Productive performance and carcass characteristics of New Zealand white and California rabbits and their crosses

Objective: Evaluate the growth performance and carcass characteristics as well as the individual and maternal heterosis effects of New Zealand White (NZB), California (CA) rabbits and their crosses. Design/methodology/approach: 450 offspring rabbits, from 48 females mated to 6 stud rabbits, were evaluated, recording the weight and litter size at birth (TCN) and at weaning (TCD), and weight (PMS), gain (GMD), consumption (CMS), and feed conversion (CONV) during 8 weeks post-weaning. The carcass live weight at slaughter, warm carcass weight with head, carcass yield and parts of the carcass were evaluated. Results: Showed differences (p <0.05) in TCN and TCD with values of 10.47 and 9.03 kits, respectively. When NZB was used as the paternal breed, obtaining an individual heterosis of 5.91% for litter size and 12.44% for weaning weight. In the productive performance and carcass characteristics, the superiority of California breed as paternal breed was evidenced, with average values of 36.05 g in GMD and 2.95 kg in CONV. The average individual weight at the end of the fattening, at 70 days of age, was 2.09 kg and the weight of the carcass 1.16 kg. Post-weaning heterosis for the characteristics evaluated during fattening were positive and moderate. Limitations on study/implications: It is necessary to carry out genetic improvement studies, with different crossing systems and to evaluate results based on the productive and reproductive behavior. Findings/conclusions: in reproductive characteristics, when using NZB as paternal breed, the offspring are superior to those obtained from CA; while in the productive variables the offspring from CA show superior results.Objective: Evaluate the growth performance and carcass characteristics as well as the individual and maternal heterosis effects of New Zealand White (NZB), California (CA) rabbits and their crosses.Design/methodology/approach: 450 offspring rabbits, from 48 females mated to 6 stud rabbits, were evaluated, recording the weight (PNC) and litter size at birth (TCN) and at weaning (TCD), as well as, and weight (PMS), weight gain (GMD), consumption (CMS), and feed conversion (CONV) for during 8 weeks post-weaning. The carcass live weight at slaughter, warm carcass weight with head, carcass yield, and carcass parts of the carcass were evaluated.Results: Showed differences (p <0.05) in TCN and TCD with values of 10.47 and 9.03 kits, respectively. When NZB was used as the paternal breed, obtaining an individual heterosis of 5.91% for litter size and 12.44% for weaning weight. In the productive performance and carcass characteristics, the superiority of the California breed as a paternal breed was evidenced, with average values of 36.05 g in GMD and 2.95 kg in CONV. The averageindividual weight at the end of the fattening, at 70 days of age, was 2.09 kg and the weight of the carcass 1.16 kg. Post-weaning heterosis for the characteristics evaluated during fattening was were positive and moderate.Limitations on study/implications: It is necessary to carry out genetic improvement studies, with different crossing systems and to evaluate results based on the productive and reproductive behavior.Findings/conclusions: in reproductive characteristics, when using NZB as apaternal breed, the offspring are superior to those obtained from CA; while inthe productive variables, the offspring from CA show superior results

Association of dengue fever with Aedes spp. abundance and climatological effects

Objective. To analyze the association of dengue fever incidence with Aedes mosquito’s abundance, and the effect of climatological and geographical variables, in a region in Morelos State, Mexico. Materials and methods. Weekly data during the period 2010 to 2014 was used. Mosquito abundance was determined using ovitraps. Confirmed dengue cases were obtained from the Epidemiological Surveillance System. Climatic variables were obtained from weather monitoringstations. The correlation between climate variables and ovitraps data was estimated using a multivariate regression model. Results. A correlation of mosquito abundance with dengue fever incidence, and a yearly pattern with seasonal variations were observed. The daily mean temperature, relative humidity and rainfall parameters were associated with mosquito egg abundance. Time lags of three and four weeks between egg counts and dengue fever incidence were observed. Conclusion. Time lags between egg counts and dengue incidence could be useful for prevention and control interventions

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"

Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad “Debates en torno a la NUEVa Agenda Urbana”, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB –Instituto de Investigación de Vivienda y Hábitat y MGyDH-Maestría en Gestión y Desarrollo Habitacional-1), hemos convidado un espacio que se concretó con potencia en un debate transdisciplinario. Convocó a intelectuales de prestigio internacional, investigadores, académicos y gestores estatales, y en una metodología de innovación articuló las voces académicas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes están trabajando en los desafíos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI

Proyecto ReNACE. Convivencia de pacientes y familiares con la enfermedad de Parkinson: resultados preliminares de la Fase I

0.101 SJR (2012) Q4, 111/118 Nursing (miscellaneous)UE

Factors influencing psychosocial adjustment and quality of life in Parkinson patients and informal caregivers

Objective: The influence that social conditions and personal attitudes may have on the quality of life (QoL) of Parkinsons disease (PD) patients and informal caregivers does not receive enough attention in health care, as a result of it not being clearly identified, especially in informal caregivers. The aim of this study was to provide a comprehensive analysis of psychosocial adjustment and QoL determinants in PD patients and informal caregivers. Methods: Ninety-one PD patients and 83 caregivers participated in the study. Multiple regression analyses were performed including benefit finding, coping, disease severity and socio-demographic factors, in order to determine how these aspects influence the psychosocial adjustment and QoL in PD patients and caregivers. Results: Regression models showed that severity of PD was the main predictor of psychosocial adjustment and QoL in patients. Nevertheless, multiple regression analyses also revealed that coping was a significant predictor of psychosocial adjustment in patients and caregivers. Furthermore, psychosocial adjustment was significantly related to QoL in patients and caregivers. Also, coping and benefit finding were predictors of QoL in caregivers but not in patients. Conclusions: Multidisciplinary interventions aimed at improving PD patients QoL may have more effective outcomes if education about coping skills, and how these can help towards a positive psychosocial adjustment to illness, were included, and targeted not only at patients, but also at informal caregivers. © 2016, The Author(s)

Compilación de Proyectos de Investigacion de 1984-2002

Instituto Politecnico Nacional. UPIICS

Compilación de Proyectos de Investigación desde el año 2003 al 2012

Listado de Proyectos de investigación de UPIICSA desde 2003 a 201