Cyclostationary Empirical Orthogonal Function Sea-Level Reconstruction

Since 1993, satellite altimetry has provided accurate measurements of sea surface height with near-global coverage. These measurements led to the first definitive estimates of global mean sea-level (GMSL) rise and have improved understanding of how sea levels are changing regionally at decadal time scales. These relatively short records, however, provide no information about the state of the ocean prior to 1993, and with the modern altimetry record spanning only 20 years, the lower frequency signals that are known to be present in the ocean are difficult or impossible to resolve. Tide gauges, on the other hand, have measured sea level over the last 200 years, with some records extending back to 1807. While providing longer records, the spatial resolution of tide gauge sampling is poor, making studies of the large-scale patterns of ocean variability and estimates of GMSL difficult. Combining the satellite altimetry with the tide gauges using a technique known as sea-level reconstruction results in a data set with the record length of the tide gauges and the near-global coverage of satellite altimetry. Cyclostationary empirical orthogonal functions (CSEOFs), derived from satellite altimetry, are combined with historical sea-level measurements from tide gauges to create the Reconstructed Sea Level data set spanning from 1950 to 2009. Previous sea-level reconstructions have utilized empirical orthogonal functions (EOFs) as basis functions, but by using CSEOFs and by addressing other aspects of the reconstruction procedure, an alternative sea-level reconstruction can be computed. The resulting reconstructed sea-level data set has weekly temporal resolution and half-degree spatial resolution

Contribution of the Pacific Decadal Oscillation to Global Mean Sea Level Trends

Understanding and explaining the trend in global mean sea level (GMSL) have important implications for future projections of sea level rise. While measurements from satellite altimetry have provided accurate estimates of GMSL, the modern altimetry record has only now reached 20 years in length, making it difficult to assess the contribution of decadal to multidecadal climate signals to the global trend. Here, we use a sea level reconstruction to study the 20 year trends in sea level since 1950. In particular, we show that the Pacific Decadal Oscillation (PDO) contributes significantly to the 20 year trends in GMSL. We estimate the PDO contribution to the GMSL trend over the past 20 years to be approximately 0.49 ± 0.25 mm/year and find that removing the PDO contribution reduces the acceleration in GMSL estimated over the past 60 years. Key Points The PDO has contributed 0.49 mm/yr to the current altimetry GMSL trend The PDO has a large impact on regional and global sea level trends Reconstructions allow for the study of decadal-scale climate variability

Sea Level Trends in Southeast Asian Seas

Southeast Asian seas span the largest archipelago in the global ocean and provide a complex oceanic pathway connecting the Pacific and Indian oceans. The Southeast Asian sea regional sea level trends are some of the highest observed in the modern satellite altimeter record that now spans almost 2 decades. Initial comparisons of global sea level reconstructions find that 17-year sea level trends over the past 60 years exhibit good agreement with decadal variability associated with the Pacific Decadal Oscillation and related fluctuations of trade winds in the region. The Southeast Asian sea region exhibits sea level trends that vary dramatically over the studied time period. This historical variation suggests that the strong regional sea level trends observed during the modern satellite altimeter record will abate as trade winds fluctuate on decadal and longer timescales. Furthermore, after removing the contribution of the Pacific Decadal Oscillation (PDO) to sea level trends in the past 20 years, the rate of sea level rise is greatly reduced in the Southeast Asian sea region. As a result of the influence of the PDO, the Southeast Asian sea regional sea level trends during the 2010s and 2020s are likely to be less than the global mean sea level (GMSL) trend if the observed oscillations in wind forcing and sea level persist. Nevertheless, long-term sea level trends in the Southeast Asian seas will continue to be affected by GMSL rise occurring now and in the future

Impact of rifaximin on the frequency and characteristics of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

BACKGROUND: Rifaximin is a non-absorbable antibiotic used to prevent relapses of hepatic encephalopathy which may also be a candidate for prophylaxis of spontaneous bacterial peritonitis (SBP). AIM: To detect the impact of rifaximin on the occurrence and characteristics of SBP. METHODS: We prospectively studied all hospitalized patients that underwent a diagnostic paracentesis in our department from March 2012 to April 2013 for SBP and recorded all clinical data including type of SBP prophylaxis, prior use of rifaximin, concomitant complications of cirrhosis, as well as laboratory results and bacteriological findings. Patients were divided into the following three groups: no antibiotic prophylaxis, prophylaxis with rifaximin or with systemically absorbed antibiotic prophylaxis. RESULTS: Our study cohort comprised 152 patients with advanced liver cirrhosis, 32 of whom developed SBP during the study period. As expected, our study groups differed regarding a history of hepatic encephalopathy and SBP before inclusion into the study. None of the 17 patients on systemic antibiotic prophylaxis developed SBP while 8/27 patients on rifaximin and 24/108 without prophylaxis had SBP (p = 0.02 and p = 0.04 versus systemic antibiotics, respectively). In general, episodes of SBP were similar for patients treated with rifaximin and those without any prophylaxis. However, Escherichia coli and enterococci were dominant in the ascites of patients without any prophylaxis, while mostly klebsiella species were recovered from the ascites samples in the rifaximin group. CONCLUSION: Rifaximin pretreatment did not lead to a reduction of SBP occurrence in hospitalized patients with advanced liver disease. However, the bacterial species causing SBP were changed by rifaximin

How do we best synergise climate mitigation actions to co-benefit biodiversity?

