Effect of Therapeutic Treatment on Delayed Onset Muscle Soreness (DOMS)

Context: Delayed onset muscle soreness (DOMS) is common after unfamiliar, repeated eccentric contractions, or intense exercise. Symptoms of DOMS can range from moderate to severe pain and point tenderness. Many therapeutic interventions are used to decrease the symptoms of DOMS, but currently there is no gold standard. Objective: The aim of this study was to explore the most efficient treatment to decrease DOMS. Participants: Twenty-seven participants (5 male, 22 female) between the ages of 18 to 25 (19.81 + 1.79) were recruited. Methods: Values of perceived soreness were recorded with the use of a visual analog scale ranging from 0 to 100 (0=none, 25=mild, 50=moderate, 75=severe, 100=worst). Participants were randomly placed into four treatment groups (cold whirlpool (CWP)=5, warm whirlpool (WWP)=5, non-steroidal anti-inflammatories (NSAIDs)=5, foam roll (FR)=6) and one control group (CON=6). Participants completed a 30 minute stepping protocol with a predetermined high intensity cadence to induce DOMS. Results: A repeated measures analysis of variance (RMANOVA) was used to analyze data. No significant differences were observed for raw score decrease or percentage of decrease of soreness values. However differences between the groups were noted. WWP had the lowest overall average raw score value (24.8) and CWP had the highest average (28.76). FR had the lowest average raw score at 72 hours (16.667) and NSAIDs had the highest average (30) at 72 hours. WWP was the first group to have the highest percentage decrease (11%) between 24 and 48 hours, whereas FR saw the greatest percentage decrease overall (25.8%) between 48 and 72 hours. CON had the greatest initial increase (23%) between zero and 24 hours, and NSAIDs had the least amount of decrease (15%) between 48 and 72 hours. Conclusion: Relief of DOMS can benefit active individuals. WWP and FR were the two best treatments to help decrease symptoms associated with DOMS by 72 hours. More research about parameters of these therapeutic interventions can help identify better therapeutic interventions for DOMS

Field studies on the deterioration of microplastic films from ultra-thin compostable bags in soil

In recent years, some countries have replaced single-use plastic bags with bags manufactured from compostable plastic film that can be used for collecting food wastes and composted together with the waste. Because industrial compost contains undeteriorated fragments of these bags, application to field soil is a potential source of small-sized residues from these bags. This study was undertaken to examine deterioration of these compostable film microplastics (CFMPs) in field soil at three different localities in Italy. Deterioration of CFMPs did not exceed 5.7% surface area reduction during the 12-month experimental period in two sites located in Northern Italy. More deterioration was observed in the Southern site, with 7.2% surface area reduction. Deterioration was significantly increased when fields were amended with industrial compost (up to 9.6%), but not with home compost. Up to 92.9% of the recovered CFMPs were associated with the soil fungus Aspergillus flavus, with 20.1%–71.2% aflatoxin-producing isolates. Application of industrial compost resulted in a significant increase in the percentage of CFMPs associated with A. flavus. This observation provides an argument for government regulation of accumulation of CFMPs and elevation of hazardous fungi levels in agricultural soils that receive industrial compost

Dissipationless Collapse of Spherical Protogalaxies and the Fundamental Plane

Following on from the numerical work of Capelato, de Carvalho & Carlberg (1995, 1997), where dissipationless merger simulations were shown to reproduce the "Fundamental Plane" (FP) of elliptical galaxies, we investigate whether the end products of pure, spherically symmetric, one-component dissipationless {\it collapses} could also reproduce the FP. Past numerical work on collisionless collapses have addressed important issues on the dynamical/structural characteristics of collapsed equilibrium systems. However, the study of collisionless collapse in the context of the nature of the FP has not been satisfactorily addressed yet. Our aim in this paper is to focus our attention on the resulting collapse of simple one-component spherical models with a range of different initial virial coefficients. We find that the characteristic correlations of the models are compatible with virialized, centrally homologous systems. Our results strengthen the idea that merging may be a fundamental ingredient in forming non-homologous objects.Comment: 9 pages, 4 Postscript figures, Astronomy & Astrophysics in press (2002). Abstract placement correcte

