123 research outputs found

    Self‐Healing Supramolecular Hydrogels for Tissue Engineering Applications

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    Self‐healing supramolecular hydrogels have emerged as a novel class of biomaterials that combine hydrogels with supramolecular chemistry to develop highly functional biomaterials with advantages including native tissue mimicry, biocompatibility, and injectability. These properties are endowed by the reversibly cross‐linked polymer network of the hydrogel. These hydrogels have great potential for realizing yet to be clinically translated tissue engineering therapies. This review presents methods of self‐healing supramolecular hydrogel formation and their uses in tissue engineering as well as future perspectives.Self‐healing supramolecular hydrogels are a novel class of biomaterials that offer unique advantages in tissue engineering. This review describes important methods of supramolecular hydrogel formation as well as recent advances and emerging applications of these hydrogels in regenerative medicine.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147853/1/mabi201800313_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147853/2/mabi201800313.pd

    Combining Cellulose and Cyclodextrins: Fascinating Designs for Materials and Pharmaceutics

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    Cellulose and cyclodextrins possess unique properties that can be tailored, combined, and used in a considerable number of applications, including textiles, coatings, sensors, and drug delivery systems. Successfully structuring and applying cellulose and cyclodextrins conjugates requires a deep understanding of the relation between structural, and soft matter behavior, materials, energy, and function. This review focuses on the key advances in developing materials based on these conjugates. Relevant aspects regarding structural variations, methods of synthesis, processing and functionalization, and corresponding supramolecular properties are presented. The use of cellulose/cyclodextrin conjugates as intelligent platforms for applications in materials science and pharmaceutical technology is also outlined, focusing on drug delivery, textiles, and sensors

    Parentaler Stress und kindliches Temperament

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    Die negativen Auswirkungen prĂ€nataler mĂŒtterlicher Belastungen fĂŒr den Fetus wurden bereits vielfach untersucht. Allerdings wurden dem Einfluss des Vaters sowie geschlechtsspezifischen Auswirkungen wenig Aufmerksamkeit geschenkt. Diese Studie beschĂ€ftigt sich daher mit den geschlechtsspezifischen Auswirkungen der prĂ€natalen elterlichen Stressbelastung auf das Temperament des Kindes im Alter von drei Monaten und drei Jahren. Die Daten der Untersuchung entstammen dem LĂ€ngsschnittprojekt „Familienentwicklung im Lebenslauf“ (FIL), welches zum Ziel hatte, die Entwicklung von Kindern und deren Familien sowie riskante individuelle und familienbezogene Entwicklungen zu untersuchen. FĂŒr die vorliegende Studie wurden die Daten der ersten drei Erhebungswellen herangezogen (t1: sechster Schwangerschaftsmonat, t2: drei Monate nach der Geburt, t3: drei Jahre nach der Geburt). Dabei konnte gezeigt werden, dass Kinder im Alter von drei Monaten hoch belasteter VĂ€ter unruhigeres Verhalten und negativere Stimmung aufwiesen als Kinder niedrig belasteter VĂ€ter Ebenso wiesen MĂ€dchen geringere RegelmĂ€ĂŸigkeit in ihren biologischen Rhythmen auf als Buben. Im Alter von drei Jahren zeigten sich schließlich geschlechtsabhĂ€ngige Temperamentsunterschiede durch die prĂ€natale mĂŒtterliche Belastung. Buben hoch belasteter MĂŒtter wiesen hĂ€ufiger schĂŒchternes und scheues Verhalten in neuen Situationen und fremden Personen gegenĂŒber als Buben moderat und niedrig belasteter MĂŒtter. Die Ergebnisse verdeutlichen den bedeutsamen Einfluss beider Elternteile in der intrauterinen Entwicklung. Bezogen auf die postnatale Entwicklung sollten VĂ€ter daher schon frĂŒhzeitig in den Schwangerschaftsverlauf integriert werden, um sich mit der Vaterrolle identifizieren zu können. Des Weiteren sollten psychologische Begleitung sowie Entspannungsverfahren fĂŒr schwangere Frauen im Zuge der Geburtsvorbereitung angeboten werden, um die negativen Auswirkungen der prĂ€natalen Stressbelastung fĂŒr den Fetus zu verringern.The effects of maternal prenatal stress on the child have been widely studied. However, little attention has been payed to the influence of the father and to the gender-specific effects of prenatal distress. This study therefore investigates the gender-related effects of prenatal parental stress on the temperament of the child at the age of three months and three years. The longitudinal project "Familienentwicklung im Lebenslauf" (FIL) hereby represents the data basis. This project aimed to investigate the development of children and their families as well as risky individual and family-related developments. For the present study, the data from the first three waves were used (t1: six month of pregnancy, t2: three months, t3: three years). The study showed that children at the age of three months of high-stressed fathers showed more restless behavior and negative mood than children of low-stressed fathers Similarly, girls showed lower regularity in their biological rhythms than boys. At the age of three years gender-specific temperamental characteristics were determined by the influence of prenatal maternal distress. Boys of high-stressed mothers were more likely to show shy behavior in new situations and when meeting strangers than boys of lower stressed mothers. The results highlight the influence of both parents in intrauterine development. Therefore, fathers should be involved as soon as possible in the course of pregnancy to be able to identify with the father role. Furthermore, psychological support and relaxation procedures should be offered for pregnant women to reduce stress in mother and fetus

    Entwicklungskreis eine Amoeba lobosa (Gymnamoeba): Amoeba Gruberi

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    Volume: 108Start Page: 713End Page: 73

    Über thermophile Bakterien aus verschiedenen Speisen und Milch

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