Neighborhood as factory--the influence of land development and civic politics on an industrial cluster in Delhi, India

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1996.Includes bibliographical references (p. 415-427).by Solomon J. Benjamin.Ph.D

Understanding urban housing transformations : a case study of Bhogal, India

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1985.Includes bibliographical references.This thesis attempts to describe dwelling transformations in the case of Bhogal, New Delhi. It is hoped to clarify the links between socio-economic forces and their resultant impact on physical form, through its transformation. The project is a refugee housing program, undertaken by the Government of India in the early 1950's to cope with the large influx of refugees during the partition between India and Pakistan. Over a period of twenty years, the project like other emergency measures , has become permanent. It is rapidly transforming to provide a livable environment. India, like other Third World environments, is on the verge of another emergency, facing unprecedented urban growth. It is obvious that the government with its limited resources, cannot cope with these pressures. There is a general agreement that the government needs to play the role of a "support" rather than a "producer", especially with regard to housing for the lower income groups. The case study exemplifies developments and transformations of existing dwelling environments in Delhi today. It therefore might help to identify some basic principles and directions along which future research might take. The case study provides a useful insight into the circumstances that allow a group of people to upgrade their circumstance both socially and economically with minimum formal assistance. The thesis also attempts to clarify informal linkages and networks that evolve to form a crucial part of the process of upgrading in this environment. This forms the bulk of the argument of the "supportive" role of the government and the need to understand existing linkages and networks to identify areas of intervention.by Solomon J. Benjamin.M.S

Difference in Brain Densities Between Chronic Alcoholic and Normal Control Patients.

The densities of the brains of 11 chronic alcoholics were compared with those of 11 age-matched normal control subjects. Densities were determined from the density numbers generated by computerized tomography at three levels of the brain-the highest level of the lateral ventricles and the next two higher levels-with adjustments made to control for possible artifacts in the data. The advantage of the dominant hemisphere over the nondominant hemisphere was lessened in alcoholic

The two electron artificial molecule

Exact results for the classical and quantum system of two vertically coupled two-dimensional single electron quantum dots are obtained as a function of the interatomic distance (d) and with perpendicular magnetic field. The classical system exhibits a second order structural transition as a function of d which is smeared out and shifted to lower d values in the quantum case. The spin-singlet - spin-triplet oscillations are shifted to larger magnetic fields with increasing d and are quenched for a sufficiently large interatomic distance.Comment: 4 pages, 4 ps figure

Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.

Adenomatoid tumors are the most common neoplasm of the epididymis, and histologically similar adenomatoid tumors also commonly arise in the uterus and fallopian tube. To investigate the molecular pathogenesis of these tumors, we performed genomic profiling on a cohort of 31 adenomatoid tumors of the male and female genital tracts. We identified that all tumors harbored somatic missense mutations in the TRAF7 gene, which encodes an E3 ubiquitin ligase belonging to the family of tumor necrosis factor receptor-associated factors (TRAFs). These mutations all clustered into one of five recurrent hotspots within the WD40 repeat domains at the C-terminus of the protein. Functional studies in vitro revealed that expression of mutant but not wild-type TRAF7 led to increased phosphorylation of nuclear factor-kappa B (NF-kB) and increased expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation. Immunohistochemistry demonstrated robust L1CAM expression in adenomatoid tumors that was absent in normal mesothelial cells, malignant peritoneal mesotheliomas and multilocular peritoneal inclusion cysts. Together, these studies demonstrate that adenomatoid tumors of the male and female genital tract are genetically defined by TRAF7 mutation that drives aberrant NF-kB pathway activation

Decadal predictability of regional scale wind speed and wind energy potentials over Central Europe

Decadal predictions on timescales from one year to one decade are gaining importance since this time frame falls within the planning horizon of politics, economy and society. The present study examines the decadal predictability of regional wind speed and wind energy potentials in three generations of the MiKlip (‘Mittelfristige Klimaprognosen’) decadal prediction system. The system is based on the global Max-Planck-Institute Earth System Model (MPI-ESM), and the three generations differ primarily in the ocean initialisation. Ensembles of uninitialised historical and yearly initialised hindcast experiments are used to assess the forecast skill for 10 m wind speeds and wind energy output (Eout) over Central Europe with lead times from one year to one decade. With this aim, a statistical-dynamical downscaling (SDD) approach is used for the regionalisation. Its added value is evaluated by comparison of skill scores for MPI-ESM large-scale wind speeds and SDD-simulated regional wind speeds. All three MPI-ESM ensemble generations show some forecast skill for annual mean wind speed and Eout over Central Europe on yearly and multi-yearly time scales. This forecast skill is mostly limited to the first years after initialisation. Differences between the three ensemble generations are generally small. The regionalisation preserves and sometimes increases the forecast skills of the global runs but results depend on lead time and ensemble generation. Moreover, regionalisation often improves the ensemble spread. Seasonal Eout skills are generally lower than for annual means. Skill scores are lowest during summer and persist longest in autumn. A large-scale westerly weather type with strong pressure gradients over Central Europe is identified as potential source of the skill for wind energy potentials, showing a similar forecast skill and a high correlation with Eout anomalies. These results are promising towards the establishment of a decadal prediction system for wind energy applications over Central Europe

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers.

The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during pregnancy. We conducted a case control study using data from the UC San Francisco Mother Child Immunogenetic Study and studies at the Inova Translational Medicine Institute. We imputed human leukocyte antigen (HLA) alleles and minor histocompatibility antigens (mHags). We created a variable of exposure to histocompatible children. We estimated an average sequence similarity matching (SSM) score for each mother based on discordant mother-child alleles as a measure of histocompatibility. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals. A total of 138 RA, 117 SLE, and 913 control mothers were analyzed. Increased risk of RA was associated with having any child compatible at HLA-B (OR 1.9; 1.2-3.1), DPB1 (OR 1.8; 1.2-2.6) or DQB1 (OR 1.8; 1.2-2.7). Compatibility at mHag ZAPHIR was associated with reduced risk of SLE among mothers carrying the HLA-restriction allele B*07:02 (n = 262; OR 0.4; 0.2-0.8). Our findings support the hypothesis that mother-child histocompatibility is associated with risk of RA and SLE

The RMS Survey: Distribution and properties of a sample of massive young stars

The Red MSX Source (RMS) survey has identified a large sample of massive young stellar objects (MYSOs) and ultra compact (UC) HII regions from a sample of ~2000 MSX and 2MASS colour selected sources. Using a recent catalogue of molecular clouds derived from the Boston University-Five College Radio Astronomy Observatory Galactic Ring Survey (GRS), and by applying a Galactic scaleheight cut off of 120 pc, we solve the distance ambiguity for RMS sources located within 18\degr 54\degr. These two steps yield kinematic distances to 291 sources out of a possible 326 located within the GRS longitude range. Combining distances and integrated fluxes derived from spectral energy distributions, we estimate luminosities to these sources and find that > 90% are indicative of the presence of a massive star. We find the completeness limit of our sample is ~10^4 Lsun, which corresponds to a zero age main sequence (ZAMS) star with a mass of ~12 Msun. Selecting only these sources, we construct a complete sample of 196 sources. Comparing the properties of the sample of young massive stars with the general population, we find the RMS-clouds are generally larger, more massive, and more turbulent. We examine the distribution of this sub-sample with respect to the location of the spiral arms and the Galactic bar and find them to be spatially correlated. We identify three significant peaks in the source surface density at Galactocentric radii of approximately 4, 6 and 8 kpc, which correspond to the proposed positions of the Scutum, Sagittarius and Perseus spiral arms, respectively. Fitting a scale height to the data we obtain an average value of ~29+-0.5 pc, which agrees well with other reported values in the literature, however, we note a dependence of the scale height on galactocentric radius with it increases from 30 pc to 45 pc between 2.5 and 8.5 kpc.Comment: Accepted for publication by MNRAS. Paper consists of 15 pages including 12 figures and four tables. Full versions of Tables 2 and 3 will only be available online. The resolution of Figure 9 has been reduced - a full resolution version of the paper can be download from here: http://www.ast.leeds.ac.uk/cgi-bin/RMS/RMS_PUBLICATIONS.cg

Disparities and guideline adherence for HPV testing among patients with oropharyngeal squamous cell carcinoma, NCDB, and SEER

BACKGROUND: Human papilloma virus testing for oropharyngeal squamous-cell carcinoma has been recommended by the National Comprehensive Cancer Network since 2012. We examine disparities, reported rates of human papillomavirus (HPV) testing, and the impact on these findings of limitations with the variable in database registries. METHODS: The HPV variable was queried for patients with oropharyngeal squamous carcinoma (OPSCC) from 2013 to 2016 in National Cancer Data Base (NCDB) and Surveillance, Epidemiology, and End Results (SEER). Multivariable regression was used to identify disparities based on sociodemographic variables. Sensitivity analyses were used to investigate limitations of the variable. RESULTS: Despite limitations in the HPV variable in the databases, there was less than 100% adherence to recommended testing, and there were significant disparities in multiple sociodemographic variables. For example, in NCDB 70% of white versus 60.4% of black patients were tested (odds ratio [OR] 0.75, confidence interval [CI] 0.66-0.85, p ≤ 0.0001); in SEER 59.8% of white and 47.6% of black patients were tested (OR 0.73, CI 0.67-0.81; p ≤ 0.0001). CONCLUSIONS: Disparities exist among patients undergoing testing for HPV-associated OPSCC and adherence to guideline recommended HPV testing has been suboptimal. In addition, the HPV variable definition, especially as it relates to p16 positivity, and use in these two registries should be improved

Selective vulnerability of the intermediate retinal capillary plexus precedes retinal ganglion cell loss in ocular hypertension

Introduction: Glaucoma, a disease of retinal ganglion cell (RGC) injury and potentially devastating vision loss, is associated with both ocular hypertension (OHT) and reduced ocular blood flow. However, the relationship between OHT and retinal capillary architecture is not well understood. In this project, we studied microvasculature damage in mice exposed to mild levels of induced OHT.Methods: Mild OHT was induced with the microbead model for 2 weeks. At this time point, some retinas were immunostained with CD31 (endothelium), Collagen IV (basement membrane), and RBPMS (RGCs) for z-stack confocal microscopy. We processed these confocal images to distinguish the three retinal capillary plexi (superficial, intermediate, and deep). We manually counted RGC density, analyzed vascular complexity, and identified topographical and spatial vascular features of the retinal capillaries using a combination of novel manual and automated workflows. Other retinas were dissociated and immunopanned to isolate RGCs and amacrine cells (ACs) for hypoxia gene array analysis.Results: RGC counts were normal but there was decreased overall retinal capillary complexity. This reduced complexity could be explained by abnormalities in the intermediate retinal capillary plexus (IRCP) that spared the other plexi. Capillary junction density, vessel length, and vascular area were all significantly reduced, and the number of acellular capillaries was dramatically increased. ACs, which share a neurovascular unit (NVU) with the IRCP, displayed a marked increase in the relative expression of many hypoxia-related genes compared to RGCs from the same preparations.Discussion: We have discovered a rapidly occurring, IRCP-specific, OHT-induced vascular phenotype that precedes RGC loss. AC/IRCP NVU dysfunction may be a mechanistic link for early vascular remodeling in glaucoma