Alternative job search strategies in remote rural and peri-urban labour markets: the role of social networks

This paper examines the importance of informal methods (especially social networking) to the job search strategies used by unemployed people. It compares three areas: a small rural town; a larger, more sparsely populated, remote rural area; and a centrally-located, peri-urban labour market. The analysis is based first on survey research undertaken with 490 job seekers across the study areas. Emerging issues were then followed up during a series of twelve focus groups. The survey research showed that job seekers in the rural study areas were significantly more likely to use social networks to look for work. However, those who had experienced repeated or long-term periods out of work, the unskilled and young people were significantly less likely to use such networks. Focus groups confirmed the perceived importance of social networking to the job search process in rural areas, in contrast to the more marginal role such methods appear to play in peri-urban settings. For many rural job seekers, formal job search activities conducted through Jobcentres were seen as largely symbolic, lacking the practical value of social networking. These results suggest that service providers seeking to assist unemployed people in rural areas need to address the problems faced by many disadvantaged job seekers who are currently caught between their lack of social network relations and the absence of local public employment service facilities in more remote communities

Probing sediment burial age, provenance and geomorphic processes in dryland dunes and lake shorelines using portable luminescence data

Luminescence signals from portable optically-stimulated luminescence readers (POSL or port-OSL) can provide expedient insights into sample relative age, and under certain conditions can be simplistically calibrated against existing luminescence chronologies to provide first-order estimates of burial age. This is most straightforward in simple sedimentary systems where samples share a common provenance and geomorphic process history. The spatially extensive southern African dune and palaeolake shoreline luminescence database, for which hundreds of non-light exposed bulk sediments are available, offers a valuable test case to examine the conditions under which POSL-bulk sediment calibration approaches are feasible. To do this we combine measurements of inherent luminescence sensitivity of bulk sediment (BSS) with analysis of sedimentary composition (petrology and presence of calcium carbonate) and texture. We show that BSS, along with POSL IRSL:BSL ratios and petrological data, account for region-to-region variations, whilst internal variability (scatter) within the lake shorelines dataset relates to variations in BSS and sediment texture. At the scale of southern African subcontinent drylands, we see that provenance and geomorphological process history influence sample mineralogical composition and POSL signal characteristic, including BSS

Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease

The effects of respiratory viral infection on the time course of chronic obstructive pulmonary disease (COPD) exacerbation were examined by monitoring changes in systemic inflammatory markers in stable COPD and at exacerbation. Eighty-three patients with COPD (mean [SD] age, 66.6 [7.1] yr, FEV1, 1.06 [0.61] L) recorded daily peak expiratory flow rate and any increases in respiratory symptoms. Nasal samples and blood were taken for respiratory virus detection by culture, polymerase chain reaction, and serology, and plasma fibrinogen and serum interleukin-6 (IL-6) were determined at stable baseline and exacerbation. Sixty-four percent of exacerbations were associated with a cold occurring up to 18 d before exacerbation. Seventy-seven viruses (39 [58.2%] rhinoviruses) were detected in 66 (39.2%) of 168 COPD exacerbations in 53 (64%) patients. Viral exacerbations were associated with frequent exacerbators, colds with increased dyspnea, a higher total symptom count at presentation, a longer median symptom recovery period of 13 d, and a tendency toward higher plasma fibrinogen and serum IL-6 levels. Non-respiratory syncytial virus (RSV) respiratory viruses were detected in 11 (16%), and RSV in 16 (23.5%), of 68 stable COPD patients, with RSV detection associated with higher inflammatory marker levels. Respiratory virus infections are associated with more severe and frequent exacerbations, and may cause chronic infection in COPD. Prevention and early treatment of viral infections may lead to a decreased exacerbation frequency and morbidity associated with COPD

Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature

Background: Premature birth is associated with decreased nephron number and an increased risk for chronic kidney disease (CKD). To inform the development of guidelines for kidney follow up of children born prematurely, we undertook a study of individuals born extremely preterm, with the aim of characterizing the prevalence and predictors of microalbuminuria, elevated blood pressure, and/or abnormal kidney volume in adolescence. Methods: Study participants (n = 42) were born before 28 weeks of gestation and were enrolled at birth in the Extremely Low Gestational Age Newborns (ELGAN) study. When participants were 15 years old, we obtained 2 manual blood pressures, a spot urine microalbumin measurement, and sonographic measurements of kidney length and volume. Results: Of the 42 participants, 60% were male, 52% were Caucasian (18% Hispanic), and 43% were African-American. Their median age was 15 (IQR 15, 15.3) years. In 33.3% of the cohort, blood pressure was elevated (>120/80 mmHg). Microalbuminuria (>30 mg/g) was present in 11.9% of the cohort, and kidney volume below the 10th percentile of normative data was present in 14%. Twenty-one (50%) of the sample had at least one kidney abnormality (microalbuminuria, elevated blood pressures, and/or kidney hypoplasia); these individuals were more likely to have experienced neonatal hypotension [55% vs. 17% among those with no kidney abnormality, p = 0.02]. Conclusions: Half of adolescents in this subset of ELGAN cohort have at least one risk factor of kidney disease (reduced kidney volume, microalbuminuria, and/or elevated blood pressures) at 15 years of age. This study suggests the importance of monitoring kidney outcomes in children after extremely preterm birth, especially those with a history of neonatal hypotension

