HOLISTIC APPROACH OF AYURVEDA IN THE MANAGEMENT OF EKA-KUSHTHA W. S. R. TO PSORIASIS - A CASE STUDY

Skin is the largest organ which reflects the both healthy and diseased condition of the body. According to ancient Ayurved samhitas, all the skin diseases are categorized under Kushtha roga. In modern world, skin has greater cosmetic importance leading to boost the confidence and personality of an individual as well as to attain the healthy mindset. The morbid condition of the skin should be treated earlier as it may attain Krichrasadhya or even Asadhya avastha also. Ancient Acharyas have been explained in detail the Panchakarma accompanying with variety of Shamana aushadhis and Sthanika chikitsa to treat the Kushtha rogas. In the present case study, a 37 years old female patient having symptoms resembling to Eka kushtha was treated with combine use of ancient Ayurvedic treatment protocols viz., Nidana parivarjana, Shodhana chikitsa, Shamana aushadhis and Sthanika chikitsa together with Pathyapathya. The assessment of Lakshanas was done by using WHO guidelines for Kushtha. This comprehensive approach of Ayurveda to treat the Eka kushtha helps to achieve the significant relief in symptoms of the patient

Revitalization of thiazolidinedione the optimum agents to be combined with SGLT 2 inhibitors to optimize glycemic control and reduce cardiovascular mortality: randomized control trial

Background: Type 2 diabetes mellitus (T2DM) significantly increases morbidity and mortality from cardiovascular disease. The present study was conducted to know the effect of thiazolidinedione and SGLT2 inhibitor on glycemic control, blood pressure and lipid profile and effect on cardiovascular mortality in T2DM. Methods: A total 80 patients of aged ≥40 years with T2DM were included and divided into 4 groups based on ongoing treatment i.e., (lifestyle modification + Tab metformin 500mg BD) + 1) Tab metformin 500mg; 2) Tab dapagliflozin 10mg OD; 3) Tab pioglitazone 15mg OD; 4) Tab pioglitazone 15mg OD + Tab Dapagliflozin 10mg OD. Results: The change in FBS, PLBS and HbA1C from pre-intervention to post-intervention was highest in the patients with DAPA + pioglitazone group followed by patients with pioglitazone group then the patients with DAPA group and lowest in patients with metformin group. There was a statistically significant difference between them, (p<0.001). The weight reduction was highest in the patients with DAPA 10mg group followed by patients with metformin group, (p<0.001). The change in SBP, DBP and change in lipid profile (triglyceride and cholesterol, LDL and HDL) from pre-intervention to post-intervention was highest in the patients with DAPA+ pioglitazone group. This change was statistically significant (p<0.001). Conclusions: The combination of pioglitazone and dapagliflozin not only helped in glycemic control but also had reduction in blood pressures, improvement in the lipid profile and caused slight weight reduction. There were no major adverse drug reactions, and no MACE was observed during the study. Hence this combination of pioglitazone and dapagliflozin may reduce the cardiovascular mortality (which needs longer duration study)

Calibration of the CMS hadron calorimeters using proton-proton collision data at √s = 13 TeV

Methods are presented for calibrating the hadron calorimeter system of the CMS detector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities |η| < 3 and are positioned inside the solenoidal magnet. An outer calorimeter, outside the magnet coil, covers |η| < 1.26, and a steel and quartz-fiber Cherenkov forward calorimeter extends the coverage to |η| < 5.19. The initial calibration of the calorimeters was based on results from test beams, augmented with the use of radioactive sources and lasers. The calibration was improved substantially using proton-proton collision data collected at √s = 7, 8, and 13 TeV, as well as cosmic ray muon data collected during the periods when the LHC beams were not present. The present calibration is performed using the 13 TeV data collected during 2016 corresponding to an integrated luminosity of 35.9 fb⁻¹. The intercalibration of channels exploits the approximate uniformity of energy collection over the azimuthal angle. The absolute energy scale of the central and endcap calorimeters is set using isolated charged hadrons. The energy scale for the electromagnetic portion of the forward calorimeters is set using Z→ ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy

Calibration of the CMS hadron calorimeters using proton-proton collision data at root s=13 TeV

Methods are presented for calibrating the hadron calorimeter system of theCMSetector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities vertical bar eta vertical bar ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy.Peer reviewe

