140 research outputs found
Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy
- Author
- Aawsaj Y
- Abayomi M
- Acharya V
- Aggarwal SK
- Ahmad A
- Ahmed I
- Ahmed J
- Ahmed J
- Ahmed T
- Ainley P
- Akhtar M
- Al Amari K
- Al-Abed YA
- Al-Akash M
- Al-Bahrani AZ
- Al-Khyatt W
- Al-Muhktar A
- Al-Sarireh B
- Al-Taan O
- Alagaratnam S
- Alam I
- Alberts J
- Alderson D
- Aldridge RC
- Aleksandrov D
- Ali H
- Ali S
- Amin K
- Andrew DR
- Appleton S
- Arhi C
- Aroori S
- Aryal K
- Asad M
- Aseem R
- Asprou FM
- Awan A
- Ayaani S
- Aymon
- Babu BI
- Bajwa DS
- Bajwa FM
- Baker AL
- Balfe P
- Ball WR
- Ballance L
- Banwell V
- Barnes J
- Barrie J
- Bartlett F
- Basheer M
- Bashir G
- Basra M
- Basu S
- Basynat P
- Batt J
- Bausbacher H
- Bawa S
- Beasley WD
- Belding R
- Bellini MI
- Bennett SP
- Bhandari CTS
- Bhattacharya V
- Blane C
- Blazeby JM
- Boal M
- Boddy A
- Boland M
- Bond-Smith G
- Booth MI
- Borowski DW
- Bowen L
- Boyce KM
- Boyd AT
- Bradley D
- Bradley N
- Brennan S
- Brett D
- Broadhurst J
- Brooke E
- Brown TH
- Bryant A
- Buchan J
- Bullen N
- Bunnell C
- Bunting DM
- Burke P
- Byrne JP
- Byrnes CK
- Campbell W
- Carney K
- Carney K
- Carroll P
- Carter CR
- Carter NC
- Carty N
- Cassidy JT
- Chambers A
- Chambers A
- Chambers A
- Chan WM
- Chang J
- Charalabopoulos A
- Chauhan N
- Cheung M
- Chishti IA
- Chitre V
- CholeS Study Grp
- CholeS Study Grp
- CholeS Study Grp
- CholeS Study Grp
- Choy A
- Cieplucha K
- Clements JM
- Coats M
- Cockbain AJ
- Coe PO
- Connelly M
- Cooke F
- Courtney MJ
- Cowley JB
- Cross KS
- Cuming T
- Cunha P
- D'Costa C
- Dalgaty F
- Dar F
- Date R
- Dave RV
- Davey P
- Davies J
- Dawson S
- De Marchi JA
- de Siqueira J
- Deguara J
- Delisle TG
- Dennison AR
- Derbyshire L
- Devoto L
- Dhillon A
- Diamond T
- Dickson-Lowe R
- Digney R
- Dindyal S
- Dobbins B
- Doe M
- Dorrian E
- Doulias T
- Downing J
- Downing J
- Drake B
- Driscoll PJ
- Duke D
- Durkin D
- Dwerryhouse SJ
- Ebdewi H
- Ebied H
- Eisawi A
- El-Dhuwaib APY
- El-Hasani SS
- Elkheir N
- Elmasry M
- Elsayed M
- Elshaer M
- Emesih S
- Farag SF
- Farooq A
- Farouk M
- Fasih T
- Fawole AS
- Fenwick S
- Ferguson G
- Ferris P
- Finch D
- Finch JG
- Finch JG
- Finlay I
- Fleming K
- Fletcher T
- Fordham IJ
- Forouzanfar A
- Forrest CR
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- Fothergill L
- Frame RJ
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- Galanopoulos G
- Gallagher PV
- Garcea G
- Gardner-Thorpe J
- Geoghegan JG
- Geogloma I
- Gerakopoulos S
- Ghareeb E
- Ghazanfar MA
- Gibson S
- Giles M
- Giovinazzo F
- Giwa L
- Goh YL
- Gopalswamy S
- Goscimski A
- Gossage JA
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- Grant AJ
- Gravante G
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- Gull S
- Gunasekera RT
- Gurung K
- Guthrie GJK
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- Halkias C
