884 research outputs found

    Coronavirus and the impact on output in the UK economy: April 2020

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    Addition of remaining public banks raises public sector net debt by £1,300 billion

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    The UK Independence Party and the Politics of Englishness

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    The rise of the UK Independence Party has been one of the most dramatic and widely discussed features of British politics in recent years. This article argues that one vital but largely overlooked facet of this phenomenon has been the politics of national identity. It argues that despite the UK Independence Party’s ostensibly unionist stance, Englishness is an important pivot around which key elements of the party’s appeal revolve, notably in terms of its Euroscepticism, its opposition to immigration and its anti-establishment narrative. It argues that the Anglo-Britishness promulgated by the UK Independence Party allows space for the celebration of English identity rather more easily than of other sub-state national identities, as it does not challenge the legitimacy of the UK state, which is itself seen as the expression of Anglo-British identity and sovereignty. Scottish nationalism, on the other hand, is seen as a threat to the union and therefore anti-English

    Tracking and modelling prices using web-scraped price microdata : towards automated daily consumer price index forecasting

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    With the increasing relevance and availability of on-line prices that we see today, it is natural to ask whether the prediction of the consumer price index (CPI), or related statistics, may usefully be computed more frequently than existing monthly schedules allow for. The simple answer is ‘yes’, but there are challenges to be overcome first. A key challenge, addressed by our work, is that web-scraped price data are extremely messy and it is not obvious, a priori, how to reconcile them with standard CPI statistics. Our research focuses on average prices and disaggregated CPI at the level of product categories (lager, potatoes, etc.) and develops a new model that describes the joint time evolution of latent daily log-inflation rates driving prices seen on the Internet and prices recorded in official surveys, with the model adapting to various product categories. Our model reveals the differing levels of dynamic behaviour across product category and, correspondingly, differing levels of predictability. Our methodology enables good prediction of product-category-specific CPI immediately before their release. In due course, with increasingly complete web-scraped data, combined with the best survey data, the prospect of more frequent intermonth aggregated CPI prediction is an achievable goal

    Motivation crowding in real consumption decisions: Who is messing with my groceries?

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    We present evidence of crowding out of intrinsic motivation in real purchasing decisions from a field experiment in a large supermarket chain. We compare three instruments, a label, a subsidy and a neutral price change, in their ability to induce consumers to switch from dirty to clean products. Interestingly a subsidy framed as an intervention is less effective than either a label or a neutrally framed price change. We argue that this provides a new explanation for crowding behaviour: consumers are resistant to having the line of demarcation between public and private decision making moved - in either direction

    Public sector finances

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    The Boys Left Behind: Where Public Policy has Failed to Prevent Child Labour in Bangladesh

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    Poor boys have been left behind by public policy efforts to expand school access in Bangladesh – the same policies which have succeeded in attracting girls to school. This article draws on original research to explore the failure to tackle the exclusion of poor boys from school, arguing that paid work has become more attractive in a context in which education is of poor quality and there are no social sanctions against child labour. Recently there has been a shift of policy attention towards poor boys, amidst concerns about security, militancy and Islamic education. Given steady economic growth, poor boys may not necessarily inherit deeper poverty, but in the absence of state or social sanctions against child labour, they are likely to inherit a position at the lower end of the social scale

    Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation

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    This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). Risk-reducing interventions can be offered to individuals with known LS-causing mutations. The mutations can be identified by comprehensive testing of the MMR genes, but this would be prohibitively expensive in the general population. Tumour-based tests - microsatellite instability (MSI) and MMR immunohistochemistry (IHC) - are used in CRC patients to identify individuals at high risk of LS for genetic testing. MLH1 (MutL homologue 1) promoter methylation and BRAF V600E testing can be conducted on tumour material to rule out certain sporadic cancers. OBJECTIVES: To investigate whether testing for LS in CRC patients using MSI or IHC (with or without MLH1 promoter methylation testing and BRAF V600E testing) is clinically effective (in terms of identifying Lynch syndrome and improving outcomes for patients) and represents a cost-effective use of NHS resources. REVIEW METHODS: Systematic reviews were conducted of the published literature on diagnostic test accuracy studies of MSI and/or IHC testing for LS, end-to-end studies of screening for LS in CRC patients and economic evaluations of screening for LS in CRC patients. A model-based economic evaluation was conducted to extrapolate long-term outcomes from the results of the diagnostic test accuracy review. The model was extended from a model previously developed by the authors. RESULTS: Ten studies were identified that evaluated the diagnostic test accuracy of MSI and/or IHC testing for identifying LS in CRC patients. For MSI testing, sensitivity ranged from 66.7% to 100.0% and specificity ranged from 61.1% to 92.5%. For IHC, sensitivity ranged from 80.8% to 100.0% and specificity ranged from 80.5% to 91.9%. When tumours showing low levels of MSI were treated as a positive result, the sensitivity of MSI testing increased but specificity fell. No end-to-end studies of screening for LS in CRC patients were identified. Nine economic evaluations of screening for LS in CRC were identified. None of the included studies fully matched the decision problem and hence a new economic evaluation was required. The base-case results in the economic evaluation suggest that screening for LS in CRC patients using IHC, BRAF V600E and MLH1 promoter methylation testing would be cost-effective at a threshold of £20,000 per quality-adjusted life-year (QALY). The incremental cost-effectiveness ratio for this strategy was £11,008 per QALY compared with no screening. Screening without tumour tests is not predicted to be cost-effective. LIMITATIONS: Most of the diagnostic test accuracy studies identified were rated as having a risk of bias or were conducted in unrepresentative samples. There was no direct evidence that screening improves long-term outcomes. No probabilistic sensitivity analysis was conducted. CONCLUSIONS: Systematic review evidence suggests that MSI- and IHC-based testing can be used to identify LS in CRC patients, although there was heterogeneity in the methods used in the studies identified and the results of the studies. There was no high-quality empirical evidence that screening improves long-term outcomes and so an evidence linkage approach using modelling was necessary. Key determinants of whether or not screening is cost-effective are the accuracy of tumour-based tests, CRC risk without surveillance, the number of relatives identified for cascade testing, colonoscopic surveillance effectiveness and the acceptance of genetic testing. Future work should investigate screening for more causes of hereditary CRC and screening for LS in endometrial cancer patients. STUDY REGISTRATION: This study is registered as PROSPERO CRD42016033879. FUNDING: The National Institute for Health Research Health Technology Assessment programme.Funding for this study was provided by the Health Technology Assessment programme of the National Institute for Health Researc

    Population Objects: Interpassive Subjects

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    While Foucault described population as the object of biopower he did not investigate the practices that make it possible to know population. Rather, he tended to naturalise it as an object on which power can act. However, population is not an object awaiting discovery, but is represented and enacted by specific devices such as censuses and what I call population metrics. The latter enact populations by assembling different categories and measurements of subjects (biographical, biometric and transactional) in myriad ways to identify and measure the performance of populations. I account for both the object and subject by thinking about how devices consist of agencements, that is, specific arrangements of humans and technologies whose mediations and interactions not only enact populations but also produce subjects. I suggest that population metrics render subjects interpassive whereby other beings or objects take up the role and act in place of the subject
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