Kajian Teknis Peningkatan Korelasi Rencana Cycle TIME Alat Angkut Di Pit Kwest PT. Kaltim Prima Coal Kalimantan Timur

Kondisi jalan angkut menjadi hal penting dalam pencapaian target produksi overburden di Pit Kwest DepartemenHatari. Hal ini berkaitan dengan jalan angkut di Pit Kwest, yang berada pada lapisan batuan yang berumur relatifmuda. Sehingga menyebabkan jalan angkut kurang kompak dan sangat rentan mengalami kerusakan. Kondisi inimenyebabkan durasi cycle time aktual alat angkut lebih lama dari alokasi cycle time rencana sehingga berdampakpada produksi yang tidak optimal. Perhitungan alokasi cycle time rencana Perusahaan untuk bulan Agustus di PitKwest adalah 17,03 menit, berdasarkan data dispatch diketahui cycle time aktual mencapai 23.06 menit. Sehinggatingkat korelasi terhadap cycle time aktual hanya sebesar 74%. Tingkat ketercapaian produksi aktual hanya sebesar79.69% atau sebesar 1.022.653,61 bcm dari target produksi 1.283.252 bcm overburden. Hal tersebut sebagai dampakdari kekurangan alokasi alat angkut yang disebabkan karena cycle time aktual yang lebih lama dari alokasi rencana,sehingga menyebabkan faktor keserasian alat gali muat dan alat angkut (match factor) turun dari rencana 0,85menjadi rata-rata 0,67. Dari metode perhitungan alokasi cycle time alat angkut dengan memperhitungkan variabelkondisi jalan angkut aktual Pit Kwest (Metode X), diperoleh alokasi cycle time alat angkut yang lebih mendekati cycletime aktual yaitu 23.73 menit. Tingkat korelasi sebesar 97.09%. Dengan menggunkan alokasi cycle time tersebut,berdasarkan perhitungan tingkat ketercapaian produksi bisa meningkat menjadi 103,41%

Plan-do-Check-Act Cycle: a Method to Improve Customer Satisfaction at a Municipal Council in Malaysia

Purpose: This study aimed to determine the use of PDCA methods in improving customer satisfaction at SP MUNICIPAL COUNCIL. Maintaining customer satisfaction is the main responsibility of my department as we are in charge of receiving complaints from the public and providing the best solution to the public. Since the major operation for SP MUNICIPAL COUNCIL is providing services to the public, it is crucial to solving any related issue regarding poor customer services and management by SP MUNICIPAL COUNCIL, long delays in solving issues from the public and others. Hence, using appropriate tools such as the PDCA method is one of the ways to achieve a continuous improvement process and improve the service quality for SP MUNICIPAL COUNCIL. The aim of this study is to overcome this issue and improve customer satisfaction, the quality of our services and reduce complaints from the public towards the management of SP MUNICIPAL COUNCIL by using the PDCA method.   Theoretical framework: Problem identification needs to be done to find the causes of customer complaints. From the findings, the factors that potentially cause the problem are customer services, workers, administration, and management system issues. Then, the next step is a repair process where the result after improvement, implementation and evaluation will be measured.   Design/methodology/approach: The method used for this study is the PDCA method in the literature review. The data of this study are compiled, analyzed and concluded, to obtain the results for the method in the literature review. The literature review compares several research papers that implement PDCA methods.   Findings: The findings show that Plan-Do-Act-Check method can give a positive impact on increasing service quality for SP MUNICIPAL COUNCIL. There are several solution and recommendation have been achieved after the discussion of the result. These solutions will help in overcome the issue faced by SP MUNICIPAL COUNCIL.   Research limitation/implication: This research only focuses on improving customer satisfaction at SP MUNICIPAL COUNCIL and only applies to departments that focus on customer services. Originality/value: This research contributes to existing literature and use new findings to overcome problem using PDCA method and fishbone analysis to identify the cause and effect of the problem

Analisis Faktor Risiko Ketidaklengkapan Imunisasi Dasar pada Bayi Dl Kecamatan Suka Makmur Kabupaten Aceh Besar

