67 research outputs found
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Adiponectin plays a key role in the regulation of the whole-body energy homeostasis by modulating glucose and lipid metabolism. Although obesity-induced reduction of adiponectin expression is primarily ascribed to a transcriptional regulation failure, the underlying mechanisms are largely undefined. Here we show that DNA hypermethylation of a particular region of the adiponectin promoter suppresses adiponectin expression through epigenetic control and, in turn, exacerbates metabolic diseases in obesity. Obesity-induced, pro-inflammatory cytokines promote DNMT1 expression and its enzymatic activity. Activated DNMT1 selectively methylates and stimulates compact chromatin structure in the adiponectin promoter, impeding adiponectin expression. Suppressing DNMT1 activity with a DNMT inhibitor resulted in the amelioration of obesity-induced glucose intolerance and insulin resistance in an adiponectin-dependent manner. These findings suggest a critical role of adiponectin gene epigenetic control by DNMT1 in governing energy homeostasis, implying that modulating DNMT1 activity represents a new strategy for the treatment of obesity-related diseases.published_or_final_versio
Spatial heterogeneity of habitat suitability for Rift Valley fever occurrence in Tanzania: an ecological niche modelling approach
- Author
- A Anyamba
- A Anyamba
- A Guisan
- A Hightower
- A Moffett
- AA Adam
- AC Holt
- AE Vorsino
- AJ Anyamba
- AK Conley
- AT Peterson
- AT Peterson
- AT Peterson
- AT Peterson
- AT Peterson
- AT Peterson
- AT Peterson
- BB Hanberry
- BZ Youssef
- C Merow
- C Sindato
- C Sindato
- C Sindato
- Calvin Sindato
- Christopher M. Barker
- CN Mweya
- DA Lapointe
- DC Wheeler
- Dirk U. Pfeiffer
- DL Warren
- DM Hartley
- DS Ellis
- DS Ellis
- EE Osnas
- EM De Clercq
- Esron D. Karimuribo
- FP Amerasinghe
- H Slater
- HH Balkhy
- J Beck
- J Elith
- J Franklin
- Janusz T. Paweska
- JJ Lawler
- JM Meegan
- JP Digoutte
- JP Durand
- JT Paweska
- JT Paweska
- Kim B. Stevens
- KJ Linthicum
- KJ Linthicum
- KP Burnham
- L Brotons
- L Mughini-Gras
- Leonard E. G. Mboera
- LJ Rissler
- M Dhimal
- M Marmion
- M Mohamed
- M Pfeffer
- M Wisz
- MA Kulkarni
- MA Ortega-Huerta
- MF Sallam
- MS Wisz
- P Dambach
- P Munyua
- PA Hernandez
- PM Nguku
- R Daubney
- R Srinivasan
- R Williams
- RD Fyumagwa
- RG Pearson
- RH Miller
- RJ Hijmans
- RM Murithi
- S Brooker
- S Guichard
- SB Neerinckx
- SJ Phillips
- SJ Phillips
- SJ Phillips
- SO Vanwambeke
- T Shoemaker
- TA Joyner
- TA Madani
- TH Lin
- V Chevalier
- V Versteirt
- VM Vieira
- X Yanga
- Y Zhou
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/09/2016
- Field of study
Despite the long history of Rift Valley fever (RVF) in Tanzania, extent of its suitable habitat in the country remains unclear. In this study we investigated potential effects of temperature, precipitation, elevation, soil type, livestock density, rainfall pattern, proximity to wild animals, protected areas and forest on the habitat suitability for RVF occurrence in Tanzania. Presence-only records of 193 RVF outbreak locations from 1930 to 2007 together with potential predictor variables were used to model and map the suitable habitats for RVF occurrence using ecological niche modelling. Ground-truthing of the model outputs was conducted by comparing the levels of RVF virus specific antibodies in cattle, sheep and goats sampled from locations in Tanzania that presented different predicted habitat suitability values. Habitat suitability values for RVF occurrence were higher in the northern and central-eastern regions of Tanzania than the rest of the regions in the country. Soil type and precipitation of the wettest quarter contributed equally to habitat suitability (32.4% each), followed by livestock density (25.9%) and rainfall pattern (9.3%). Ground-truthing of model outputs revealed that the odds of an animal being seropositive for RVFV when sampled from areas predicted to be most suitable for RVF occurrence were twice the odds of an animal sampled from areas least suitable for RVF occurrence (95% CI: 1.43, 2.76, p < 0.001). The regions in the northern and central-eastern Tanzania were more suitable for RVF occurrence than the rest of the regions in the country. The modelled suitable habitat is characterised by impermeable soils, moderate precipitation in the wettest quarter, high livestock density and a bimodal rainfall pattern. The findings of this study should provide guidance for the design of appropriate RVF surveillance, prevention and control strategies which target areas with these characteristics
Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
- Author
- Ababneh H
- Abantanga FA
- Abbas AS
- Abdel-Maboud M
- Abdelhafeez H
- Abdelsalam S
- Abdelwahab M
- Abdessamad E
- Abdul-Mumin A
- Abdulai AB
- Abdulkarim A
- Abdulwahed E
- Abib SDV
- Abodest A
