6 research outputs found

    Lubiprostone plus polyethylene glycol electrolyte lavage solution (PEG-ELS) versus PEG-ELS for bowel preparation in chronic constipation: a randomized controlled trial

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    Abstract Colonoscopy is considered the standard procedure for early detection and prevention of colorectal cancer. Adequate bowel cleansing is an important determinant of the efficacy of colonoscopy screening. Currently, there is no standard method of bowel preparation for patients with chronic constipation. The aim was to access the rate of adequate bowel cleansing achieved using split-dose polyethylene glycol electrolyte lavage solution (PEG-ELS) plus lubiprostone in comparison with split-dose PEG-ELS alone. A single-centre, endoscopist-blinded, randomized controlled trial was conducted. Seventy-eight constipated patients aged 18–75 years who were indicated for colonoscopy in the gastroenterology unit of Srinagarind Hospital, Khon Kaen University, between February 2020 and February 2021 were randomly allocated to receive either split-dose PEG-ELS in combination with lubiprostone (N = 39) or split-dose PEG-ELS alone (N = 39) before colonoscopy. Adequate bowel cleansing was defined as an Ottawa bowel preparation score ≤ 7. The rate of adequate bowel cleansing was comparable between the PEG-ELS plus lubiprostone group and the PEG-ELS alone group (50% vs. 52.9%, p value = 0.81) with a relative risk of 1.13 (95% CI = 0.43–2.91). There were no significant differences in adenoma detection rate (41.2% vs. 35.3%, p value = 0.62), adverse events, acceptance, compliance, or patient satisfaction between the 2 groups. No additional benefit to successful bowel preparation was achieved by the combination of lubiprostone and PEG-ELS in chronic constipation patients undergoing colonoscopy

    Additional file 1: Table S1. of A significant cancer burden and high mortality of intrahepatic cholangiocarcinoma in Thailand: a nationwide database study

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    The Nationwide Hospital Admission Data, the National Health Security Office (NHSO), Thailand, showed an average of 1,051,146 patients/year or 1,365,557 admissions/year with diagnosis of gastrointestinal diseases (GI) during 2009–2013. Table S2 Hospitalization patients with diagnosis of ICC based on ICD-221 (N = 72,479 admissions) during the 5-year period. Table S3. Comparison ICC patients who had length of hospital stay (LOS) ≤7 days and those with LOS >7 days. Table S4. The average cost of hospitalization and the in-hospital mortality rate classified by disease; during 2009–2013 from the Nationwide Hospital Admission Data of Thailand. (DOCX 20 kb
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