The influence of the drugs “Brovermectin-granulate TM” and “Avesstim TM” on indicators of non-specific resistance of one year-old carp fish infested with monogeneans

The article presents data on the study of the influence of the drugs “Brovermectin-granulate TM” and “Avesstim TM” on indicators of non-specific resistance of one-year-old carp fish infested with monogeneans. For conducting experiments, 14 experimental groups were formed (two groups of each species of fish affected by Dactylogyrus lamellatus, Gyrodactylus hypophthalmichtіdis, Eudiplozoon nipponicum ). The fish of the first experimental group were administered “Brovermectin-granulate TM”, and the second experimental group were administerec a complex of drugs “Brovermectin-granulate TM” and “Avesstim TM”. Fish infected with various ectoparasites (Dactylogyrus lamellatus, Gyrodactylus hypophthalmichtіdis, Eudiplozoon nipponicum ) served as controls. Fish of each group were kept in separate aquariums with a capacity of 40 dm3 with artificial aeration at a temperature of 20–22 °С. Their care and feeding was carried out according to the relevant norms and rations. During the entire period of research, the behavior and clinical condition of the fish were observed. The pre-experimental period of acclimatization of annuals was 7 days. The use of the drug “Brovermectin-granulate TM” to one-year-old white carp, crucian carp and scaly carp affected by monogeneans had a stimulating effect on the resistance of their organism. At the same time, the simultaneous use of the specified drug with the immunomodulator “Avesstim TM” contributed to better activation of the humoral link of non-specific immunity in sick fish. To normalize the organism homeostasis, correct metabolism and activate the humoral link of non-specific immunity during a monogenoid invasion of carp, it is recommended to feed them with a combined feed of the drugs “Brovermectin-granulate TM” and the immunomodulator “Avesstim TM”

Heterogeneous structure of the lithosphere in the Black Sea from a multidisciplinary analysis of geophysical fields

Magnetic, gravity, geothermal, seismic and tomographic data from the lithosphere were first jointly examined. A multidisciplinary interpretation has resulted in a new and consistent model for lithospheric density, magnetic, thermal and velocity heterogeneities. Faults of different orders for the crystalline crust have been mapped in details. Large deep fault zones were recognized. Among them is the most prominent Odessa-Sinop-Ordu (OSO) fault zone, which played a key role in the opening and development of the Black Sea Depression. A fundamental difference was revealed between the crustal and mantle structure and geophysical parameters of the Western Black Sea Basin (WBSB) and Eastern Black Sea Basin (EBSB). These dissimilarities are in the size of «non-granitic» crust, pattern and intensity of heat flow, topography of the lower boundary of the thermal lithosphere, mantle seismic velocity and structure of magnetic and residual gravity anomalies. Based on new information it was demonstrated that the WBSB and EBSB were diachronously formed on two large distinct continental blocks with independent post-rift development of the sub-basins. The rifting of the western sub-basin commenced earlier than that of the eastern one. The EBSB is characterized by younger thermal activity than the WBSB and consequently it was stabilized later. The Mid Black Sea High (MBSH) is not a single tectonic unit but is formed by two ridges of various crystalline crustal structure and age shifted relative to each other by the faults of the OSO zone

The state of the immune system of rats under conditions of oxidative stress and the influence of the feed additive “Sylimevit”

The immune system plays a crucial role in maintaining the body's homeostasis, determining the state of health of animals and their ability to adapt. The work aimed to investigate the effect of a feed additive based on milk thistle fruits, selenium, metiphene, and vitamins A, E, and C on rats' immune status under experimental tetrachloromethane poisoning conditions. The study was conducted on young white male Wistar laboratory rats. Intragastric administration of tetrachloromethane twice (with an interval of 48 hours) in a dose of 0.1 ml per 100 g of body weight in a 50 % oil solution was used for the experimental intoxication of rats. The animals of the second experimental group were fed the feed additive “Sylimevit” for 30 days together with feed at a dose of 0.1 g per 100 g of body weight. The introduction of tetrachloromethane in experimental groups of rats led to the development of oxidative stress, which occurs due to specific chemical processes in the body of experimental animals. It was found that the development of oxidative stress caused by tetrachloromethane leads to suppression of the humoral and nonspecific link of the immune system of rats. This is manifested in a decrease in the bactericidal and lysozyme activity of the blood serum, a decrease in the phagocytic index, and the phagocytic activity of neutrophils. In addition, an increase in the number of circulating immune complexes was observed. It was also established that feeding the feed additive “Sylimevit” strengthens the immune defense of the body of rats poisoned with tetrachloromethane. This feed additive helps to strengthen the body's defense mechanisms, increasing the immune response and helping to resist the toxic effects of tetrachloromethane

