Aplicação de BI no processo de recuperação de credito: um estudo de caso.

Este trabalho apresenta um estudo de caso de aplicação da tecnologia de Business Inteligence - BI em conjunto com o processo de planejamento estratégico de modo a proporcionar melhorias em processos operacionais e por sua vez ganhos financeiros. O trabalho baseou-se na aplicação de ferramentas de BI e algoritmos de processamento analítico em uma empresa que atua no mercado de cobrança. A análise do estudo de caso concentra-se em demonstrar os resultados operacionais e financeiros mais eficientes no que tange à cobrança de carteiras de clientes selecionados para os experimentos possibilitando o alcance de objetivos e metas organizacionai

July 2017 ENCALS statement on edaravone

Peer reviewe

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Lacunar syndromes, Aspects on risk factors, pathophysiology, diagnosis and prognosis.

The aims of the studies in the thesis were; 1.to investigate incidence, risk factors in comparison to non lacunar stroke patients, initial course and long term prognosis in pure motor stroke (PMS) 2.to determine topography and most probable pathogenetic mechanism of lesions in sensorimotor stroke (SMS). 3.to study if diffusion weighted magnetic resonance tomography(DWI) contribute to a more precise and earlier diagnosis in the acute phase of stroke patients presenting as lacunar syndromes 4.to study location and characteristics of focal abnormalities on DWI in patients with capsular warning syndromes(CWS) and to explore potential underlying mechanisms of the transient symptoms. Results and conclusions; patients with PMS had significantly higher frequency of hypertension than non lacunar strokes and the frequency was related to age. Short term prognosis was favourable. Long term follow-up showed an annual rate of mortality of 6% and for risk of recurrence 2.4%. Patients had an increased mortality after five years compared to sex and age matched population. In 69% of the patients with SMS, small vessel disease (lacunar infarcts) from presumed single perforant artery occlusion was considered the most probable underlying mechanism. Early examination with DWI, demonstrated in patients with lacunar syndromes, in 90% a lesion compatible with in situ small vessel disease. In patients with CWS and TIAs only DWI demonstrated lesions confined to the thalamus or globus pallidus without oinvolvement of the classical motor pathways whereas patients with permanent deficits had lesions involving the corticospinal pathway in putamen/corona radiata or the brainstem. Pathophysiology of CWS is complex. We hypothesise a transient involvement of peri-infarct depolarisation affecting more remote motor pathways or hemodynamic mechanism in perforating arterial territories

Pure motor stroke from presumed lacunar infarct - Long-term prognosis for survival and risk of recurrent stroke

Background and Purpose-A low risk of recurrent stroke and death after lacunar infarction has previously been reported, but follow-up has been limited to less than or equal to5 years. Methods-One hundred eighty patients with pure motor stroke, collected between 1983 and 1986 from a hospital-based stroke registry, were followed up until at least 10 years after the index stroke. Two patients were lost to follow-up. Survival status was determined from the official population registry and compared with survival rates of the Swedish population, matched for age and sex. Cox proportional hazards regression analyses were used to identify independent prognostic predictors. Results-During follow-up 106 (60%) of the 178 patients died, most commonly as a result of coronary heart disease. During the first 5 years after the stroke, survival rates were similar to those of the general population. Beyond this time the risk of death was increased among patients with pure motor stroke, with an excess of 10 to 15 percent units compared with the general population. Independent determinants for death were age (P <0.01), male sex (P <0.01), and nonuse of acetylsalicylic acid (P=0.02). Recurrent stroke occurred in 42 (23.5%) of the patients, corresponding to an annual risk of 2.4%. Hypertension (P=0.025) and diabetes (P=0.024) were independent risk factors for recurrent stroke. Conclusions-For the first few years after lacunar infarct, the risk of death was similar to that of the general population, but later a clear excess of death was observed. The long-term prognosis in lacunar infarction appears less favorable than previously reported

Diffusion-weighted MRI findings in patients with capsular warning syndrome

Background and Purpose: The 'capsular warning syndrome' (CWS) of recurrent stereotyped episodes of motor or sensory dysfunction is clinically well recognized, and is associated with a high risk of imminent lacunar infarction with permanent deficits resembling those of CWS. However, the pathophysiology of CWS has not been well characterized. We report a clinicoanatomic correlation with MR imaging studies in the acute and chronic phases in patients with CWS. Material and Methods: Between April 1997 and March 2001, we prospectively studied 8 patients, mean age 73.3 years, presenting with 4 - 17 motor or sensorimotor transient ischemic attacks ( TIAs; duration 2 - 90 min) up to 3 days after onset of the first episode. Four patients were free of symptoms between the attacks and had no residua, whereas 4 patients developed a pure motor or sensorimotor stroke within 1 - 3 days after symptom onset. Diffusion-weighted echoplanar MRI (DWI) and T-2-weighted MRI studies were performed within 1 week after symptom onset and were repeated 1 - 2 months later. Results: Seven of the 8 patients had an appropriate lesion on DWI in the acute phase. DWI abnormalities in the 3 patients with TIAs were 4 - 10 mm in diameter and confined to the lateral thalamus or medial globus pallidus without involving the internal capsule, whereas 4 patients who developed a stroke had abnormalities localized to the putamen extending to corona radiata ( 3 patients), or the pontomesencephalic junction ( 1 patient). All 6 patients who underwent follow-up MRI had an infarct on T-2-weighted images corresponding to, but usually smaller than, the acute phase DWI abnormality. Conclusions: Small infarcts in the basal ganglia or the pons, close to central motor pathways, appear to be the primary lesion in CWS. The pathophysiology of CWS is complex, and may involve hemodynamic mechanisms in penetrating arterial territories, as well as molecular mechanisms, such as peri-infarct depolarizations affecting adjacent motor pathways. Copyright (C) 2004 S. Karger AG, Basel

Carbon nanotubes as electrode for supercapacitors

Both silicon wafers and thermally oxidized silicon wafers are diced into 14x14 mm2 pieces to fit the circular active area with 11 mm diameter used in voltammetry. 50 nm of tungsten is sputtered on both sides of the chips for edge coverage to have better electrical contact of back side and grown side. A catalyst layer consisting of aluminum (5 nm) and iron (2 nm) is deposited using electron beam evaporation. The CNTs are grown by chemical vapor deposition at 700 \ub0C using acetylene and hydrogen gasses as carbon source and carrier. First, the catalyst is pretreated at 500 \ub0C in the environment of continuous hydrogen flow at around 8 mbar pressure. Then acetylene is introduced and the temperature is raised to 700 \ub0C within a few seconds. Sample (1) consists of: Si, W, Al, Fe; sample (2) consists of: Si, SiO2, W, Al, Fe.Measurements were carried out by a three electrode system with Ag/AgCl as reference electrode, Pt as counter electrode and 1M KOH as electrolyte. The capacitance was calculated from the voltammogram (Figure 1). The voltammetry was carried out with 5 cycles per sample. Sample (1) yields a capacitance of 0,0475 F and (2) a apacitance of 0,04 F for the active geometrical surface at sweep rate 20 mV/s (Table 1). Calculated capacitances are from the voltammogram values, where the capacitance is the absolute value between -0,1 - 0,1 V divided by 2 and divided by the sweep rate.C = Δ|I| / s,where Δ|I| is the difference in current, s is the sweep rate (dE/dt) and C is the capacitance. An estimation of CNT weight using SEM pictures yields approximately 0,3 mg. The measured weight from a scale is in the range 0,8 - 1,4 mg which gives a specific capacitance of 13P1: 46,9 \ub1 12,7 F/g and 14P1:39,3 \ub1 10,7 F/g for the two samples respectively.Future improvements of these CNT electrodes will be to produce longer nanotubes and a more dense structure. Both these parameters will increase the surface area and by that yield a higher capacitance for the electrode. By con-trolling the vertical alignment of the CNTs in combination with production methods containing cheap materials and by using industrial fabrication techniques the energy density can be improved. This makes vertically aligned CNT a very promising material as electrode material for supercapacitors