4 research outputs found
How to look for supersymmetry under the lamppost at the LHC
We apply a model-independent, agnostic approach to the collider phenomenology
of supersymmetry (SUSY), in which all mass parameters are taken as free inputs
at the weak scale. We consider the gauginos, higgsinos, and the first two
generations of sleptons and squarks, and analyze all possible mass hierarchies
among them ( in total) in which the lightest superpartner
is neutral, leading to missing energy. In each case, we identify the full set
of the dominant (i.e. least suppressed by phase space, small mixing angles or
Yukawa couplings) decay chains originating from the lightest colored
superpartner. Our exhaustive search reveals several quite dramatic yet
unexplored multilepton signatures with up to 8 isolated leptons (plus possibly
up to 2 massive gauge or Higgs bosons) in the final state. Such events are
spectacular, background-free for all practical purposes, and may lead to a
discovery of SUSY in the very early stage () of LHC
operations at 7 TeV.Comment: 4 pages, 4 figure
SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans
SelenoDB (http://www.selenodb.org) aims to provide high-quality annotations of selenoprotein genes, proteins and SECIS elements. Selenoproteins are proteins that contain the amino acid selenocysteine (Sec) and the first release of the database included annotations for eight species. Since the release of SelenoDB 1.0 many new animal genomes have been sequenced. The annotations of selenoproteins in new genomes usually contain many errors in major databases. For this reason, we have now fully annotated selenoprotein genes in 58 animal genomes. We provide manually curated annotations for human selenoproteins, whereas we use an automatic annotation pipeline to annotate selenoprotein genes in other animal genomes. In addition, we annotate the homologous genes containing cysteine (Cys) instead of Sec. Finally, we have surveyed genetic variation in the annotated genes in humans. We use exon capture and resequencing approaches to identify single nucleotide polymorphisms in more than 50 human populations around the world. We thus present a detailed view of the genetic divergence of Sec- and Cys-containing genes in animals and their diversity in humans. The addition of these data sets into the second release of the database provides a valuable resource for addressing medical and evolutionary questions in selenium biology
SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans
SelenoDB (http://www.selenodb.org) aims to provide high-quality annotations of selenoprotein genes, proteins and SECIS elements. Selenoproteins are proteins that contain the amino acid selenocysteine (Sec) and the first release of the database included annotations for eight species. Since the release of SelenoDB 1.0 many new animal genomes have been sequenced. The annotations of selenoproteins in new genomes usually contain many errors in major databases. For this reason, we have now fully annotated selenoprotein genes in 58 animal genomes. We provide manually curated annotations for human selenoproteins, whereas we use an automatic annotation pipeline to annotate selenoprotein genes in other animal genomes. In addition, we annotate the homologous genes containing cysteine (Cys) instead of Sec. Finally, we have surveyed genetic variation in the annotated genes in humans. We use exon capture and resequencing approaches to identify single-nucleotide polymorphisms in more than 50 human populations around the world. We thus present a detailed view of the genetic divergence of Sec- and Cys-containing genes in animals and their diversity in humans. The addition of these datasets into the second release of the database provides a valuable resource for addressing medical and evolutionary questions in selenium biology.This work was supported by the Plan Nacional and the Instituto Nacional de BIoinformatica (Spain