HOLISTIC APPROACH OF AYURVEDA IN THE MANAGEMENT OF EKA-KUSHTHA W. S. R. TO PSORIASIS - A CASE STUDY

Skin is the largest organ which reflects the both healthy and diseased condition of the body. According to ancient Ayurved samhitas, all the skin diseases are categorized under Kushtha roga. In modern world, skin has greater cosmetic importance leading to boost the confidence and personality of an individual as well as to attain the healthy mindset. The morbid condition of the skin should be treated earlier as it may attain Krichrasadhya or even Asadhya avastha also. Ancient Acharyas have been explained in detail the Panchakarma accompanying with variety of Shamana aushadhis and Sthanika chikitsa to treat the Kushtha rogas. In the present case study, a 37 years old female patient having symptoms resembling to Eka kushtha was treated with combine use of ancient Ayurvedic treatment protocols viz., Nidana parivarjana, Shodhana chikitsa, Shamana aushadhis and Sthanika chikitsa together with Pathyapathya. The assessment of Lakshanas was done by using WHO guidelines for Kushtha. This comprehensive approach of Ayurveda to treat the Eka kushtha helps to achieve the significant relief in symptoms of the patient

Revitalization of thiazolidinedione the optimum agents to be combined with SGLT 2 inhibitors to optimize glycemic control and reduce cardiovascular mortality: randomized control trial

Background: Type 2 diabetes mellitus (T2DM) significantly increases morbidity and mortality from cardiovascular disease. The present study was conducted to know the effect of thiazolidinedione and SGLT2 inhibitor on glycemic control, blood pressure and lipid profile and effect on cardiovascular mortality in T2DM. Methods: A total 80 patients of aged ≥40 years with T2DM were included and divided into 4 groups based on ongoing treatment i.e., (lifestyle modification + Tab metformin 500mg BD) + 1) Tab metformin 500mg; 2) Tab dapagliflozin 10mg OD; 3) Tab pioglitazone 15mg OD; 4) Tab pioglitazone 15mg OD + Tab Dapagliflozin 10mg OD. Results: The change in FBS, PLBS and HbA1C from pre-intervention to post-intervention was highest in the patients with DAPA + pioglitazone group followed by patients with pioglitazone group then the patients with DAPA group and lowest in patients with metformin group. There was a statistically significant difference between them, (p<0.001). The weight reduction was highest in the patients with DAPA 10mg group followed by patients with metformin group, (p<0.001). The change in SBP, DBP and change in lipid profile (triglyceride and cholesterol, LDL and HDL) from pre-intervention to post-intervention was highest in the patients with DAPA+ pioglitazone group. This change was statistically significant (p<0.001). Conclusions: The combination of pioglitazone and dapagliflozin not only helped in glycemic control but also had reduction in blood pressures, improvement in the lipid profile and caused slight weight reduction. There were no major adverse drug reactions, and no MACE was observed during the study. Hence this combination of pioglitazone and dapagliflozin may reduce the cardiovascular mortality (which needs longer duration study)

Calibration of the CMS hadron calorimeters using proton-proton collision data at √s = 13 TeV

Methods are presented for calibrating the hadron calorimeter system of the CMS detector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities |η| < 3 and are positioned inside the solenoidal magnet. An outer calorimeter, outside the magnet coil, covers |η| < 1.26, and a steel and quartz-fiber Cherenkov forward calorimeter extends the coverage to |η| < 5.19. The initial calibration of the calorimeters was based on results from test beams, augmented with the use of radioactive sources and lasers. The calibration was improved substantially using proton-proton collision data collected at √s = 7, 8, and 13 TeV, as well as cosmic ray muon data collected during the periods when the LHC beams were not present. The present calibration is performed using the 13 TeV data collected during 2016 corresponding to an integrated luminosity of 35.9 fb⁻¹. The intercalibration of channels exploits the approximate uniformity of energy collection over the azimuthal angle. The absolute energy scale of the central and endcap calorimeters is set using isolated charged hadrons. The energy scale for the electromagnetic portion of the forward calorimeters is set using Z→ ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy

