749 research outputs found
Sistem Pendukung Keputusan Penilaian Kinerja Guru di SDN Mohammad Toha Menggunakan Metode Analytical Hierarchy Process (AHP)
Penilaian kinerja guru merupakan proses analisis dalam rangka menghasilkan pengajaran yang baik. Proses penilaian terhadap kinerja guru di SD Negeri Mohammad Toha belum begitu detail (rinci), dan masih manual. Dengan penilaian yang tidak rinci tersebut, dikhawatirkan akan adanya penilaian yang bersifat subjektif (berdasarkan kepentingan pribadi), yang dapat menimbulkan kecemburuan sosial bagi guru yang tidak menerima prestasi. Untuk mengatasi permasalahan tersebut maka dirancangsebuah sistem pendukung keputusan menggunakan Metode Analythical Hierarchy Process(AHP). Adapun dalam penelitian ini menggunakan 14 kriteria . Dalam penelitian ini alat bantu pembuatan aplikasinya menggunakan bahasa pemrograman PHP, sedangkan basisdata nya menggunakan MySQL. Hasil akhir dari penelitian ini didapatkan bahwa sistem pendukung keputusan dengan metode AHP mampu mengatasi permasalahan dalam melakukan penilaian kinerja guru di SD Negeri Mohammad Toha
Kualitas Beberapa Telur Bermerek Khusus Dibandingkan Dengan Telur Ayam Ras Dan Buras
Quality of Branded Eggs as Compared to Layer and Domestic Chicken Eggs.Many branded eggs found in the market claimed as low in cholesterol (Low Cholesterol Egg, Golden Egg), or claimed as high in omega-3 fatty acid content (Omega-3 Egg), besides common domestic and layer chicken eggs. This brand trend attracted the consumer to buy. Nonetheless, there is a need to evaluate further on the quality they claimed besides the physical quality. The evaluation was done regarded of those 5 types of eggs on their outer measurements (shape abnormalities, size indexes, shell thickness); and inner measurements (Haugh Units, yolk color score). The results indicated that all egg types had normal appearance with size indexes of 1.24-1.38. The Haugh Units was arround 28.7-67.3 and yolk color score was arround 5.0-13.3. Based on those results, the zerro week marketed eggs (Group I) clasified as A quality and the one week marketed eggs (Group II) were B quality. The data on chemical analyses indicated that the omega-3 fatty acid content was significantly the highest (p<0.05) in Omega-3 egg, while the cholesterol content was \u27similar in all types of eggs. The easiest way to judge the quality are from the shape and size of the eggs. Those have to be in normal shape and uniform size. While the claimed on low cholesterol content is not proven
Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis
Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Methods: Torn supraspinatus tendon (established pathology) and matched intact subscapularis tendon (representing ‘early pathology’) biopsies were collected from patients undergoing arthroscopic shoulder surgery. Control samples of subscapularis tendon were collected from patients undergoing arthroscopic stabilisation surgery. Markers of inflammation and HMGB1 were quantified by reverse transcriptase PCR (RT-PCR) and immunohistochemistry. Human tendon-derived primary cells were derived from hamstring tendon tissue obtained during hamstring tendon anterior cruciate ligament reconstruction and used through passage 3. In vitro effects of recombinant HMGB1 on tenocyte matrix and inflammatory potential were measured using quantitative RT-PCR, ELISA and immunohistochemistry staining.
Results: Tendinopathic tissues demonstrated significantly increased levels of the danger molecule HMGB1 compared with control tissues with early tendinopathy tissue showing the greatest expression. The addition of recombinant human HMGB1 to tenocytes led to significant increase in expression of a number of inflammatory mediators, including interleukin 1 beta (IL-1β), IL-6, IL-33, CCL2 and CXCL12, in vitro. Further analysis demonstrated rhHMGB1 treatment resulted in increased expression of genes involved in matrix remodelling. Significant increases were observed in Col3, Tenascin-C and Decorin. Moreover, blocking HMGB1 signalling via toll-like receptor 4 (TLR4) silencing reversed these key inflammatory and matrix changes.
Conclusion: HMGB1 is present in human tendinopathy and can regulate inflammatory cytokines and matrix changes. We propose HMGB1 as a mediator driving the inflammatory/matrix crosstalk and manipulation of the HMGB1/TLR4 axis may offer novel therapeutic approaches targeting inflammatory mechanisms in the management of human tendon disorders
Genetic Classification of Populations using Supervised Learning
There are many instances in genetics in which we wish to determine whether
two candidate populations are distinguishable on the basis of their genetic
structure. Examples include populations which are geographically separated,
case--control studies and quality control (when participants in a study have
been genotyped at different laboratories). This latter application is of
particular importance in the era of large scale genome wide association
studies, when collections of individuals genotyped at different locations are
being merged to provide increased power. The traditional method for detecting
structure within a population is some form of exploratory technique such as
principal components analysis. Such methods, which do not utilise our prior
knowledge of the membership of the candidate populations. are termed
\emph{unsupervised}. Supervised methods, on the other hand are able to utilise
this prior knowledge when it is available.