In Indonesia the immunization program is resolved to achieve the universal child immunization (UCI). In 1990 the International agreement was made to give the complete immunization to all children. The children with incomplete immmunization status could increase the KLB PD31 opportunities. The purpose of the research was to achieve the illustration of incomplete baby immunization and to determine factors related to the incomplete child immunization in Sub district Suka Makmur, Aceh Besar District. It was an analytic study using a cross sectional design. The respondents were 96 mothers who had 12-23 month babies. The risk factors were age, education, occupation, income, knowledge on immunization, age at the first time contact. Data were collected by structured interview and analized by Odds Ratio (OR). Results showed the prevalence of incomplete immunization child status was about 38.6%. The age of first time contact, the mother's knowledge about immunization and the distance between the house and the immunization service centre were associated with the child immunization status

Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients

Objective: To provide quick and accurate clinical diagnostic tools those are currently not available leading to improper management of colorectal cancer (CRC) patients. Methods: The metabolomic profiles of 10 CRC patients treated with 5-fluorouracil and 24 healthy volunteers were analysed. The subjects were genotyped for UGT1A1*28, DPYD 1896 T>C and DPYD*5. Results: Our results show alterations in the metabolism of bile acid, glycolysis and fatty acid in patients. The distinctive metabolite profiles established using PLSDA identify several biomarkers for diagnostic use in clinical settings. The predictive PLSDA model revealed 100% accuracy of metabolites differentiating CRC patients and healthy volunteers. In addition, the metabolic profiles associated with different genotypes of DPYD and UGT1A1 explains the impact of genetic variation on differential drug responses. Conclusion: Pharmacogenetics and metabolomics profiles are potential platforms for more comprehensive monitoring of patient's disease progress and drug response. Further study is however needed to validate the use of biomarkers identified

Seroprevalence of parvovirus B19 and its clinical effect among anaemic SCA patients in Northeastern Nigeria

ABSTRACT Sickle cell anaemia (SCA) is a globally widespread genetic disorder affecting 5% of the world's over 6 billion people. Parvovirus infection and the resulting aplastic crisis is a recognised complication in individuals with SCA. Aplastic crisis increases the need for blood transfusion and its attendant risk of Transfusion Transmissible Infection (TTI). Hence there is a vicious cycle in which Parvovirus B19 causes aplastic crisis which in turn causes increased transfusion need; and transfusion increases risk of transfusion transmissible infection in which parvovirus B19 is included in certain parts of the world. Sickle cell anaemia is associated with foetal death and infection with parvovirus B19 increases the risk to early mortality. The objective of this study was to determine the seroprevalence of parvovirus B19 among SCA and compare with that of controls in the study area. Furthermore clinical and laboratory profile of subjects were analysed to identify possible correlation with parvovirus B19 seropositivity and explore the possibility of involvement of white cell and platelets. A total of 90 subjects comprising 45 consecutive SCA case subjects and 45 age-and sex-matched non SCA controls were studied in a cross sectional comparative study. Ten millilitres of blood was drawn from the antecubital fossa of each subject after obtaining informed consent. The 10mls of blood was divided into two aliquots, 4.5 mls was added into EDTA anticoagulated bottle and was used for basic complete blood count (CBC), while the remaining 5mls was added into a plain specimen container allowed to clot and serum obtained to test for anti-parvovirus B19 IgG and IgM using an immunochromatography based technique specifically BIOCARD TM Parvo B19 diagnostic test kit. There was male preponderance in the study. The SCA subjects comprised 26 males and 19 females (male to female ratio = 1.4:1), while the non-SCA controls comprised 25 males and 20 females (male to female ratio 1.3:1).. The analysis of anti-parvovirus B19 IgG antibody revealed a prevalence of 23.3% among SCA cases with 18.9% among controls. The haematological profile is not affected by IgG seropositivity. However pregnancy outcome revealed that the total number of stillbirths is 12 among IgG seropositive SCA cases which is higher than the 6 encountered in IgG seronegative SCA subjects; the difference is statistically significant (p=0.04)

COVID-19 Vaccine Hesitancy and Determinants of Acceptance among Healthcare Workers, Academics and Tertiary Students in Nigeria

The COVID-19 pandemic has resulted in millions of human deaths, prompting the rapid development and regulatory approval of several vaccines. Although Nigeria implemented a COVID-19 vaccination program on 15 March 2021, low vaccine acceptance remains a major chal-lenge. To provide insight on factors associated with COVID-19 vaccine hesitancy (VH), we conducted a national survey among healthcare workers, academics, and tertiary students, between 1 September 2021 and 31 December 2021. We fitted a logistic regression model to the data and exam-ined factors associated with VH to support targeted health awareness campaigns to address public

Pharyngeal carriage of Neisseria species in the African meningitis belt.