Dust enshrouded star-forming activity in Arp 299

We present mid-infrared spectro-imaging (5 - 16 microns) observations of the infrared luminous interacting system Arp 299 (=Mrk171 =IC694+NGC3690) obtained with the ISOCAM instrument aboard ISO. Our observations show that nearly 40% of the total emission at 7 and 15 microns is diffuse, originating from the interacting disks of the galaxies. Moreover, they indicate the presence of large amounts of hot dust in the main infrared sources of the system and large extinctions toward the nuclei. While the observed spectra have an overall similar shape, mainly composed of Unidentified Infrared Bands (UIB) in the short wavelength domain, a strong continuum at ~ 13 microns and a deep silicate absorption band at 10 microns, their differences reveal the varying physical conditions of each component. For each source, the spectral energy distribution (SED) can be reproduced by a linear combination of a UIB "canonical" spectral template and a hot dust continuum due to a 230-300 K black body, after independently applying an extinction correction to both of them. We find that the UIB extinction does not vary much throughout the system (A_V ~ 5 mag) suggesting that most UIBs originate from less enshrouded regions. IC694 appears to dominate the infrared emission of the system and our observations support the interpretation of a deeply embedded nuclear starburst located behind an absorption of about 40 mag. The central region of NGC3690 displays a hard radiation field characterized by a [NeIII]/[NeII] ratio > 1.8. It also hosts a strong continuum from 5 to 16 microns which can be explained as thermal emission from a deeply embedded (A_V ~ 60 mag) compact source, consistent with the mid-infrared signature of an active galactic nucleus (AGN), and in agreement with recent X-ray findings.Comment: to be published in Astronomy and Astrophysics - 12 page

Dust and gas in luminous infrared galaxies - results from SCUBA observations

We present new data taken at 850 $\mu$m with SCUBA at the JCMT for a sample of 19 luminous infrared galaxies. Fourteen galaxies were detected. We have used these data, together with fluxes at 25, 60 and 100 $\mu$m from IRAS, to model the dust emission. We find that the emission from most galaxies can be described by an optically thin, single temperature dust model with an exponent of the dust extinction coefficient ($k_\lambda \propto \lambda^{-\beta}$) of $\beta \simeq 1.5 - 2$. A lower $\beta\simeq 1$ is required to model the dust emission from two of the galaxies, Arp 220 and NGC 4418. We discuss various possibilities for this difference and conclude that the most likely is a high dust opacity. In addition, we compare the molecular gas mass derived from the dust emission, $M_{dust}$, with the molecular gas mass derived from the CO emission, $M_{CO}$, and find that $M_{CO}$ is on average a factor 3 higher than $M_{dust}$.Comment: 10 pages, 6 figures, latex, with MN-macros, accepted by MNRAS - revised version (changed flux values for some galaxies

Evaluating Non-pharmacological Approaches to Nursing Home Dementia Care: A Protocol

BACKGROUND: The COVID-19 pandemic has underscored the daily challenges nursing home (NH) staff face caring for the residents living with Alzheimer\u27s Disease and Related Dementias ( METHODS: This clustered randomized trial will compare CONCLUSION: This trial will be the first-ever evaluation of team- and problem-based approaches to ADRD care across multiple NHs and geographic regions. Results can provide health system leaders and policymakers with evidence on how to optimize ADRD training for staff in an effort to enhance ADRD care delivery

Obscured Activity: AGN, Quasars, Starbursts and ULIGs observed by the Infrared Space Observatory

Some of the most active galaxies in the Universe are obscured by large quantities of dust and emit a substantial fraction of their bolometric luminosity in the infrared. Observations of these infrared luminous galaxies with the Infrared Space Observatory (ISO) have provided a relatively unabsorbed view to the sources fuelling this active emission. The improved sensitivity, spatial resolution and spectroscopic capability of ISO over its predecessor Infrared Astronomical Satellite (IRAS), has enabled significant advances in the understanding of the infrared properties of active galaxies. ISO surveyed a wide range of active galaxies which, in the context of this review, includes those powered by intense bursts of star-formation as well as those containing a dominant active galactic nucleus (AGN). Mid infrared imaging resolved for the first time the dust enshrouded nuclei in many nearby galaxies, while a new era in infrared spectroscopy was opened by probing a wealth of atomic, ionic and molecular lines as well as broad band features in the mid and far infrared. This was particularly useful since it resulted in the understanding of the power production, excitation and fuelling mechanisms in the nuclei of active galaxies including the intriguing but so far elusive ultraluminous infrared galaxies. Detailed studies of various classes of AGN and quasars greatly improved our understanding of the unification scenario. Far-infrared imaging and photometry also revealed the presence of a new very cold dust component in galaxies and furthered our knowledge of the far-infrared properties of faint starbursts, ULIGs and quasars. We summarise almost nine years of key results based upon ISO data spanning the full range of luminosity and type of active galaxies.Comment: Accepted for publication in 'ISO science legacy - a compact review of ISO major achievements', Space Science Reviews - dedicated ISO issue. To be published by Springer in 2005. 62 pages (low resolution figures version). Higher resolution PDFs available from http://users.physics.uoc.gr/~vassilis/papers/VermaA.pdf or http://www.iso.vilspa.esa.es/science/SSR/Verma.pd

Older adults’ preferences for, adherence to and experiences of two self-management falls prevention home exercise programmes: a comparison between a digital programme and a paper booklet

Background: Fall prevention exercise programmes are known to be effective, but access to these programmes is not always possible. The use of eHealth solutions might be a way forward to increase access and reach a wider population. In this feasibility study the aim was to explore the choice of programme, adherence, and self-reported experiences comparing two exercise programmes – a digital programme and a paper booklet. Methods: A participant preference trial of two self-managed fall prevention exercise interventions. Community-dwelling adults aged 70 years and older exercised independently for four months after one introduction meeting. Baseline information was collected at study start, including a short introduction of the exercise programme, a short physical assessment, and completion of questionnaires. During the four months intervention period, participants self-reported their performed exercises in an exercise diary. At a final meeting, questionnaires about their experiences, and post-assessments, were completed. For adherence analyses data from diaries were used and four subgroups for different levels of participation were compared. Exercise maintenance was followed up with a survey 12 months after study start. Results: Sixty-seven participants, with mean age 77 ± 4 years were included, 72% were women. Forty-three percent chose the digital programme. Attrition rate was 17% in the digital programme group and 37% in the paper booklet group (p = .078). In both groups 50–59% reported exercise at least 75% of the intervention period. The only significant difference for adherence was in the subgroup that completed ≥75% of exercise duration, the digital programme users exercised more minutes per week (p = .001). Participants in both groups were content with their programme but digital programme users reported a significantly higher (p = .026) degree of being content, and feeling supported by the programme (p = .044). At 12 months follow-up 67% of participants using the digital programme continued to exercise regularly compared with 35% for the paper booklet (p = .036). Conclusions: Exercise interventions based on either a digital programme or a paper booklet can be used as a self-managed, independent fall prevention programme. There is a similar adherence in both programmes during a 4-month intervention, but the digital programme seems to facilitate long-term maintenance in regular exercise

Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy

Background A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets. Methods Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis. Results A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p < 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p < 0.001). Conclusion We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty

Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions

<p>Abstract</p> <p>Background</p> <p>Cervical cancer is the second most common cancer in women worldwide. NK and cytotoxic T cells play an important role in the elimination of virus-infected and tumor cells through NKG2D activating receptors, which can promote the lysis of target cells by binding to the major histocompatibility complex class I-related chain A (MICA) proteins. Increased serum levels of MICA have been found in patients with epithelial tumors. The aim of this study was to compare the levels of soluble MICA (sMICA) and NKG2D-expressing NK and T cells in blood samples from patients with cervical cancer or precursor lesions with those from healthy donors.</p> <p>Methods</p> <p>Peripheral blood with or without heparin was collected to obtain mononuclear cells or sera, respectively. Serum sMICA levels were measured by ELISA and NKG2D-expressing immune cells were analyzed by flow cytometry. Also, a correlation analysis was performed to associate sMICA levels with either NKG2D expression or with the stage of the lesion.</p> <p>Results</p> <p>Significant amounts of sMICA were detected in sera from nearly all patients. We found a decrease in the number of NKG2D-expressing NK and T cells in both cervical cancer and lesion groups when compared to healthy donors. Pearson analysis showed a negative correlation between sMICA and NKG2D-expressing T cells; however, we did not find a significant correlation when the analysis was applied to sMICA and NKG2D expression on NK cells.</p> <p>Conclusion</p> <p>Our results show for the first time that high sMICA levels are found in sera from patients with both cervical cancer and precursor lesions when compared with healthy donors. We also observed a diminution in the number of NKG2D-expressing NK and T cells in the patient samples; however, a significant negative correlation between sMICA and NKG2D expression was only seen in T cells.</p