Endocrinal toxicity of industrial solvents – A mini review

537-549Endocrine system can be affected by various organic compounds. The review describes the effects of major industrial solvents on adrenal, thyroid and parathyroid glands in man and experimental animals. Further, their toxicity in pancreas, pituitary, testis and ovary has also been discussed. An attempt has been made to offer a historical and general information on solvent toxicity in endocrine glands. Possible mechanisms, in brief, have also been discussed. Endocrine toxicity caused by industrial solvents deserves more attention than hitherto paid. An understanding of hormonal disorders caused by industrial solvents will be important from occupational health point of view

Melatonin mijenja jetrenu funkciju u štakora izloženih benzenu

In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzenetreated rats thanks to its antioxidative properties.Svrha je ovog ispitivanja bila utvrditi zaštitno djelovanje melatonina od oštećenja jetrene funkcije izazvanog benzenom u Wistar štakora. Nakon 30-dnevne primjene, melatonin je značajno snizio hepatosomatski indeks te razine bilirubina i hidroksiprolina u muških i ženskih štakora. Premda nije utjecao na aspartat aminotransferazu, povoljno je djelovao na alanin aminotransferazu i alkalnu fosfatazu. Naši rezultati upućuju na to da melatonin djelotvorno mijenja jetrenu funkciju u štakora izloženih benzenu, upravo zbog svojih antikoksidativnih svojstva