Crustal and Upper Mantle Velocity Model along the DOBRE-4 Profile from North Dobruja to the Central Region of the Ukrainian Shield : 1. Seismic Data

For studying the structure of the lithosphere in southern Ukraine, wide-angle seismic studies that recorded the reflected and refracted waves were carried out under the DOBRE-4 project. The field works were conducted in October 2009. Thirteen chemical shot points spaced 35-50 km apart from each other were implemented with a charge weight varying from 600 to 1000 kg. Overall 230 recording stations with an interval of 2.5 km between them were used. The high quality of the obtained data allowed us to model the velocity section along the profile for P-and S-waves. Seismic modeling was carried out by two methods. Initially, trial-and-error ray tracing using the arrival times of the main reflected and refracted P-and S-phases was conducted. Next, the amplitudes of the recorded phases were analyzed by the finite-difference full waveform method. The resulting velocity model demonstrates a fairly homogeneous structure from the middle to lower crust both in the vertical and horizontal directions. A drastically different situation is observed in the upper crust, where the Vp velocities decrease upwards along the section from 6.35 km/s at a depth of 15-20 km to 5.9-5.8 km/s on the surface of the crystalline basement; in the Neoproterozoic and Paleozoic deposits, it diminishes from 5.15 to 3.80 km/s, and in the Mesozoic layers, it decreases from 2.70 to 2.30 km/s. The sub-crustal Vp gradually increases downwards from 6.50 to 6.7-6.8 km/s at the crustal base, which complicates the problem of separating the middle and lower crust. The Vp velocities above 6.80 km/s have not been revealed even in the lowermost part of the crust, in contrast to the similar profiles in the East European Platform. The Moho is clearly delineated by the velocity contrast of 1.3-1.7 km/s. The alternating pattern of the changes in the Moho depths corresponding to Moho undulations with a wavelength of about 150 km and the amplitude reaching 8 to 17 km is a peculiarity of the velocity model.Peer reviewe

Compact Source of Electron Beam for Facility of Electron-Beam Welding with the Location of the Electron Gun and the Source of High Voltage in a Single Monoblock. Concept and Bench Tests of the Monoblok Prototype

Представлен прототип компактного источника электронного пучка для установок электронно-лучевой сварки с расположением электронной пушки и источника высоковольтного напряжения в едином моноблоке. Размещение электронной пушки, источника высоковольтного напряжения, электроники управления пучком и питания накала катода источника электронного пучка для электронно-лучевой сварки в едином корпусе-моноблоке снижает вес и стоимость (за счёт уменьшения количества используемых материалов), объём и занимаемые производственные площади. Это существенно расширяет возможности применения представляемого типа источников электронного пучка в разнообразных областях деятельности человека, в том числе в космических технологиях в открытом пространстве космоса. Цель работы – показать целесообразность концепции компоновки источника электронного пучка в едином корпусе-моноблоке на примере стендовых испытаний прототипа источника-моноблока. Спроектирован и изготовлен прототип источника-моноблока. Проведены его предварительные стендовые испытания с лазерным подогревом катода. Обсуждаются возможные применения. Получен электронный ток источника до 70 мА с энергией 90 кэВ. Данный результат демонстрирует возможность практической реализации нового способа компоновки источника электронного пучкаA prototype of an electron beam compact source for electron-beam welding is presented. The electron gun and a high-voltage source are united in a single monoblock. The placement of the electron gun, the high-voltage source, the beam control electronics and the power supply of the cathode heating of the electron beam source for electron beam welding in a single monoblock housing reduces weight and cost by reducing the amount of materials used, volume and occupied production areas. This significantly expands the possibilities of using the presented type of electron beam sources in various fields of human activity, including space technologies in the open space of space. The purpose of the work is to show the expediency of the concept of arranging the electron beam source in the single monoblock housing as the example of bench tests of the source prototype. The prototype of the monoblock was designed and manufactured. Its preliminary bench tests with laser cathode heating were carried out. Its possible applications are discussed. An electron source current up to 70 mA with an energy of 90 keV was obtained. The result obtained demonstrates the possibility of practical implementation of a new method of arranging an electron beam sourc

The Large Hadron-Electron Collider at the HL-LHC

The Large Hadron-Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operations. This report represents an update to the LHeC's conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton-nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron-hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.Peer reviewe