- Abou Chaar MK
- Abu Teir SN
- Abualkher K
- Abukhalaf SA
- AbuZa'nouneh F
- Adam E
- Adegboye MO
- Adekanmbi AF
- Ademola-Popoola DS
- Ademuyiwa AO
- Adeyeye AA
- Adhnon A
- Adly M
- Adwi M
- Afolaranmi OJ
- Ahammed MT
- Ahmad Z
- Ahmed A
- Ahmed A
- Ahmed M
- Ajayi EI
- Aji N
- Ajinkpang S
- Akinoso A
- Akinsete AM
- Akova E
- Akter M
- Akter T
- Al Ayed A
- Al Balushi Z
- Al Bolowi N
- Al Bulushi I
- Al Fayez FN
- Al Hamadani O
- Al Shamsi A
- Al Sharqi A
- Al Sharqi J
- Al Shraideh A
- Al Sibai S
- Al-Agele Y
- Al-Basiti A
- Al-Dabaibeh S
- Al-Furais S
- Al-Rawas AAS
- Alakaloko FM
- Alalawi Y
- Alam MA
- Alameer E
- Alamre A
- Albanna AAM
- Alelayan AF
- Alfa Y
- Alhendy M
- Ali AM
- Ali N
- Ali S
- Alias H
- Aliyu T
- Alkhalil MAA
- Allam AR
- Almasri M
- Almihashhish MMF
- AlMirza A
- Almjersah A
- Almowafy RM
- Alnajjar R
- Alrahawy MMA
- AlShabibi AS
- Alshahri M
- Alshamikh MS
- Altaf S
- Ameh EA
- Amira G
- Amirali A
- Ammouze I
- Anwar A
- Ara Z
- Aremu A
- Arshad M
- Asaduzzaman M
- Ashwinee A
- AsifIqbal M
- Atef M
- Au D
- Axiaq A
- Ayasra F
- Aydogmus E
- Ayman A
- Azab MA
- Azeez SA
- Aziz DAA
- Aziz TT
- Azzam A
- Azzam AY
- Baddourah RM
- Badran YS
- Baertschiger RM
- Bahaa A
- Bahaaeldin M
- Bajaj A
- Bamidele OO
- Bandyopadhyay S
- Banu T
- Barola H
- Bascarevic V
- Basher AKMK
- Bassiony M
- Bdurrzzaq A
- Becktell K
- Belkacem B
- Bell N
- Benaouda H
- Benkhial FS
- Bhatti W
- Bhullar KK
- Biala M
- Bimpong KA
- Bode CO
- Boettcher M
- Bogdanovic I
- Bonna M
- Bonsaana GB
- Bouderbala A
- Bouhuwaish A
- Brachini G
- Brar A
- Brown BJ
- Brown R
- Burzeiza EM
- Buyukkapu S
- Bvulani B
- Bwala KJ
- Byrne MHV
- Cakmak G
- Calvagna V
- Carlesse FADC
- Carrolan E
- Casey A
- Chaoui G
- Charuvila S
- Chaubey D
- Chitnis M
- Christison-Lagay E
- Chylinska A
- Cicerchia P
- Cirillo B
- Coelho SD
- Cooper S
- Cozzi D
- Craig BT
- Crespo MD
- Crow K
- Danfodiyo U
- Daniel S
- Dawud B
- de Carvalho LG
- de Carvalho RV
- de Oliveira EP
- de Souza FKM
- Deeb MA
- Der EM
- Dhiman J
- Diz FL
- Do Bom-Sucesso M
- Dobs M
- Dominic C
- Dreimann M
- Drid B
- Drucker M
- Dukundane A
- Dutta R
- Ebada MA
- Effendi I
- Egbuchulem KI
- Ekwunife OH
- El Chazli Y
- El Kassas M
- El Refaee E
- El-Qurneh O
- Elbahnasawy M
- Eldaly U
- Elebute OA
- Elfiky M
- Elhadi M
- Elhaj NOY
- Elhassan MMA
- Elkaoune Y
- Elmandouh O
- Elmandouh R
- Elshenawy A
- Erhabor J
- Erwee D
- Etchill EW
- Fadel S
- Fahmawee T
- Fan JD
- Fanelli MCA
- Faried M
- Fatungase OM
- Fayngor R
- Fehintola AB
- Ferman SE
- Festus K
- Frosch KH
- Fuseini HY
- Galea N
- Gallardo MTP
- Galli-Tsinopoulou A
- Gallo G
- Gandhi S
- Garrigo MM
- Gawrieh B
- Gentle L
- Ghamgh R
- Ghamry MAM
- Ghandour K
- Ghattaura H
- Ghosh D
- Ghozy S
- Goke O
- Gomes P
- Gounni M
- Govind V
- Govindarajan KK
- Grujicic D
- Guillen G
- Gupta M
- Guzlan A
- Hager EI
- Haider F
- Hajar B
- Hamam O
- Hamdan A
- Hamid HKS
- Hamilton E
- Hamizi K
- Han WSP
- Hanafy E
- Harky A
- Harrison I
- Hasanuzzaman M
- Hassanin M
- Hattor KA
- Hatzipantelis E
- Hemlae H
- Hessissen L
- Heuer A
- Hicdonmez T
- Holail MM
- Hraib M
- Humad H
- Hussain SNF
- Ibelli T
- Ibrahim AB
- Ibrahim KOO
- Ibrahim RB
- Idros R
- Ihediwa GC
- Ikechukwu O
- Ikeda A
- Ilic R
- Imran FA
- Irungu EM
- Islam N
- Islam S
- Ismail RMJ
- Jacobsen AS
- Jain R
- Jaisingh DN
- Jasim D
- Jibrin B
- Jindal B
- Johari N
- John B
- John MJ
- Jones T
- KaderAlsaeiti S
- Kadir MY
- Kakkar S
- Kala S
- Kalra G
- Kamboj S
- Kara Y
- Karagiannidis G
- Karim S
- Karplus G
- Karthigeyan M
- Karunanithi G
- Kayal S
- Kebudi R
- Kendirlioglu BC
- Khan M
- Khan M
- Khan MR
- Khan R
- Khayyam N
- Khernane N
- Khoury V
- Kleinman E
- Kloeber JA
- Kopke L
- Kpiniong MJ
- Kumar V
- Kumar V
- Kumari P
- Kunfah SMP
- Kwarteng PG
- Labib A
- Ladipo-Ajayi O
- Laghari FA
- Laila H
- Lakhoo K
- Lal DR
- Lami M
- Lapolla P
- Latiff ZA
- Lau D
- Lawal TA
- Lazic I
- Leon JLG
- Levinson R
- Lim YY
- Lima FFD
- Lo WB
- Lobo F
- Loh AHP
- Loh CK
- Lopez S
- Lorabi S
- Lukong CS
- Luyt J
- Madan R
- Madasu A
- Madhusudanan S
- Mahal H
- Mahalik SK
- Malika M
- Mamdouh K
- Martin B
- Masoud FM
- Masoud HM
- Massoud JG
- Matei AC
- Mathew J
- Matola B
- Mazloum A
- Mbwele B
- McClafferty K
- Mehmood A
- Melamed D
- Meneghini S
- Meyer J
- Michael V
- Mijalcic R
- Milicevic M
- Mingoli A
- Mitul AR
- Mohindra S
- Molino JA
- Monteiro J
- Monteiro JM
- Morshed AKMA
- Mortada AS
- Moses O
- Moujtahid H
- Moussa A
- Mshelbwala PM
- Mughal A
- Muhammad S
- Muma K
- Muma S
- Munezero D
- Murphy M
- Musa KM
- Musa KO
- Musiu P
- Muthukumar A
- Nabi A
- Nadeem A
- Nadeem K
- Nagras S
- Nah SA
- Nahar K
- Najman T
- Nambi G
- Naredi BK
- Nasef RMM
- Nasir AA
- Nastasovic T
- Nath UK
- Nathani P
- Nauhaus H
- Nautiyal H
- Nay S
- Nazari A
- Nesrine A
- Ng YJ
- Ngongola A
- Nguma I
- Nitschke C
- Nri-Ezedi CA
- Nuhu-Koko A
- Nunes S
- Nwatah VE
- Nweze KD
- O'Sullivan BJ
- Obadaini OO
- Obat M