Genetic relationships within and among Iberian fescues (Festuca L.) based on PCR-amplified markers

The genus Festuca comprises approximately 450 species and is widely distributed around the world. The Iberian Penninsula, with more than 100 taxa colonizing very diverse habitats, is one of its main centers of diversification. This study was conducted to assess molecular genetic variation and genetic relatedness among 91 populations of 31 taxa of Iberian fescues, based on several molecular markers (random amplified polymorphic DNA, amplified fragment length polymorphisms, and trnL sequences). The analyses showed the paraphyletic origin of the broad-leaved (subgenus Festuca, sections Scariosae and Subbulbosae, and subgenus Schedonorus) and the fine-leaved fescues (subgenus Festuca, sections Aulaxyper, Eskia, and Festuca). Schedonorus showed a weak relationship with Lolium rigidum and appeared to be the most recent of the broad-leaved clade. Section Eskia was the most ancient and Festuca the most recent of the fine-leaved clade. Festuca and Aulaxyper were the most related sections, in concordance with their taxonomic affinities. All taxa grouped into their sections, except F. ampla and F. capillifolia (section Festuca), which appeared to be more closely related to Aulaxyper and to a new independent section, respectively. Most populations clustered at the species level, but some subspecies and varieties mixed their populations. This study demonstrated the value in combining different molecular markers to uncover hidden genetic relationships between populations of Festuca

WD 0141−675: a case study on how to follow-up astrometric planet candidates around white dwarfs

This work combines spectroscopic and photometric data of the polluted white dwarf WD 0141−675, which has a now retracted astrometric super-Jupiter candidate, and investigates the most promising ways to confirm Gaia astrometric planetary candidates and obtain follow-up data. Obtaining precise radial velocity measurements for white dwarfs is challenging due to their intrinsic faint magnitudes, lack of spectral absorption lines, and broad spectral features. However, dedicated radial velocity campaigns are capable of confirming close-in giant exoplanets (a few MJup) around polluted white dwarfs, where additional metal lines aid radial velocity measurements. Infrared emission from these giant exoplanets is shown to be detectable with JWST Mid-Infrared Instrument (MIRI) and will provide constraints on the formation of the planet. Using the initial Gaia astrometric solution for WD 0141−675 as a case study, if there were a planet with a 33.65 d period or less with a nearly edge-on orbit, (1) ground-based radial velocity monitoring limits the mass to <15.4 MJup, and (2) space-based infrared photometry shows a lack of infrared excess and in a cloud-free planetary cooling scenario, a substellar companion would have to be <16 MJup and be older than 3.7 Gyr. These results demonstrate how radial velocities and infrared photometry can probe the mass of the objects producing some of the astrometric signals, and rule out parts of the brown dwarf and planet mass parameter space. Therefore, combining astrometric data with spectroscopic and photometric data is crucial to both confirm and characterize astrometric planet candidates around white dwarfs

WD 0141−675: a case study on how to follow-up astrometric planet candidates around white dwarfs

This work combines spectroscopic and photometric data of the polluted white dwarf WD 0141−675, which has a now retracted astrometric super-Jupiter candidate, and investigates the most promising ways to confirm Gaia astrometric planetary candidates and obtain follow-up data. Obtaining precise radial velocity measurements for white dwarfs is challenging due to their intrinsic faint magnitudes, lack of spectral absorption lines, and broad spectral features. However, dedicated radial velocity campaigns are capable of confirming close-in giant exoplanets (a few MJup) around polluted white dwarfs, where additional metal lines aid radial velocity measurements. Infrared emission from these giant exoplanets is shown to be detectable with JWST Mid-Infrared Instrument (MIRI) and will provide constraints on the formation of the planet. Using the initial Gaia astrometric solution for WD 0141−675 as a case study, if there were a planet with a 33.65 d period or less with a nearly edge-on orbit, (1) ground-based radial velocity monitoring limits the mass to <15.4 MJup, and (2) space-based infrared photometry shows a lack of infrared excess and in a cloud-free planetary cooling scenario, a substellar companion would have to be <16 MJup and be older than 3.7 Gyr. These results demonstrate how radial velocities and infrared photometry can probe the mass of the objects producing some of the astrometric signals, and rule out parts of the brown dwarf and planet mass parameter space. Therefore, combining astrometric data with spectroscopic and photometric data is crucial to both confirm and characterize astrometric planet candidates around white dwarfs.https://arxiv.org/abs/2310.05778Published versio

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike antibodies, with an additional 600 of 2,204 (27%) patients generating low levels (<380 AU ml−1). Vaccine failure rates were highest in ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis on immunosuppressive therapy (6/30, 20%) and solid organ transplant recipients (20/81, 25% and 141/458, 31%). SARS-CoV-2-specific T cell responses were detected in 513 of 580 (88%) patients, with lower T cell magnitude or proportion in hemodialysis, allogeneic hematopoietic stem cell transplantation and liver transplant recipients (versus healthy controls). Humoral responses against Omicron (BA.1) were reduced, although cross-reactive T cell responses were sustained in all participants for whom these data were available. BNT162b2 was associated with higher antibody but lower cellular responses compared to ChAdOx1 nCoV-19 vaccination. We report 474 SARS-CoV-2 infection episodes, including 48 individuals with hospitalization or death from COVID-19. Decreased magnitude of both the serological and the T cell response was associated with severe COVID-19. Overall, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach