Management of Amavata through kati vasti and matra vasti with Eranda beeja ksheera paka – A single arm open-label trial

Introduction: In Amavata, the Vata Dosha is vitiated and Ama accumulates in the sandhi. When ama localises in the body\u27s tissues or joints, it may cause the afflicted joints to experience pain, stiffness, swelling, soreness, and other symptoms. Eranda Paka, a remedy for Amavata that includes Eranda Bija as one of its constituents, has been employed. Materials and Method: Based on the inclusion criteria, a total of 50 patients visited the outpatient department of Krishna Ayurved hospital, Ahmedabad Ayurved hospital, HPC Engineering Co, Krish Engineers, for this study. Individuals with traditional manifestations of Angamarda, Aruchi, Trishna, Hrullasa, Gaurava, Jwara, Shula, Shotha, and so forth were chosen. Results: Eranda paka significantly (p=<0.0001) improved the objective parameters, after the treatment 28% patients were without Angmardana, 30% patients were without Aruchi, 52% patients Trishna condition was normal, 30% patients Hrullasa condition was normal, 20% patients were without jwara, Apaka and Gaurava condition, 24% patients were without Agnimandya and 30% patients Daurbalya condition improved. In addition, after the treatment a significant improvement also reported in ESR, eosinophil and Rh factor. Conclusion: Amavata can be correlated with modern medicine Rheumatic arthritis. Ayurveda explains it as an imbalance of Ama and vata. Eranda Paka significantly improved the both subjective and objective parameter. Along with disease symptoms, a significant improvement reported in biochemical parameter i.e., Rh factor. After the treatment a significant improvement reported Amavata condition.

Unveiling the Therapeutic Potentials of Ghee: Insights from Ayurvedic Texts and Contemporary Research

Background: Recent research has brought attention to the bioactive properties of dairy fats, leading to a shift in the scientific community’s perspective. Ghee, a clarified butter integral to Indian culture and cuisine, has been extensively documented in Ayurveda for its therapeutic benefits. Objective: To examine the health benefits of ghee as described in Ayurvedic texts and modern scientific literature, identifying areas of alignment and divergence. Methods: Ayurvedic Review: Analysis of 11 classical texts spanning 3000+ years, identifying 4000 references to milk derivatives, including 774 mentions of ghee. Benefits were categorised into 15 clusters.  Modern Literature Review: Examination of studies published between 1990 and 2023, focusing on ghee’s therapeutic applications. Results: Ayurvedic Insights: Ghee is highlighted for cognitive enhancement, gastrointestinal health, and nourishment, with 2913 references to the benefits of milk derivatives. Modern Insights: Research primarily emphasises ghee’s role in wound healing, skin health, and cardiovascular benefits. Discussion: Ayurvedic and modern perspectives offer complementary insights. While modern science has explored ghee’s topical and cardiovascular applications, Ayurveda underscores its systemic benefits, including cognitive and digestive health. Conclusion: The integration of Ayurvedic knowledge and modern science could unlock ghee’s therapeutic potential, addressing chronic and age-related diseases. Future interdisciplinary research is crucial for validating traditional applications and discovering innovative treatments.

Integrated Approach of Panchakarma and Viddha karma for the Management of Carpal Tunnel Syndrome: A Case Report

Background: Carpal Tunnel Syndrome (CTS) is a peripheral neuropathy that most commonly impacts the median nerve, characterized by pain, numbness, and tingling along the pathway of the median nerve. The prevalence of CTS is estimated to range between 4% and 5%. As the condition is prone to recurrence, there is a need to adopt management approaches that provides significant results. The clinical features of CTS can be correlated with Vata vyadhi in Ayurveda. Aim & Objective: To evaluate the efficacy of Panchakarma therapy and Viddha Karma combined with Yogaraja guggulu, Trayodashanga guggulu, Asthiposhak vati, and Sukhasarak vati in managing CTS by using Boston Carpal Tunnel Questionnaire (BCTQ) score. Methodology: A case report of 52-year-old male patient presented with pain in the right hand, accompanied by numbness, tingling sensations, and difficulty in performing routine activities for 3 months. On examination Tinel’s sign, Phalen’s maneuver were positive, with high BCTQ score, Visual Analogue Scale scored 7, and was advised to perform nerve conduction study. He was diagnosed with CTS with nerve conduction velocity less than 40 m/s. Panchakarma procedures such as Sthanik snehan (localized massage) with Nirgundi Taila, Shashtikshali pinda swedan (sudation with medicated cooked bolus of rice) for 15 days and 3 sittings of viddha karma (Dry needle puncture) at the interval of 5 days, along with internal Ayurvedic medications as mentioned above were adopted for 21 days. Results: Following the treatment, significant improvement was observed in all symptoms, with 67.5% relief in symptoms as reflected by BCTQ scores. Conclusion: Panchakarma therapy and Ayurvedic medications are effective in managing CTS

