Estereotipos de género en universitarios españoles sobre el riesgo psicosocial en la infancia

Recent studies have shown that gender stereotypes are not sensitive to social changes. There is a gap in how gender is treated in college. This study is part of an innovation project to improve teaching quality in university. We aim to analyze the presence of gender stereotypes related to at-risk childhood in a sample of 113 university students. Most students considered that some circumstances, like substance consumption, are more likely in boys. On the contrary, they think that looking after siblings or anxiety are more common in girls. Results show the need to incorporate the gender perspective into universities. The special needs of the at-risk girls require further research and specialized training.Estudios recientes han mostrado que los estereotipos de género no son sensibles a los cambios sociales. Hay un vacío sobre cómo el género es tratado en la educación universitaria. Este estudio se enmarca en un proyecto de innovación para la mejora de la calidad docente en la universidad. Pretendemos analizar la presencia de estereotipos de género relacionados con menores en riesgo en una muestra de 113 universitarios. La mayoría de los estudiantes considera que algunas circunstancias, como el uso de sustancias, son más probables en chicos. Por el contrario, piensan que el tener que cuidar de los hermanos o la ansiedad son más comunes en chicas. Los resultados muestran la necesidad de incorporar la perspectiva de género en las universidades. Las necesidades de las chicas en riesgo requieren más investigación y formación especializada

A Three-Dimensional Dynamic Supramolecular "Sticky Fingers" Organic Framework.

Engineering high-recognition host-guest materials is a burgeoning area in basic and applied research. The challenge of exploring novel porous materials with advanced functionalities prompted us to develop dynamic crystalline structures promoted by soft interactions. The first example of a pure molecular dynamic crystalline framework is demonstrated, which is held together by means of weak "sticky fingers" van der Waals interactions. The presented organic-fullerene-based material exhibits a non-porous dynamic crystalline structure capable of undergoing single-crystal-to-single-crystal reactions. Exposure to hydrazine vapors induces structural and chemical changes that manifest as toposelective hydrogenation of alternating rings on the surface of the [60]fullerene. Control experiments confirm that the same reaction does not occur when performed in solution. Easy-to-detect changes in the macroscopic properties of the sample suggest utility as molecular sensors or energy-storage materials

Ivabradine Induces Cardiac Protection against Myocardial Infarction by Preventing Cyclophilin-A Secretion in Pigs under Coronary Ischemia/Reperfusion.

In response to cardiac ischemia/reperfusion, proteolysis mediated by extracellular matrix metalloproteinase inducer (EMMPRIN) and its secreted ligand cyclophilin-A (CyPA) significantly contributes to cardiac injury and necrosis. Here, we aimed to investigate if, in addition to the effect on the funny current (I(f)), Ivabradine may also play a role against cardiac necrosis by reducing EMMPRIN/CyPA-mediated cardiac inflammation. In a porcine model of cardiac ischemia/reperfusion (IR), we found that administration of 0.3 mg/kg Ivabradine significantly improved cardiac function and reduced cardiac necrosis by day 7 after IR, detecting a significant increase in cardiac CyPA in the necrotic compared to the risk areas, which was inversely correlated with the levels of circulating CyPA detected in plasma samples from the same subjects. In testing whether Ivabradine may regulate the levels of CyPA, no changes in tissue CyPA were found in healthy pigs treated with 0.3 mg/kg Ivabradine, but interestingly, when analyzing the complex EMMPRIN/CyPA, rather high glycosylated EMMPRIN, which is required for EMMPRIN-mediated matrix metalloproteinase (MMP) activation and increased CyPA bonding to low-glycosylated forms of EMMPRIN were detected by day 7 after IR in pigs treated with Ivabradine. To study the mechanism by which Ivabradine may prevent secretion of CyPA, we first found that Ivabradine was time-dependent in inhibiting co-localization of CyPA with the granule exocytosis marker vesicle-associated membrane protein 1 (VAMP1). However, Ivabradine had no effect on mRNA expression nor in the proteasome and lysosome degradation of CyPA. In conclusion, our results point toward CyPA, its ligand EMMPRIN, and the complex CyPA/EMMPRIN as important targets of Ivabradine in cardiac protection against IR.post-print361 K

Transcriptomic analysis reveals sex-specific differences in the expression of Dcl1 and Fis1 genes in the radio-adaptive response of thymocytes to TRP53-mediated apoptosis

BACKGROUND: Radio-Adaptive Response (RAR) is a biological defense mechanism whereby exposure to low dose ionizing radiation (IR) mitigates the detrimental effects of high dose irradiation. RAR has been widely observed in vivo using as endpoint less induction of apoptosis. However, sex differences associated with RAR and variations between males and females on global gene expression influenced by RAR have not been still investigated. In addition, the response to radiation-induced apoptosis is associated with phosphorylation of TRP53 at both the serine 15 (ser-18 in the mouse) and serine 392 (ser-389 in mice) residues, but the role of these two phosphorylated forms in male and female RAR remains to be elucidated. RESULTS: We analyzed the effect of administering priming low dose radiation (0.075 Gy of X-rays) prior to high dose radiation (1.75 Gy of γ-rays) on the level of caspase-3-mediated apoptosis and on global transcriptional expression in thymocytes of male and female mice. Here, we provide the first evidence of a differential sex effect of RAR on the reduction of thymocyte apoptosis with males showing lesser levels of caspase-3-mediated apoptosis than females. Analysis of transcriptomic profiles of 1944 genes involved in apoptosis signaling in radio-adapted thymocytes identified 17 transcripts exhibiting differential expression between both sexes. Among them, Dlc1 and Fis1 are closely related to the apoptosis mediated by the TRP53 protein. Our data demonstrate that overexpression of Dlc1 and Fis1 occur concomitantly with a highest accumulation of phosphoserine-18-TRP53 and caspase-3 in radio-adapted thymocytes of female mice. In an opposite way, both down-modulation of Fis1 and phosphoserine-389-TRP53 accumulation appear to be associated with protection from thymocyte apoptosis mediated by caspase-3 in males. CONCLUSIONS: Transcriptomic analysis performed in this work reveals for the first time sex-specific differences in gene expression influenced by RAR. Our results also suggest a sex-dependent dual role for phosphoserine-18-TRP53 and phosphoserine-389-TRP53 in the regulation of the radio-adaptive response in mouse thymocytes.This work was supported in part by grants from Spanish Nuclear Security Council (CSN-UAM 29072011) to JS, two grants funded by Spanish Ministry of Economy and Competitiveness (SAF 2012-36566; SAF2015-70561-R (MINECO/FEDER, EU)), and one funded by Carlos III Health Institute (CIBERER 3-749/172.03) to JFD.S

Distribution of Methylene Blue after Injection into the Epidural Space of Anaesthetized Pregnant and Non-Pregnant Sheep

The aim of the study was to determine the distribution of different volumes of methylene blue solution injected into the epidural space in anaesthetized pregnant and non-pregnant sheep, to evaluate its cranial distribution and to compare between them. Fifteen pregnant and fifteen non-pregnant sheep were included in the study. Sheep were anaesthetized and received 0.05, 0.1, or 0.2 mL/kg of a lumbosacral epidural solution containing 0.12% methylene blue in 0.9% saline. Thirty minutes after the epidural injection, the ewes were euthanized. The extension of the dye within the epidural space was measured, and the correlation between the volume of the dye injected and the number of stained vertebrae was evaluated. The cranial migration of the dye between pregnant and non-pregnant sheep was also compared. The results show that the volume of methylene blue injected epidurally into pregnant and non-pregnant sheep correlated directly with its cephalic distribution into the epidural space; and a volume of 0.1 mL/kg or 0.2 mL/kg stained up to the first lumbar segment in pregnant and non-pregnant sheep, respectively. Also, the results suggest that the volume of drugs administered into the epidural space of pregnant sheep should be half the volume that would be used in non-pregnant sheep

Spider diversity (Arachnida: Araneae) in two different coffee management systems and surrounding tropical forest during two contrasting seasons in Oaxaca, Mexico

This study focuses on species richness, abundance, diversity, and seasonal variation of spiders in two coffee plantations with different crop management and a portion of tropical forest in two municipalities of La Costa region of Oaxaca, Mexico, using manual collection, foliage beating and pitfall traps. We collected 2,210 spiders belonging to 35 families, 100 genera and 146 species. The inventory includes 51 new species records for Oaxaca. Completeness values for two estimators indicate that the level of representation of inventories range from 68.25% to 78.44%, and the proportion of singletons range from 33.72% to 38.14%. Spider abundance in the rainy season was significantly lower than during the dry season. Spider abundance in the Tropical Forest was significantly lower than Monoculture site with the foliage beating method. Polyculture was the site with the lowest spider abundance with the pitfall traps. Rarefaction curves did not show significant differences in species richness between the sites and seasons. Hutcheson t-test showed that spider diversity was significantly lower in Monoculture than Tropical Forest during the rainy season. This study contributes to the knowledge of the arachnofauna of Mexico and particularly of the state of Oaxaca.Este estudio se enfoca en la riqueza de especies, abundancia, diversidad y variación estacional de las arañas en dos cultivos de café con diferente manejo y una porción de bosque tropical en dos municipios de la región Costa de Oaxaca, México, utilizando la colecta manual, agitación del follaje y trampas de caída. Se recolectaron 2,210 arañas pertenecientes a 35 familias, 100 géneros y 146 especies. El inventario incluye 51 nuevos registros de especies para Oaxaca. Los valores de completitud de dos estimadores indican que el nivel de representación de los inventarios oscila entre el 68.25 % y el 78.44 %, mientras que la proporción de singletons fue de 33.72 % y 38.14 %. La abundancia de arañas en la estación lluviosa fue significativamente menor que durante la estación secas. La abundancia de arañas en el Bosque Tropical fue significativamente menor que en el Monocultivo con el método de agitación de follaje. El Policultivo fue el sitio con menor abundancia de arañas con el método de trampas de caída. Las curvas de rarefacción no mostraron diferencias significativas en la riqueza de especies entre los sitios y estaciones. La prueba t de Hutcheson mostró que la diversidad de arañas fue significativamente menor en el Monocultivo que en el Bosque Tropical durante la estación lluviosa. Este estudio contribuye al conocimiento de la aracnofauna de México y particularmente del estado de Oaxaca