Acknowledgements We thank Yuka Otsuki Estrada for help in designing and producing the table, and all other authors of the IPBES-IPCC report on the scientific outcome of the IPBES-IPCC co-sponsored workshop on biodiversity and climate change (Pörtner et al., 2021) for cross-cutting discussions during preparation of this analysis. Although this paper is based on the report of the IPBES-IPCC co882 sponsored workshop, the views expressed here represent the individual views of the authors. We would also like to thank the scientific steering committee of the IPBES-IPCC co-sponsored workshop, review editors, the IPCC and IPBES Secretariat, especially Anne Larigauderie, and Technical Support Units. In memory of our friend and co-author, Bob Scholes, who sadly died during the preparation of this synthesis, and who will be sorely missed by all.Peer reviewedPostprin

AlGaInP red-emitting light emitting diode under extremely high pulsed pumping

Efficiency of commercial 620 nm InAlGaP Golden Dragon-cased high-power LEDs has been studied under extremely high pump current density up to 4.5 kA/cm2 and pulse duration from microsecond down to sub-nanosecond range. No efficiency decrease and negligible red shift of the emission wavelength is observed in the whole range of drive currents at nanosecond-range pulses with duty cycles well below 1%. Analysis of the pulse-duration dependence of the LED efficiency and emission spectrum suggests the active region overheating to be the major mechanism of the LED efficiency reduction at higher pumping, dominating over the electron overflow and Auger recombination

Temperature effects on optical properties and efficiency of red AlGaInP-based light emitting diodes under high current pulse pumping

In this paper, current-dependent emission spectra and efficiency measured on the same AlGaInP red light-emitting diode (LED) pumped with the current pulses of very different durations are recorded. This enabled for the first time distinguishing between high-carrier concentration and self-heating effects on the efficiency decline at high current magnitudes. The electron leakage to the p-side of the LED structure, which is the major mechanism of the efficiency reduction, is found to rise substantially when the device self-heating starts to develop. As a result, in comparison to continuous-wave excitation, driving the LED with sub-microsecond current pulses allows suppressing the device self-heating and, eventually, increasing the operating current by an order of magnitude without noticeable efficiency losses. Based on the reduced ABC-model, neglecting Auger recombination, the light extraction efficiency, injection efficiency, and internal quantum efficiency of the LED are estimated, suggesting light extraction to be the most critical factor for the overall efficiency of the LED. The coupled spectral/power LED characterization using the variable-duration current pulse pumping is found to be an effective approach for analyzing mechanisms of the device operation

Evaluation of a Novel Thiol–Norbornene-Functionalized Gelatin Hydrogel for Bioprinting of Mesenchymal Stem Cells

Introduction: Three-dimensional bioprinting can be considered as an advancement of the classical tissue engineering concept. For bioprinting, cells have to be dispersed in hydrogels. Recently, a novel semi-synthetic thiolene hydrogel system based on norbornene-functionalized gelatin (GelNB) and thiolated gelatin (GelS) was described that resulted in the photoclick hydrogel GelNB/GelS. In this study, we evaluated the printability and biocompatibility of this hydrogel system towards adipose-tissue-derived mesenchymal stem cells (ASCs). Methods: GelNB/GelS was synthesized with three different crosslinking densities (low, medium and high), resulting in different mechanical properties with moduli of elasticity between 206 Pa and 1383 Pa. These hydrogels were tested for their biocompatibility towards ASCs in terms of their viability, proliferation and differentiation. The extrusion-based bioprinting of ASCs in GelNB/GelS-high was performed to manufacture three-dimensional cubic constructs. Results: All three hydrogels supported the viability, proliferation and chondrogenic differentiation of ASCs to a similar extent. The adipogenic differentiation of ASCs was better supported by the softer hydrogel (GelNB/GelS-low), whereas the osteogenic differentiation was more pronounced in the harder hydrogel (GelNB/GelS-high), indicating that the differentiation fate of ASCs can be influenced via the adaption of the mechanical properties of the GelNB/GelS system. After the ex vivo chondrogenic differentiation and subcutaneous implantation of the bioprinted construct into immunocompromised mice, the production of negatively charged sulfated proteoglycans could be observed with only minimal inflammatory signs in the implanted material. Conclusions: Our results indicate that the GelNB/GelS hydrogels are very well suited for the bioprinting of ASCs and may represent attractive hydrogels for subsequent in vivo tissue engineering applications

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

Identification and Functional Analyses of 11 769 Full-length Human cDNAs Focused on Alternative Splicing

We analyzed diversity of mRNA produced as a result of alternative splicing in order to evaluate gene function. First, we predicted the number of human genes transcribed into protein-coding mRNAs by using the sequence information of full-length cDNAs and 5′-ESTs and obtained 23 241 of such human genes. Next, using these genes, we analyzed the mRNA diversity and consequently sequenced and identified 11 769 human full-length cDNAs whose predicted open reading frames were different from other known full-length cDNAs. Especially, 30% of the cDNAs we identified contained variation in the transcription start site (TSS). Our analysis, which particularly focused on multiple variable first exons (FEVs) formed due to the alternative utilization of TSSs, led to the identification of 261 FEVs expressed in the tissue-specific manner. Quantification of the expression profiles of 13 genes by real-time PCR analysis further confirmed the tissue-specific expression of FEVs, e.g. OXR1 had specific TSS in brain and tumor tissues, and so on. Finally, based on the results of our mRNA diversity analysis, we have created the FLJ Human cDNA Database. From our result, it has been understood mechanisms that one gene produces suitable protein-coding transcripts responding to the situation and the environment