45 research outputs found
Partial Return Yoke for MICE
The international Muon Ionization Cooling Experiment (MICE) is a large scale experiment which is presently assembled at the Rutherford Appleton Laboratory in Didcot, UK. The purpose of MICE is to demonstrate the concept of ionization cooling experimentally. Ionization cooling is an important accelerator concept which will be essential for future HEP experiments such as a potential Muon Collider or a Neutrino Factory. The MICE experiment will house up to 18 superconducting solenoids, all of which produce a substantial amount of magnetic flux. Recently it was realized that this magnetic flux leads to a considerable stray magnetic field in the MICE hall. This is a concern as technical equipment in the MICE hall may may be compromised by this. In July 2012 a concept called partial return yoke was presented to the MICE community, which reduces the stray field in the MICE hall to a safe level. This report summarizes the general concept, engineering considerations and the expected shielding performance
Learning to Rank Question Answer Pairs with Holographic Dual LSTM Architecture
We describe a new deep learning architecture for learning to rank question
answer pairs. Our approach extends the long short-term memory (LSTM) network
with holographic composition to model the relationship between question and
answer representations. As opposed to the neural tensor layer that has been
adopted recently, the holographic composition provides the benefits of scalable
and rich representational learning approach without incurring huge parameter
costs. Overall, we present Holographic Dual LSTM (HD-LSTM), a unified
architecture for both deep sentence modeling and semantic matching.
Essentially, our model is trained end-to-end whereby the parameters of the LSTM
are optimized in a way that best explains the correlation between question and
answer representations. In addition, our proposed deep learning architecture
requires no extensive feature engineering. Via extensive experiments, we show
that HD-LSTM outperforms many other neural architectures on two popular
benchmark QA datasets. Empirical studies confirm the effectiveness of
holographic composition over the neural tensor layer.Comment: SIGIR 2017 Full Pape
The role of the systematic inflammatory response in predicting outcomes in patients with advanced inoperable cancer: systematic review and meta analysis
Introduction:
Cancer remains a leading cause of death worldwide. While a curative intent is the aim of any surgical treatment many patients either present with or go onto develop disseminated disease requiring systemic anti-cancer therapy with a palliative intent. Given their limited life expectancy appropriate allocation of treatment is vital. It is recognised that systemic chemoradiotherapy may shorten the quality/quantity of life in patients with advanced cancer. It is against this background that the present systematic review and meta-analysis of the prognostic value of markers of the systemic inflammatory response in patients with advanced cancer was conducted.
Methods:
An extensive literature review using targeted medical subject headings was carried out in the MEDLINE, EMBASE, and CDSR databases until the end of 2016. Titles were examined for relevance and studies relating to duplicate datasets, that were not published in English and that did not have full text availability were excluded. Full texts of relevant articles were obtained and were then examined to identify any further relevant articles.
Results:
The majority of studies were retrospective. The systemic inflammatory response, as evidenced by a number of markers at clinical thresholds, was reported to have independent prognostic value, across tumour types and geographical locations. In particular, C-reactive protein (CRP, 63 studies), albumin (33 studies) the Glasgow Prognostic Score (GPS, 44 studies) and the Neutrophil Lymphocyte Ratio (NLR, 59 articles) were consistently validated across tumour types and geographical locations. There was considerable variation in the thresholds reported to have prognostic value when CRP and albumin were examined. There was less variation in the thresholds reported for NLR and still less for the GPS.
Discussion:
The systemic inflammatory response, especially as evidenced by the GPS and NLR, has reliable prognostic value in patients with advanced cancer. Further prospective studies of their clinical utility in randomised clinical trials and in treatment allocation are warranted
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Status of the 25 T, 100 mm Bore HTS Solenoid for an Axion Dark Matter Search Experiment
This paper presents the design and test results of the pancake coils for the 25 T, 100 mm bore solenoid that Brookhaven National Laboratory (BNL) is building for the Insti-tute for Basic Science (IBS) in Korea for an Axion dark matter search. The design is based on second generation (2G) High Temperature Superconducting (HTS) tape with no-insulation winding. The major challenges in the high field, large aperture solenoid are the large stresses and the quench protection. Moreo-ver, the design should be robust for reliable operation in a user facility environment. The paper will also present the construction and test results of two ∼100 mm bore double pancake coils creat-ing a peak field of up to ∼17 T and similar hoop stresses as will be in the 25 T solenoid. The coils were subject to several severe tests, including the simulations of large defects and extended quench studies at ∼4 K. The most striking part of these studies was the demonstration of how fast (a few hundred milliseconds) these coils can turn from the superconducting state to the normal state (quench or thermal runaway). This removes the past concerns of protecting high field HTS coils because of the low quench propa-gation velocities. © 2019 IEEE
The integral field unit for the James Webb space telescope's near-infrared spectrograph
The European Space Agency (ESA) is providing the Near Infrared Spectrograph (NIRSpec) developed by EADS Astrium GmbH to fly on the James Webb Space Telescope (JWST). NIRSpec covers the 0.6-5.0 µm domain. It will be primarily operated as a multi-object spectrograph, using a MEMS micro-shutter array (MSA) provided by NASA to select multiple objects from the field of view at an intermediate image plane formed by the NIRSpec fore-optics. The MSA apertures form multiple entrance slits of the spectrometer section