Aproximación al catálogo de las orquídeas de la provincia de Valladolid

Se ha realizado una primera aproximación a la orquidoflora presente en la provincia de Valladolid, que consta por el momento de un total de 23 taxones incluidos en 9 géneros. Se aportan nuevos datos para 19 de los 23 taxones de orquídeas presentes en Valladolid y uno de ellos (Orchis purpurea Huds.) es primera cita provincial; además, 8 de ellos han servido de testigo para la indicación provincial de Flora iberica.A first approach to the list of taxa belonging to Orchidaceae in the Valladolid province has been carried out. This list comprises, at the moment, 23 taxa included in 9 genera. New records for 19 of 23 the taxa are reported and one of this (Orchis purpurea Huds.) have been found in the province for the first time; this study has also contributed to Flora iberica with 8 new provincial references

Prevention of Child Sexual Abuse (CSA) Using Audiovisual Material. Proposal

El presente trabajo sobre la Prevención del Abuso Sexual Infantil es una propuesta de intervención bajo el modelo de salud pública por medio de la utilización de material audiovisual, dicho material es propiedad de Fundación PAS (Prevención del Abuso Sexual), el cual es un material de acceso abierto en la internet y pretende que cualquier persona, padre de familia, profesor, psicólogo o especialista lo pueda utilizar en beneficios de niños y adolescentes puesto que ha sido elaborado por especialistas en la materia y de la misma manera se pretende que otros especialistas y personas en general tengan el material y lo puedan poner en práctica. Cabe mencionar que esta asociación tiene desde el año 2010 trabajando con la prevención del ASI desde diversas vertientes y cubriendo los diferentes posibles involucrados, niñas, niños, adolescentes, mamás, papás, maestros y profesionales del cuidado, que puedan impactar en la prevención, considerando que el material está realizado, como ya se mencionó, por expertos y está probado en la población infantil, se determinó como una ventaja el utilizar los videos que se proporcionan en la página de la asociación. además, se trabajará desde la promoción y prevención de la salud desde la transmisión de información sobre lo que es el ASI y cómo se puede prevenir.The present work on the Prevention of Child Sexual Abuse is a proposal for intervention under the public health model through the use of audiovisual material, said material is property of Fundación PAS (Prevention of Sexual Abuse), which is a material of open access on the internet and intends that any person, parent, teacher, psychologist or specialist can use it for the benefits of children and adolescents since it has been prepared by specialists in the field and in the same way it is intended that other specialists and people in general have the material and can put it into practice. It is worth mentioning that this association has been working with the prevention of CSA since 2010 from various aspects and covering the different possible stakeholders, girls, boys, adolescents, mothers, fathers, teachers and care professionals, who can impact prevention, considering Since the material is made, as already mentioned, by experts and is tested on the child population, it was determined as an advantage to use the videos provided on the association's page. In addition, we will work on health promotion and prevention by transmitting information about what ASI is and how it can be prevented

Maternal and Foetal Cardiovascular Effects of the Anaesthetic Alfaxalone in 2-Hydroxypropyl- β -cyclodextrin in the Pregnant Ewe

The objective of this study was to determine the pharmacodynamics effects of the anaesthetic alfaxalone in 2-hydroxypropyl- β -cyclodextrin in pregnant sheep after the intravenous injection of a 2 mg/kg weight dose. Six pregnant Ripollesa sheep, weighing 47.1 ± 4.4 kg, were used. Twenty-four hours after instrumentation, sheep were anaesthetized with intravenous alfaxalone in cyclodextrin. Time to standing from anaesthesia was 30.0 ± 10.81 min. Foetal heart rate increased significantly during the first 5 min after alfaxalone administration. Significant differences were observed in maternal diastolic arterial blood pressure between minute 10 and minutes 90, 120, 150, 180, 210, and 240. Significant differences were observed for foetal systolic arterial blood pressure between 5 and 30 min after alfaxalone administration. Significant differences in foetal pH were detected during the entire study period, whereas maternal pH returned to baseline values by 60 min after alfaxalone administration. The present study indicated that alfaxalone in 2-hydroxypropyl- β -cyclodextrin administered as an intravenous bolus at 2 mg/kg body weight produced minimal adverse effects and an uneventful recovery from anaesthesia in pregnant sheep and their foetus