In this paper we demonstrate that in such cases modern supervised approaches
are a more appropriate tool for detecting genetic differences between
populations. We apply two such methods, (neural networks and support vector
machines) to the classification of three populations (two from Scotland and one
from Bulgaria). The sensitivity exhibited by both these methods is considerably
higher than that attained by principal components analysis and in fact
comfortably exceeds a recently conjectured theoretical limit on the sensitivity
of unsupervised methods. In particular, our methods can distinguish between the
two Scottish populations, where principal components analysis cannot. We
suggest, on the basis of our results that a supervised learning approach should
be the method of choice when classifying individuals into pre-defined
populations, particularly in quality control for large scale genome wide
association studies.Comment: Accepted PLOS On
The Tuber Extract and Flour of Dioscorea Alatanormalize the Blood Lipid Profile of Rabbits Treated with High Cholesterol Diets
Background: Dioscorea alata(DA) tuber has potential to prevent the condition of hyperlipidemia due to the bioactive compound, such as anthocyanins, diosgenin, and dietary fiber that beneficial in normalizing blood lipid profiles. In this research, the effect of water extract and flour of DA tuber administration was examined on rabbits treated with high cholesterol diets.Methods:DA tuber extract and flour were administrated to the rabbits for 60 days using completely randomised design. The ration treatment are as follows: 1) Basal ration as negative control (K0), 2) Basal ration + 0.5% cholesterol, as positive control (K1), 3) Basal ration + 0.5% cholesterol + DA extract 1.8 g/100 g (KE1), 4) Basal ration + cholesterol 0.5% + DA extract 3.6 g/100 g (KE2), 5) Basal ration with 15% DA flour + 0.5% cholesterol (KT1) and 6) Basal ration with 30% DA flour + 0.5% cholesterol (KT2). The Total cholesterol, HDL, LDL cholesterol in serum were analysed at baseline, days 28, days 56 and at the end of study.Results:The administration of high cholesterol (1%) ration increased blood lipid levels by 16 fold compared to that of control. The administration of 15% and 30% of DA flour could maintain blood lipid profile to normal condition, in particular at 30% substitution DA flour. However the water extract of DA can not maintain a normal blood lipids of high cholesterol treated rabbitsConclusion: Dioscorea alata flour has suggested to have anti-hyperlipidemia effect. (Health Science Indones 2014;1:23-9
Trajectories of university adjustment in the United Kingdom: Emotion management and emotional self-efficacy protect against initial poor adjustment
Little is known about individual differences in the pattern of university adjustment. This study explored longitudinal associations between emotional self-efficacy, emotion management, university adjustment, and academic achievement in a sample of first year undergraduates in the United Kingdom (N=331). Students completed measures of adjustment to university at three points during their first year at university. Latent Growth Mixture Modeling identified four trajectories of adjustment: (1) low, stable adjustment, (2) medium, stable adjustment, (3) high, stable adjustment, and (4) low, increasing adjustment. Membership of the low, stable adjustment group was predicted by low emotional self-efficacy and low emotion management scores, measured at entry into university. This group also had increased odds of poor academic achievement, even when grade at entry to university was controlled. Students who increased in adjustment had high levels of emotion management and emotional self-efficacy, which helped adaptation. These findings have implications for intervention
Spirometry reference equations for central European populations from school age to old age.
Spirometry reference values are important for the interpretation of spirometry results. Reference values should be updated regularly, derived from a population as similar to the population for which they are to be used and span across all ages. Such spirometry reference equations are currently lacking for central European populations. To develop spirometry reference equations for central European populations between 8 and 90 years of age. We used data collected between January 1993 and December 2010 from a central European population. The data was modelled using "Generalized Additive Models for Location, Scale and Shape" (GAMLSS). The spirometry reference equations were derived from 118'891 individuals consisting of 60'624 (51%) females and 58'267 (49%) males. Altogether, there were 18'211 (15.3%) children under the age of 18 years. We developed spirometry reference equations for a central European population between 8 and 90 years of age that can be implemented in a wide range of clinical settings
Famine: Lessons Learned
Famine: Lessons Learned was produced as the world was responding to four potential famines simultaneously – in Nigeria, South Sudan, Yemen and Somalia. Much has been written and researched on famine, and many lessons on how to best prevent and respond to famine have been learned the hard way. This paper therefore draws on lessons learned from the last 30-plus years of famine crises and response, going back to famines in Ethiopia and Sudan in the 1980s, up to the most recent famine in Somalia in 2011
Effect of deformation on components of internal stress tensor in grains of FCC-polycristal
Study of contributions of internal stress tensor components in deformed of austenitic steel was carriedout. The tensor components of internal stresses were determined with using bending extinction contours observing on electron microscope images of the steel
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