Elucidating the anti inflammatory potential of bio active hydrogel from Carica papaya leaf extracts using combination of in silico and in vitro methods

The investigation on medicinal plants have been gaining importance around the world especially in Asian nations due to the presence of wide range of bioactive phytochemicals. The presence of diverse bioactive compounds makes medicinal plants more demandable for curing several diseases, such as inflammatory diseases, and diabetes. Carica papaya is one such plant found very commonly throughout the country and reported to have a massive traditional properties. The present study addresses the in vitro and in silico study of the plant leaf extract for a potential anti inflammatory effect. The plant showed adequate anti-inflammatory effect through in silico and in vitro models. The compounds identified by GC-MS are put through molecular docking studies and virtual toxicity studies. Out of all the compounds, pigenin (-9.9 kcal/mol), quercetin (-9.4 kcal/mol), and kaempferol (-9.2 kcal/mol) have the best binding energy as compared to the standard diclofenac indicating that the extract can find its usage as anti-inflammatory drug. Further the claim was confirmed by in vitro study using BSA method. As compared to standard diclofenac (IC50: 0.47 mg/ml) the IC50 value of papaya extract was found to be only 0.198 mg/ml indicating a significant increase in inhibition at low concentration of the extract. A set of hydrogel formulations were designed to deliver the extract and it was found that formulation F3 containing 0.5% w/v extract was the most suitable with pH of 7.02 and spreadability of 15.11 gcm/s. Hence, a highly potent natural anti-inflammatory formulation is reported to be developed in this study

Mahakumbh 2025: A Divine Confluence of Traditions, Rituals, and Spiritual Essence

Mahakumbh 2025, the world’s largest spiritual congregation, is deeply rooted in the tradition of ritual bathing in the sacred waters of the Ganga at Triveni Sangam. This practice is not only a religious observance but also carries scientific significance. Millions of devotees believe that bathing in the holy river during this auspicious period cleanses sins and paves the path to Moksha. However, modern research also highlights the antibacterial and self-cleansing properties of the Ganga, making this ritual a blend of faith and science. Bathing during Mahakumbh is believed to align with cosmic and environmental factors, enhancing immunity, reducing stress, and promoting mental clarity. Cold water immersion further activates the parasympathetic nervous system, improving circulation and overall well-being. Auspicious days such as Makar Sankranti, Mauni Amavasya, and Maghi Purnima witness the largest gatherings for the Shahi Snan (royal bath), where saints and devotees participate in this transformative ritual. The culmination of the event on Maha Shivaratri marks the final holy bath, symbolizing spiritual renewal. Thus, Mahakumbh 2025 not only upholds ancient traditions but also offers a scientific rationale for ritualistic bathing, reinforcing its positive impact on both spiritual and physical well-being

Safety and Good Governance

The Mahakumbh is a massive religious and cultural gathering held at Prayagraj, India, attracting millions of devotees from across the globe. The state government has meticulously planned and implemented numerous safety and infrastructure measures to ensure the smooth and secure operation of the Mahakumbh 2025. Over 50,000 security personnel, including police, home guards, and specialized teams such as NDRF and SDRF, are deployed to manage the large-scale event. Cutting-edge technology, including over 2700 AI-powered CCTV cameras and various other surveillance systems, is employed for real-time monitoring. The fair area is equipped with essential amenities, such as fire stations, water police control rooms, and fire-fighting robots, ensuring prompt response to emergencies. The state government has also focused on improving the infrastructure, with the construction of new bridges, roads, and power sub-stations. A significant emphasis is placed on improving transportation with upgrades to Prayagraj Airport, railway stations, and roadways to handle the influx of devotees. Additionally, F.R. codes are being introduced for easy access to essential services such as emergency healthcare, food, and accommodation. The preparations for Mahakumbh 2025 reflect a fusion of tradition and modernity, with technological advancements enhancing the experience of the devotees. This strategic blend ensures the efficient handling of the largest religious congregation in the world

In-vitro Evaluation of the Siddha Formulation Mahaveera Mezhugu (MVM) for Anti-Cancer Activity Against MCF-7 Human Breast Cancer Cells