Ayurvedic Management of Asthidhatu kshaya: A Comparative clinical study

Joint disorders are most commonly occurring in the world and India also. Asthidhatu kshaya has become one of the major health hazard that cripple millions of lives. Age related degeneration in the bone mass, over exercise, vataprakopaka ahara vihara etc are the causes of Asthidhatu kshaya. Asthishoola, sandhishaithilya, srama etc are the symptoms produced due to Asthidhatu kshaya. Charaka and Vagbhata have mentioned ksheera vasti with tikta dravyas to treat asthivaha srotas vyadhis. In this ksheera vasti, Amruta and Patola are used as tikta dravyas. The present study was a open clinical trial. In this study, total 30 patients were taken for the study and divided into 2 equal groups: Group A &amp; Group B. (Group A) - Pana prayoga : Amruta patola ksheerapaka - 160 ml for 45 days. (Group B) -Vasti prayoga: Amruta Patola ksheeravasti - 160 ml for 45 days.The effect of the therapy was assessed on the basis of changes observed in the subjective and objective parameters. Subjective parameters taken for the assessment were asthishoola, sandhi shaithilyam, srama, sparshasahatwa. The objective parameters taken were assessment of bone mineral density (BMD) and serum calcium. Tests were done on standard parameters, before and after the treatment. It was observed that Amruta Patola ksheera pana and vasti both are effective in Asthidhatu kshaya. But, ksheera vasti was more effective and useful than ksheera pana in Asthidhatu kshaya. The detail scientific data will be discussed in full paper.Â

STRUCTURAL PROPERTIES OF POLYPROPYLENE FIBER REINFORCED CONCRETE

In this paper, the structural properties are studied for Compressive Strength of polypropylene fiber in concrete with natural sand. Different cut length of 20mm to 30mm with an increment of 5 and different volume fractions of polypropylene fiber 0.0% to 1% with an increment of 0.25% by weight of cement are used. Concrete mix prepared with locally available Natural sand as a normal mix is used. Concrete mixes are designed for infrastructural development industry. It has a capacity to enhance its property with the help of other suitable materials like Polypropylene Fiber. Currently man-made micro fibers and natural fibers have been incorporated into concrete. Initially natural fibers were used in concrete but it has some drawbacks mainly in durability hence man-made fibres are preferred. Man Made Polypropylene fiber is adaptable thermoplastic material which is formed by polymerizing monomer units of polypropylene molecule into very long polymer molecules or chains in the presence of channel under carefully controlled heat &amp; pressure. Concrete mixes are designed for M20 and M30 grades for the experimentation. Mechanical, thermal and other properties are studied. There is improvement in compressive strength by addition of Polypropylene fiber in concrete

Pragmatic Approach for Online Document Verification Using Block-Chain Technology

As we all know, India has a plethora of universities, and many people graduate from them. Because it is possible for someone to falsify a degree, a secure based verification mechanism is required. It will be achieved in an existing system through the exchange of e-mails or postal mail; however, this is a time-consuming process that is insecure owing to human involvement. And, in order to solve these drawbacks, we implemented block chain technology into our system. When there is a security risk, block chain comes to mind. When it comes to data breaches, education is also not far away. For attackers, student data with little financial information has become a valuable commodity. At the same time, student verification is becoming a serious worry at educational institutions, which are being breached to generate phony identities and records. As a result, the greater the digitization of student information, the greater the need to protect student privacy

Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies

Objective: To compare three treatment modalities in scabies for safety, efficacy, and economy in a local population of Nagpur. Materials and Methods: This was a prospective, randomized, comparative clinical trial conducted in 103 participants, randomly allocated to three groups. First group received benzyl benzoate (BB) 25% lotion, second group received permethrin 5% cream, whereas third group received tablet ivermectin 200 µg/kg as a single dose. The participants were recalled after one week for follow-up evaluation. If there were no signs of cure, the same intervention was repeated. The participants were followed up for two weeks for cure rate, adverse drug reaction (ADR) monitoring, and postintervention observation. The follow-up was stopped after two weeks. Statistics: Fischer′s exact test using Graph pad Instat v 3.05. Results: Ivermectin showed 100% cure rate after two weeks of treatment. Permethrin decreased pruritus by 76% at the end of one week and had significantly better cure rate than ivermectin. At the end of two weeks treatment, this finding was reversed, that is, cure rate in ivermectin group was 100%. For cost-effectiveness analysis, treatment regimens were formulated hypothetically for comparison from Markov population tree for decision analysis. It was found that BB and ivermectin each consecutively for two weeks were most cost effective regimens giving complete cure in four weeks, while ivermectin was the fastest regimen giving the same results in two weeks. Conclusion: Benzyl benzoate as first line intervention and ivermectin in the remaining gave best cost-effective results in the study patients of scabies