The many-valued theorem prover 3TAP. 3rd. edition

This is the 3TAP handbook. 3TAP is a many-valued tableau-based theorem prover developed at the University of Karlsruhe. The handbook serves a triple purpose: first, it documents the history and development of the prover 3TAP; second, it provides a user\u27s manual, and third it is intended as a reference manual for future developers, including porting hints. This version of the handbook describes 3TAP Version 3.0 as of September 30,1994

The Use of Proof Plans to Sum Series

We describe a program for finding closed form solutions to finite sums. The program was built to test the applicability of the proof planning search control technique in a domain of mathematics outwith induction. This experiment was successful. The series summing program extends previous work in this area and was built in a short time just by providing new series summing methods to our existing inductive theorem proving system CLAM. One surprising discovery was the usefulness of the ripple tactic in summing series. Rippling is the key tactic for controlling inductive proofs, and was previously thought to be specialised to such proofs. However, it turns out to be the key sub-tactic used by all the main tactics for summing series. The only change required was that it had to be supplemented by a difference matching algorithm to set up some initial meta-level annotations to guide the rippling process. In inductive proofs these annotations are provided by the application of mathematical induction. This evidence suggests that rippling, supplemented by difference matching, will find wide application in controlling mathematical proofs. The research reported in this paper was supported by SERC grant GR/F/71799, a SERC PostDoctoral Fellowship to the first author and a SERC Senior Fellowship to the third author. We would like to thank the other members of the mathematical reasoning group for their feedback on this project

Efficacy of topical pale sulfonated shale oil in the treatment of venous leg ulcers: A randomized, controlled, multicenter study

BackgroundVenous leg ulcers are a growing socioeconomic burden. Pale sulfonated shale oils (PSSO) are used for therapy of inflammatory skin diseases and have been shown to enhance wound healing in vitro and in vivo. The aim of this study was to investigate whether PSSO is capable of enhancing venous ulcer healing beyond compression therapy alone.MethodsOne hundred nineteen patients were enrolled in this randomized, multicenter, observer-blind study. In the treatment group, PSSO 10% was applied daily for 20 weeks, and the control group received the vehicle only. Wounds were covered by a nonadherent gauze dressing, and compression therapy with short-stretch elastic bandages was performed in an outpatient setting. The primary study end point was defined as cumulative reduction in wound area; the secondary study end point was treatment success as assessed by both physicians and patients. Additionally, adverse events, including changes with respect to physical examination and vital signs, were documented.ResultsAt the end of the study period, ulcer size was significantly more reduced in the PSSO group compared with the vehicle group (15 ± 15.9 to 6.2 ± 12.9 cm2 vs 11.4 ± 14.5 to 10.8 ± 15.7 cm2; P = .0005). The cumulative relative reduction in ulcer area was significantly higher in the PSSO group (−4391 ± 4748.7 vs −231.9 ± 6283.6 % × days; P < .0001). Relative reduction in wound area was significantly greater in the PSSO group as early as 6 weeks after the beginning of treatment (−47.4 ± 28.4 vs −23.8 ± 42.2%; P < .001). PSSO was judged successful both by physicians and patients. There were no significant differences in adverse events (PSSO, 9 [12.2%]; vehicle, 7 [11.1%]. Similarly, tolerability of PSSO was equal to the tolerability of the vehicle.ConclusionPale sulfonated shale oils were capable of favoring venous ulcer healing in addition to compression therapy. PSSO should be considered for future wound care protocols for treatment of venous leg ulcers

MTBseq: a comprehensive pipeline for whole genome sequence analysis of Mycobacterium tuberculosis complex isolates

Analyzing whole-genome sequencing data of Mycobacterium tuberculosis complex (MTBC) isolates in a standardized workflow enables both comprehensive antibiotic resistance profiling and outbreak surveillance with highest resolution up to the identification of recent transmission chains. Here, we present MTBseq, a bioinformatics pipeline for next-generation genome sequence data analysis of MTBC isolates. Employing a reference mapping based workflow, MTBseq reports detected variant positions annotated with known association to antibiotic resistance and performs a lineage classification based on phylogenetic single nucleotide polymorphisms (SNPs). When comparing multiple datasets, MTBseq provides a joint list of variants and a FASTA alignment of SNP positions for use in phylogenomic analysis, and identifies groups of related isolates. The pipeline is customizable, expandable and can be used on a desktop computer or laptop without any internet connection, ensuring mobile usage and data security. MTBseq and accompanying documentation is available from https://github.com/ngs-fzb/MTBseq_source

Isotope Shift in the Dielectronic Recombination of Three-electron \u3csup\u3eA\u3c/sup\u3eNd⁵⁷⁺

Isotope shifts in dielectronic recombination spectra were studied for Li-like ANd57+ ions with A = 142 and A = 150. From the displacement of resonance positions energy shifts δE142 150(2s-2p1/2) = 40.2(3)(6) meV [(stat)(sys)] and δE142 150(2s - 2p3/2) = 42.3(12)(20)meV of 2s - 2pj transitions were deduced. An evaluation of these values within a full QED treatment yields a change in the mean-square charge radius of 142 150δ⟨ r2⟩ = -1.36(1)(3) fm2. The approach is conceptually new and combines the advantage of a simple atomic structure with high sensitivity to nuclear size

Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.

A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine

Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches.

Mycobacterium africanum (Maf) causes a substantial proportion of human tuberculosis in some countries of West Africa, but little is known on this pathogen. We compared the genomes of 253 Maf clinical isolates from Ghana, including N = 175 Lineage 5 (L5) and N = 78 Lineage 6 (L6). We found that the genomic diversity of L6 was higher than in L5 despite the smaller sample size. Regulatory proteins appeared to evolve neutrally in L5 but under purifying selection in L6. Even though over 90% of the human T cell epitopes were conserved in both lineages, L6 showed a higher ratio of non-synonymous to synonymous single nucleotide variation in these epitopes overall compared to L5. Of the 10% human T cell epitopes that were variable, most carried mutations that were lineage-specific. Our findings indicate that Maf L5 and L6 differ in some of their population genomic characteristics, possibly reflecting different selection pressures linked to distinct ecological niches