226 research outputs found

    Efficient hydrogen storage in up-scale metal hydride tanks as possible metal hydride compression agents equipped with aluminium extended surfaces

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    In the current work, a three-dimensional computational study regarding coupled heat and mass transfer during both the hydrogenation and dehydrogenation process in upscale cylindrical metal hydride reactors is presented, analysed and optimized. Three different heat management scenarios were examined at the degree to which they provide improved system performance. The three scenarios were: 1) plain embedded cooling/heating tubes, 2) transverse finned tubes and 3) longitudinal finned tubes. A detailed optimization study was presented leading to the selection of the optimized geometries. In addition, two different types of hydrides, LaNi5 and an AB2-type intermetallic were studied as possible candidate materials for using as the first stage alloys in a two-stage metal hydride hydrogen compression system. As extracted from the above results, it is clear that the case of using a vessel equipped with 16 longitudinal finned tubes is the most efficient way to enhance the hydrogenation kinetics when using both LaNi5 and the AB2-alloy as the hydride agents. When using LaNi5 as the operating hydride the case of the vessel equipped with 60 embedded cooling tubes presents the same kinetic behaviour with the case of the vessel equipped with 12 longitudinal finned tubes, so in that way, by using extended surfaces to enhance the heat exchange can reduce the total number of tubes from 60 to 12. For the case of using the AB2-type material as the operating hydride the performance of the extended surfaces is more dominant and effective compared to the case of using the embedded tubes, especially for the case of the longitudinal extended surfaces

    The Bio-Politics of Population Control and Sex Selective Abortion in China and India

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    China and India, two countries with skewed sex ratios in favor of males, have introduced a wide range of policies over the past few decades to prevent couples from deselecting daughters, including criminalizing sex-selective abortion through legal jurisdiction. This article aims to analyze how such policies are situated within the bio-politics of population control and how some of the outcomes reflect each government’s inadequacy in addressing the social dynamics around abortion decision making and the social, physical, and psychological effects on women’s wellbeing in the face of criminalization of sex-selective abortion. The analysis finds that overall, the criminalization of sex selection has not been successful in these two countries. Further, the broader economic, social, and cultural dynamics which produce bias against females must be a part of the strategy to combat sex selection, rather than a narrow criminalization of abortion which endangers women’s access to safe reproductive health services and their social, physical, and psychological wellbeing

    De jure determinants of new firm formation: how the pillars of constitutions influence entrepreneurship

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    This paper provides empirical evidence supporting the view that constitutions are the primary and fundamental institutional determinant of entrepreneurship. It shows that some of the provisions contained in national constitutions are positively and significantly associated with a standard measure of entrepreneurial dynamics, namely the rate of new business density. Using for 115 countries a novel dataset containing the characteristics of the constitutions enacted in the world, applying an IV-GMM treatment to deal with the endogeneity of constitutional rules, and controlling for de facto variables, the paper finds that provisions about the right to conduct/establish a business, the right to strike, consumer protection, anti-corruption, and compulsory education promote higher rates of new firm formation. Contrasting results are instead obtained for provisions concerning protection of intellectual property rights

    Experimental repurposing of metformin for Crohn’s disease in trinitrobenzene sulfonic acid induced colitis model in BALB/c mice

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    Background: Inflammatory bowel disease (IBD) is characterized by repetitive episodes of inflammation of the gastrointestinal tract caused by an abnormal immune response to gut microflora. It includes two types: Ulcerative colitis (UC), which causes widespread colon inflammation, and Crohn’s disease (CD). The current therapy focuses on symptom relief and provides inadequate maintenance of remission and quality of life improvement. Metformin has already been repurposed in few studies with dextran sulphate sodium (DSS) induced colitis. We aimed to evaluate the effect of metformin in TNBS induced acute on chronic colitis, to mimic the relapsing-remitting nature of CD in humans, which has not been done before. Methods: Objectives were, phase I- evaluation of the effect of metformin in TNBS induced acute colitis in BALB/c mice. Phase II- evaluation of the effect of metformin in TNBS induced chronic colitis in BALB/c mice. Phase III- Evaluation of the effect of metformin in TNBS induced acute on chronic colitis in BALB/c mice. Materials And Methods: Trinitrobenzene sulfonic acid (TNBS) was used for inducing both acute, chronic and acute on chronic colitis in BALB/c mice. 36 BALB/c mice were divided into 4 groups i.e. normal control, disease control, positive control and test drug. Effect on DAI score, lower colon weight by length ratio, macroscopy and histopathology were assessed. Results: Metformin showed significant improvement (p<0.05) in all the variables assessed i.e. reduction of (Disease Activity Index) DAI score, lower colon weight by length ratio, lower colon macroscopic score and lower histopathological score in comparison to the disease control group in all the phases i.e. acute (day 5), chronic (day 22) and acute on chronic (day 25). However, the effects were comparable to the positive control. Conclusions: Metformin has potential to be repurposed for Crohn’s disease as it showed comparable efficacy in all three phases
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