TOPAS Internet-Basiertes Stress- und Angstmanagement-Programm für Frauen mit vorzeitigen Wehen

Im Bereich von Frühgeburtsbestrebungen spielen u.a. psychosoziale Faktoren sowie die stressassoziierte Aktivierung der mütterlichen Hypothalamus-Hypophysen-Nebennierenrinden (engl. hypothalamic-pituitary-adrenal, HPA) Achse eine bedeutende Rolle. Spezifische Untersuchungen zu psychotherapeutischen Interventionen, welche das Risiko für eine Frühgeburt bei Frauen mit Frühgeburtsbestrebungen vermindern könnten, sind bisher nur spärlich vorhanden. Das Ziel dieser kumulativen Dissertation ist es, ein internet-basiertes kognitiv-verhaltenstherapeutisches Stressmanagementprogramm (IB-CBSM) bei schwangeren Frauen mit vorzeitigen Wehen zu evaluieren. Neben Fragen zur Durchführbarkeit und subjektiven Akzeptanz bei den Teilnehmerinnen, zielten, die im Rahmen des Projektes durchgeführten Untersuchungen, darauf ab zu prüfen, inwiefern IB-CBSM wirksame Effekte auf den Schwangerschaftsverlauf und auf die mit Stress assoziierten psychologischen und biologischen Parameter zeigt. Als Vergleichsgruppe diente eine Kontrollbedingung, welche spezifische Übungen zur Aufmerksamkeitsdistraktion beinhaltete und die teilnehmenden Frauen im gleichen zeitlichen Umfang beschäftigen sollte, wie die Teilnehmerinnen der Interventionsgruppe. Artikel 1 Internet-based stress management for women with preterm labour—a case-based experience report (Scherer et al., 2014) beschrieb eine Fallstudie der Teilnehmerin L.B. Die Struktur und die Inhalte des Programms wurden anhand des Bearbeitungsprozesses von L.B. detailliert erläutert. Der Artikel hatte zum Ziel, die Machbarkeit und Benutzerfreundlichkeit des IB-CBSM für schwangere Frauen mit vorzeitigen Wehen zu untersuchen. Die positiven Rückmeldungen von L.B. zu den Entspannungsübungen und dem erhöhten Selbstwirksamkeitserleben sowie die motivierte Teilnahme und kontinuierliche Nutzung zeigte die gute Anwendbarkeit der implementierten Programminhalte auf. Der Bearbeitungsverlauf von L.B. wies zudem darauf hin, dass die Programmelemente selbst erklärend aufgebaut waren und die gewählte Programmstruktur eine eigenständige Nutzung ermöglichte. Zusätzlich zeigte sich, dass die Arbeit mit dem IB-CBSM Programm einen positiven Effekt auf die psychische Befindlichkeit der Teilnehmerin hatte. Aufbauend auf den Erkenntnissen zur Machbarkeit und Benutzerfreundlichkeit evaluierte Artikel 2 Patient satisfaction and psychological well-being after internet-based cognitive behavioral stress management (IB-CBSM) for women with preterm labor: A randomized controlled trial (Scherer et al., 2016) die Patientenzufriedenheit und therapeutische Beziehung. Die Resultate zur Zufriedenheit der Teilnehmerinnen zeigten, dass Frauen, welche das IB-CBSM Programm bearbeitet hatten, eine signifikant höhere Zufriedenheit mit der erhaltenen Intervention berichteten, als Frauen in der Kontrollgruppe. Zusätzlich erreichten Teilnehmerinnen des IB-CBSM im Bereich der therapeutischen Beziehung