86 research outputs found
Black hole spin: theory and observation
In the standard paradigm, astrophysical black holes can be described solely
by their mass and angular momentum - commonly referred to as `spin' - resulting
from the process of their birth and subsequent growth via accretion. Whilst the
mass has a standard Newtonian interpretation, the spin does not, with the
effect of non-zero spin leaving an indelible imprint on the space-time closest
to the black hole. As a consequence of relativistic frame-dragging, particle
orbits are affected both in terms of stability and precession, which impacts on
the emission characteristics of accreting black holes both stellar mass in
black hole binaries (BHBs) and supermassive in active galactic nuclei (AGN).
Over the last 30 years, techniques have been developed that take into account
these changes to estimate the spin which can then be used to understand the
birth and growth of black holes and potentially the powering of powerful jets.
In this chapter we provide a broad overview of both the theoretical effects of
spin, the means by which it can be estimated and the results of ongoing
campaigns.Comment: 55 pages, 5 figures. Published in: "Astrophysics of Black Holes -
From fundamental aspects to latest developments", Ed. Cosimo Bambi, Springer:
Astrophysics and Space Science Library. Additional corrections mad
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Correction Volume: 10, Article Number: 2068 DOI: 10.1038/s41467-019-10160-w WOS:000466339700001General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P <5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.Peer reviewe
An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems
New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous WIA in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods. Little, while not much new information has been gathered on soil organisms. The impact on marine coastal ecosystems is still largely uncharted. The chronic lethality of neonicotinoids to insects and crustaceans, and the strengthened evidence that these chemicals also impair the immune system and reproduction, highlights the dangers of this particular insecticidal classneonicotinoids and fipronil. , withContinued large scale – mostly prophylactic – use of these persistent organochlorine pesticides has the potential to greatly decreasecompletely eliminate populations of arthropods in both terrestrial and aquatic environments. Sublethal effects on fish, reptiles, frogs, birds and mammals are also reported, showing a better understanding of the mechanisms of toxicity of these insecticides in vertebrates, and their deleterious impacts on growth, reproduction and neurobehaviour of most of the species tested. This review concludes with a summary of impacts on the ecosystem services and functioning, particularly on pollination, soil biota and aquatic invertebrate communities, thus reinforcing the previous WIA conclusions (van der Sluijs et al. 2015)
Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia
Detection of soluble intermediates of the fibrinogen-fibrin conversion using erythrocytes coated with fibrin monomers
Comparison of 125I-fibrinogen kinetics and fibrinopeptide A in patients with disseminated neoplasias
Bildungsstörung oder Umsatzsteigerung von Antithrombin III im Verlauf einer schweren erworbenen Koagulopathie?
Repair of an aortoiliac aneurysm associated with chronic disseminated intravascular coagulopathy
β2-adrenoceptor signaling reduction is involved in the inflammatory response of fibroblast-like synoviocytes from adjuvant-induced arthritic rats
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