Vascular complications after liver transplantation: A 5-year experience

During the past 5 years, 104 angiographic studies were performed in 87 patients (45 children and 42 adults) with 92 transplanted livers for evaluation of possible vascular complications. Seventy percent of the studies were abnormal. Hepatic artery thrombosis was the most common complication (seen in 42% of children studied, compared with only 12% of adults) and was a major complication that frequently resulted in graft failure, usually necessitating retransplantation. In six children, reconstitution of the intrahepatic arteries by collaterals was seen. Three survived without retransplant. Arterial stenosis at the anastomosis or in the donor hepatic artery was observed in 11% of patients. Portal vein thrombosis or stenosis occurred in 13% of patients. Two children and one adult with portal vein thrombosis demonstrated hepatopetal collaterals that reconstituted the intrahepatic portal vessels. Uncommon complications included anastomotic and donor hepatic artery pseudoaneurysms, a hepatic artery-dissecting aneurysm, pancreaticoduodenal mycotic aneurysms, hepatic artery-portal vein fistula, biliary-portal vein fistula, hepatic vein occlusion, and inferior vena cava thrombosis

Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria.

Mycobacteria share with other actinomycetes the ability to produce large quantities of triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known as lipid droplets (LD). Mycobacterium tuberculosis (M. tb), the etiologic agent of tuberculosis, acquires fatty acids from the human host which are utilized to synthesize TAG, subsequently stored in the form of ILI to meet the carbon and nutrient requirements of the bacterium during long periods of persistence. However, environmental factors governing mycobacterial ILI formation and degradation remain poorly understood. Herein, we demonstrated that in the absence of host cells, carbon excess and nitrogen starvation promote TAG accumulation in the form of ILI in M. smegmatis and M. abscessus, used as surrogate species of M. tb. Based on these findings, we developed a simple and reversible in vitro model to regulate ILI biosynthesis and hydrolysis in mycobacteria. We also showed that TAG formation is tgs1 dependent and that lipolytic enzymes mediate TAG breakdown. Moreover, we confirmed that the nitrogen-deprived and ILI-rich phenotype was associated with an increased tolerance towards several drugs used for treating mycobacterial infections. Importantly, we showed that the presence of ILI substantially enhanced the bacterial burden and granuloma abundance in zebrafish embryos infected with lipid-rich M. abscessus as compared to embryos infected with lipid-poor M. abscessus, suggesting that ILI are actively contributing to mycobacterial virulence and pathogenesis

Study of filamentation with a high power high repetition rate ps laser at 1.03 µm

International audienceWe study the propagation of intense, high repetition rate laser pulses of picosecond duration at 1.03 µm central wavelength through air. Evidence of filamentation is obtained from measurements of the beam profile as a function of distance, from photoemission imaging and from spatially resolved sonometric recordings. Good agreement is found with numerical simulations. Simulations reveal an important self shortening of the pulse duration, suggesting that laser pulses with few optical cycles could be obtained via double filamentation. An important lowering of the voltage required to induce guided electric discharges between charged electrodes is measured at high laser pulse repetition rate.-repetition-rate picosecond pump laser based on a Yb:YAG disk amplifier for optical parametric amplification

Two-color interferometer for the study of laser filamentation triggered electric discharges in air

International audienceWe present a space and time resolved interferometric plasma diagnostic for use on plasmas where neutral-bound electron contribution to the refractive index cannot be neglected. By recording simultaneously the plasma optical index at 532 and 1064 nm, we are able to extract independently the neutral and free electron density profiles. We report a phase resolution of 30 mrad, corresponding to a maximum resolution on the order of 4 × 10 22 m −3 for the electron density, and of 10 24 m −3 for the neutral density. The interferometer is demonstrated on centimeter-scale sparks triggered by laser filamentation in air with typical currents of a few tens of A

The Marketing Firm: Retailer and consumer contingencies

acceptedVersionpublishedVersio

Hezbollah\u27s Operations and Networks in the United States: Two Decades in Reviews

Executive Summary ● This report aims to provide a comprehensive examination of Hezbollah-affiliated activity in America by examining all publicly-known federal criminal cases from 1997 to 2020 in the United States with a concrete link to Hezbollah. The authors found evidence of 128 individuals that meet these criteria. ● The majority of cases involve small, centralized hubs of Hezbollah operatives, who engage in illegal activities in conjunction with wider criminal enterprises to create an array of networks across America. These relationships of convenience have resulted in Hezbollah operatives collaborating with financially-motivated individuals, criminals, and other non-ideological actors, in furtherance of a broader operational mission. These arrangements, in turn, have allowed Hezbollah to profit financially and deepen its influence in the United States, even as many such cases display minimal direct connective links to the terrorist organization itself. ● Based on analysis of the cases, the authors identified two distinct categories of participation in Hezbollah-affiliated activity in America: individuals who provided financial support to Hezbollah (109 individuals), and those who provided operational support (19 individuals). ○ 87% of individuals provided financial or material support to Hezbollah as money launderers, bundlers, fraudsters, and goods smugglers, with many raising funds from others to be provided to Hezbollah or directly providing funds to the group themselves. This finding supports existing assessments that Hezbollah’s primary aspirations in the United States are to use it as a financial support hub. ○ 13% of individuals in the dataset engaged in operational conduct in support of Hezbollah, including as human smugglers, weapons procurers, pre-operational surveillance, and travelers who sought to join the group. Despite the prominence of Hezbollah’s financing activities in the United States, elements within Hezbollah remain intent on developing the capacity and capability to plot attacks on U.S. soil. ● The vast majority (92%) of cases involved network activities between two or more individuals. Larger geographic hubs operated out of Michigan (55 cases), California (19 cases), North Carolina (16 cases), and New York (15 cases). 90% of individuals operating in these four states and 76% of all cases in this dataset were a part of just six networks. ○ Large parts of network activity involved individuals with limited evidence to suggest a direct link to Hezbollah. As discussed above, these individuals actively collaborated with persons with an evidenced connection to the terrorist organization, and in many cases appear to be driven primarily by financial rather than ideological motivations. This in and of itself is a manifestation of Hezbollah’s activities in the United States, which sought to use local criminal actors in furtherance of their illegal activities. Further, in several significant instances, network activity often involved friends or family members engaged in organized conspiracies. ● 84% of individuals were convicted and sentenced to an average of 49.6 months in prison. Notably, only 19 of the 128 individuals (14%) were charged with providing material support to Hezbollah, while the others were charged with non-terrorism related offenses. Individuals sentenced on terrorism material support charges received an average sentence length of 85.6 months, almost twice as long as the average sentence for individuals not sentenced on material support charges. ● Hezbollah-affiliated individuals were primarily male (83%) and tended to be older (average age: 37) than members of other designated foreign terrorist organizations in the US, in particular the Islamic State (average age: 28)

Gluon mass generation in the PT-BFM scheme

In this article we study the general structure and special properties of the Schwinger-Dyson equation for the gluon propagator constructed with the pinch technique, together with the question of how to obtain infrared finite solutions, associated with the generation of an effective gluon mass. Exploiting the known all-order correspondence between the pinch technique and the background field method, we demonstrate that, contrary to the standard formulation, the non-perturbative gluon self-energy is transverse order-by-order in the dressed loop expansion, and separately for gluonic and ghost contributions. We next present a comprehensive review of several subtle issues relevant to the search of infrared finite solutions, paying particular attention to the role of the seagull graph in enforcing transversality, the necessity of introducing massless poles in the three-gluon vertex, and the incorporation of the correct renormalization group properties. In addition, we present a method for regulating the seagull-type contributions based on dimensional regularization; its applicability depends crucially on the asymptotic behavior of the solutions in the deep ultraviolet, and in particular on the anomalous dimension of the dynamically generated gluon mass. A linearized version of the truncated Schwinger-Dyson equation is derived, using a vertex that satisfies the required Ward identity and contains massless poles belonging to different Lorentz structures. The resulting integral equation is then solved numerically, the infrared and ultraviolet properties of the obtained solutions are examined in detail, and the allowed range for the effective gluon mass is determined. Various open questions and possible connections with different approaches in the literature are discussed.Comment: 54 pages, 24 figure

A Candidate M31/M32 Intergalactic Microlensing Event

We report the discovery of a microlensing candidate projected 2'54" from the center of M32, on the side closest to M31. The blue color (R-I= 0.00 +/- 0.14) of the source argues strongly that it lies in the disk of M31, while the proximity of the line of sight to M32 implies that this galaxy is the most likely host of the lens. If this interpretation is correct, it would confirm previous arguments that M32 lies in front of M31. We estimate that of order one such event or less should be present in the POINT-AGAPE data base. If more events are discovered in this direction in a dedicated experiment, they could be used to measure the mass function of M32 up to an unknown scale factor. By combining microlensing observations of a binary-lens event with a measurement of the M31-M32 relative proper motion using the astrometric satellites SIM or GAIA, it will be possible to measure the physical separation of M31 and M32, the last of the six phase-space coordinates needed to assign M32 an orbit.Comment: Submitted to ApJ Letters. 13 pages, 2 figure