Calibration of the CMS hadron calorimeters using proton-proton collision data at root s=13 TeV

Methods are presented for calibrating the hadron calorimeter system of theCMSetector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities vertical bar eta vertical bar ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy.Peer reviewe

Ayurvedic Management of Asthidhatu kshaya: A Comparative clinical study

Joint disorders are most commonly occurring in the world and India also. Asthidhatu kshaya has become one of the major health hazard that cripple millions of lives. Age related degeneration in the bone mass, over exercise, vataprakopaka ahara vihara etc are the causes of Asthidhatu kshaya. Asthishoola, sandhishaithilya, srama etc are the symptoms produced due to Asthidhatu kshaya. Charaka and Vagbhata have mentioned ksheera vasti with tikta dravyas to treat asthivaha srotas vyadhis. In this ksheera vasti, Amruta and Patola are used as tikta dravyas. The present study was a open clinical trial. In this study, total 30 patients were taken for the study and divided into 2 equal groups: Group A &amp; Group B. (Group A) - Pana prayoga : Amruta patola ksheerapaka - 160 ml for 45 days. (Group B) -Vasti prayoga: Amruta Patola ksheeravasti - 160 ml for 45 days.The effect of the therapy was assessed on the basis of changes observed in the subjective and objective parameters. Subjective parameters taken for the assessment were asthishoola, sandhi shaithilyam, srama, sparshasahatwa. The objective parameters taken were assessment of bone mineral density (BMD) and serum calcium. Tests were done on standard parameters, before and after the treatment. It was observed that Amruta Patola ksheera pana and vasti both are effective in Asthidhatu kshaya. But, ksheera vasti was more effective and useful than ksheera pana in Asthidhatu kshaya. The detail scientific data will be discussed in full paper.Â

A Case Control Study to Elucidate the Effects of Maternal Anthropometric Characteristics and Other Factors on Birth Weight of Newborn

Background: Birth weight reflects mother’s health and nutritional status during pregnancy. This study was conducted to measure the effect of various maternal factors on birth weight; and also to study the strength of association between risk factors and low birth weight. Methods: A case-control study was conducted among neonates delivered in tertiary care Hospital from June 2013 to July 2014 among mothers who delivered in the hospital and their singleton newborns. Birth weight was measured for all newborns and these mothers undergone anthropometric measurements and were asked relevant questions. Results: The proportion of low birth weight was 27.73%. Maternal age of more than 30 years (odds ratio 1.98; χ2=3.86, P=0.04), gestational age at the time of birth (OR 4.37; χ2=44.21, P=0.000) occupation of mother (OR 1.69, χ2=4.54, P=0.03) maternal height <145 cm (OR 2.74, χ2=17.97, P= 0.000), maternal weight <45 kg (OR 1.90, X2 =8.19, P= 0.004) and complications during pregnancy (OR 1.78 χ2=6.55,  P =0.01) have a significant association with LBW infant. Conclusion: LBW rate was higher when Maternal age more than 30, early gestational age at the time of birth, occupation of mother, maternal height <145 cm, maternal weight < 45 kg and complications during pregnancy

Intrauterine Devices and Reproductive Tract Infections: A Cross-Sectional Study in Urban Slum

Introduction: The concern that intrauterine devices (IUDs) might cause or facilitate reproductive tract infection has limited its use. Objectives: The study aims to explore the relationship between re- productive tract infections & IUD use. Materials and Methods: A hospital based cross sectional study con- ducted in STI/RTI Clinic located in urban slums of Mumbai, involv- ing total 169 married females of reproductive age group who pre- sented with symptoms of RTI and using atleast one type of contra- ceptive method, who attended OPD from January to March 2012. Tool for interview was the questionnaire about sociodemographic profile, contraceptive practices, and symptoms of the participants. Disease specific laboratory methods were used to confirm diagnosis of RTI. Results: 47(27.81%) females were using IUD as contraceptive method in this study. Proportion of the symptoms was more among IUD us- ers than non IUD users. 33(70.2%) had suffered from STI / RTI who were using IUDs as compared to 63 (51.6%) non-IUD users showing statistically significant association. Conclusion: There is a statistically significant association between use of IUD and RTI

