134 research outputs found
Multiresponse parameter estimation and compartmental analysis of time resolved fluorescence spectra. Application to conformational dynamics of charge-separated species in solution
Neutral H density at the termination shock: a consolidation of recent results
We discuss a consolidation of determinations of the density of neutral
interstellar H at the nose of the termination shock carried out with the use of
various data sets, techniques, and modeling approaches. In particular, we focus
on the determination of this density based on observations of H pickup ions on
Ulysses during its aphelion passage through the ecliptic plane. We discuss in
greater detail a novel method of determination of the density from these
measurements and review the results from its application to actual data. The H
density at TS derived from this analysis is equal to 0.087 \pm 0.022 cm-3, and
when all relevant determinations are taken into account, the consolidated
density is obtained at 0.09 \pm 0.022 cm-3. The density of H in CHISM based on
literature values of filtration factor is then calculated at 0.16 \pm 0.04
cm-3.Comment: Submitted to Space Science Review
Nucleon axial and pseudoscalar form factors from the covariant Faddeev equation
We compute the axial and pseudoscalar form factors of the nucleon in the
Dyson-Schwinger approach. To this end, we solve a covariant three-body Faddeev
equation for the nucleon wave function and determine the matrix elements of the
axialvector and pseudoscalar isotriplet currents. Our only input is a
well-established and phenomenologically successful ansatz for the
nonperturbative quark-gluon interaction. As a consequence of the axial
Ward-Takahashi identity that is respected at the quark level, the
Goldberger-Treiman relation is reproduced for all current-quark masses. We
discuss the timelike pole structure of the quark-antiquark vertices that enters
the nucleon matrix elements and determines the momentum dependence of the form
factors. Our result for the axial charge underestimates the experimental value
by 20-25% which might be a signal of missing pion-cloud contributions. The
axial and pseudoscalar form factors agree with phenomenological and lattice
data in the momentum range above Q^2 ~ 1...2 GeV^2.Comment: 17 pages, 7 figures, 1 tabl
Influence of fast interstellar gas flow on dynamics of dust grains
The orbital evolution of a dust particle under the action of a fast
interstellar gas flow is investigated. The secular time derivatives of
Keplerian orbital elements and the radial, transversal, and normal components
of the gas flow velocity vector at the pericentre of the particle's orbit are
derived. The secular time derivatives of the semi-major axis, eccentricity, and
of the radial, transversal, and normal components of the gas flow velocity
vector at the pericentre of the particle's orbit constitute a system of
equations that determines the evolution of the particle's orbit in space with
respect to the gas flow velocity vector. This system of differential equations
can be easily solved analytically. From the solution of the system we found the
evolution of the Keplerian orbital elements in the special case when the
orbital elements are determined with respect to a plane perpendicular to the
gas flow velocity vector. Transformation of the Keplerian orbital elements
determined for this special case into orbital elements determined with respect
to an arbitrary oriented plane is presented. The orbital elements of the dust
particle change periodically with a constant oscillation period or remain
constant. Planar, perpendicular and stationary solutions are discussed.
The applicability of this solution in the Solar system is also investigated.
