Removal of hydrogen from Ti VT 1-0 under action of accelerated electrons

The process of hydrogen removal from titanium of VT1-0 grade under the action of accelerated electrons has been studied experimentally. The irradiation was carried out by an electron beam with energies of 25-40 keV during 15-60 min. The information on the hydrogen content in samples from titanium of VT1-0 grade has been obtained both before and after irradiation with accelerated electrons. The activation energy of hydrogen desorption from titanium has been calculated. It was found that the increase of the time and the energy of an irradiation lead to the decrease of the residual hydrogen content in the titanium samples

Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer

Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69–11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group

Nano metal fluorides: small particles with great properties

The recently developed fluorolytic sol–gel route to metal fluorides opens a very broad range of both scientific and technical applications of the accessible high surface area metal fluorides, many of which have already been applied or tested. Specific chemical properties such as high Lewis acidity and physical properties such as high surface area, mesoporosity and nanosize as well as the possibility to apply metal fluorides on surfaces via a non-aqueous sol make the fluorolytic synthesis route a very versatile one. The scope of its scientific and technical use and the state of the art are presented.Peer Reviewe

Pathologist-level classification of histopathological melanoma images with deep neural networks

Background: The diagnosis of most cancers is made by a board-certified pathologist based on a tissue biopsy under the microscope. Recent research reveals a high discordance between individual pathologists. For melanoma, the literature reports 25-26% of discordance for classifying a benign nevus versus malignant melanoma. Deep learning was successfully implemented to enhance the precision of lung and breast cancer diagnoses. The aim of this study is to illustrate the potential of deep learning to assist human assessment for a histopathologic melanoma diagnosis. Methods: Six hundred ninety-five lesions were classified by an expert histopathologist in accordance with current guidelines (350 nevi and 345 melanomas). Only the haematoxylin and eosin stained (H&E) slides of these lesions were digitalised using a slide scanner and then randomly cropped. Five hundred ninety-five of the resulting images were used for the training of a convolutional neural network (CNN). The additional 100 H&E image sections were used to test the results of the CNN in comparison with the original class labels. Findings: The total discordance with the histopathologist was 18% for melanoma (95% confidence interval [CI]: 7.4-28.6%), 20% for nevi (95% CI: 8.9-31.1%) and 19% for the full set of images (95% CI: 11.3-26.7%). Interpretation: Even in the worst case, the discordance of the CNN was about the same compared with the discordance between human pathologists as reported in the literature. Despite the vastly reduced amount of data, time necessary for diagnosis and cost compared with the pathologist, our CNN archived on-par performance. Conclusively, CNNs indicate to be a valuable tool to assist human melanoma diagnoses. (C) 2019 The Author(s). Published by Elsevier Ltd

Map view restoration of Aegean–West Anatolian accretion and extension since the Eocene

The Aegean region (Greece, western Turkey) is one of the best studied continental extensional provinces. Here, we provide the first detailed kinematic restoration of the Aegean region since 35 Ma. The region consists of stacked upper crustal slices (nappes) that reflect a complex paleogeography. These were decoupled from the subducting African-Adriatic lithospheric slab. Especially since !25 Ma, extensional detachments cut the nappe stack and exhumed its metamorphosed portions in metamorphic core complexes. We reconstruct up to 400 km of trench-perpendicular (NE-SW) extension in two stages. From 25 to 15 Ma, the Aegean forearc rotated clockwise relative to the Moesian platform around Euler poles in northern Greece, accommodated by extensional detachments in the north and an inferred transfer fault SE of the Menderes massif. The majority of extension occurred after 15 Ma (up to 290 km) by opposite rotations of the western and eastern parts of the region. Simultaneously, the Aegean region underwent up to 650 km of post-25 Ma trench-parallel extension leading to dramatic crustal thinning on Crete. We restore a detachment configuration with the Mid-Cycladic Lineament representing a detachment that accommodated trench-parallel extension in the central Aegean region. Finally, we demonstrate that the Sakarya zone and Cretaceous ophiolites of Turkey cannot be traced far into the Aegean region and are likely bounded by a pre-35 Ma N-S fault zone. This fault became reactivated since 25 Ma as an extensional detachment located west of Lesbos Island. The paleogeographic units south of the Izmir-Ankara-Sava suture, however, can be correlated from Greece to Turkey