Characterization of greater middle eastern genetic variation for enhanced disease gene discovery

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics

The effects of light distribution, color temperature, and Illuminance on the drawings’ quality of fine arts and Design students

This study was performed to analyze the light from a psychological point of view and explore how different types of light affect the emotions and performance of students of the College of Fine Arts and Design (CFAD) when illuminance and color temperature were changed. With deep interest in the feature of lighting environments, that effectively increase positive moods and the quality of drawings produced by students. The techniques used for evaluation were field survey, and simulation lighting measurement tool (light meter). The experimental conditions consist of two types of artificial light and daylight. Participants rated their emotions of the lighting environment and draw to test their performance on each condition. The findings showed that students who participated felt more relaxed and more pleasant and performed better in fluorescent artificial light and all artificial lights with natural light conditions. A DIALux evo simulation was used for the comparison study. Finally, some guidelines were highlighted to provide a suitable lighting environment for higher-quality drawings by fine arts and design students