Melatonin protects rats from radiotherapy-induced small intestine toxicity

Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities following radiotherapy. Prevention of radiation enteropathy requires protection of the small intestine. However, despite the prevalence and burden of this pathology, there are currently no effective treatments for radiotherapy-induced gut toxicity, and this pathology remains unclear. The present study aimed to investigate the changes induced in the rat small intestine after external irradiation of the tongue, and to explore the potential radio-protective effects of melatonin gel. Male Wistar rats were subjected to irradiation of their tongues with an X-Ray YXLON Y.Tu 320-D03 irradiator, receiving a dose of 7.5 Gy/day for 5 days. For 21 days post-irradiation, rats were treated with 45 mg/day melatonin gel or vehicle, by local application into their mouths. Our results showed that mitochondrial oxidative stress, bioenergetic impairment, and subsequent NLRP3 inflammasome activation were involved in the development of radiotherapy-induced gut toxicity. Oral treatment with melatonin gel had a protective effect in the small intestine, which was associated with mitochondrial protection and, consequently, with a reduced inflammatory response, blunting the NF-κB/NLRP3 inflammasome signaling activation. Thus, rats treated with melatonin gel showed reduced intestinal apoptosis, relieving mucosal dysfunction and facilitating intestinal mucosa recovery. Our findings suggest that oral treatment with melatonin gel may be a potential preventive therapy for radiotherapy-induced gut toxicity in cancer patients.This study was partially supported by grant no. SAF2009-14037 from the Spanish Ministry of Economy and Competitivity (MINECO), GREIB.PT_2010_04 from the CEIBiotic Program of the University of Granada, Spain, and CTS-101 from the Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía, Spain

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

A global analysis of terrestrial plant litter dynamics in non-perennial waterways

Perennial rivers and streams make a disproportionate contribution to global carbon (C) cycling. However, the contribution of intermittent rivers and ephemeral streams (IRES), which sometimes cease to flow and can dry completely, is largely ignored although they represent over half the global river network. Substantial amounts of terrestrial plant litter (TPL) accumulate in dry riverbeds and, upon rewetting, this material can undergo rapid microbial processing. We present the results of a global research collaboration that collected and analysed TPL from 212 dry riverbeds across major environmental gradients and climate zones. We assessed litter decomposability by quantifying the litter carbon-to-nitrogen ratio and oxygen (O2) consumption in standardized assays and estimated the potential short-term CO2 emissions during rewetting events. Aridity, cover of riparian vegetation, channel width and dry-phase duration explained most variability in the quantity and decomposability of plant litter in IRES. Our estimates indicate that a single pulse of CO2 emission upon litter rewetting contributes up to 10% of the daily CO2 emission from perennial rivers and stream, particularly in temperate climates. This indicates that the contributions of IRES should be included in global C-cycling assessments

Climate based seed zones for Mexico: spatial grids to guide reforestation under observed and projected climate change

This database entry provides climate-based seed zone system for Mexico to address climate change observed over the last 30 years and projected climate change for the 2050s. The database corresponds to a journal publication by Castellanos-Acuña et al. (2018), available at https://doi.org/10.1007/s11056-017-9620-6. This seed zone classification is based on bands of two climate variables that have often been shown to drive genetic adaptation of tree species: mean coldest month temperature (MCMT), and an aridity index (AHM). MCMT was divided into ten bands of 3°C intervals, with the limits of these bands being, temperatures below <2°C, 2-5°, 5-8°, 8-11°, 11-14°, 14-17°, 17-20°, 20-23°, 23-26°, >26°C. AHM was divided into seven bands with intervals that are approximately equal width under a log-transformation: <20, 20-30, 30-45, 45-65, 65-95, 95-140, and >140 °C/mm. The gridded files provided in this database entry, the classes are coded as integer numbers, with the last digit representing the AHM class (1-7) and the first or first and second digit representing the MCMT class (1-10)

Human Resource Allocation and Scheduling for Software Project Management

Software project management consists of a number of planning, organizing, staffing, directing and controlling activities. Human resources feature prominently in all of these activities and, as a consequence, they can affect and determine project management decisions. Therefore, in order to help guarantee the success of a software project, managers must take into consideration this type of resource when performing the aforementioned activities. This chapter specifically investigates human resources from a planning perspective and, in particular, focuses on the responsibilities of allocating developers and teams to project tasks, scheduling developers and teams, as well as forming development teams. These responsibilities are often challenging to undertake because they are accompanied by time, budget and quality constraints, which software project managers find difficult to balance correctly. The purpose of the chapter is to explore the most recent research work in the field of human resource allocation and scheduling, and to specifically examine the motivation behind each approach and the goals and benefits to real-world practitioners. In addition, the chapter investigates development team formation, which can be considered as an indirect method of allocating human resources to a software project. This perspective, in particular, sheds light on current and future trends, which lean towards incorporating human-centric aspects of software development in planning activities