Gaussian Process Modelling for Uncertainty Quantification in Convectively-Enhanced Dissolution Processes in Porous Media

Numerical groundwater flow and dissolution models of physico-chemical processes in deep aquifers are usually subject to uncertainty in one or more of the model input parameters. This uncertainty is propagated through the equations and needs to be quantified and characterised in order to rely on the model outputs. In this paper we present a Gaussian process emulation method as a tool for performing uncertainty quantification in mathematical models for convection and dissolution processes in porous media. One of the advantages of this method is its ability to significantly reduce the computational cost of an uncertainty analysis, while yielding accurate results, compared to classical Monte Carlo methods. We apply the methodology to a model of convectively-enhanced dissolution processes occurring during carbon capture and storage. In this model, the Gaussian process methodology fails due to the presence of multiple branches of solutions emanating from a bifurcation point, i.e., two equilibrium states exist rather than one. To overcome this issue we use a classifier as a precursor to the Gaussian process emulation, after which we are able to successfully perform a full uncertainty analysis in the vicinity of the bifurcation point

Gender dysphoria and autism spectrum disorder: a systematic review of the literature

Introduction. There is a growing clinical recognition that a significant proportion of patients with Gender Dysphoria, have concurrent Autism Spectrum Disorder (ASD). Aim. The purpose of this review is to systematically appraise the current literature regarding the co-occurrence of Gender Dysphoria and ASD. Methods. A systematic literature search using Medline/Pubmed, PsycINFO and Embase were conducted from 1966 to July 2015. Main Outcome Measures. A total of 58 articles were generated from the search. Nineteen of these publications met the inclusion criteria. Results. The literature investigating ASD in children and adolescents with Gender Dysphoria have found a higher prevalence rate of ASD compared to the general population. There is a limited amount of research in adults. Only one study showed that adults attending services for Gender Dysphoria had increased ASD scores. Another study showed a higher proportion of atypical gender identity in adults with ASD. Conclusions. Although the research is limited, especially with adults, there is an increasing amount of evidence that suggests a co-occurrence between Gender Dysphoria and ASD. Further research is vital for educational and clinical purposes

The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders : A hypothesis paper

© 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.Peer reviewedPublisher PD

Belief-Attribution in Adults with and without Autistic Spectrum Disorders

An important aspect of daily life is the ability to infer information about the contents of other people’s minds, such as what they can see and what they know, in order to engage in successful interactions. This is referred to as possession of a ‘Theory of Mind’ (ToM). Past research has shown that adults with Autistic Spectrum Disorders (ASD) often show deficits in social communication abilities, although can successfully pass tests of explicit ToM. The current study utilized a computerized false-belief task to explore subtle differences (i.e., measuring response times and accuracy rates) in how efficiently ToM capacities – specifically, belief-attribution – are utilized in adults with and without ASD. In the task, participants were asked to attribute a belief-state to either themselves or another person, following establishment of a true or false-belief scenario. Results revealed comparable patterns of ToM engagement across individuals with and without ASD, with faster and more accurate responses to ‘Self’ versus ‘Other’ oriented questions, and slower response times when shifting between the ‘Self’ and ‘Other’ perspective compared to when maintaining a perspective. However, autistic individuals showed a particular deficit in correctly identifying a belief-state in false-belief trials, in which two contrasting belief-states had to be held in mind, suggesting more difficulty disengaging from current, reality based belief-states than neuro-typical individuals

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