- Ochieng L
- Offiong U
- Ogundele IO
- Ogundoyin OO
- Ogunsua OO
- Ojha BK
- Okunlola AI
- Olalekan AL
- Olaosebikan R
- Olori S
- Olulana ID
- Omokanye KO
- Omran A
- Oni O
- Osuigwe AN
- Owen RL
- Oyesakin AB
- Ozair A
- Ozdemir GN
- Paasche C
- Pachl M
- Padilha MAC
- Pagaduan AL
- Pancharatnam R
- Parwani D
- Patel A
- Patil NR
- Patil P
- Patrick FA
- Paunovic A
- Peter N
- Peters NJ
- Pillarisetti S
- Piplani R
- Portela L
- Priemel M
- Pulock OS
- Qasem AG
- Qatora M
- Qayyum Z
- Qureshi TI
- Ragab S
- Rahim F
- Rahim N
- Rahman LOA
- Rahman SMR
- Rahmoun R
- Rahul SK
- Raj R
- Rajkumar KS
- Rana AN
- Rana MM
- Raza MR
- Reiter A
- Rhee D
- Robinson D
- Roseline NM
- Roth AS
- Royyuru S
- Ruzgar NM
- Saada B
- Saadeldin AM
- Sakar M
- Saleem A
- Saleem R
- Saleh A
- Salehi M
- Sallam I
- Salloum H
- Salman G
- Salunke P
- Samad L
- Sambandan K
- Samir A
- Sapienza P
- Saracoglu A
- Saracoglu KT
- Sayed F
- Sayomi OT
- Scepanovic V
- Schuelke MR
- Sehrawat A
- Seyi-Olajide JO
- Shabani MM
- Shater W
- Shelft M
- Sherief M
- Sherif A
- Sheth M
- Shikha A
- Shinondo P
- Shirke M
- Sholadoye TT
- Shou B
- Siegel A
- Simpson R
- Singh KK
- Singh S
- Singh V
- Smith C
- Smith T
- Solimam ESA
- Souad B
- Sriram S
- Stangenberg M
- Stanimirovic A
- Suleiman DE
- Sultan I
- Suresh V
- Suroy A
- Taha AO
- Tahir A
- Tahir S
- Taibat IT
- Tawel H
- Tawheed A
- Taylor EH
- Tebha SS
- Temiye EO
- Testi AM
- ThankGod NO
- Thompson N
- Togarepi N
- Tolani MA
- Tragiannidis A
- Tripathi M
- Tsotridou E
- Turk K
- Twaha A
- Ukoha K
- Ullrich S
- Umar AM
- Umar AM
- Umeh EO
- Umuroglu T
- Valetopoulou A
- Vasquez JEM
- Velasco P
- Viezens L
- Vojcek A
- Waleed K
- White O
- Wilson S
- Wong JHL
- Wright K
- Yahia G
- Yahya FS
- Yassaad OM
- Yasser A
- Yhoshu E
- Yip SS
- Yousf AME
- Yusof NM
- Zahid S
- Zaman ASK
- Zambon M
- Zani A
- Zarrish J
- Zekkour MA
- Zerizer Y
- Zia N
- Zubaidi SA
- Zuberi H
- Zuberi HK
- Publication venue
- place:BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
- Publication date
- 01/01/2022
- Field of study
Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
- Babalola O
- Badra R
- Bagraith K
- Baili E
- Balabel M
- Balconi A
- Baldari L
- Baldi C
- Baldini E
- Bali K
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandovas JP
- Bankhead-Kendall Brittany K
- Banky B
- Banuelos Romero E
- Baptista VH
- Barker D
- Barlow Emma
- Barod Ravi
- Barone R
- Baronio G
- Barrat B
- Barros Vieira A
- Bartalucci B
- Bartolini I
- Bashir Y
- Bass G
- Batistotti P
- Batstone Martin
- Baxevanidou K
- Beard David
- Becker R
- Bekele K
- Belia F
- Belkhadir ZH
- Bellacci A
- Belli A
- Bellolio F
- Bellora P
- Belluco C
- Belvedere A
- Bendjemar L
- Benkabbou A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Berselli M
- Bertelli G
- Bertolani E
- Besser N
- Beyer K
- Beyrne C
- Bezerra Santos T
- Bhangu Aneel A
- Bhat GA
- Bhat MA
- Biala M
- Bianchini M
- Bianco F
- Biel Juan Rey
- Bigam D
- Biondi A
- Birolo SL
- Bisagni P
- Blanco-Colino Ruth
- Bodanese B
- Boeker C
- Bondurri A
- Bong C
- Boni L
- Bonilla A
- Bonnet S
- Bordoni P
- Borges Castro F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boutros M
- Bowman S
- Boyce R
- Brachini G
- Bradulskis S
- Braham H
- Brar Amanpreet
- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
- Buarque Igor Lima
- Buarque Lima
- Bucci Fares A
- Buerba GA
- Burgan D
- Burke Joshua
- Butt U
- Bywater Edward
- Caccetta M
- Calabro M
- Camacho C
- Camara P
- Camarneiro R
- Caminsky N
- Campagnaro T
- Canas-Martinez A
- Canonico G
- Capelli P
- Capezzuoli L
- Capolupo GT
- Capunge I
- Caram EL
- Carannante F
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carissimi F
- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
- Chowdri N
- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
- Claro M
- Coccolini F
- Cocozza E
- Coelho Nunes M
- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
- Cordera F
- Corless K
- Corrigan M
- Cosentino Marino L
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
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- Yousri Mohamed
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- Youssef Arkan
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- Yusuf Stephen
- Yuzgec Ayse Nilufer
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- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
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- Abusalem L
- Abuseif M
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- Acharya P
- Ackom E
- Acquah E
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- Adams R
- Adamu A
- Adawi I
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- Adebanjo A
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- Adebola O
- Adedeji A
- Adekoya A
- Adel A
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- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
