Left coronary arteriovenous malformation with fistulous connections to the left and right ventricles

A 20-year-old man with right bundle branch block in recordedECG was referred to our department. His physical examinationwas unremarkable. Transthoracic echocardiography showeda severe hypertrophy of the interventricular septum (22 mm)which contained multiple echo-free spaces of the vascularnature. A flow pattern suggestive to a coronary artery fistulainto the left ventricle was recorded. The patient was referredfor a coronary angiography, which revealed an arteriovenousmalformation starting from the septal branch of the enlarged leftanterior descending artery. The malformation communicatedwith the lumen of the left (arterial phase) and right ventricle(venous phase) as well. The posterior descending artery wasfed exclusively from the described arteriovenous malformation.99mTc MIBI SPECT images showed a moderately reversible perfusiondefect in the inferior wall, suggesting non-critical ischemiaof this region

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Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1970.Bibliography: leaf 15.M.S

Left coronary arteriovenous malformation with fistulous connections to the left and right ventricles

A 20-year-old man with right bundle branch block in recorded ECG was referred to our department. His physical examination was unremarkable. Transthoracic echocardiography showed a severe hypertrophy of the interventricular septum (22 mm) which contained multiple echo-free spaces of the vascular nature. A flow pattern suggestive to a coronary artery fistula into the left ventricle was recorded. The patient was referred for a coronary angiography, which revealed an arteriovenous malformation starting from the septal branch of the enlarged left anterior descending artery. The malformation communicated with the lumen of the left (arterial phase) and right ventricle (venous phase) as well. The posterior descending artery was fed exclusively from the described arteriovenous malformation. 99mTc MIBI SPECT images showed a moderately reversible perfusion defect in the inferior wall, suggesting non-critical ischemia of this region

Identity, group membership, psychological consistency: the discriminated in the economics of discrimination

In economics, we start from the fact that the discriminated element is almost absent from the theory of discrimination. Indeed, while the reasons why one person discriminates against another are well established, we have done little research on the reaction of the discriminated individual. By bringing together concepts such as psychological coherence and group identity, we propose a framework that summarizes some of the strategies adopted by the discriminated individual. We also analyze the conditions under which an individual may consider moving away from the groups to which he or she is assimilated in order to avoid discrimination, to the detriment of his or her psychological coherence and group identity.En économie, nous partons du fait que l'élément discriminé est presque absent de la théorie de la discrimination. En effet, si les raisons qui font qu'une personne en discrimine une autre sont bien établies, nous avons peu étudié la réaction de l'individu discriminé. En rassemblant des concepts tels que la cohérence psychologique et l'identité de groupe, nous proposons un cadre qui résume certaines stratégies adoptées par le discriminé. Nous analysons également les conditions dans lesquelles un individu peut envisager de s'éloigner des groupes auxquels il est assimilé, afin d'éviter la discrimination, au détriment de sa cohérence psychologique et de son identité de groupe

POST 2012 CLIMATE CHANGE AGREEMENT

Addressing climate change requires a thorough and sincere communication not only as to the scale of the challenge the world faces but also as to the international cooperation possibilities and countries willingness to commit to the challenge. Taking the lead in this group, European Union has acknowledged the fact that climate change is a serious social, political and economic challenge. Following the indications provided by the scientific rationale as to the urgent action that is required, European Community has involved itself in fight against the phenomena by engaging in working on a feasible solution to this problem. European Commission in particular has been taking upon its shoulders much of the workload in this field and has proved its dedication especially by involving stakeholders in constant dialogue on the subject. Sharing the ambitions of the European Commission in creating a cleaner world, the major goal of this paper is to provide the Commission with a series of recommendations from a development/political, environmental and economic perspective to ensure that the ambitions become a reality, and therefore a success. Accordingly, this paper provides an overview of sectoral and general approaches' effectiveness in terms of their economic and environmental as well as compliance prospects. Conclusion wraps up the paper providing a number of recommendations stemming mainly from stakeholders input's analysis

Optimum levels of crude protein and metabolizable energy in diet as well as sexual effect on performance and carcass of Thai Native Crossbred Chicken (Pradu Hang Dam x Hubbard JA 57 Ki) during 1–13 weeks of age