We consider icy particles with radii from 1 to 10 micrometers. The presented
solution is valid for these particles in orbits with semi-major axes from 200
to 3000 AU and eccentricities smaller than 0.8, approximately. The oscillation
periods for these orbits range from 10^5 to 2 x 10^6 years, approximately.Comment: 22 pages, 3 figures; Accepted for publication in Celestial Mechanics
and Dynamical Astronom
Epidemiological impact of waning immunization on a vaccinated population
This is an epidemiological SIRV model based study that is de- signed to analyze the impact of vaccination in containing infection spread, in a 4-tiered population compartment comprised of susceptible, infected, recov- ered and vaccinated agents. While many models assume a lifelong protection through vaccination, we focus on the impact of waning immunization due to conversion of vaccinated and recovered agents back to susceptible ones. Two asymptotic states exist, the \disease-free equilibrium" and the \endemic equi- librium" and we express the transitions between these states as function of the vaccination and conversion rates and using the basic reproduction number. We nd that the vaccination of newborns and adults have dierent consequences on controlling an epidemic. Also, a decaying disease protection within the re- covered sub-population is not sucient to trigger an epidemic on the linear level. We perform simulations for a parameter set modelling a disease with waning immunization like pertussis. For a diusively coupled population, a transition to the endemic state can proceed via the propagation of a traveling infection wave, described successfully within a Fisher-Kolmogorov framework
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs) is evident, it is unknown whether the first responding B cells, expressing IgM, display similar characteristics or if cross-reactivity is crucially dependent on somatic hypermutation (SHM). We now studied the reactivity of (germline) AMPA-IgM to further understand the breach of B cell tolerance and to identify if cross-reactivity depends on extensive SHM. Moreover, we investigated whether AMPA-IgM can efficiently recruit immune effector mechanisms. Methods Polyclonal AMPA-IgM were isolated from RA patients and assessed for cross-reactivity towards PTM antigens. AMPA-IgM B cell receptor sequences were obtained by single cell isolation using antigen-specific tetramers. Subsequently, pentameric monoclonal AMPA-IgM, their germline counterparts and monomeric IgG variants were generated. The antibodies were analysed on a panel of PTM antigens and tested for complement activation. Results Pentameric monoclonal and polyclonal AMPA-IgM displayed cross-reactivity to multiple antigens and different PTMs. PTM antigen recognition was still present, although reduced, after reverting the IgM into germline. Valency of AMPA-IgM was crucial for antigen recognition as PTM-reactivity significantly decreased when AMPA-IgM were expressed as IgG. Furthermore, AMPA-IgM was 15- to 30-fold more potent in complement-activation compared to AMPA-IgG. Conclusions We provide first evidence that AMPA-IgM are cross-reactive towards different PTMs, indicating that PTM (cross-)reactivity is not confined to IgG and does not necessarily depend on extensive somatic hypermutation. Moreover, our data indicate that a diverse set of PTM antigens could be involved in the initial tolerance breach in RA and suggest that AMPA-IgM can induce complement-activation and thereby inflammation.Pathophysiology and treatment of rheumatic disease
Pion condensation in a dense neutrino gas
We argue that using an equilibrated gas of neutrinos it is possible to probe
the phase diagram of QCD for finite isospin and small baryon chemical
potentials. We discuss this region of the phase diagram in detail and
demonstrate that for large enough neutrino densities a Bose-Einstein condensate
of positively charged pions arises. Moreover, we show that for nonzero neutrino
density the degeneracy in the lifetimes and masses of the charged pions is
lifted.Comment: 10 pages, 7 figures. Modifications to Section II, IIIc, and I
Sediment routing and basin evolution in Proterozoic to Mesozoic east Gondwana: A case study from southern Australia
Sedimentary rocks along the southern margin of Australia host an important record of the break-up history of east Gondwana, as well as fragments of a deeper geological history, which collectively help inform the geological evolution of a vast and largely underexplored region. New drilling through Cenozoic cover has allowed examination of the Cretaceous rift-related Madura Shelf sequence (Bight Basin), and identification of two new stratigraphic units beneath the shelf; the possibly Proterozoic Shanes Dam Conglomerate and the interpreted Palaeozoic southern Officer Basin unit, the Decoration Sandstone. Recognition of these new units indicates an earlier basinal history than previously known. Lithostratigraphy of the new drillcore has been integrated with that published from onshore and offshore cores to present isopach maps of sedimentary cover on the Madura Shelf. New palynological data demonstrate progression from more localised freshwater-brackish fluvio-lacustrine clastics in the early Cretaceous (Foraminisporis wonthaggiensis â Valanginian to Barremian) to widespread topography-blanketing, fully marine, glauconitic mudrocks in the mid Cretaceous (Endoceratium ludbrookiae â Albian). Geochronology and Hf-isotope geochemistry show detrital zircon populations from the Madura Shelf are comparable to those from the southern Officer Basin, as well as Cenozoic shoreline and palaeovalley sediments in the region. The detrital zircon population from the Shanes Dam Conglomerate is defined by a unimodal ~1400 Ma peak, which correlates with directly underlying crystalline basement of the Madura Province. Peak ages of ~1150 Ma and ~1650 Ma dominate the age spectra of all other samples, indicating a stable sediment reservoir through much of the Phanerozoic, with sediments largely sourced from the Albany-Fraser Orogen and Musgrave Province (directly and via multiple recycling events). The Madura Shelf detrital zircon population differs from published data for the Upper CretaceousCeduna Delta to the east, indicating significant differences in sediment provenance and routing between the Ceduna Sub-basin and central Bight Basin
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (Nâ=â53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
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