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- Hamady Z
- Hamdan A
- Hamdan MF
- Hamilton E
- Hancorn K
- Haque M
- Haque SU
- Hardy TJ
- Hargreaves A
- Harilingam ACM
- Harris A
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- Hawkins H
- Heath J
- Hebbar M
- Henderson LT
- Henley N
- Heshaishi M
- Hewes J
- Hewes JC
- Heywood N
- Higgs SM
- Hill ADK
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- Hindley C
- Hirst NA
- Hisham E
- Ho W-M
- Hoban JR
- Hodgkins KA
- Hodson J
- Holroyd DJ
- Hooks G
- Hopwood B
- Hornby ST
- Hornsby J
- Hosie KB
- Hosie KB
- Hossack MR
- Hossain T
- Hoti E
- Hou D
- Hrycaiczuk A
- Hughes M
- Hunter DI
- Hussain A
- Hussain A
- Hussain AA
- Hussain N
- Iftikhar SY
- Iqbal N
- Iskandar E
- Issa E
- Ivanovski I
- Jackson A
- Jackson C
- Jafferbhoy SF
- Jambulingam P
- Jamdar S
- Jamel S
- Janeczko A
- Jaunoo S
- Jayanthi NVG
- Jelley C
- Jennings NA
- Joel A
- Johnpulle MA
- Johnston D
- Johnstone M
- Johnstone M
- Joji N
- Jones C
- Jones E
- Jones GH
- Jones MA
- Jones MJ
- Jones RP
- Jones SM
- Kadhim A
- Kadirkamanathan S
- Kallaway C
- Kanakala V
- Kanavati O
- Kansal N
- Kaptanis S
- Karavadra B
- Karim L
- Karunakaran P
- Katbeh T
- Kaur P
- Kausar A
- Kelly ME
- Kendal C
- Kennedy D
- Kenny R
- Keogh K
- Khalil AM
- Khan A
- Khan MA
- Khan MAS
- Khan RB
- Khan S
- Khan S
- Khawaja A
- Khawaja Z
- Khogali E
- Kimble A
- Kinghorn A
- Kirkham AJ
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- Kourkulos M
- Krysztopik R
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- Kyriakidis D
- Lalla K
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- Lammy S
- Lane R
- Larkin D
- Law J
- Lawther R
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- Lee K
- Lee M
- Leeder P
- Lennon H
- Lewis M
- Lim HCC
- Lim PJ
- Lindsay D
- Lloyd D
- Lo C
- Lodhia J
- Longbotham DA
- Loughlin P
- Lovett B
- Luhmann A
- Luther AA
- Lyons EM
- Macano CAW
- MacArtney M
- Macdonald A
- Madanipour S
- Madbak K
- Madurska M
- Magee CJ
- Maguire D
- Maharaj G
- Majeed A
- Malcolm C
- Malde D
- Malik NS
- Mallik M
- Mansour S
- Manu M
- Manzelli A
- Marriott P
- Marriott P
- Martin J
- Martin S
- Martin ST
- Marudanayagam R
- Mason D
- Mathur P
- Mawhinney A
- Mbuvi J
- McAree B
- McCain S
- McCallum IJD
- McClarey A
- McCune K
- McDermott F
- McEntee GP
- McGlone ER
- McGuigan A
- McIlmunn C
- McKay D
- McKenzie S
- McNair AGK
- Mealy K
- Menzies D
- Mercer SJ
- Milburn J
- Mirza AK
- Mirza D
- Miu V
- Mockford KA
- Mohamed S
- Mohan HM
- Mok KWJ
- Monk D
- Morcous P
- Morrison TEM
- Mothe BS
- Mowbray N
- Mozolowski KL
- Mukherjee D
- Murphy JO
- Murtaza G
- Nally DM
- Napetti S
- Nassar AH
- Nassar AHM
- Naumann D
- Nedujchelyn Y
- Needham PJ
- Newton K
- Newton RC
- Ngu WS
- Nicholson GA
- Nicholson J
- Nicholson JA
- Nicol L
- Nicolay CR
- Nieto T
- Nijjar RS
- Nilsen-Nunn A
- Nilsson F
- Noble F
- Nofal E
- Noor N
- Nunes QM
