6 research outputs found
Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis
- Author
- A. Sugawara
- Aiyar
- Alchi
- Basile
- Border
- Buhlmann
- Chang
- Chini
- Dobrzynski
- Eddy
- Eto
- Fraser
- Gonzalez-Cuadrado
- H. Yokoi
- Haneda
- Hirata
- I. Tanaka
- Iwasaki
- K. Mori
- K. Nakao
- K. Sawai
- Kanegae
- Kasahara
- Kawai
- Kitamura
- Klahr
- Kohno
- Kuwasako
- Luodonpaa
- M. Kasahara
- M. Koshikawa
- M. Mukoyama
- Maruyama
- Masaki
- McLatchie
- Michibata
- Miyake
- Miyashita
- Moriyama
- Mukoyama
- Nagae
- Nath
- Nishikimi
- Niu
- Niwa
- Parameswaran
- Parameswaran
- Plank
- Sakata
- Shimekake
- Shimosawa
- Strutz
- T. Kuwabara
- T. Kuwahara
- T. Nagae
- T. Suganami
- T. Yoshioka
- Tomoda
- Tsuruda
- Wiggins
- Withers
- Y. Ogawa
- Y. Saito
- Yokoi
- Yokoi
- Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
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- Abdelrazik M.
- Abdullah T.
- Abe R.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Biological Monitoring of Exposure to Inorganic Lead in Pregnant Women of Meerut City (Uttar Pradesh), India
- Author
- Amitai Y Katz D, Lifshitz M, Gofin R, Tepferberg M, Almog S.
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- De Bruin A.
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- Zielhuis RL.
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- Publication venue
- 'Informatics Publishing Limited'
- Publication date
- Field of study
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- S. L. Gaff in and S. Watanabe J
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- Y Ohta
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- YA Sharonov
- YA Sharonov
- YA Sharonov
- YE Erokhin
- YJ Kang
- YK Turakulov
- YK Turakulov
- YK Yip
- YP Lin
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- YP Meyer
- YP Meyer
- YP Myer
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- YS Choong
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- YYH Chao
- Z Bradic
- Z Gasyna
- Z Vogel
- Z Zak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
- Abraheem A
- Abu Alragheb BO
- Abulail JA
- Acklery A
- Acosta-Herrera M
- Adachi T
- Adachi Y
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agravante K
- Agrawal A
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar SEV
- Aguilar-Salinas CA
- Aguilera-Albesa S
- Agüero D
- Ahmad HF
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Ahram M
- Ai M
- Ain Q
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Ani A
- Al-Ja’afreh MM
- Al-Kadash A
- Al-Kasasbeh MM
- Al-Moasseb H
- Al-Muftah W
- Al-Sarraj Y
- Alamer LM
- Alasdair F
- Alawneh FM
- Alawneh LM
- Albaiceta GM
- Albano G
- Albillos A
- Albrecht W
- Aldridge J
- Alexander P
- Alfonso J
- Alhousani TN
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Aliberti S
- ALjalamdeh M
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allen U
- Allibone S
- Allison KS
- Allouzy SK
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almoguera B
- Alpuche-Aranda C
- AlRawashdeh TJ
- Alsafadi DB
- Alshaer W
- Alsoub FS
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alzuraiqi MR
- Amamio M
- Aman NF
- Amin V
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- Andreou P
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- Andrew A
- Andrew B
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- Andrews SJ
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- Antoine P
- Antony S
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- Anzai T
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- Arai D
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- Auld D
- Auld F
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- Baird Y
- Baker M
- Bakthavatsalam D
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- Verdugo RA
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- Verlander M
- Vertue M
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- Yermakovich D
- Yeung RSM
- Yi X
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- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
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- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
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- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
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- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
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- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
- Archer K
- Arciero E
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armstrong J
- Armstrong JA
- Armstrong L
- Armstrong R
- Arning N
- Arnold S
- Arora J
- Artuso R
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ascolillo S
- Ashish A
- Ashley E
- Ashraf S
- Ashraf S
- Ashton L
- Ashworth M
- Asiimwe IG
- Aslibekyan S
- Asselta R
- Atanasovska B
- Atkinson D
- Atkinson EG
- Attwood B
- Aucella F
- Augustin M
- Auld D
- Auld F
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- Austin P
- Auton A
- Auton A
- Avendano-Ortiz J
- Awano N
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- Aziz F
- Azuma M
- Azuure C
- Azzolini E
- Baba R
- Baba T
- Bach B
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- Badalamenti S
- Badia JR
- Badji RM
- Bahmer T
- Baikady RR
- Baillie JK
- Baillie JK
- Baillie JK
- Baillie JK
- Baines B
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- Bakthavatsalam D
- Balaconis MK
- Baldassarri M
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- Bandla N
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- Baptista D
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- Barbieri C
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- Barda B
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- Beckmann ND
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- Belbin GM
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- Below JE
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- Bergomi P
- Berkowitz N
- Bernardo D
- Bernasconi A
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- Berridge J
- Bertrand A
- Best N
- Bettini LR
- Beudel M
- Bevan E
- Bewley J
- Bhardwaj N
- Bhatia N
- Bhatterjee R
- Bhuie P
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- Bianco C
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- Biondi A
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- Bird S
- Birkinshaw I
- Birney E
- Birt M
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- Black E
- Black K
- Blackledge B
- Blackledge B
- Blackman H
- Blakemore H
- Blanco-Grau A
- Blasi F
- Blay N
- Blay N
- Blow S
- Blunt M
- Boada M
- Board S
- Bocciardi R
- Bocciolone M
- Bochud M
- Bochud P-Y
- Bochud PY
- Bochud PY
- Bochud PY
- Bociek A
- Boer C
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- Bogaard HJ
- Bogaert D
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- Bokhari M
