Physiotherapy informed by Acceptance and Commitment Therapy (PACT):Protocol for a randomised controlled trial of PACT versus usual physiotherapy care for adults with chronic low back pain

INTRODUCTION: Chronic low back pain (CLBP) is a common condition and source of significant suffering, disability and healthcare costs. Current physiotherapy treatment is moderately effective. Combining theory-based psychological methods with physiotherapy could improve outcomes for people with CLBP. The primary aim of this randomised controlled trial (RCT) is to evaluate the efficacy of Physiotherapy informed by Acceptance and Commitment Therapy (PACT) on functioning in patients with CLBP. METHODS AND ANALYSIS: The PACT trial is a two-armed, parallel-group, multicentre RCT to assess the efficacy of PACT in comparison with usual physiotherapy care (UC). 240 patients referred to physiotherapy with CLBP will be recruited from three National Health Service (NHS) hospitals trusts. Inclusion criteria are: age ≥18 years, CLBP ≥12-week duration, scoring ≥3 points on the Roland-Morris Disability Questionnaire (RMDQ) and adequate understanding of spoken and written English to participate. Patients will be randomised to PACT or UC (120 per arm stratified by centre) by an independent randomisation service and followed up at 3 and 12 months post randomisation. The sample size of 240 will provide adequate power to detect a standardised mean difference of 0.40 in the primary outcome (RMDQ; 5% significance, 80% power) assuming attrition of 20%. Analysis will be by intention to treat conducted by the trial statistician, blind to treatment group, following a prespecified analysis plan. Estimates of treatment effect at the follow-up assessments will use an intention-to-treat framework, implemented using a linear mixed-effects model. ETHICS AND DISSEMINATION: This trial has full ethical approval (14/SC/0277). It will be disseminated via peer-reviewed publications and conference presentations. The results will enable clinicians, patients and health service managers to make informed decisions regarding the efficacy of PACT for patients with CLBP. TRIAL REGISTRATION: number ISRCTN95392287; Pre-results

Weight loss and competition weight in Ultimate Fighting Championship (UFC) athletes

Previous research has demonstrated that professional mixed martial arts (MMA) athletes employ a variety of weight manipulation strategies to compete at given weight classes. Although there is much literature demonstrating weight manipulation methods, minimal research exists analyzing how much weight MMA athletes lose prior to the official weigh-in. Moreover, there is minimal research examining how much weight professional MMA athletes gain between the official weigh-in and competition. Therefore, the purpose of the current study was to analyze weight loss/regain in professional MMA athletes. Data collected from 616 professional MMA athletes (31.1 ± 4.0 yrs. ; 177.1 ± 4.7 cm) competing for the Ultimate Fighting Championship (UFC) between 2020 and 2022 were used for the study. The athlete’s weight was obtained 72 h, 48 h, and 24 h prior to the official weigh-in, at the official weigh-in, and prior to competition. Random effects analysis was utilized to compare weight at a variety of time points between different weight classes. All statistics were analyzed, and significance was set at p ≤ 0.05. There is a significant (p ≤ 0.05) difference between weight classes and time points in professional MMA. MMA athletes decrease body weight significantly prior to the official weigh-in. MMA athletes increase body weight significantly between official weigh-in and competition. Based on these data, it appears that MMA athletes average a weight loss of nearly 7 % within 72 h prior to the official weigh-in. The data also suggest that athletes gain nearly 10 % of total weight between the official weigh-in and competition

Automatic estimation of gestational age in ultrasound images based on direct least-squares fitting of ellipse

Measurement of the fetal head biparietal diameter (BPD) and head circumference (HC) is crucial for estimation of fetal age. Due to the noisy nature of ultrasound images and variation in image acquisition and measurement techniques, manual measurements of these parameters are subject to inter- and intraobserver variability. In this study, we present an approach for estimation of gestational age in ultrasound images, based on direct least-squares fitting of an ellipse. The process goes through three steps: image preprocessing, object extraction, and fitting an ellipse to the resultant shape and measuring its parameters. The proposed technique was tested and evaluated on 20 ultrasound images of fetal head. The images had a combination of noise and low contrast. Excellent linear correlation between manual and automatic measurement was obtained, which verifies the reliability of the proposed automatic approach

Cold gas in elliptical galaxies

We explore the evolution of the cold gas (molecular and neutral hydrogen) of elliptical galaxies and merger remnants ordered into a time sequence on the basis of spectroscopic age estimates. We find that the fraction of cold gas in early merger remnants decreases significantly for ~1-2 Gyr, but subsequent evolution toward evolved elliptical systems sees very little change. This trend can be attributed to an initial gas depletion by strong star-formation which subsequently declines to quiescent rates. This explanation is consistent with the merger picture for the formation of elliptical galaxies. We also explore the relation between HI-to-H2 mass ratio and spectroscopic galaxy age, but find no evidence for a statistically significant trend. This suggests little net HI to H2 conversion for the systems in the present sample.Comment: 11 pages, 6 figures, accepted for publication by MNRA

Hedonic Prices of Malawi Burley Tobacco

Abstract Tobacco is notorious for being one of the most difficult commodities to grade. Here, we determine the implicit prices of various tobacco characteristics using a hedonic price model. The factors affecting the price received for burley tobacco include reputation of the producer, month of auction and lot size in addition to most of the twenty-six different variables representing quality characteristics. Many of these factors can be controlled by producers through production, harvesting, and curing practices. The implicit prices should help farmers evaluate whether they should adopt processes to increase quality. In spite of the large number of factors included, only about half of the price variation across lots could be explained. Thus, the difficulty of grading tobacco is confirmed. Since a universally acceptable grading system is unlikely, any attempts to develop an electronic market will likely need to include pictures of the tobacco and may need to measure additional characteristics such as texture and aroma

