Inheriting Bayer's Legacy-Joint Remosaicing and Denoising for Quad Bayer Image Sensor

Pixel binning based Quad sensors have emerged as a promising solution to overcome the hardware limitations of compact cameras in low-light imaging. However, binning results in lower spatial resolution and non-Bayer CFA artifacts. To address these challenges, we propose a dual-head joint remosaicing and denoising network (DJRD), which enables the conversion of noisy Quad Bayer and standard noise-free Bayer pattern without any resolution loss. DJRD includes a newly designed Quad Bayer remosaicing (QB-Re) block, integrated denoising modules based on Swin-transformer and multi-scale wavelet transform. The QB-Re block constructs the convolution kernel based on the CFA pattern to achieve a periodic color distribution in the perceptual field, which is used to extract exact spectral information and reduce color misalignment. The integrated Swin-Transformer and multi-scale wavelet transform capture non-local dependencies, frequency and location information to effectively reduce practical noise. By identifying challenging patches utilizing Moire and zipper detection metrics, we enable our model to concentrate on difficult patches during the post-training phase, which enhances the model's performance in hard cases. Our proposed model outperforms competing models by approximately 3dB, without additional complexity in hardware or software

Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance

Abstract Oesophageal carcinoma is the fourth leading cause of cancer-related death in China, and more than 90% of these tumours are oesophageal squamous cell carcinoma (ESCC). Although several ESCC genomic sequencing studies have identified mutated somatic genes, the number of samples in each study was relatively small, and the molecular basis of ESCC has not been fully elucidated. Here, we performed an integrated analysis of 490 tumours by combining the genomic data from 7 previous ESCC projects. We identified 18 significantly mutated genes (SMGs). PTEN, DCDC1 and CUL3 were first reported as SMGs in ESCC. Notably, the AJUBA mutations and mutational signature4 were significantly correlated with a poorer survival in patients with ESCC. Hierarchical clustering analysis of the copy number alteration (CNA) of cancer gene census (CGC) genes in ESCC patients revealed three subtypes, and subtype3 exhibited more CNAs and marked for worse prognosis compared with subtype2. Moreover, database annotation suggested that two significantly differential CNA genes (PIK3CA and FBXW7) between subtype3 and subtype2 may serve as therapeutic drug targets. This study has extended our knowledge of the genetic basis of ESCC and shed some light into the clinical relevance, which would help improve the therapy and prognosis of ESCC patients

YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner

RNA-binding proteins (RBPs) are critical regulators of transcription and translation that are often dysregulated in cancer. Although RBPs are increasingly recognized as being important for normal hematopoiesis and for hematologic malignancies as oncogenes or tumor suppressors, RBPs that are essential for the maintenance and survival of leukemia remain elusive. Here we show that YBX1 is specifically required for maintaining myeloid leukemia cell survival in an N6-methyladenosine (m6A)-dependent manner. We found that expression of YBX1 is significantly upregulated in myeloid leukemia cells, and deletion of YBX1 dramatically induces apoptosis and promotes differentiation coupled with reduced proliferation and impaired leukemic capacity of primary human and mouse acute myeloid leukemia cells in vitro and in vivo. Loss of YBX1 has no obvious effect on normal hematopoiesis. Mechanistically, YBX1 interacts with insulin-like growth factor 2 messenger RNA (mRNA)-binding proteins (IGF2BPs) and stabilizes m6A-tagged RNA. Moreover, YBX1 deficiency dysregulates the expression of apoptosis-related genes and promotes mRNA decay of MYC and BCL2 in an m6A-dependent manner, which contributes to the defective survival that results from deletion of YBX1. Thus, our findings have uncovered a selective and critical role of YBX1 in maintaining myeloid leukemia survival, which might provide a rationale for the therapeutic targeting of YBX1 in myeloid leukemia

Key parameters of 3PE coating peel strength test

Peel strength is the key performance indicator for 3 PE coating, and the repeatability and reproducibility of peel strength test results will be significantly affected by the difference between different test methods and the preciseness of standards. Considering that the procedures of peel strength test specified in the appendixes of the current national and international product standards are too simple and not stringent enough with the test methods varying greatly, the effects of peeling rate, peeling angle, test temperature, peeling length and result evaluation on the results of peel strength test were studied, the value of the test parameters and the specific operating requirements were defined, and suggestions on peel strength test method and failure mode of 3 PE coating were put forward. Based on this research, Test method for measurement of peel strength of multilayer polyolefin coating systems(NACE TM 21420-2018) and pipeline coating test method-Part 2: Peel strength test(SY/T 4113.2-2018) were formulated

Research on 3PE coating peel strength test for failure modes

The peel strength test is the main method to evaluate the adhesion performance and coating quality of 3-layerpolyethylene (3PE) coating, and the key information concerning coating process control and raw material performance ofpipeline can be obtained by analyzing the peel strength and failure modes of coating peeled. Through the analysis on 40 testresults of 16 typical 3PE samples under different test conditions, 7 types of failure modes of 3PE coating were summarized, and the relationship between various failure modes and the coating process and material performance were analyzed.Futhermore, the effect of test temperature and peeling rate on the failure modes of coating was also studied. The samesample may present different failure modes in different temperature ranges. With the increase of peeling rate, the peelingsection will show increase in roughness and even be torn. Research result provides data support to the judgment on theresults of peel strength test and the improvement of standard indicators of 3PE coating

Transfer-Free Fabrication of Graphene Scaffolds on High‑k Dielectrics from Metal–Organic Oligomers

In situ fabrication of graphene scaffold–ZrO₂ nanofilms is achieved by thermal annealing of Zr-based metal–organic oligomers on SiO₂ substrates. The structural similarities of the aromatic moieties in the ligand (phenyl-, naphthyl-, anthryl-, and pyrenyl-) compared to graphene play a major role in the ordering of the graphene scaffolds obtained. The depth profiling analysis reveals ultrathin carbon-pure or carbon-rich surfaces of the graphene scaffold–ZrO₂ nanofilms. The graphene scaffolds with ∼96.0% transmittance in the visible region and 4.8 nm in thickness can be grown with this non-chemical vapor deposition method. Furthermore, the heterogeneous graphene scaffold–ZrO₂ nanofilms show a low sheet resistance of 17.0 kΩ per square, corresponding to electrical conductivity of 3197 S m^–1. The strategy provides a facile method to fabricate graphene scaffolds directly on high-k dielectrics without transferring process, paving the way for its application in fabricating electronic devices