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- Bolze A
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- Bonta PI
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- Borra C
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- Bosari S
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- Bosse Y
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- Botta G
- Botta M
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- Boujemla B
- Bouras K
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- Bouysran Y
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- Bradshaw Z
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- Branney D
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- Brealey D
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- Brennan B
- Brenner B
- Brenner T
- Bretherick AD
- Brett M
- Brett S
- Brickell K
- Bridgett V
- Brimfield L
- Brinkworth E
- Briton K
- Brittain-Long R
- Britvan B
- Bromley M
- Brooke H
- Brooks S
- Brouwer MC
- Brown A
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- Brown E
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- Bruce M
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- Brunton M
- Brusco A
- Bruttini M
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- Buckley C
- Buckley S
- Bugiani M
- Bujanda L
- Bulik CM
- Bulle E
- Bullock K
- Bulteel N
- Bunni L
- Burda D
- Burden T
- Burn I
- Burnett C
- Burns K
- Burt K
- Burtenshaw A
- Burtenshaw A
- Burton M
- Busani S
- Busson A
- Bussotti M
- Bustamante C
- Butcher D
- Buti M
- Butler A
- Butler S
- Butler-Laporte G
- Butler-Laporte G
- Butler-Laporte G
- Butler-Laporte G
- Butte MJ
- Butterworth AS
- Butterworth-Cowin N
- Button H
- Buxbaum JD
- Buxbaum JD
- Buxbaum JD
- Byun J
- Caba Llero-Garralda A
- Cabrelli L
- Caceres M
- Cadilla CL
- Cagova L
- Caldarelli GP
- Calderon EJ
- Callaghan M
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- Camby S
- Cameli P
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- Campbell R
- Campos S
- Camsooksai J
- Canaccini A
- Canakoglu A
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- Capasso M
- Capitani K
- Cappadona C
- Cappelli S
- Capps N
- Carbral-Ortega L
- Cardamone G
- Carella M
- Carey DJ
- Carli D
- Carlucci N
- Carmody M
- Carmody S
- Carnahan M
- Carnero-Montoro E
- Carrabba M
- Carracedo AD
- Carreras Nolla A
- Carreras A
- Carriero ML
- Carson G
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- Carter S
- Carungcong J
- Caruth V
- Casey M
- Cass E
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- Castelli F
- Castle K
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- Castori M
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- Caterson J
- Cathcart S
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- Catterall BWA
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- Caulfield MJ
- Cavazza A
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- Cawthron K
- Cazzaniga M
- Cea C
- Cecconi M
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- Ceri S
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- Chadbourn I
- Chadwick D
- Chadwick D
- Chambler D
- Chan G
- Chan R
- Chand M
- Chandler B
- Chang D
- Chang TS
- Chang X
- Chang Y
- Chapman S
- Charles B
- Charlesworth R
- Charney AW
- Charnock R
- Chasse M
- Chassot J
- Chaudhary K
- Chavan S
- Chechi K
- Chee N
- Cheema Y
- Chen H-H
- Cheng N
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- Chernitsov A
- Cherubini A
- Chetam L
- Cheyne C
- Chiba S
- Chihara Y
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- Childs D
- Chittoor G
- Chiu A
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- Chukkambotla S
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- Cirulli ET
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- Clapham M
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- Clarinval M
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- Clark V
- Clarke D
- Clarke EA
- Clarke N
- Clarkson M
- Clayton S
- Clement I
- Clements S
- Clerc O
- Cloherty A
- Clohisey S
- Clohisey S
- Clohisey S
- Clohisey S
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- Cockrell M
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- Cordioli M
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- Takagi H
- Takahashi K
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- Takahashi M
- Takahashi M
- Takahashi T
- Takaku Y
- Takano K
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- Taki R
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- Tanigawa Y
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- Taniyama D
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- Tateishi T
- Tateno H
- Tatham K
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- Tavares S
- Tavecchia L
- Taylor A
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- Team AC
- Team GHR
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- Tedder RS
- Teles A
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- Tench H
- Tenesa A
- Tentorio P
- Terai H
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- Terron Arcos V
- Tetla D
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- Thirumaran M
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- Thompson AAR
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- Uffelmann E
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- Vari MS
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- Veelo D
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- Veerapen K
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- Verdugo RA
- Vergori A
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- Verma A
- Verma SS
- Vertue M
- Vertue M
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- Vlaar APJ
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- Von Frenckell C
- von Hohenstaufen K
- von Mering C
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- Vuylsteke A
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- Waddy S
- Wagstaff V
- Waite AAC
- Wakabayashi A
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- Wyllie DH
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- Yi X
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- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Youlton N
- Younes SE
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- Zak A
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- Zanella A
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- Zanelli G
- Zara F
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- Zborowski AC
- Zeberg H
- Zechner M
- Zechner M
- Zguro K
- Zhai R
- Zhang JE
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- Zhao JH
- Zhen J
- Zheng C
- Zheng T
- Zhou W
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- Zhu W
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- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease