Rip/singularity free cosmology models with bulk viscosity

In this paper we present two concrete models of non-perfect fluid with bulk viscosity to interpret the observed cosmic accelerating expansion phenomena, avoiding the introduction of exotic dark energy. The first model we inspect has a viscosity of the form ${\zeta} = {\zeta}_0 + ({\zeta}_1-{\zeta}_2q)H$ by taking into account of the decelerating parameter q, and the other model is of the form ${\zeta} = {\zeta}_0 + {\zeta}_1H + {\zeta}_2H^2$. We give out the exact solutions of such models and further constrain them with the latest Union2 data as well as the currently observed Hubble-parameter dataset (OHD), then we discuss the fate of universe evolution in these models, which confronts neither future singularity nor little/pseudo rip. From the resulting curves by best fittings we find a much more flexible evolution processing due to the presence of viscosity while being consistent with the observational data in the region of data fitting. With the bulk viscosity considered, a more realistic universe scenario is characterized comparable with the {\Lambda}CDM model but without introducing the mysterious dark energy.Comment: 9 pages, 6 figures, submitted to EPJ-

Shrunken p -Values for Assessing Differential Expression with Applications to Genomic Data Analysis

In many scientific problems involving high-throughput technology, inference must be made involving several hundreds or thousands of hypotheses. Recent attention has focused on how to address the multiple testing issue; much focus has been devoted toward the use of the false discovery rate. In this article, we consider an alternative estimation procedure titled shrunken p -values for assessing differential expression (SPADE). The estimators are motivated by risk considerations from decision theory and lead to a completely new method for adjustment in the multiple testing problem. In addition, the decision-theoretic framework can be used to derive a decision rule for controlling the number of false positive results. Some theoretical results are outlined. The proposed methodology is illustrated using simulation studies and with application to data from a prostate cancer gene expression profiling study.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66004/1/j.1541-0420.2006.00616.x.pd

The Influence of Caffeine Expectancies on Simulated Soccer Performance in Recreational Individuals

Caffeine (CAF) has been reported to improve various facets associated with successful soccer play, including gross motor skill performance, endurance capacity and cognition. These benefits are primarily attributed to pharmacological mechanisms. However, evidence assessing CAF’s overall effects on soccer performance are sparse with no studies accounting for CAF’s potential psychological impact. Therefore, the aim of this study was to assess CAF’s psychological vs. pharmacological influence on various facets of simulated soccer performance. Utilising a double-dissociation design, eight male recreational soccer players (age: 22 ± 5 years, body mass: 78 ± 16 kg, height: 178 ± 6 cm) consumed CAF (3 mg/kg/body mass) or placebo (PLA) capsules, 60 min prior to performing the Loughborough Intermittent Shuttle Test (LIST) interspersed with a collection of ratings of perceived exertion (RPE), blood glucose and lactate, heart rate and performing the Loughborough Soccer Passing Test (LSPT). Whole-body dynamic reaction time (DRT) was assessed pre- and post- LIST, and endurance capacity (TLIM) post, time-matched LIST. Statistical analysis was performed using IBM SPSS (v24) whilst subjective perceptions were explored using template analysis. Mean TLIM was greatest (p < 0.001) for synergism (given CAF/told CAF) (672 ± 132 s) vs. placebo (given PLA/told PLA) (533 ± 79 s). However, when isolated, TLIM was greater (p = 0.012) for CAF psychology (given PLA/told CAF) (623 ± 117 s) vs. pharmacology (given CAF/told PLA) (578 ± 99 s), potentially, via reduced RPE. Although DRT performance was greater (p = 0.024) post-ingestion (+5 hits) and post-exercise (+7 hits) for pharmacology vs. placebo, psychology and synergism appeared to improve LSPT performance vs. pharmacology. Interestingly, positive perceptions during psychology inhibited LSPT and DRT performance via potential CAF over-reliance, with the opposite occurring following negative perceptions. The benefits associated with CAF expectancies may better suit tasks that entail lesser cognitive-/skill-specific attributes but greater gross motor function and this is likely due to reduced RPE. In isolation, these effects appear greater vs. CAF pharmacology. However, an additive benefit may be observed after combining expectancy with CAF pharmacology (i.e., synergism).N/

Critical Perspectives on Our Current Moment: An Experiment in Teaching for 2020

During the summer of 2020, the DePaul College of Liberal Arts and Social Sciences (LAS) offered twenty-two incoming students a special interdisciplinary online course, giving them the opportunity to learn and reflect on the crises of 2020 with faculty, staff, and one another. This article’s authors (who are the class’s faculty and students) describe the construction and execution of this course and reflect on the experience. Course topics included “the social contract; equity and justice; historical, cultural, and artistic responses to upheaval; global interconnections; and the way forward.” The course fulfilled DePaul’s mission to help students “engage questions of intellect and ethics in our contemporary world.” Students created reflective maps that connected what they were learning to their own lives and feelings, and they submitted videos explaining the project. Five appear in this article, illustrating how students learned to think differently and embark on new kinds of action

Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes

Aims  To study the pharmacodynamics and pharmacokinetics of selatogrel, a novel P2Y12 receptor antagonist for subcutaneous administration, in patients with chronic coronary syndromes (CCS). Methods and results  In this double-blind, randomized study of 345 patients with CCS on background oral antiplatelet therapy, subcutaneous selatogrel (8 mg, n = 114; or 16 mg, n = 115) was compared with placebo (n = 116) (ClinicalTrials.gov: NCT03384966). Platelet aggregation was assessed over 24 h (VerifyNow assay) and 8 h (light transmittance aggregometry; LTA). Pharmacodynamic responders were defined as patients having P2Y12 reaction units (PRU) <100 at 30 min post-dose and lasting ≥3 h. At 30 min post-dose, 89% of patients were responders to selatogrel 8 mg, 90% to selatogrel 16 mg, and 16% to placebo (P < 0.0001). PRU values (mean ± standard deviation) were 10 ± 25 (8 mg), 4 ± 10 (16 mg), and 163 ± 73 (placebo) at 15 min and remained <100 up to 8 h for both doses, returning to pre-dose or near pre-dose levels by 24 h post-dose. LTA data showed similarly rapid and potent inhibition of platelet aggregation. Selatogrel plasma concentrations peaked ∼30 min post-dose. Selatogrel was safe and well-tolerated with transient dyspnoea occurring overall in 7% (16/229) of patients (95% confidence interval: 4–11%). Conclusions  Selatogrel was rapidly absorbed following subcutaneous administration in CCS patients, providing prompt, potent, and consistent platelet P2Y12 inhibition sustained for ≥8 h and reversible within 24 h. Further studies of subcutaneous selatogrel are warranted in clinical scenarios where rapid platelet inhibition is desirable

Examining the effects of experimental/academic electroacoustic and popular electronic musics on the evolution and development of human–computer interaction in music

This article focuses on how the development of human–computer interaction in music has been aided and influenced by both experimental/academic electroacoustic art music and popular electronic music. These two genres have impacted upon this ever-changing process of evolution in different ways, but have together been paramount to the establishment of interactivity in music as we understand it today; which is itself having wide-ranging implications upon the modern-day musical landscape as a whole—both in the way that we, as listeners and audience members, purchase and consume music as well as conceptualise and think about it

Senescence and cancer : a review of clinical implications of senescence and senotherapies

Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour suppressive process, both by preventing cancer cell proliferation and suppressing malignant progression from pre-malignant to malignant disease. It may also be a key effector mechanism of many types of anticancer therapies, such as chemotherapy, radiotherapy, and endocrine therapies, both directly and via bioactive molecules released by senescent cells that may stimulate an immune response. However, senescence may contribute to reduced patient resilience to cancer therapies and may provide a pathway for disease recurrence after cancer therapy. A new group of drugs, senotherapies, (drugs which interact with senescent cells to interfere with their pro-aging impacts by either selectively destroying senescent cells (senolytic drugs) or inhibiting their function (senostatic drugs)) are under active investigation to determine whether they can enhance the efficacy of cancer therapies and improve resilience to cancer treatments. Senolytic drugs include quercetin, navitoclax, and fisetin and preclinical and early phase clinical data are emerging of their potential role in cancer treatments, although none are yet in routine use clinically. This article provides a review of these issues

The Ursinus Weekly, April 29, 1971

Hermann F. Eilts addresses Ursinus • New Weekly staff named; Charles L. Chambers, editor • Pi Gamma Mu elects new president, Dr. Eugene Herbert Miller of Ursinus, at their annual national board meeting • Cub and Key Society names new members • The Myrin Library dedication set for Sunday, May 22, 1971 • Editorial: Statement of purpose • No psychologist this year, administration tells SFARC • Campus perspective: Changing with the times • Marchers invade Washington for week of demonstrations • Editorial: Before you march • Letters to the editor: Eating in garbage; Sex objects • Ecology crushes UC apathy as recycling days continue • Academic committee studies curriculum • Faculty suggest change in eligibility of students • Showboat to highlight Spring I.F. weekend • A marathon that wasn\u27t : Freshmen still determined • Wilma Scott Heide of N.O.W. talks of women\u27s liberation • Chancellor Helfferich to direct the Campus Chest presentation • Movie critic: Ryan\u27s daughter • Albert and trio prove victorious • Tennis team starts slow; Bears find winning ways • Golf tees off; Squad now 3-5https://digitalcommons.ursinus.edu/weekly/1144/thumbnail.jp