Laser fresnel distance measuring system and method

A method and system for determining range to a target are provided. A beam of electromagnetic energy is transmitted through an aperture in an opaque screen such that a portion of the beam passes through the aperture to generate a region of diffraction that varies as a function of distance from the aperture. An imaging system is focused on a target plane in the region of diffraction with the generated image being compared to known diffraction patterns. Each known diffraction pattern has a unique value associated therewith that is indicative of a distance from the aperture. A match between the generated image and at least one of the known diffraction patterns is indicative of a distance between the aperture and target plane

Editors' Note

Editors' Note for the Proceedings of the 2021 Annual Meeting on Phonology (AMP 2021), held at York University in October 2021

Principal component analysis of the Spitzer IRS spectra of ultraluminous infrared galaxies

We present the first principal component analysis (PCA) applied to a sample of 119 Spitzer Infrared Spectrograph (IRS) spectra of local ultraluminous infrared galaxies (ULIRGs) at z<0.35. The purpose of this study is to objectively and uniquely characterise the local ULIRG population using all information contained in the observed spectra. We have derived the first three principal components (PCs) from the covariance matrix of our dataset which account for over 90% of the variance. The first PC is characterised by dust temperatures and the geometry of the mix of source and dust. The second PC is a pure star formation component. The third PC represents an anti-correlation between star formation activity and a rising AGN. Using the first three PCs, we are able to accurately reconstruct most of the spectra in our sample. Our work shows that there are several factors that are important in characterising the ULIRG population, dust temperature, geometry, star formation intensity, AGN contribution, etc. We also make comparison between PCA and other diagnostics such as ratio of the 6.2 microns PAH emission feature to the 9.7 micron silicate absorption depth and other observables such as optical spectral type.Comment: 12 pages. MNRAS accepte

Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume

© 2009 Nelson et al; licensee BioMed Central Ltd.Background Pericardial adipose tissue (PAT) has been shown to be an independent predictor of coronary artery disease. To date its assessment has been restricted to the use of surrogate echocardiographic indices such as measurement of epicardial fat thickness over the right ventricular free wall, which have limitations. Cardiovascular magnetic resonance (CMR) offers the potential to non-invasively assess total PAT, however like other imaging modalities, CMR has not yet been validated for this purpose. Thus, we sought to describe a novel technique for assessing total PAT with validation in an ovine model. Methods 11 merino sheep were studied. A standard clinical series of ventricular short axis CMR images (1.5T Siemens Sonata) were obtained during mechanical ventilation breath-holds. Beginning at the mitral annulus, consecutive end-diastolic ventricular images were used to determine the area and volume of epicardial, paracardial and pericardial adipose tissue. In addition adipose thickness was measured at the right ventricular free wall. Following euthanasia, the paracardial adipose tissue was removed from the ventricle and weighed to allow comparison with corresponding CMR measurements. Results There was a strong correlation between CMR-derived paracardial adipose tissue volume and ex vivo paracardial mass (R2 = 0.89, p < 0.001). In contrast, CMR measurements of corresponding RV free wall paracardial adipose thickness did not correlate with ex vivo paracardial mass (R2 = 0.003, p = 0.878). Conclusion In this ovine model, CMR-derived paracardial adipose tissue volume, but not the corresponding and conventional measure of paracardial adipose thickness over the RV free wall, accurately reflected paracardial adipose tissue mass. This study validates for the first time, the use of clinically utilised CMR sequences for the accurate and reproducible assessment of pericardial adiposity. Furthermore this non-invasive modality does not use ionising radiation and therefore is ideally suited for future studies of PAT and its role in cardiovascular risk prediction and disease in clinical practiceAdam J Nelson, Matthew I Worthley, Peter J Psaltis, Angelo Carbone, Benjamin K Dundon, Rae F Duncan, Cynthia Piantadosi, Dennis H Lau, Prashanthan Sanders, Gary A Wittert and Stephen G Worthle

A comprehensive set of simulations of high-velocity collisions between main sequence stars

We report on a very large set of simulations of collisions between two main sequence (MS) stars. These computations were done with the ``Smoothed Particle Hydrodynamics'' method. Realistic stellar structure models for evolved MS stars were used. In order to sample an extended domain of initial parameters space (masses of the stars, relative velocity and impact parameter), more than 15000 simulations were carried out. We considered stellar masses ranging between 0.1 and 75 Msun and relative velocities up to a few thousands km/s. To limit the computational burden, a resolution of 2000-30000 particles per star was used. The primary goal of this study was to build a complete database from which the result of any collision can be interpolated. This allows us to incorporate the effects of stellar collisions with an unprecedented level of realism into dynamical simulations of galactic nuclei and other dense stellar clusters. We make the data describing the initial condition and outcome (mass and energy loss, angle of deflection) of all our simulations freely available on the Internet. We find that the outcome of collisions depends sensitively on the stellar structure and that, in most cases, using polytropic models is inappropriate. Published fitting formulas for the collision outcomes, established from a limited set of collisions, prove of limited use because they do not allow robust extrapolation to other stellar structures or relative velocities.Comment: 45 pages, 44 figures. Modified to reflect the changes in the published version (MNRAS). PDF version with high-res figures at http://obswww.unige.ch/~freitag/papers/article_collisions.pdf, simulation data at http://obswww.unige.ch/~freitag/MODEST_WG4/FB_Collision_Data/, movies at http://obswww.unige.ch/~freitag/collisions/animations/index.htm