signifikant höhere Werte als Frauen in der Kontrollgruppe. Dies weist darauf hin, dass das IB-CBSM im Vergleich zur Kontrollbedingung die Bedürfnisse der Teilnehmerinnen besser berücksichtigt. Die im IB-CBSM zusätzlich beobachteten Zusammenhänge zwischen einzelnen Subskalen der Therapiebeziehung und der Reduktion der psychischen Belastung im Bereich von Angst und Stress unterstreichen darüber hinaus die Wichtigkeit der Passung zwischen den Bedürfnissen der Teilnehmer/innen und den im Rahmen der Intervention bereitgestellten Programmelementen. Zusätzlich weisen die dokumentierten Zusammenhänge zwischen der therapeutischen Beziehung und der Zufriedenheit darauf hin, dass zufriedenstellende therapeutische Interventionen von der erlebten Qualität der Therapiebeziehung profitieren können. Der Artikel 3 Efficacy of an internet-based cognitive behavioral stress management training in women with idiopathic preterm labor: A randomized controlled intervention study (Urech et al., eingereicht) widmete sich der Prüfung der Wirksamkeit der entwickelten Intervention im Vergleich zur Kontrollgruppen-Bedingung auf der Ebene von Geburtsoutcome, der psychischen Befindlichkeit und des biologischen Stressparameters Cortisol. Der Beitrag bezog die Gesamtstichprobe mit ein, 60 schwangere Frauen mit vorzeitigen Wehen, welche die Studie erfolgreich bearbeitet hatten. Während kein Gruppenunterschied für die berücksichtigten Parameter zum Geburtsoutcome und zum psychischen Befinden nachgewiesen werden konnte, zeigte sich bezüglich der Befindlichkeit eine signifikante Verbesserung zwischen der Prä-/Post-Intervention Erhebung. Die analysierten Cortisolwerte der Cortisol Awakening Response (CAR) blieben über die Messzeitpunkte hinweg stabil und unterschieden sich in beiden Gruppenbedingungen nicht signifikant. Die CAR zum Zeitpunkt nach der Interventionsphase war negativ assoziiert mit der Schwangerschaftsdauer. Die Untersuchungen zeigten, dass das entwickelte IB-CBSM Programm für Frauen mit vorzeitigen Wehen benutzerfreundlich aufgebaut wurde, sowie die Bedürfnisse der Teilnehmerinnen zufriedenstellend berücksichtigt. Die psychische Adaptation der betroffenen Frauen hat sich durch die Bearbeitung des IB-CBSM deutlich verbessert, was für positive Effekte des Interventionsprogramms spricht. Jedoch zeigten auch Frauen der Kontrollbedingung ein verbessertes psychisches Wohlbefinden. Dementsprechend unterstützt die vorliegende Studie die Annahme, dass eine Intervention an sich positive Auswirkungen auf das psychologische Wohlbefinden von schwangeren Frauen hat. Bezüglich des Geburtsoutcome und der Cortisol-Parameter konnten keine signifikanten Effekte beobachtet werden. Schlussfolgernd weisen die vorliegenden Befunde, unter Berücksichtigung der Daten zur Zufriedenheit und Therapiebeziehung, darauf hin, dass insbesondere ein spezifisches IB-CBSM den individuellen Bedürfnissen von Frauen mit vorzeitigen Wehen gerecht wird und somit als Intervention eine gute Passung und Eignung vorweisen kann

An Eclectic Approach to Individualized Reading in the First Grade

Past experience has revealed a definite need to release children, at least partially, from the traditional ability groupings and allow more flexible groupings. The past also revealed that individual children\u27s unique interests and abilities were not being provided for. Since the teaching of reading occupies a central position in the elementary grades, and since children have a wide range of reading abilities and interests, an investigation of individualized reading was prompted

Mobiliário para ambeinte de escola da primeira infância inspirado na abordagem Reggio Emilia

Este trabalho de Conclusão de Curso (TCC) trata do desenvolvimento de um mobiliário para um mini atelier destinado a escolas públicas de educação infantil brasileiras considerando os aspectos da abordagem humanista criada por Loris Malaguzzi, na cidade de Reggio Emilia, na Itália. Por meio de um referencial teórico, normativas, pesquisa com educadoras e análise de produtos similares foram levantadas questões pertinentes ao desenvolvimento pedagógico da criança, suas necessidades, interesses e desafios. A pesquisa tem a contribuição de estudos da área do Design Cenográfico, referente à dinâmica cênica, que emprega elementos produzidos em materiais leves e que se caracterizam por sua multifuncionalidade e mobilidade. As metodologias aplicadas foram o Design Centrado no Humano da IDEO, que tem um olhar direcionado ao entendimento da criança e da abordagem, e o Ecodesign, de Elizabeth Platcheck, que visa o mobiliário, em uma perspectiva mais técnica e sustentável. A partir do projeto conceitual que trouxe como tema a simplicidade da criança foi iniciado o processo de geração de alternativas, seguido de um refinamento para três novas soluções. A alternativa selecionada apresenta a modelagem 3D, o modelo físico e o detalhamento técnico de um mobiliário multifuncional para as práticas preconizadas pela abordagem italiana, com mobilidade para utilização tanto em ambientes internos, como externos da escola infantil.This Course Completion Work (TCC) deals with the development of furniture for a mini atelier for Brazilian public schools of early childhood education, considering aspects of the humanist approach created by Loris Malaguzzi, in the city of Reggio Emilia, Italy. By means of a theoretical framework, regulations, research with an educator and analysis of similar products, questions related to the pedagogical development of children, their needs, interests and challenges were raised. The research has the contribution of studies in the area of Scenographic Design, referring to the scenic dynamics, which uses elements produced in light materials and which are characterized by their multifunctionality and mobility. The methodologies applied were IDEO's Human-Centered Design, which focuses on understanding the child and the approach, and Elizabeth Platcheck's Ecodesign, which focuses on furniture from a more technical and sustainable perspective. From the conceptual project that has as its theme the simplicity of the child, the process of generating alternatives was started, followed by a refinement for three new solutions. The selected alternative presents the 3D modeling, the physical model and the technical detailing of a multifunctional furniture for the practices recommended by the Italian approach, with mobility for use both in internal and external environments of the kindergarten

Metagenome, metatranscriptome, and metaproteome approaches unraveled compositions and functional relationships of microbial communities residing in biogas plants

The production of biogas by anaerobic digestion (AD) of agricultural residues, organic wastes, animal excrements, municipal sludge, and energy crops has a firm place in sustainable energy production and bio-economy strategies. Focusing on the microbial community involved in biomass conversion offers the opportunity to control and engineer the biogas process with the objective to optimize its efficiency. Taxonomic profiling of biogas producing communities by means of high-throughput 16S rRNA gene amplicon sequencing provided high-resolution insights into bacterial and archaeal structures of AD assemblages and their linkages to fed substrates and process parameters. Commonly, the bacterial phyla Firmicutes and Bacteroidetes appeared to dominate biogas communities in varying abundances depending on the apparent process conditions. Regarding the community of methanogenic Archaea, their diversity was mainly affected by the nature and composition of the substrates, availability of nutrients and ammonium/ammonia contents, but not by the temperature. It also appeared that a high proportion of 16S rRNA sequences can only be classified on higher taxonomic ranks indicating that many community members and their participation in AD within functional networks are still unknown. Although cultivation-based approaches to isolate microorganisms from biogas fermentation samples yielded hundreds of novel species and strains, this approach intrinsically is limited to the cultivable fraction of the community. To obtain genome sequence information of non-cultivable biogas community members, metagenome sequencing including assembly and binning strategies was highly valuable. Corresponding research has led to the compilation of hundreds of metagenome-assembled genomes (MAGs) frequently representing novel taxa whose metabolism and lifestyle could be reconstructed based on nucleotide sequence information. In contrast to metagenome analyses revealing the genetic potential of microbial communities, metatranscriptome sequencing provided insights into the metabolically active community. Taking advantage of genome sequence information, transcriptional activities were evaluated considering the microorganism’s genetic background. Metaproteome studies uncovered enzyme profiles expressed by biogas community members. Enzymes involved in cellulose and hemicellulose decomposition and utilization of other complex biopolymers were identified. Future studies on biogas functional microbial networks will increasingly involve integrated multi-omics analyses evaluating metagenome, transcriptome, proteome, and metabolome datasets. © 2018, The Author(s)

FORMAÇÃO CONTINUADA DE PROFESSORES EM AMBIENTE VIRTUAL DE APRENDIZAGEM : POSSIBILIDADES DE AÇÃO E REFLEXÃO PARA A PRÁTICA INCLUSIVA

Este trabalho analisa a contribuição da formação continuada em ambiente virtual no fazer pedagógico do professor da educação básica da rede pública de ensino, no processo de inclusão de aluno com deficiência. Apresenta os resultados da pesquisa Formação Continuada de Professores para a Educação Inclusiva: Desafios de Aprender e Ensinar em Ambientes Virtuais, elaborada no âmbito do Mestrado Profissional em Inclusão Social e Acessibilidade da Universidade Feevale/Novo Hamburgo, defendida em fevereiro de 2012. O ambiente investigado é o Curso de Formação Continuada de Professores em Tecnologias de Informação e Comunicação Acessíveis, desenvolvido pelo Núcleo de Informática na Educação Especial – NIEE/UFRGS/UAB/MEC, durante o primeiro semestre de 2011. A opção metodológica da investigação é de natureza epistemológica qualitativa e, do ponto de vista dos procedimentos técnicos, caracteriza-se como pesquisa-ação com abordagem sócio-histórica, apoiando-se nas ideias de Vygotsky (1896-1934). Foram analisadas as publicações de 18 professores cursistas no ambiente TelEduc. A pesquisa se propôs a apresentar subsídios para uma reflexão acerca da relevância da formação continuada de professor em ambiente virtual, como uma alternativa válida e de qualidade para a efetivação da Política Nacional de Educação Especial na Perspectiva da Educação Inclusiva, bem como para a prática reflexiva da ação docente.Palavras-chave: Educação inclusiva. Tecnologia da informação e comunicação. Formação continuada de professor. Ambiente virtual de aprendizagem

Redes temáticas em fotologs: proposições iniciais para o estudo de caso sobre Síndrome de Down (SD)

A partir do entendimento de que blogs e fotologs podem ser ferramentas de socialização e de inclusão de Pessoas com Necessidades Sociais (PNE), este artigo pretende descrever a netnografia como metodologia para seleção da amostra e obtenção de dados e sua pertinência para o mapeamento de rede de fotologs de pais de crianças com Síndrome de Down (SD). O predomínio absoluto de fotologs nesta rede temática, requer que se examine a relação entre o tema desta rede (SD) e o suporte em que ela se constitui. Para tanto, é necessário investigar o estado da arte sobre fotologs, bem como definições, características e problematizações em torno da SD como subsídios teóricos fundamentais para a definição dos próximos passos da pesquisa

Modeling the cognitive effects of diet discontinuation in adults with phenylketonuria (PKU) using pegvaliase therapy in PAH-deficient mice

Existing phenylalanine hydroxylase (PAH)-deficient mice strains are useful models of untreated or late-treated human phenylketonuria (PKU), as most contemporary therapies can only be initiated after weaning and the pups have already suffered irreversible consequences of chronic hyperphenylalaninemia (HPA) during early brain development. Therefore, we sought to evaluate whether enzyme substitution therapy with pegvaliase initiated near birth and administered repetitively to C57Bl/6-Pahenu2/enu2 mice would prevent HPA-related behavioral and cognitive deficits and form a model for early-treated PKU. The main results of three reported experiments are: 1) lifelong weekly pegvaliase treatment prevented the cognitive deficits associated with HPA in contrast to persisting deficits in mice treated with pegvaliase only as adults. 2) Cognitive deficits reappear in mice treated with weekly pegvaliase from birth but in which pegvaliase is discontinued at 3 months age. 3) Twice weekly pegvaliase injection also prevented cognitive deficits but again cognitive deficits emerged in early-treated animals following discontinuation of pegvaliase treatment during adulthood, particularly in females. In all studies, pegvaliase treatment was associated with complete correction of brain monoamine neurotransmitter content and with improved overall growth of the mice as measured by body weight. Mean total brain weight however remained low in all PAH deficient mice regardless of treatment. Application of enzyme substitution therapy with pegvaliase, initiated near birth and continued into adulthood, to PAH-deficient Pahenu2/enu2 mice models contemporary early-treated human PKU. This model will be useful for exploring the differential pathophysiologic effects of HPA at different developmental stages of the murine brain. Keywords: Behavior; Cognition; Dopamine; Hyperphenylalaninemia; Pegvaliase; Phenylalanine hydroxylase; Phenylketonuria; Serotonin; Tryptophan; Tryptophan hydroxylase; Tyrosine; Tyrosine hydroxylase

Aplicativos para Dispositivos Móveis: novas possibilidades para o desenvolvimento de coleção de moda

O desenvolvimento de coleções ou produtos faz parte das atividades de um estudante de moda, sendo esta prática inerente à sua profissão Tradicionalmente, as práticas relacionadas à criação de moda eram realizadas manualmente, mas com o surgimento de softwares específicos passaram a ser realizadas no computador. Entretanto, destaca-se que o crescente uso de dispositivos móveis como smartphones e tablets impulsionou o uso de aplicativos diversos, que cada vez mais são incorporados à rotina de diferentes sujeitos. Portanto, este estudo propõe uma pesquisa exploratória, com objetivo de identificar aplicativos que possam ser empregados durante algumas etapas do desenvolvimento de coleção, tanto no meio acadêmico quanto profissional. Como resultados são indicados cinco aplicativos voltados para as fases de pesquisa, tema de coleção, cartela de cores e desenho: Paper by Fifty Three, Bamboo Paper, Moodboard, myPantone e Prêt à Template

ARHGEF9 disease: Phenotype clarification and genotype-phenotype correlation.

ObjectiveWe aimed to generate a review and description of the phenotypic and genotypic spectra of ARHGEF9 mutations.MethodsPatients with mutations or chromosomal disruptions affecting ARHGEF9 were identified through our clinics and review of the literature. Detailed medical history and examination findings were obtained via a standardized questionnaire, or if this was not possible by reviewing the published phenotypic features.ResultsA total of 18 patients (including 5 females) were identified. Six had de novo, 5 had maternally inherited mutations, and 7 had chromosomal disruptions. All females had strongly skewed X-inactivation in favor of the abnormal X-chromosome. Symptoms presented in early childhood with delayed motor development alone or in combination with seizures. Intellectual disability was severe in most and moderate in patients with milder mutations. Males with severe intellectual disability had severe, often intractable, epilepsy and exhibited a particular facial dysmorphism. Patients with mutations in exon 9 affecting the protein's PH domain did not develop epilepsy.ConclusionsARHGEF9 encodes a crucial neuronal synaptic protein; loss of function of which results in severe intellectual disability, epilepsy, and a particular facial dysmorphism. Loss of only the protein's PH domain function is associated with the absence of epilepsy

As metodologias ativas no ensino da contabilidade: relato de experiências na sala de aula/ The active methodologies in accounting education: report of experiences in the classroom

O objetivo desse artigo é relatar as experiências de aplicações de metodologias ativas em um curso de ciências contábeis de uma instituição privada de ensino superior. A pesquisa caracteriza-se como descritiva com abordagem qualitativa realizada através de um estudo de caso. As metodologias de ensino utilizadas foram sala de aula invertida e aprendizagem baseada em problema. Os resultados apresentam as perspectivas do docente e dos discentes. Na opinião dos discentes as metodologias  propiciaram um melhor entendimento do conteúdo desenvolvido na sala de aula, aproximando a teoria da prática no mercado de trabalho. Para os docentes a avaliação positiva em termos de aprendizagem e relacionamento interpessoal reforçam que a utilização das metodologias ativas deve ser adotada no Curso de Ciências Contábeis