OBJECTIVES: Neisseria meningitidis, together with the non-pathogenic Neisseria species (NPNs), are members of the complex microbiota of the human pharynx. This paper investigates the influence of NPNs on the epidemiology of meningococcal infection. METHODS: Neisseria isolates were collected during 18 surveys conducted in six countries in the African meningitis belt between 2010 and 2012 and characterized at the rplF locus to determine species and at the variable region of the fetA antigen gene. Prevalence and risk factors for carriage were analyzed. RESULTS: A total of 4694 isolates of Neisseria were obtained from 46,034 pharyngeal swabs, a carriage prevalence of 10.2% (95% CI, 9.8-10.5). Five Neisseria species were identified, the most prevalent NPN being Neisseria lactamica. Six hundred and thirty-six combinations of rplF/fetA_VR alleles were identified, each defined as a Neisseria strain type. There was an inverse relationship between carriage of N. meningitidis and of NPNs by age group, gender and season, whereas carriage of both N. meningitidis and NPNs was negatively associated with a recent history of meningococcal vaccination. CONCLUSION: Variations in the prevalence of NPNs by time, place and genetic type may contribute to the particular epidemiology of meningococcal disease in the African meningitis belt

Pharyngeal carriage of Neisseria species in the African meningitis belt.

OBJECTIVES: Neisseria meningitidis, together with the non-pathogenic Neisseria species (NPNs), are members of the complex microbiota of the human pharynx. This paper investigates the influence of NPNs on the epidemiology of meningococcal infection. METHODS: Neisseria isolates were collected during 18 surveys conducted in six countries in the African meningitis belt between 2010 and 2012 and characterized at the rplF locus to determine species and at the variable region of the fetA antigen gene. Prevalence and risk factors for carriage were analyzed. RESULTS: A total of 4694 isolates of Neisseria were obtained from 46,034 pharyngeal swabs, a carriage prevalence of 10.2% (95% CI, 9.8-10.5). Five Neisseria species were identified, the most prevalent NPN being Neisseria lactamica. Six hundred and thirty-six combinations of rplF/fetA_VR alleles were identified, each defined as a Neisseria strain type. There was an inverse relationship between carriage of N. meningitidis and of NPNs by age group, gender and season, whereas carriage of both N. meningitidis and NPNs was negatively associated with a recent history of meningococcal vaccination. CONCLUSION: Variations in the prevalence of NPNs by time, place and genetic type may contribute to the particular epidemiology of meningococcal disease in the African meningitis belt.MenAfriCar was funded by the Wellcome Trust (086546/Z/08/Z) and the Bill and Melinda Gates Foundation (51251). Kanny Diallo holds a Wellcome Trust Training Fellowship in Public Health and Tropical Medicine.This is the final version of the article. It first appeared from Elsevier via https://doi.org/10.1016/j.jinf.2016.03.01

The role of Guanxi in green supply chain management in Asia's emerging economies: A conceptual framework

In recent decades, rapid industrial modernization and economic growth have brought substantial environmental problems such as air pollution, hazardous waste, and water pollution for the Asian Emerging Economies (AEE), in particular China, Taiwan, India, Malaysia, Indonesia, Thailand, and South Korea. These countries have started to adopt green supply chain management (GSCM) as a strategy to reduce the environmental impact. There are anecdotal evidences that the adoption of GSCM in this region is partly influenced by Guanxi – a cultural norm, which plays a significant role in relationship governance within supply chain activities among the AEE. Based on a systematic literature review, we develop a conceptual framework that characterizes the drivers and barriers for the adoption of GSCM practices, incorporating Guanxi as a moderator in the manufacturing sector of the AEE. The conceptual framework addresses the roles of two types of Guanxi in the adoption of GSCM: the relational Guanxi at individual level based on social exchange theory and the aggregated Guanxi at firm level derived from social capital theory. This recognition of Guanxi at two separate decision levels help companies better manage their relationships while they green their supply chains. Directions for future research and managerial implications are discussed accordingly