Immunization Status of Children Under 5 Years in A Tribal Area, Parol, Thane District

Background: Infectious diseases are a major cause of morbidity and mor- tality in children. One of the most cost-effective and easy methods for the healthy well-being of a child is immunization. In India, immunization services are offered free in public health facilities, but despite rapid in- creases, the immunization rate remains low in some areas. Objectives: The objective of the study was to study the socio- demographic profile and immunization status of the children aged less than 5yrs. Materials and Methodology: The present study was carried out in a tribal area of Parol in Thane district. In this descriptive cross sectional study tribal children in the age group of 1-5 years were assess for their immunization status. Results: Completely immunized children were 71.1%, partially immu- nized were 17.8% and 11.1% were not immunized. The most common reason for not immunizing the child was ‘fear of side effects’ (40%) and for partially immunizing the child was ‘visit to native place’ or ‘other sibling not well’ (37.5%). There was significant association between poor immunization status and Muslim religion of the children, poor socio- economic status, home delivery, and not having immunization card. Conclusion: The overall coverage of immunization among the tribal area is good but still it has pockets of poor immunization

STRUCTURAL PROPERTIES OF POLYPROPYLENE FIBER REINFORCED CONCRETE

In this paper, the structural properties are studied for Compressive Strength of polypropylene fiber in concrete with natural sand. Different cut length of 20mm to 30mm with an increment of 5 and different volume fractions of polypropylene fiber 0.0% to 1% with an increment of 0.25% by weight of cement are used. Concrete mix prepared with locally available Natural sand as a normal mix is used. Concrete mixes are designed for infrastructural development industry. It has a capacity to enhance its property with the help of other suitable materials like Polypropylene Fiber. Currently man-made micro fibers and natural fibers have been incorporated into concrete. Initially natural fibers were used in concrete but it has some drawbacks mainly in durability hence man-made fibres are preferred. Man Made Polypropylene fiber is adaptable thermoplastic material which is formed by polymerizing monomer units of polypropylene molecule into very long polymer molecules or chains in the presence of channel under carefully controlled heat &amp; pressure. Concrete mixes are designed for M20 and M30 grades for the experimentation. Mechanical, thermal and other properties are studied. There is improvement in compressive strength by addition of Polypropylene fiber in concrete

UNSEEN TUBERCULOSIS: STUDY AMONG INPATIENTS OF A TERTIARY CARE HOSPITAL OF NORTH KARNATAKA

Objective: Tuberculosis (TB) remains a significant global health challenge, particularly in high-burden countries like India. However, high proportion of people never diagnosed or treated. Delayed diagnosis poses a significant threat to hospital inpatients, health-care workers, and medical trainees. Hence, systematic screening of high-risk groups, including hospital inpatients, has been recommended as a strategy to identify TB. Using signs and symptoms as an independent screening tool remains a global challenge for its relatively low accuracy. However, it could still be of value when it was used in a specific target population like inpatients of hospital. Hence, this study is aimed to determine the proportion of presumptive and active TB cases among inpatients. Methods: A hospital-based cross-sectional study was conducted among inpatients above 18 years of age admitted in non-emergency wards admitted during March to April 2023 at ESIC Hospital in Kalaburagi. A pre-existing TB diagnosis and patients admitted to critical care units were excluded. The convenient sampling method was used to recruit participants. Data were collected through using a pre-designed, semi-structured questionnaire. The patients who presented with one of the four symptoms for screening had undergone investigations such as cartridge-based nucleic acid amplification test, chest X-ray, and sputum microscopy to confirm the diagnosis, and the findings were recorded as proportion. Results: Out of 1363 inpatients, 35 (2.5%) patients had classified as presumptive TB case. Out of 35, 3 (8.57%) were found to be actual TB cases. All patients who had positive results for TB were young patients and belonged to low socioeconomic class. Two of three were rifampicin-sensitive TB cases. Conclusion: Timely screening of the patient’s is of utmost importance to avoid further spread of TB infection among inpatients. The higher prevalence of actual TB cases in younger adults needs further exploration