Alien Registration- Clayton, Jenny (Auburn, Androscoggin County)

https://digitalmaine.com/alien_docs/30371/thumbnail.jp

Identification of molecular genetic contributants to canine cutaneous mast cell tumour metastasis by global gene expression analysis

<div><p>Cutaneous mast cell tumours are one of the most common canine cancers. Approximately 25% of the tumours metastasise. Activating <i>c-kit</i> mutations are present in about 20% of tumours, but metastases occur in the absence of mutations. Tumour metastasis is associated with significantly diminished survival in spite of adjuvant chemotherapy. Available prognostic tests do not reliably predict whether a tumour will metastasise. In this study we compared the global expression profiles of 20 primary cutaneous mast cell tumours that metastasised with those of 20 primary tumours that did not metastasise. The objective was to identify genes associated with mast cell tumour metastatic progression that may represent targets for therapeutic intervention and biomarkers for prediction of tumour metastasis. Canine Gene 1.1 ST Arrays were employed for genome-wide expression analysis of formalin-fixed, paraffin-embedded biopsies of mast cell tumours borne by dogs that either died due to confirmed mast cell tumour metastasis, or were still alive more than 1000 days post-surgery. Decreased gene expression in the metastasising tumours appears to be associated with a loss of cell polarity, reduced cell-cell and cell-ECM adhesion, and increased cell deformability and motility. Dysregulated gene expression may also promote extracellular matrix and base membrane degradation, suppression of cell cycle arrest and apoptosis, and angiogenesis. Down-regulation of gene expression in the metastasising tumours may be achieved at least in part by small nucleolar RNA-derived RNA and microRNA-effected gene silencing. Employing cross-validation, a linear discriminant analysis-based classifier featuring 19 genes that displayed two-fold differences in expression between metastasising and non-metastasising tumours was estimated to classify metastasising and non-metastasising tumours with accuracies of 90–100% and 70–100%, respectively. The differential expression of 9 of the discriminator genes was confirmed by quantitative reverse transcription-PCR.</p></div

The Sloan Digital Sky Survey Reverberation Mapping Project: Hα and Hβ reverberation measurements from first-year spectroscopy and photometry

Funding: UK Sciences and Technology Facilities Council STFC grant ST/M001296/1 (KH).We present reverberation mapping results from the first year of combined spectroscopic and photometric observations of the Sloan Digital Sky Survey Reverberation Mapping Project. We successfully recover reverberation time delays between the g+i band emission and the broad Hβ emission line for a total of 44 quasars, and for the broad Hα emission line in 18 quasars. Time delays are computed using the JAVELIN and CREAM software and the traditional interpolated cross-correlation function (ICCF): using well-defined criteria, we report measurements of 32 Hβ and 13 Hα lags with JAVELIN, 42 Hβ and 17 Hα lags with CREAM, and 16 Hβ and eight Hα lags with the ICCF. Lag values are generally consistent among the three methods, though we typically measure smaller uncertainties with JAVELIN and CREAM than with the ICCF, given the more physically motivated light curve interpolation and more robust statistical modeling of the former two methods. The median redshift of our Hβ-detected sample of quasars is 0.53, significantly higher than that of the previous reverberation mapping sample. We find that in most objects, the time delay of the Hα emission is consistent with or slightly longer than that of Hβ. We measure black hole masses using our measured time delays and line widths for these quasars. These black hole mass measurements are mostly consistent with expectations based on the local – relationship, and are also consistent with single-epoch black hole mass measurements. This work increases the current sample size of reverberation-mapped active galaxies by about two-thirds and represents the first large sample of reverberation mapping observations beyond the local universe (z < 0.3).PostprintPeer reviewe

Alien Registration- Clayton, Jenny (Auburn, Androscoggin County)

https://digitalmaine.com/alien_docs/30371/thumbnail.jp

Erratum: “The Sloan Digital Sky Survey Reverberation Mapping Project: H α and H β Reverberation Measurements from First-year Spectroscopy and Photometry” (2017, ApJ, 851, 21)

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Erratum: The sloan digital sky survey reverberation mapping project: Hα and Hβ reverberation measurements from first-year spectroscopy and photometry (Astrophysical Journal (2017) 851 (21) DOI: 10.3847/1538-4357/aa98dc)

© 2018. The American Astronomical Society. All rights reserved. We found a bug in the formula used to calculate the uncertainties in the virial products. This error produced incorrect uncertainties for the virial products and consequently the black hole mass (MBH) measurements reported in Tables 4 and 5. These uncertainties were used to produce Figures 12, 13, and 14. This error is minor and does not affect any of our results or their interpretation, and thus no edits to the text are necessary. We here provide updated/corrected tables and figures produced with the correct MBH uncertainties. (Table Presented) and (Figure Presented)