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- Adenekan B
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- Adeniyi A
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- Adesanya O
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- Adesina A
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- Adesuyi A
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- Adhitama N
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- Afana S
- Afandy A
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- Agalianos C
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- Agbedinu K
- Agius M
- Aglan A
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- Ahlonsou G
- Ahlqvist S
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- Ahmed A
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- Ahounou EYS
- Aigrain Y
- Aiyaman C
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- Akeel N
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- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
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- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
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- Ata AAA
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- Atiyeh A
- Atkins ET
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- Attard M
- Attia A
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- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
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- Baillie K
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- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
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- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
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- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
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- Bekhet AH
- Bekhet NM
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- Bello B
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- Benevento A
- Benevento A
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- Bennai RM
- Benons N
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- Bertuello I
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- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
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- Bjorklund I
- Blacker S
- Blackwell J
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- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
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- Bokhari S
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- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda Luque G
- Borda-Luque G
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
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- Bradulskis S
- Bratu M
- Bratu MR
- Bratu R-M
- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt MT
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- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Cakaloglu HC
- Caliman C
- Callan R
- Camacho R
- Cameron B
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- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
- Canta Calua A
- Capito C
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- Careta MC
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- Carmela Lapitan M
- Carmona JM
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- Carrasco N
- Carreira J-A
- Carreiro De Freitas AV
- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
- Coccolini F
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- Cocorullo G
- Cohen DM
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- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
- Coompson CL
- Corbellini C
- Corbellino M
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- Corro-Diaz S
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- Costa-Maia J
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- Costas-Chavarri A
- Courboin E
- Court E
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- Cragg J
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- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
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- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
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- Darweesh M
- Darwish AKZ
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- Datta U
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- Dayie M
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- De Franciscis S
- De Luca E
- De Marco P
- De Sousa AV
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- Dean R
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- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
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- Edye M
- Eid MM
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- Ekow M
