strictly Stat1 dependent. Loss of IDO1+ Paneth cells in murine intestinal adenomas with tumor cell-specific Stat1 deletion had profound effects on the intratumoral immune cell composition. Patient samples and TCGA expression data suggested corresponding cells in human colorectal tumors. Thus, our data uncovered an immune escape mechanism of CRC and identify IDO1+ Paneth cells as a target for immunotherapy

IDO1 + Paneth cells promote immune escape of colorectal cancer

Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an important strategy to revert immunosuppression. However, the underlying mechanisms of immune escape are still poorly understood. Here we discover Indoleamine-2,3-dioxygenase-1 (IDO1)+ Paneth cells in the stem cell niche of intestinal crypts and tumors, which promoted immune escape of colorectal cancer (CRC). Ido1 expression in Paneth cells was strictly Stat1 dependent. Loss of IDO1+ Paneth cells in murine intestinal adenomas with tumor cell-specific Stat1 deletion had profound effects on the intratumoral immune cell composition. Patient samples and TCGA expression data suggested corresponding cells in human colorectal tumors. Thus, our data uncovered an immune escape mechanism of CRC and identify IDO1+ Paneth cells as a target for immunotherapy

Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring

Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as BPA replacements, are being increasingly detected in human biological matrices. BPA and some of its analogues are classified as endocrine disruptors suspected of contributing to adverse health outcomes such as altered reproduction and neurodevelopment, obesity, and metabolic disorders among other developmental and chronic impairments. One of the aims of the H2020 European Human Biomonitoring Initiative (HBM4EU) is the implementation of effect biomarkers at large scales in future HBM studies in a systematic and standardized way, in order to complement exposure data with mechanistically-based biomarkers of early adverse effects. This review aimed to identify and prioritize existing biomarkers of effect for BPA, as well as to provide relevant mechanistic and adverse outcome pathway (AOP) information in order to cover knowledge gaps and better interpret effect biomarker data. A comprehensive literature search was performed in PubMed to identify all the epidemiologic studies published in the last 10 years addressing the potential relationship between bisphenols exposure and alterations in biological parameters. A total of 5716 references were screened, out of which, 119 full-text articles were analyzed and tabulated in detail. This work provides first an overview of all epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid and thyroid hormones, metabolic and allergy/immune biomarkers previously studied. Then, promising effect biomarkers related to altered neurodevelopmental and reproductive outcomes including brainderived neurotrophic factor (BDNF), kisspeptin (KiSS), and gene expression of nuclear receptors are prioritized, providing mechanistic insights based on in vitro, animal studies and AOP information. Finally, the potential of omics technologies for biomarker discovery and its implications for risk assessment are discussed. To the best of our knowledge, this is the first effort to comprehensively identify bisphenol-related biomarkers of effect for HBM purposes.European Union Commission H2020-EJP-HBM4EU 733032HBM4EU Initiativ