This study aimed to determine the optimum dietary levels of CP, ME and sexual effect on performance of Pradu Hang Dam x Hubbard JA 57 Ki. The experiment had 3 phases, namely 1–5, 6–10 and 11–13 weeks of the birds’ age, using 1,440 oneday old chicks with equal number of males and females in separate pens. Each sex was randomly allotted to 6 groups of 3 replicates, containing 40 birds/rep. The diets for the 3 phases contained 21, 19, 17 vs 19, 17, 15% CP, respectively. Each CP level contained 3 ME levels (3.2, 2.9 and 2.6 kcal/g) according to a 2x3 Factorial in Randomized Complete Block design, having sex as a block. The results showed that high CP diets gave higher BWG, lower FI, better FCR, FCG, with higher percentage of carcass and drumstick (P<0.05). Higher ME diets (3.2 and 2.9 kcal ME/g) gave significantly higher BWG, lower FI, better FCR, FCG, higher percentage of carcass, drumstick and abdominal fat than the 2.6 kcal ME/g diet (P<0.05). Males had significantly higher BWG and FI than females. The optimum rations for this crossbreed during the 3 phases were 21, 19 and 17% CP respectively with 3.2 kcal ME/g

Risk prediction of developing venous thrombosis in combined oral contraceptive users.

Venous thromboembolism (VTE) is a complex multifactorial disease influenced by genetic and environmental risk factors. An example for the latter is the regular use of combined oral contraceptives (CC), which increases the risk to develop VTE by 3 to 7 fold, depending on estrogen dosage and the type of progestin present in the pill. One out of 1'000 women using CC develops thrombosis, often with life-long consequences; a risk assessment is therefore necessary prior to such treatment. Currently known clinical risk factors associated with VTE development in general are routinely checked by medical doctors, however they are far from being sufficient for risk prediction, even when combined with genetic tests for Factor V Leiden and Factor II G20210A variants. Thus, clinical and notably genetic risk factors specific to the development of thrombosis associated with the use of CC in particular should be identified. Step-wise (logistic) model selection was applied to a population of 1622 women using CC, half of whom (794) had developed a thromboembolic event while using contraceptives. 46 polymorphisms and clinical parameters were tested in the model selection and a specific combination of 4 clinical risk factors and 9 polymorphisms were identified. Among the 9 polymorphisms, there are two novel genetic polymorphisms (rs1799853 and rs4379368) that had not been previously associated with the development of thromboembolic event. This new prediction model outperforms (AUC 0.71, 95% CI 0.69-0.74) previously published models for general thromboembolic events in a cross-validation setting. Further validation in independent populations should be envisaged. We identified two new genetic variants associated to VTE development, as well as a robust prediction model to assess the risk of thrombosis for women using combined oral contraceptives. This model outperforms current medical practice as well as previously published models and is the first model specific to CC use

Delegation to autonomous agents promotes cooperation in collective-risk dilemmas

Home assistant chat-bots, self-driving cars, drones or automated negotiations are some of the several examples of autonomous (artificial) agents that have pervaded our society. These agents enable the automation of multiple tasks, saving time and (human) effort. However, their presence in social settings raises the need for a better understanding of their effect on social interactions and how they may be used to enhance cooperation towards the public good, instead of hindering it. To this end, we present an experimental study of human delegation to autonomous agents and hybrid human-agent interactions centered on a public goods dilemma shaped by a collective risk. Our aim to understand experimentally whether the presence of autonomous agents has a positive or negative impact on social behaviour, fairness and cooperation in such a dilemma. Our results show that cooperation increases when participants delegate their actions to an artificial agent that plays on their behalf. Yet, this positive effect is reduced when humans interact in hybrid human-agent groups. Finally, we show that humans are biased towards agent behaviour, assuming that they will contribute less to the collective effort

RNA

Next-generation sequencing is an increasingly popular and efficient approach to characterize the full set of microRNAs (miRNAs) present in human biosamples. MiRNAs' detection and quantification still remain a challenge as they can undergo different post transcriptional modifications and might harbor genetic variations (polymiRs) that may impact on the alignment step. We present a novel algorithm, OPTIMIR, that incorporates biological knowledge on miRNA editing and genome-wide genotype data available in the processed samples to improve alignment accuracy. OPTIMIR was applied to 391 human plasma samples that had been typed with genome-wide genotyping arrays. OPTIMIR was able to detect genotyping errors, suggested the existence of novel miRNAs and highlighted the allelic imbalance expression of polymiRs in heterozygous carriers. OPTIMIR is written in python, and freely available on the GENMED website (http://www.genmed.fr/index.php/fr/) and on Github (github.com/FlorianThibord/OptimiR)

Lower Leg Injury Mechanism Investigation During an IED Blast Under a Vehicle Using an Anatomic Leg Model

Attacks with improvised explosive device (IED) constituted the main threat to, for example, Polish soldiers in Iraq and Afghanistan. Improving safety during transport in an armored vehicle has become an important issue. The main purpose of the presented research is to investigate the mechanism of lower leg injuries during explosion under an armored vehicle. Using a numerical anatomic model of the lower leg, the analysis of the leg position was carried out. In all presented positions, the stress limit of 160 (MPa) was reached, which indicates bone damage. There is a difference in stress distribution in anatomic elements pointing to different injury mechanisms