Over one in ten new cases of cancer detected in women are related to breast cancer, making it the most common disease diagnosed in this demographic. It is the second leading cause of cancer-related deaths worldwide for women. The many cancer treatments and their potential adverse effects made people aware of the need to look for safe, affordable substitutes for cancer treatment. The Siddha system can offer a lot of formulations in the management of breast cancer. There are also many literary works that facilitate this. Efficacy of Mahaveera Mezhugu (MVM) is a Herbo-mineral siddha preparation it is indicated for Vatharogam, Megarogam. This MVM has been used for siddha clinically to treat breast cancer. but there is no scientific data to validate this medicine. Hence this study aims to evaluate the anticancer potential of Mahaveera Mezhugu through an in-vitro study in the MCF-7 Human Breast cell line, determined by dimethyl sulphoxide (DMSO, MTT and Annexin V- Fitc apoptosis by flow cytometry assay. LC50 concentration was found at 5.1879371 µg/mL.  The Siddha system, which combines many well-researched drugs, has shown clinically significant improvements in the treatment of breast cancer. Further research and large randomized control trial are needed to determine the effects of the drug

Mushroom Extracts in the Management of Diabetes: A Systematic Review with Special Reference to Oyster Mushrooms

A multifactorial metabolic illness with a significant risk of death called diabetes mellitus is defined by elevated blood glucose levels. The quality of life, the health care system, and the economics of nations are all significantly impacted by diabetes and its persistent problems. There are numerous commercial medications available today that are successful in treating hyperglycemia but have several substantial side effects and are unable to appreciably modify the course of diabetes complications. Mushrooms and their bioactive constituents like polysaccharides and terpenoids, are useful in the cure of diabetes mellitus. This systematic review aims to provide an overview of the effects of mushrooms on diabetes. Details on relevant studies were examined using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) norms. Although the mechanism of Pleurotus mushrooms in treating diabetes is still unknown, the anti-diabetic properties of many other species of oyster mushrooms have not been thoroughly researched. More research on edible medicinal mushrooms is required to close the research gap and use their clinical potential to prevent metabolic diseases

Misdiagnosed case of an ano-scrotal fistula treated with partial excision of tract and Ksharasutra - A case report

Anal fistula can sometimes extend to the scrotum, resulting in varied presentations that can lead to misdiagnoses such as scrotal infection, abscess, or sinus, particularly when minimal or no symptoms are present in the anus. This case report presents a 50-year-old male patient initially diagnosed with a scrotal sinus who underwent excision one year ago. He presented with persistent pus discharge from the scrotum without anal complaints. So the case was initially diagnosed as a scrotal sinus based on clinical examination and ultrasonography findings, the true pathology of an ano-scrotal fistula was only revealed during surgery. This unexpected finding was effectively managed by partial fistulectomy and Ksharasutra therapy. This case underscores the importance of thorough preoperative assessment and intraoperative vigilance. The successful outcome demonstrates the necessity for flexibility in surgical planning and the potential benefits of integrative approaches in complex fistula-in ano.

Pharmacological Insights and Phyto-Chemical Profiling of Dhanyaka (Coriandrum Sativum Linn) for Therapeutic Applications

The Dhanyaka (Coriander) is botanically identified as Coriandrum sativum Linn belongs to Apiaceae (Shatapushpa Kula) family. It is a commonly used spices and medicine in Ayurveda. In Ayurveda, Ardha Dhanyaka (wet coriander), Sushka Dhanyaka (dry coriander), and Dhanyaka Shaka (fresh coriander leaves) are different forms of coriander used for their medicinal properties.             Dhanyaka (Coriandrum sativum Linn) beeja (seeds) consists of, kashaya, tikta rasa (astringent and bitter taste), snigdha laghu guna (unctuous, light properties), ushna veerya (hot in potency) and madhura vipaka (undergoes sweet metabolism). It acts as tridhosha shamaka (mitigates vata, pitta and kapha), deepana (appetizer), pachana (enhances digestion), mutrala (diuretics), jwaraghna (anti-pyretic), grahi (absorbent), trishnanigrahana (subsides excessive thirst), dahahara (cooling), chardighna (antiemetic), swasahara (anti-asthmatic), krimighna (anti-microbial), and hridya (cardiac tonic). Observations and results: The qualitative and quantitative analysis shows oil yield 7.89% and 9.25%, odour- pleasant, colour- greenish brown, taste- spicy, acid value - 8.569 & 7.568, iodine value - 42.12 & 82.39, saponification value - 285.36 & 236.23, ester value- 265.35 &226.521 in aqueous & methanol respectively. Phytochemical analysis of Dhanyaka extract shows presence of carbohydrates, alkaloids, flavonoids, glycosides, tannins, gas chromatography and mass spectrometric analysis indicates the presence of β-linalool as major chemical constituent along with other essential components, which is widely used in the markets of food, pharmaceutical, cosmetic and aromatherapy