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- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
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- Fairfield C
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- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
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- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
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- Garcia Septiem J
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- Gemeah M
- Gemenetzis G
- Gemenetzis G
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- Germanos S
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- Gerosa A
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- Geuoshy A
- Ghaben A
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- Ghazy AA
- Gheith A
- Ghetia M
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- Ghoneim O
- Giacci L
- Giardino FR
- Giavarini L
- Giglio MC
- Gilbert R
- Gilbert RW
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- Giraldo RSR
- Giuliani S
- Giuliani S
- Giuriato TF
- Gkiokas G
- Glasbey J
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- Glasbey JC
- GlobalSurg Collaborative
- Glover TE
- Glover-Addy H
- Glynn M
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- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzales Montejo MS
- Gonzales Stuva JP
- Gonzalez M
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- Gosling S
- Gosling SG
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- Gouldthorpe C
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- Gray D
- Grech N
- Green N
- Grella MG
- Gribauskaite J
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Elastic band resistance training influences transforming growth factor-ß receptor I mRNA expression in peripheral mononuclear cells of institutionalised older adults: the Vienna Active Ageing Study (VAAS)
- Author
- A Bye
- A Kozomara
- A Pera
- A Pfeiffer
- A Sledzinska
- AM Touvra
- AS Jahromi
- AS Ryan
- B Czarkowska-Paczek
- B Franzke
- B Franzke
- B Halper
- Barbara Schober-Halper
- Barbara Wessner
- Bernhard Franzke
- BP Lewis
- CH Wang
- CJ Jones
- D Finger
- DM Mijnarends
- DS Lim
- E Ceco
- E Esmatjes
- Eva-Maria Strasser
- F Olivieri
- FA Wanderley
- G Gatterer
- G Pawelec
- H Bruunsgaard
- H Guo
- I Agarwal
- I Bautmans
- JE Donnelly
- JP Gumucio
- JP Habashi
- K Perreault
- Karl-Heinz Wagner
- LR Stolzenburg
- M Hofmann
- M Romano
- MA Williams
- Marlene Hofmann
- MD Peterson
- MD Phillips
- MF Folstein
- Michael Quittan
- MO Li
- N Mathur
- N Sallam
- Norbert Bachl
- P Lavoie
- PA Frischmeyer-Guerrerio
- PE Miller
- R Kumarswamy
- RM Liu
- S Griffiths-Jones
- S Oesen
- Stefan Oesen
- TE Brinkley
- Thomas Wolf
- TM Steffen
- TT Peternelj
- U Blank
- UR Mikkelsen
- Y Ando
- Y Bordon
- Y Lin
- Y Mavros
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Al Saied G
- Al Subaie N
- Al-Aarag Aa
- Al-Azraqi Iaa
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi Jj
- Al-Faqawi M
- Al-Farram H
- Al-Hameedi Hii
- Al-Hasani Rkmj
- Al-Khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-Saqqa S
- Al-Saqqa Sw
- Al-Shammari A
- Al-Slaibi I
- Al-Taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alexander P
- Alexander P
- Alexandre C
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- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi Msa
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali Cdm
- Ali E
- Ali Fm
- Ali H
- Ali S
- Ali Sawew
- Ali Ss
- Ali Tha
- Ali W
- Alihonou T
- Alimi Q
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen Jly
- Allen-Ingabire Jc
- Allott R
- Almallah A
- Almanon Cl
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby Mh
- Alnawam E
- Alnuqaydan Sa
- Alnusairat A
- Alomar In
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf Mu
- Alsaggaf Mu
- Alser Oh
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry Am
- Altwijri A
- Alvarez Iiz
- Alvi Ar
- Alwafai Mg
- Aly Ak
- Aly Mym
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzahrani M
- Alzahrani Mna
- Alzayat T
- Aman Nf
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer Ma
- Amin Haa
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar Ms
- Amoah M
- Amoako J
- Amoako Pt
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika Ffa
- Andreotti D
- Andress C
- Andriola V
- Ang Yl
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar Aw
- Anwar N
- Anwer W
- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
- Arachchi Pp
- Arachchige Lajj
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- Arango Mcm
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- Arango Mcm
- Araujo Jslr
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- Arnaud Ap
- Arshad Mm
- Arslan E
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- Arulampalam T
- Aruldas N
- Asaat Ul Razi S
- Asal M
- Asar Yh
- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
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- Asi F