- O'Dwyer P
- O'Neill MA
- O'Neill S
- O'Reilly DA
- O'shea KM
- O'Sullivan AW
- Obeidallah MR
- Ogedegbe A
- Old OJ
- Orchard P
- Orizu MN
- Packer JR
- Padwick R
- Panteleimonitis S
- Parappally CP
- Parmar J
- Pasquali S
- Patel A
- Patel K
- Patel S
- Pati P
- Pearce B
- Pearson KL
- Peirce C
- Pellen M
- Peter MB
- Peterson M
- Pezzuto R
- Photi E
- Phull M
- Pinho-Gomes AC
- Pollock S
- Popplewell M
- Pore N
- Porter J
- Prasad AR
- Prasad R
- Preston SR
- Preziosi G
- Prince S
- Psica A
- Puig S
- Puntis DJ
- Puri Y
- Qandeel H
- Rabie M
- Radwan R
- Rae DM
- Rahman S
- Rajaganeshan R
- Rajendran I
- Ramage MI
- Rao STV
- Rate AJ
- Raza S
- Read E
- Reddy M
- Reece-Bolton O
- Reed J
- Reid A
- Rengifo C
- Rhys T
- Richards CH
- Riera M
- Ritchie J
- Robb W
- Roberts GP
- Robinson S
- Robinson S
- Robinson SJ
- Rodriguez D
- Rodriguez DU
- Roebuck A
- Rogers PN
- Rolph RC
- Roy S
- Rutherford CL
- Sadat MM
- Sakai N
- Sampat K
- Samuel N
- Sarmah PB
- Sarvananthan K
- Sarveswaran J
- Satheesan S
- Saunders M
- Sayegh M
- Segaran A
- Sekhar H
- Sen G
- Seymour K
- Shabo W
- Shah N
- Shah R
- Shahin Y
- Sheel ARG
- Shenoy H
- Shetty V
- Shier D
- Shingler GM
- Shiwani MH
- Shrestha AK
- Siddiqi N
- Siddiqui MN
- Siddiqui Z
- Sillo TO
- Silva M
- Simpson DJ
- Singh S
- Singh-Ranger D
- Sinha S
- Skelly BL
- Slavin JP
- Slawinski C
- Sloane J
- Smith SR
- Smith SR
- Spearman J
- Spence G
- Spreadborough P
- Spreadborough P
- Starmer BZ
- Stevenson TEJ
- Stewart DJ
- Stirland E
- Subramanium D
- Sufi PA
- Sukha A
- Sutcliffe R
- Suttie S
- Sutton CMLR
- Szentpali K
- Tang C-B
- Tanner N
- Tate S
- Tayeh S
- Taylor GW
- Teasdale RL
- Templeton A
- Terrace J
- Thakkar R
- Thomas G
- Thompson RLE
- Tilston MP
- Toh SKC
- Tolofari S
- Tomlinson MA
- Trevatt AEJ
- Trotter M
- Tsang A
- Tsavellas G
- Tuck L
- Turner P
- Tutton MG
- Ullah MF
- Upchurch EA
- Urbonas T
- Varghase J
- Vass DG
- Vaughan EM
- Vijay V
- Vijayan D
- Vijayanand D
- Villatoro E
- Virupaksha S
- Vitone LJ
- Vohra RS
- Vohra RS
- Wadley M
- Wainwright D
- Wajed S
- Wallace T
- Wardle S
- Warren C
- Watkin H
- Watson AJM
- Watson NF
- Wayman J
- Weaver S
- Weber B
- Weber B
- Weerasinghe C
- Welbourn H
- West Midlands Research Collaborative
- Wheatley K
- White TJ
- Wijetunga I
- Wild JRL
- Wilkinson MD
- Williams SV
- Williamson TK
- Willson PD
- Wilson MSJ
- Wilson TR
- Winter DC
- Winter H
- Wood CPJ
- Wood P
- Wood S
- Woodman T
- Yahya S
- Yao C
- Yeldham G
- Yoganathan T
- Youssef H
- Zafar S
- Zafrani Z
- Zarsadias P
- Zeeshan S
- Zhang C
- Zino S
- Ziprin P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background
A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets.
Methods
Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis.
Results
A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p < 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p < 0.001).
Conclusion
We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty
Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection
- Author
- A-Ming Huang
- AW O'Sullivan
- BC Lee
- CC Chuang
- CC Tsai
- Chi-Chung Chen
- Chi-Yun Wang
- Chia-Chang Chuang
- Chiou-Feng Lin
- FA Bozza
- H Lue
- H Lue
- H Matsui
- J Branger
- JA Baugh
- JB Lubetsky
- JL Powell
- LI Hor
- Lien-I Hor
- M Bozza
- M Emonts
- MD Sanchez-Nino
- MS Strom
- P Damas
- Po-Chin Tseng
- PR Hsueh
- Pui-Ching Choi
- PW West
- RA Mitchell
- S Kenzel
- SF Liu
- SH Shin
- SR Chiang
- T Calandra
- T Calandra
- T Roger
- T Tsuchiya
- Wen-Teng Chang
- WT Chang
- Y Al-Abed
- Y Gore
- Yin-Ching Chuang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
When Too Much Is Not Enough: Obsessive-Compulsive Disorder as a Pathology of Stopping, Rather than Starting
- Author
- A Lazarov
- A Lazarov
- A Sclafani
- AL Hinds
- Andrea L. Hinds
- AR Aron
- AS Pietrefesa
- Ben J. Harrison
- C Beste
- CA Winstanley
- CA Winstanley
- CA Winstanley
- CD Chambers
- D Joel
- D Mataix-Cols
- D Mataix-Cols
- DJ Stein
- DM Eagle
- DM Eagle
- DM Eagle
- DV Sheehan
- ED Huey
- Erik Z. Woody
- EZ Woody
- EZ Woody
- EZ Woody
- F Verbruggen
- FD Zeeb
- G Collier
- GF Reed
- GF Reed
- GL Burns
- GP Smith
- H Brown
- H Szechtman
- Henry Szechtman
- J Tooby
- JH Strubbe
- JY Rotge
- K Wahl
- KJ Flannelly
- KL Hoffman
- KL Hoffman
- L Besiroglu
- LJ Summerfeldt
- LJ Summerfeldt
- Louis A. Schmidt
- MB First
- Michael Van Ameringen
- MM Nielen
- P Boyer
- P Boyer
- P Teitelbaum
- P Trower
- R Penadés
- R Sun
- RK Pitman
- RL Leahy
- RT Abed
- S Belayachi
- S Khodarahimi
- S Moritz
- S Moritz
- S Moritz
- S Moritz
- S Saxena
- S Saxena
- S Taylor
- S Wise
- SC Woods
- SL Neuberg
- SM Groman
- SR Chamberlain
- SR Chamberlain
- SW Porges
- SW Porges
- TH Moran
- TW Robbins
- W Dalley Jeffrey
- Publication venue
- Public Library of Science
- Publication date
- 26/01/2012
- Field of study
Background: In obsessive-compulsive disorder (OCD), individuals feel compelled to repeatedly perform security-related behaviors, even though these behaviours seem excessive and unwarranted to them. The present research investigated two alternative ways of explaining such behavior: (1) a dysfunction of activation—a starting problem—in which the level of excitation in response to stimuli suggesting potential danger is abnormally strong; versus (2) a dysfunction of termination— a stopping problem—in which the satiety-like process for shutting down security-related thoughts and actions is abnormally weak. Method: In two experiments, 70 patients with OCD (57 with washing compulsions, 13 with checking compulsions) and 72 controls were exposed to contamination cues—immersing a hand in wet diapers —and later allowed to wash their hands, first limited to 30 s and then for as long as desired. The intensity of activation of security motivation was measured objectively by change in respiratory sinus arrythmia. Subjective ratings (e.g., contamination) and behavioral measures (e.g., duration of hand washing) were also collected. Results: Compared to controls, OCD patients with washing compulsions did not differ significantly in their levels of initial activation to the threat of contamination; however, they were significantly less able to reduce this activation by engaging in the corrective behavior of hand-washing. Further, the deactivating effect of hand-washing in OCD patients with checkin
Phototrophic biofilms and their potential applications
- Author
- A Blanco
- A Gross
- AA Dam van
- AA Tsygankov
- AB Jensen
- AFM Elsayed
- AL Ruffroberts
- AS Steunou
- BEM Schaub
- BK Chan
- BR Boles
- BW Kim
- C Fortin
- C Wiegand
- D Kratochvil
- DE Nicodem
- DJ Marais Des
- DL Parker
- DLN Rao
- DM Ward
- E Epping
- E Flores
- E Larsen
- EA Edwards
- EO Omoregie
- F Chaillan
- G Mazor
- G Roeselers
- G Roeselers
- G Schumacher
- G Schumacher
- G. Muyzer
- G. Roeselers
- H Cypionka
- HA Kobayashi
- HC Flemming
- I Ferrera
- J Bender
- J Bender
- J Bleijswijk van
- J Garcia
- J Kromkamp
- J Vymazal
- J Vymazal
- J Wimpenny
- JP Zehr
- K Schutz
- K Simek
- KE Havens
- L Blaha
- LH Kaufman
- LJ Stal
- LS Davis
- M Ashraf
- M Benthien
- M Habte
- M Martinez-Alonso
- M. C. M. van Loosdrecht
- MA Syed
- MJ Ferris
- MM Bateson
- MS Girvan
- N Sorkhoh
- NA Sorkhoh
- NP Revsbech
- NW Lem
- P Lindberg
- P Phillips
- P Tamagnini
- PV Bhaskar
- R Guerrero
- R.J. Craig
- RB Coffin
- RC Prince
- RJ Craggs
- RL Mancinelli
- RL Naylor
- RM Abed
- RN Singh
- RW Castenholz
- RW Castenholz
- S Nayar
- SK Apte
- SK Liehr
- SK Mehta
- SR Ragusa
- TC Wang
- TF Thingstad
- TJ Hurse
- VF Magalhaes
- WR Barclay
- Y Ariosa
- Y Cohen
- Y Liu
- Y Racault
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2007
- Field of study
Phototrophic biofilms occur on surfaces exposed to light in a range of terrestrial and aquatic environments. Oxygenic phototrophs like diatoms, green algae, and cyanobacteria are the major primary producers that generate energy and reduce carbon dioxide, providing the system with organic substrates and oxygen. Photosynthesis fuels processes and conversions in the total biofilm community, including the metabolism of heterotrophic organisms. A matrix of polymeric substances secreted by phototrophs and heterotrophs enhances the attachment of the biofilm community. This review discusses the actual and potential applications of phototrophic biofilms in wastewater treatment, bioremediation, fish-feed production, biohydrogen production, and soil improvement
Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish
- Author
- A Ben-Dor
- A Kalsotra
- A Stamatakis
- A Tchoudakova
- AG McArthur
- AI Saeed
- Akira Kubota
- AL Shen
- AM Morrison
- Andrew G McArthur
- B Thisse
- C Handschin
- C Li
- C Liu
- C Sabourault
- CA Godard
- D Alsop
- D Choudhary
- D Choudhary
- D Edler
- D Rozman
- D Schlenk
- David R Nelson
- DC Lamb
- DJ Waxman
- DM Otto
- DR Nelson
- DR Nelson
- DR Nelson
- DR Nelson
- DW Nebert
- DW Russell
- E Birney
- EE Schadt
- EJ Reschly
- FP Guengerich
- GE Corley-Smith
- GJ Weber
- GV Callard
- H Qiu
- H Yoshioka
- HJ Hsu
- HJ Hsu
- HM Goldstone
- HP Tseng
- I Stoilov
- I Stoilov
- IO Sirbu
- JA White
- JA White
- Jared V Goldstone
- JB Cheng
- JC Prasad
- JH Postlethwait
- JJ Schlezinger
- JJ Stegeman
- JL Hoffmann
- JL Wang-Buhler
- JM Trant
- John J Stegeman
- JP Hardwick
- Juliano Zanette
- JV Goldstone
- JV Goldstone
- JV Goldstone
- K Cheshenko
- K Laue
- K Stark
- K Stark
- K Yamazaki
- KK Wu
- KM Spoorendonk
- L Wang
- LY Zhou
- LY Zhou
- M Celander
- M Karlgren
- M Karlgren
- M Kishida
- M Kishida
- M Nakano
- M Uehara
- M Westerfield
- Maria E Jönsson
- MC Fishman
- MC Hu
- MD Kinkel
- ME Jönsson
- ME Jönsson
- MF Oleksiak
- MF Oleksiak
- MJ Aryee
- ML Scornaienchi
- ML Scornaienchi
- MO James
- N Mast
- N Mast
- N Strushkevich
- Q Zhao
- R Goto-Kazeto
- RC Edgar
- RE Hernandez
- RJ White
- RN Hines
- S Mosadeghi
- S Reijntjes
- S Whelan
- SJ Sawyer
- SR Bair
- SR Eddy
- SS Abu-Abed
- SS Chuang
- T Bresolin
- TA Craig
- Thiago Parente
- WJ Ray
- WW Lai
- X Gu
- X Gu
- Y Liu
- Y Sato
- Y Wang
- YC Li
- YK Kawai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2010
- Field of study
© The Authors, 2010. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in BMC Genomics 11 (2010): 643, doi:10.1186/1471-2164-11-643.Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function. CYP enzymes catalyze oxidative transformation leading to activation or inactivation of many endogenous and exogenous chemicals, with consequences for normal physiology and disease processes. Many CYPs potentially have roles in developmental specification, and many chemicals that cause developmental abnormalities are substrates for CYPs. Here we identify and annotate the full suite of CYP genes in zebrafish, compare these to the human CYP gene complement, and determine the expression of CYP genes during normal development. Zebrafish have a total of 94 CYP genes, distributed among 18 gene families found also in mammals. There are 32 genes in CYP families 5 to 51, most of which are direct orthologs of human CYPs that are involved in endogenous functions including synthesis or inactivation of regulatory molecules. The high degree of sequence similarity suggests conservation of enzyme activities for these CYPs, confirmed in reports for some steroidogenic enzymes (e.g. CYP19, aromatase; CYP11A, P450scc; CYP17, steroid 17a-hydroxylase), and the CYP26 retinoic acid hydroxylases. Complexity is much greater in gene families 1, 2, and 3, which include CYPs prominent in metabolism of drugs and pollutants, as well as of endogenous substrates. There are orthologous relationships for some CYP1 s and some CYP3 s between zebrafish and human. In contrast, zebrafish have 47 CYP2 genes, compared to 16 in human, with only two (CYP2R1 and CYP2U1) recognized as orthologous based on sequence. Analysis of shared synteny identified CYP2 gene clusters evolutionarily related to mammalian CYP2 s, as well as unique clusters. Transcript profiling by microarray and quantitative PCR revealed that the majority of zebrafish CYP genes are expressed in embryos, with waves of expression of different sets of genes over the course of development. Transcripts of some CYP occur also in oocytes. The results provide a foundation for the use of zebrafish as a model in toxicological, pharmacological and chemical disease research.This work was supported by NIH grants R01ES015912 and P42ES007381 (Superfund Basic Research Program at Boston University) (to JJS). MEJ was a Guest Investigator at the Woods Hole Oceanographic Institution (WHOI) and was supported by grants from the Swedish research council Formas and Carl Trygger's foundation. AK was a Post-doctoral Fellow at WHOI, and was supported by a fellowship from the Japanese Society for Promotion of Science (JSPS). JZ and TP were Guest Students at the WHOI and were supported by a CAPES Ph.D. Fellowship and CNPq Ph.D. Sandwich Fellowship (JZ), and by a CNPq Ph.D. Fellowship (TP), from Brazil
Population‐based cohort study of outcomes following cholecystectomy for benign gallbladder diseases
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- Abayomi M
- Acharya V
- Aggarwal SK
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- Zeeshan S
- Zhang C
- Ziprin P
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2016
- Field of study
Background The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all‐cause 30‐day readmissions and complications in a prospective population‐based cohort. Methods Data were collected on consecutive patients undergoing cholecystectomy in acute UK and Irish hospitals between 1 March and 1 May 2014. Potential explanatory variables influencing all‐cause 30‐day readmissions and complications were analysed by means of multilevel, multivariable logistic regression modelling using a two‐level hierarchical structure with patients (level 1) nested within hospitals (level 2). Results Data were collected on 8909 patients undergoing cholecystectomy from 167 hospitals. Some 1451 cholecystectomies (16·3 per cent) were performed as an emergency, 4165 (46·8 per cent) as elective operations, and 3293 patients (37·0 per cent) had had at least one previous emergency admission, but had surgery on a delayed basis. The readmission and complication rates at 30 days were 7·1 per cent (633 of 8909) and 10·8 per cent (962 of 8909) respectively. Both readmissions and complications were independently associated with increasing ASA fitness grade, duration of surgery, and increasing numbers of emergency admissions with gallbladder disease before cholecystectomy. No identifiable hospital characteristics were linked to readmissions and complications. Conclusion Readmissions and complications following cholecystectomy are common and associated with patient and disease characteristics
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.
- Author
- Hugh Calkins
- Gerhard Hindricks
- Riccardo Cappato
- Young-Hoon Kim
- Eduardo B. Saad
- Luis Aguinaga
- Joseph G. Akar
- Vinay Badhwar
- Josep Brugada
- John Camm
- Peng-Sheng Chen
- Shih-Ann Chen
- Mina K. Chung
- Jens Cosedis Nielsen
- Anne B. Curtis
- D. Wyn Davies
- John D. Day
- André d’Avila
- N.M.S. de Groot
- Luigi Di Biase
- Mattias Duytschaever
- James R. Edgerton
- Kenneth A. Ellenbogen
- Patrick T. Ellinor
- Sabine Ernst
- Guilherme Fenelon
- Edward P. Gerstenfeld
- David E. Haines
- Michel Haissaguerre
- Robert H. Helm
- Elaine Hylek
- Warren M. Jackman
- Jose Jalife
- Jonathan M. Kalman
- Josef Kautzner
- Hans Kottkamp
- Karl Heinz Kuck
- Koichiro Kumagai
- Richard Lee
- Thorsten Lewalter
- Bruce D. Lindsay
- Laurent Macle
- Moussa Mansour
- Francis E. Marchlinski
- Gregory F. Michaud
- Hiroshi Nakagawa
- Andrea Natale
- Stanley Nattel
- Ken Okumura
- Douglas Packer
- Evgeny Pokushalov
- Matthew R. Reynolds
- Prashanthan Sanders
- Mauricio Scanavacca
- Richard Schilling
- Claudio Tondo
- Hsuan-Ming Tsao
- Atul Verma
- David J. Wilber
- Teiichi Yamane
- H Calkins
- H Calkins
- AK Jacobs
- JL Anderson
- CT January
- P Kirchhof
- P Jais
- H Calkins
- DL Packer
- KH Kuck
- SR Dukkipati
- VY Reddy
- A Natale
- DJ Wilber
- H Sohara
- C Pappone
- G Stabile
- GB Forleo
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- M Bassiouny
- R Krittayaphong
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- F Furlanello
- OM Wazni
- J Cosedis Nielsen
- CA Morillo
- A Hakalahti
- M Hocini
- YW Chen
- K Inada
- MS Chen
- PJ Gentlesk
- MN Khan
- MR MacDonald
- RJ Hunter
- C Tondo
- BA Lutomsky
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- TJ Bunch
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- I Olivotto
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- P Leong-Sit
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- P Koopman
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- CA Abreu Filho
- G Doukas
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- DC Cheng
- P Budera
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- AM Gillinov
- JS Rankin
- Y Louagie
- B Chiappini
- SD Barnett
- JR Edgerton
- JR Edgerton
- D Lockwood
- SC Malaisrie
- A Cherniavsky
- JS Yoo
- AH Driessen
- LV Boersma
- MC Henn
- SP Krul
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- XH Wang
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- DM Lloyd-Jones
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- EA Fender
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- KR Kanter
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- SP Ponamgi
- L Biase Di
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- TJ Bunch
- R Cappato
- C Tan
- S Mohanty
- S Mohanty
- R Cappato
- AM Gillinov
- FW Mohr
- N Doll
- B Sonmez
- MI Scanavacca
- B Borchert
- KK Ghia
- GW Gilcrease
- F Stockigt
- O Yousuf
- PG Jackson
- G Nolker
- JT Medeiros De Vasconcelos
- A Rillig
- P Chavez
- JC Mateos
- HB Shim
- E Black-Maier
- P Santangeli
- L Biase Di
- OM Wazni
- M Schmidt
- A Hakalahti
- L Biase Di
- SH Hohnloser
- H Calkins
- R Cappato
- L Biase Di
- M Bassiouny
- AA Bin Abdulhak
- R Providencia
- RA Winkle
- HL Armbruster
- JF Ren
- S Saksena
- J Baran
- JF Ren
- E Anter
- CS Sriram
- K Maleki
- OM Wazni
- D Shah
- JF Ren
- CJ Bruce
- S Asbach
- DF Briceno
- K Chilukuri
- K Thygesen
- SC Helps
- GS Krivonyak
- B Cauchemez
- T Kuwahara
- OW Franzen
- KH Ryu
- F Gaita
- C Herrera Siklody
- A Verma
- Y Greef De
- T Deneke
- FM Merchant
- L Lickfett
- F Gaita
- JW Schrickel
- T Deneke
- LD Sauren
- M Wieczorek
- M Bendszus
- RW Kruis
- C Medi
- H Ichiki
- E Nagy-Balo
- SE Vermeer
- K Neven
- KL Ripley
- H Ahmed
- R Kawasaki
- HW Lim
- K Yokoyama
- SM Singh
- T Kuwahara
- FM Contreras-Valdes
- LR Leite
- CM Tschabrunn
- T Deneke
- BJ Carroll
- P Muller
- T Tsuchiya
- MS Arruda
- T Kuwahara
- T Kuwahara
- A Chugh
- JS Koruth
- S Zellerhoff
- S Zellerhoff
- M Khan
- PJ Kahrilas
- NJ Shaheen
- U Halm
- H Knopp
- N Dagres
- C Eitel
- W Hazell
- A Cazavet
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- L Queneherve
- MF Gunes
- MA Qadeer
- CR Ellis
- SR Markar
- JG Andrade
- A Deshmukh
- R Cappato
- OJ Eick
- JD Fisher
- LF Hsu
- TJ Bunch
- LF Hsu
- Y Michowitz
- TS Tsang
- MD O'Neill
- Y Takahashi
- A Chugh
- H Makimoto
- T Kitamura
- S Ouali
- A Mykytsey
- C Sticherling
- KC Wong
- G Fayad
- JP Piccini
- D Lakkireddy
- JM Dumonceau
- TJ Bunch
- T Kuwahara
- S Miyazaki
- N Chopra
- TW Schwartz
- W Ajaj
- CF Pisani
- T Kanaeda
- LW Lo
- J Janssens
- MP Jones
- R Tavernier
- R Grove
- D Lakkireddy
- HM Zeljko
- CV Desimone
- O Gurbuz
- M Mansour
- RC Wu
- S Deftereos
- S Deftereos
- G Stabile
- M Luckie
- T Lambert
- S Torihashi
- DR Kim
- M Kesek
- KH Kuck
- H Sohara
- RF Evonich
- KR Chun
- H Hoyt
- EN Guhl
- MJ Earley
- AV Sarabanda
- A Guiot
- A Metzner
- Y Okumura
- M Arruda
- S Miyazaki
- E Wissner
- CS Elayi
- H Liu
- S Yong Ji
- F Franceschi
- S Miyazaki
- B Mondesert
- F Sacher
- JG Andrade
- C Pappone
- SR Dukkipati
- ES Katz
- D Caponi
- R Proietti
- JD Ferguson
- H Calkins
- BD Lindsay
- P Kovoor
- L Macle
- L Lickfett
- J Ector
- J Chen
- Y Khaykin
- G Stabile
- R Ponti De
- T Kleemann
- D Steven
- JP Weiss
- O Dragusin
- VY Reddy
- A Bulava
- H Cochet
- DN Gibson
- MB Shoemaker
- TD Welch
- C Witt
- L Pilote
- J Kosiuk
- H Ghanbari
- D Scherr
- Y Liu
- PA Noseworthy
- D Patel
- S Kochhauser
- J Kosiuk
- F Abhishek
- B Aldhoon
- G Mugnai
- Y Murakawa
- C Palaniswamy
- P Peichl
- J Waigand
- D Lakkireddy
- CC Tanaka-Esposito
- A Errahmouni
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
S
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abed Abud A
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Achkar B
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmad A
- Ahmadov F
- Ahmed WS
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- Aielli G
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- Akbiyik M
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
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- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
