Innowacyjność, konkurencyjność, jakość, wiedza i uczenie się komponentami rozwoju organizacji w zmiennym otoczeniu

Z wprowadzenia: "Monografia składa się z trzech części. Pierwsza z nich łączy problematykę innowacyjności i konkurencyjności z rozwojem organizacji. Literatura z zakresu zarządzania odnosi się tu do kwestii rozwoju organizacji oraz wariantów tego rozwoju, mając na uwadze, w perspektywie strategicznej, uzyskanie przez organizację określonej pozycji, a także przewagi konkurencyjnej. Rozpatrywane są różne czynniki zewnętrzne i wewnętrzne tego rozwoju – jednym z istotniejszych jest innowacyjność. Jest ona postrzegana zarówno w perspektywie zewnętrznej, jak i wewnętrznej. Z perspektywy zewnętrznej analizowany jest wpływ innowacji (w szczególności o charakterze przełomowym) na szanse rozwojowe firm. Często dotyczą one sposobu realizacji działalności wytwórczej czy usługowej przedsiębiorstw. Podkreśla się także znaczenie wpływu innowacji o charakterze społecznym na rozwój przedsiębiorstw. Z kolei innowacyjność wewnętrzna firm wiąże się często z realizacją własnych innowacji, najczęściej o charakterze inkrementalnym. Rozpatrywane są także różne poziomy innowacyjności: ponadnarodowy, krajowy, lokalny, wreszcie na poziomie poszczególnych organizacji. W części pierwszej opracowania odniesiono się także do problematyki innowacyjności i konkurencyjności krajów Unii Europejskiej oraz do problematyki innowacyjności przedsiębiorstw różnych branż, zwracając m.in. uwagę na rolę kapitału ludzkiego."(...

Bacteriocin BacSp222 and its succinylated forms inhibit proinflammatory activities toward innate immune cells

Purpose: The zoonotic opportunistic pathogen Staphylococcus pseudintermedius 222 produces BacSp222 – an atypical peptide exhibiting the features of a bacteriocin, a virulence factor, and a molecule modulating the host inflammatory reaction. The peptide is secreted in an unmodified form and, additionally, two forms modified posttranslationally by succinylation. This study is a comprehensive report focusing on the proinflammatory properties of such molecules. Methods: The study was performed on mouse monocyte/macrophage-like and endothelial cell lines as well as human neutrophils. The following peptides were studied: BacSp222, its succinylated forms, the form deprived of formylated methionine, and a reference bacteriocin – nisin. The measurements of the nitric oxide (NO) level, induced NO synthase (iNOS) expression, the profile of secreted cytokines, NF-kappa-B activation, reactive oxygen species (ROS) biosynthesis, and the formation of extracellular traps were conducted to evaluate the proinflammatory activity of the studied peptides. Results: BacSp222 and its succinylated forms effectively induced NO production and iNOS expression when combined with IFN-gamma in macrophage-like cells. All natural BacSp222 forms used alone or with IFN-gamma stimulated the production of TNF-alpha, MCP-1, and IL-1-alpha, while the co-stimulation with IFN-gamma increased IL-10 and IL-27. Upregulated TNF-alpha secretion observed after BacSp222 exposition resulted from increased expression but not from membrane TNF-alpha proteolysis. In neutrophils, all forms of bacteriocin upregulated IL-8, but did not induce ROS production or NETs formation. In all experiments, the activities of deformylated bacteriocin were lower or unequivocal in comparison to other forms of the peptide. Conclusion: All naturally secreted forms of BacSp222 exhibit proinflammatory activity against monocyte-macrophage cells and neutrophils, confirming that the biological role of BacSp222 goes beyond bactericidal and cytotoxic effects. The atypical posttranslational modification (succinylation) does not diminish its immunomodulatory activity in contrast to the lower antibacterial potential or cytotoxicity of such modified form established in previous studies

Upwelling events, coastal offshore exchange, links to biogeochemical processes - Highlights from the Baltic Sea Science Congress

The Baltic Sea Science Congress was held at Rostock University, Germany, from 19 to 22 March 2007. In the session entitled"Upwelling events, coastal offshore exchange, links to biogeochemical processes" 20 presentations were given,including 7 talks and 13 posters related to the theme of the session.This paper summarises new findings of the upwelling-related studies reported in the session. It deals with investigationsbased on the use of in situ and remote sensing measurements as well as numerical modelling tools. The biogeochemicalimplications of upwelling are also discussed.Our knowledge of the fine structure and dynamic considerations of upwelling has increased in recent decades with the advent ofhigh-resolution modern measurement techniques and modelling studies. The forcing and the overall structure, duration and intensity ofupwelling events are understood quite well. However, the quantification of related transports and the contribution to the overall mixingof upwelling requires further research. Furthermore, our knowledge of the links between upwelling and biogeochemical processes is stillincomplete. Numerical modelling has advanced to the extent that horizontal resolutions of c. 0.5 nautical miles can now be applied,which allows the complete spectrum of meso-scale features to be described. Even the development of filaments can be describedrealistically in comparison with high-resolution satellite data.But the effect of upwelling at a basin scale and possible changes under changing climatic conditions remain open questions

Predictors of enhancing human physical attractiveness : data from 93 countries

International audienc

Predictors of enhancing human physical attractiveness: Data from 93 countries

People across the world and throughout history have gone to great lengths to enhance their physical appearance. Evolutionary psychologists and ethologists have largely attempted to explain this phenomenon via mating preferences and strategies. Here, we test one of the most popular evolutionary hypotheses for beauty-enhancing behaviors, drawn from mating market and parasite stress perspectives, in a large cross-cultural sample. We also test hypotheses drawn from other influential and non-mutually exclusive theoretical frameworks, from biosocial role theory to a cultural media perspective. Survey data from 93,158 human participants across 93 countries provide evidence that behaviors such as applying makeup or using other cosmetics, hair grooming, clothing style, caring for body hygiene, and exercising or following a specific diet for the specific purpose of improving ones physical attractiveness, are universal. Indeed, 99% of participants reported spending >10 min a day performing beauty-enhancing behaviors. The results largely support evolutionary hypotheses: more time was spent enhancing beauty by women (almost 4 h a day, on average) than by men (3.6 h a day), by the youngest participants (and contrary to predictions, also the oldest), by those with a relatively more severe history of infectious diseases, and by participants currently dating compared to those in established relationships. The strongest predictor of attractiveness-enhancing behaviors was social media usage. Other predictors, in order of effect size, included adhering to traditional gender roles, residing in countries with less gender equality, considering oneself as highly attractive or, conversely, highly unattractive, TV watching time, higher socioeconomic status, rightwing political beliefs, a lower level of education, and personal individualistic attitudes. This study provides novel insight into universal beauty-enhancing behaviors by unifying evolutionary theory with several other complementary perspectives

Predictors of enhancing human physical attractiveness: Data from 93 countries

International audienc