- Asilah Smd
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- Ata Aaa
- Ata Ay
- Atiyeh A
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- Atobatele K
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- Attard M
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- Attia Am
- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
- Aziz Dna
- Aziz Mra
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- Azodo Ia
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- Azzie G
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- Badr Mfm
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- Badwi Nm
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- Baillie K
- Baillie K
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- Bakhaidar M
- Baki Be
- Bakr A
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- Baky Fahmy MA
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- Balila Rmh
- Balkan Aza
- Ballouhey Q
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- Balmaceda R
- Balmaceda R
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- Bamford R
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- Bamicha A
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- Bandoh D
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- Barendegere V
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- Barmayehvar B
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- Barreda Lma
- Barrientos Lam
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- Barrios E
- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
- Bassit Ka
- Basso Sm
- Basson S
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- Batt J
- Bautista Acm
- Bautista Acm
- Bayram S
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- Beaton C
- Bedada Ag
- Bediako-Bowan A
- Behar N
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- Beisa V
- Bekhet Ah
- Bekhet Nm
- Beleñ
- Belkouchi A
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- Bello B
- Benammi S
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- Benevento A
- Benger M
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- Benyaiche C
- Bermú
- Bernardo Cg
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- Bertuello I
- Beuran M
- Beuran M
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- Bezzina M
- Bhangu A
- Bhangu A
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- Bhangu A
- Bhargava A
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- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal Kf
- Bhopal Kf
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- Billy M
- Birindelli A
- Birring A
- Bisset C
- Bjö
- Bjö
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksø
- Blower E
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- Boakye-Yiadom K
- Boal M
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- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
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- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda-Luque G
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- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botero Jam
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- Botto N
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- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
- Boyce T
- Bré
- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu Mr
- Bratu Rm
- Braungart S
- Bravo Jac
- Bray Ld
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat Sd
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
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- Brunoni B
- Bsisu I
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- Bugaev N
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- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
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- Bustangi N
- Butt Mt
- Cabrera Ccrr
- Cacurri A
- Cadogan Dd
- Cahill R
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- Camacho R
- Cameron B
- Camilleri Gm
- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan Jf
- Campagnaro T
- Canto Md
- Capito C
- Capleton P
- Carabott K
- Cardozo Jt
- Cardozo Ram
- Careta Mc
- Carlucci M
- Carmona Jm
- Carneros Vj
- Carpio J
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- Carreira Ja
- Cassar K
- Castillo Vdp
- Castro Mr
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
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- Cengiz Y
- Cengiz Y
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- Chachulski W
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- Chai Fy
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan Tk
- Chan Xw
- Chan Z
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- Chang Ky
- Chapman A
- Chapman Sj
- Charles A
- Cheah Aez
- Chen Cy
- Chen Jhc
- Chen Ky
- Chen Tl
- Chenn R
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- Chetta N
- Cheung Yhe
- Chew Ls
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
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- Chin Yr
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- Chiong Jac
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- Chiu S
- Chiu Smy
- Choi J
- Choi P
- Chong Bfhk
- Chong Cl
- Chong Cl
- Chong Cl
- Chong Cs
- Chong Hy
- Chong Hy
- Choudhry A
- Chow Cyn
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- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung Kj
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark Dj
- Clark T
- Clegg-Lampety Jn
- Clegg-Lamptey Jn
- Clement Kd
- Clements Jm
- Clerico G
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- Coccolini F
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- Cohen F
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- Coletti M
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- Confalonieri G
- Conlon Kc
- Connor K
- Connor K
- Contreras E
- Contreras-Vergara Al
- Coomber R
- Coompson Cl
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Correa Jc
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
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- Cross K
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- Cruz H
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- Currow C
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- Dé
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- Da Silva LA
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- Dablouk Mo
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- Dahy A
- Dainius E
- Dakubo J
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
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- Darweesh M
- Darwish Ak
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
- Davies R
- Davor A
- Dawnay G
- Dawood K
- Dawoud H
- Dayie M
- De Boni D
- De Bono P
- De Bono P
- De Castro Segundo LCB
- De Franciscis S
- De Freitas AVC
- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
- de Lima CVB
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
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- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
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- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
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- Doughty J
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- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
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- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy Mm
- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
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- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
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- Elhamouly S
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- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
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- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
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- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
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- Gü
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- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
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- Gemeah M
- Gemenetzis G
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- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
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- Ghetia M
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- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
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- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
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- Younis A
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- Youssef H
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- Zachariades Dc
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- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Solvent-Free Melting Techniques for the Preparation of Lipid-Based Solid Oral Formulations
- Author
- A Abd-Elbary
- A Bogomolov
- A Christiansen
- A Edimo
- A Faham
- A Karataş
- A Maschke
- A Michalk
- A Padsalgi
- A Patel
- A Patil
- A Pauli-Bruns
- A San Vicente
- A Seo
- A Seo
- A Szuts
- A Thomas
- A Vervaeck
- AA Obaidat
- AA Zaky
- AB Dennis
- AB Fonseca Antunes Da
- AC Vial-Bernasconi
- AG Balducci
- Andreas Zimmer
- AR Paradkar
- AS Achanta
- AS Sallam
- AT Patil
- AT Serajuddin
- B Albertini
- B Campisi
- B Chauhan
- B Ganesh
- BS Bhoop
- BS Ghotra
- BS Sudha
- BY Hong
- C Brabander De
- C Cavallari
- C Freitas
- C Gendre
- C Himawan
- C Long
- C Montousse
- C Olbrich
- C Reitz
- C Reitz
- C Reitz
- C Reitz
- C Vervaet
- CJ Porter
- D Chapman
- D Charro
- D Juarez-Soberanez
- D Shukla
- D Shukla
- D Voinovich
- D Voinovich
- D Voinovich
- D Xia
- D Yang
- DA Bhagwat
- DE Zecevic
- DJ Hauss
- DM Jones
- DM Koller
- DM Sakarkar
- DM Sakarkar
- E Mehuys
- E Mehuys
- E Mehuys
- E Monteagudo
- E Roblegg
- EN Griffin
- ES Ghali
- ES Lutton
- F Damian
- F Kreye
- F Kreye
- FQ Li
- G Abdelbary
- G Kulah
- G Oliveira
- G Sax
- G Sax
- G Walker
- GM Walker
- H Abdelkader
- H Chen
- H Eliasen
- H Eliasen
- H Ljusberg-Wahren
- H Mayama
- H Sato
- H Sohi
- H Suzuki
- H Suzuki
- H Wikstrom
- HF Giles
- HJ Prado
- HJ Robson
- I Aleksić
- I Bauman
- I Ilic
- I Masic
- I Mašić
- J Aronhime
- J Breitenbach
- J Breitkreutz
- J Hamdani
- J Hamdani
- J Hamdani
- J Holstborg
- J Kowalski
- J Krause
- J Liu
- J Priyanka
- J Rantanen
- J Siepmann
- J Vaassen
- J Wahlich
- J Walsh
- J-H Oh
- JB Brubach
- JB Cannon
- JB Schwartz
- JC Bakala N’Goma
- JK Patel
- JM Keen
- JM Keen
- JP Kennedy
- JP Kennedy
- JS Aronhime
- JW Kim
- JØ Christensen
- K Chansanroj
- K Chansanroj
- K Dewettinck
- K Kavitha
- K Mohsin
- K Sachs-Barrable
- K Sato
- K Sato
- K Shiino
- K Shiino
- K Vithani
- Karin Becker
- KJ Wadher
- KJ Wadher
- KM Wasan
- KW Smith
- L Pham
- L Rodriguez
- LC Li
- LJ Thomsen
- LJ Thomsen
- LW Chan
- M Cerdeira
- M Emås
- M Grassi
- M Grassi
- M Grove
- M Haupt
- M Ingelman-Sundberg
- M Kidokoro
- M Lu
- M Maheshwari
- M Molke
- M Nargis
- M Omar
- M Rao
- M Savolainen
- M Srivastav
- M Windbergs
- M Windbergs
- M Windbergs
- M Windbergs
- M Windbergs
- M Wirges
- M Özyazıcı
- MA Massik El
- MA Repka
- MA Repka
- MA Repka
- MEB Rao
- MH Shah
- MJ Jozwiakowski
- MJ Lee
- MJ Maltesen
- MK Kumar
- ML Herrera
- MM Crowley
- MMS Choi
- MRP Rao
- MS Soliman
- MU Uhumwangho
- MU Uhumwangho
- N Ahuja
- N Garti
- N Garti
- N Khan
- N Khan
- N Parmar
- N Passerini
- N Passerini
- N Passerini
- N Passerini
- N Sinchaipanid
- N Yuksel
- NH Zangenberg
- P Barthelemy
- P Bukovec
- P Holm
- P Lang
- P Pivette
- P Pivette
- P Pivette
- P Upadhyay
- PA Tuerck
- PC Wu
- PD Halle
- PJ Weiss
- PK Okuro
- PK Siripuram
- PL Chandrikapure
- PMM Schrooyen
- PP Amrutkar
- PV Parab
- PWS Heng
- R Bodmeier
- R Chokshi
- R Dubey
- R Kamble
- R Kraciuk
- R Thies
- R Thies
- R Thies
- R Witzleb
- R Witzleb
- RH Müller
- RK Deore
- RM Martins
- S Adnan
- S Biswal
- S Bose
- S Cheboyina
- S Cheboyina
- S Cheboyina
- S Deepak
- S El-Shanawany
- S Galal
- S Gittings
- S Gouin
- S Hülsmann
- S Jatwani
- S Kukec
- S Kukec
- S Kukec
- S Madan
- S Qi
- S Qi
- S Schulze
- S Shimpi
- S Srivastava
- SA Barker
- SA Chime
- SG Sudke
- SG Sudke
- SG Sudke
- SG Sudke
- SG Sudke
- SG Sudke
- SH Shah
- Sharareh Salar-Behzadi
- SK Dordunoo
- SL Shimpi
- SM Abd El-Halim
- SM Iveson
- SM Khoo
- SR Vippagunta
- T Maejima
- T Maejima
- T Malkin
- T Pongjanyakul
- T Quinten
- T Schaefer
- T Schæfer
- T Vilhelmsen
- T Yajima
- T Yajima
- U Quintavalle
- V Jannin
- V Jannin
- V Jannin
- V Kroselj
- VP Chavda
- W El-Refaie
- W Fang
- W Sutananta
- W Sutananta
- WC Griffin
- WC Griffin
- World Health Organization
- X Yan
- Y Akiyama
- Y Akiyama
- Y Kato
- Y Miyagawa
- Y Nitanai
- Y Rosiaux
- YE Zhang
- YE Zhang
- YW Choy
- Z Knezevic
- Z Ustunol
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mitochondrial pathway of apoptosis and related proteins in placenta of pregnant Egyptian women with pre-eclampsia
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 11/05/2010
- Field of study
Apoptosis within the placenta is increased in pregnancies complicated by pre-eclampsia (PE).This study aimed at evaluating the mitochondrial pathway of apoptosis in placenta of pregnant women with pre-eclampsia and correlate it with severity and pregnancy outcome . Apoptosis was assessed by measuring DNA fragmentation%,Bcl-2, p53 and caspase-9 in placental tissues from 25 pregnancies complicated by pre-eclampsia, and 25 placentas of normal pregnancy (NP). DNA fragmentation, p53 and caspase-9, were significantly increased while, Bcl-2 was significantly decreased in the placenta of pre-eclampsia group compared to control. No significant difference between mild and severe pre-eclampsia subgroupsregarding these parameters could be found. DNA fragmentation was negatively correlated with Bcl-2 in PE group. Moreover, DNA fragmentation was negatively correlated with maternal age in both PE and control groups. A significant positive correlation between placental DNA fragmentation and gestational age in the NP group was observed. A significant negative correlation between caspase-9 activity, and fetal weight in PE group was found. It can be concluded that Hypoxia and ischemia induced by pre-eclampsia, up regulate p53 and reduce Bcl-2 expression with activation of caspase-9 and increasing DNA fragmentation in placental tissue. These results implicate the mitochondrial pathway in enhancing apoptosis in preeclamptic placenta and affecting fetal outcome but not the severity.Keywords : Apoptosis, p53, Bcl-2, Caspase-9, Mitochondria,Pre-eclampsia
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