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- Anulli F
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- Aparo MA
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- Cheng CL
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- Cherkaoui El Moursli R
- Cheu E
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- Chiarella V
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- Clawson SE
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- Zakareishvili T
- Zakharchuk N
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- Zanzi D
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- Zeißner SV
- Zemaityte G
- Zeng JC
- Zenin O
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- Zerradi S
- Zerwas D
- Zgubič M
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- Zhang DF
- Zhang G
- Zhang J
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- Zhao P
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhou N
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- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
Measurements of sensor radiation damage in the ATLAS inner detector using leakage currents
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- Zeissner SV
- Zeitnitz C
- Zemaityte G
- Zeng JC
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- Zerwas D
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- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zou W
- Zwalinski L
- Publication venue
- IOP
- Publication date
- 01/01/2021
- Field of study
Non-ionizing energy loss causes bulk damage to the silicon sensors of the ATLAS pixel and strip detectors. This damage has important implications for data-taking operations, charged-particle track reconstruction, detector simulations, and physics analysis. This paper presents simulations and measurements of the leakage current in the ATLAS pixel detector and semiconductor tracker as a function of location in the detector and time, using data collected in Run 1 (2010–2012) and Run 2 (2015–2018) of the Large Hadron Collider. The extracted fluence shows a much stronger |z|-dependence in the innermost layers than is seen in simulation. Furthermore, the overall fluence on the second innermost layer is significantly higher than in simulation, with better agreement in layers at higher radii. These measurements are important for validating the simulation models and can be used in part to justify safety factors for future detector designs and interventions.publishedVersio
Measurements of W+W−+ ≥ 1 jet production cross-sections in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abed Abud A
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Achkar B
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akilli E
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
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- Alfonsi A
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- Alunno Camelia E
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- Alviggi MG
- Amaral Coutinho Y
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- Åkesson TPA
- Öncel ÖO
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- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
Fiducial and differential cross-section measurements of W+W− production in
association with at least one hadronic jet are presented. These measurements are sensitive
to the properties of electroweak-boson self-interactions and provide a test of perturbative
quantum chromodynamics and the electroweak theory. The analysis is performed using
proton-proton collision data collected at p
s = 13TeV with the ATLAS experiment, corresponding
to an integrated luminosity of 139 fb−1. Events are selected with exactly one oppositely
charged electron-muon pair and at least one hadronic jet with a transverse momentum
of pT > 30 GeV and a pseudorapidity of |�| < 4.5. After subtracting the background
contributions and correcting for detector effects, the jet-inclusive W+W−+ � 1 jet fiducial
cross-section and W+W−+ jets differential cross-sections with respect to several kinematic
variables are measured. These measurements include leptonic quantities, such as the lepton
transverse momenta and the transverse mass of the W+W− system, as well as jet-related
observables such as the leading jet transverse momentum and the jet multiplicity. Limits on
anomalous triple-gauge-boson couplings are obtained in a phase space where interference
between the Standard Model amplitude and the anomalous amplitude is enhanced
- …